"Patients with certain connective tissue diseases may have an increased risk of severe allergic reactions to collagen injections. These connective tissue diseases include, but are not limited to, rheumatoid arthritis, scleroderma, and juvenile rheumatoid arthritis. They also include polymyositis and dermatomyositis (PM/DM), which are chronic, progressive, and sometimes fatal inflammatory disorders.

"Thus, collagen injections should be used with caution in people who have had these diseases. Some experts recommend that people who have had these diseases should either not be given collagen injections at all or should be given multiple skin tests before treatment.

"Scleroderma Lips Deep lines around the lips worry many scleroderma sufferers but unfortunately collagen injections and laser treatment are not advisable as they may cause scarring. Tightening of the skin of the face may lead to microstomia - a small mouth. Facial and mouth exercises may help. "Disappearing lips" can be a very upsetting cosmetic problem and a reputable plastic surgeon may be able to perform an operation called a mucosal advancement. Royal Free Hospital (Also see Dental Involvement)"

I'm not aware that Restylane has been tested/approved for use with scleroderma, though.

"The safety of Restylane in patients with increased susceptibility to keloid formation and hypertrophic scarring has not been studied. Restylane should not be used in patients with known susceptibility to keloid formation or hypertrophic scarring."

Scarring can be quite an issue with scleroderma patients, so it would be advisable for everyone to consult a scleroderma expert before attempting any sort of correction.

Sometimes, distraction is the best treatment of all. For example, if you wear a purple hat with a large green feather, people will certainly notice and remember the hat or the feather, before noticing or remembering any other feature.