Form 8.3 - Shire - Amendment

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY A PERSON
WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the “Code”)

1.KEY INFORMATION

(a)

Full name of discloser:

Barclays PLC.

(b)

Owner or controller of interest and short

positions disclosed, if different from 1(a):

(c)

Name of offeror/offeree in relation to whose

SHIRE PLC

relevant securities this form relates:

(d)

If an exempt fund manager connected with an

offeror/offeree, state this and specify identity of

offeror/offeree:

(e)

Date position held/dealing undertaken:

03 July 2018

(f)

In addition to the company in 1(c) above, is the discloser making

YES:

disclosures in respect of any other party to the offer?

TAKEDA PHARMACEUTICAL CO LTD

2.POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more
than one class of relevant securities of the offeror or offeree named in
1(c), copy table 2(a) or (b) (as appropriate) for each additional class
of relevant security.

(a)Interests and short positions in the relevant securities
of the offeror or offeree to which the disclosure relates following the
dealing (if any)

Class of relevant security:

5p ordinary

Interests

Short Positions

Number

(%)

Number

(%)

(1)

Relevant securities owned

and/or controlled:

9,147,908

1.00%

4,457,685

0.49%

(2)

Cash-settled derivatives:

434,873

0.05%

4,954,278

0.54%

(3)

Stock-settled derivatives (including options)

and agreements to purchase/sell:

239,300

0.03%

263,800

0.03%

(4)

TOTAL:

9,822,081

1.08%

9,675,763

1.06%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including
traded options), or agreements to purchase or sell relevant securities,
should be given on a Supplemental Form 8 (Open Positions).

(b)Rights to subscribe for new securities (including
directors’ and other employee options)

Class of relevant security in relation to which subscription
right exists:

Details, including nature of the rights concerned and relevant
percentages:

3.DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant
securities of the offeror or offeree named in 1(c), copy table 3(a),
(b), (c) or (d) (as appropriate) for each additional class of relevant
security dealt in.

The currency of all prices and other monetary amounts should be
stated.

(a)Purchases and sales

Class of relevant

Purchase/sale

Number of

Price per unit

security

securities

ADR

Purchase

5

168.1800 USD

5p ordinary

Purchase

22

42.4025 GBP

ADR

Purchase

30

168.0500 USD

5p ordinary

Purchase

35

42.5000 GBP

5p ordinary

Purchase

73

42.4625 GBP

5p ordinary

Purchase

74

42.4450 GBP

5p ordinary

Purchase

89

42.4250 GBP

5p ordinary

Purchase

90

42.4850 GBP

ADR

Purchase

100

168.0400 USD

ADR

Purchase

100

167.8100 USD

ADR

Purchase

100

168.4100 USD

ADR

Purchase

200

168.8500 USD

ADR

Purchase

210

168.5309 USD

ADR

Purchase

300

168.2000 USD

5p ordinary

Purchase

300

42.5326 GBP

5p ordinary

Purchase

383

42.5770 GBP

ADR

Purchase

400

168.4375 USD

ADR

Purchase

400

168.3756 USD

5p ordinary

Purchase

448

42.4494 GBP

5p ordinary

Purchase

500

42.4092 GBP

ADR

Purchase

500

168.6400 USD

5p ordinary

Purchase

665

42.6600 GBP

5p ordinary

Purchase

684

42.3611 GBP

ADR

Purchase

702

168.1873 USD

5p ordinary

Purchase

854

42.7240 GBP

ADR

Purchase

1,100

168.3609 USD

5p ordinary

Purchase

1,271

42.5305 GBP

ADR

Purchase

1,484

168.0300 USD

5p ordinary

Purchase

1,524

42.3403 GBP

5p ordinary

Purchase

1,621

42.4296 GBP

ADR

Purchase

2,500

168.2513 USD

5p ordinary

Purchase

2,709

42.6996 GBP

ADR

Purchase

2,800

168.2637 USD

5p ordinary

Purchase

3,106

42.4766 GBP

5p ordinary

Purchase

3,343

42.4004 GBP

5p ordinary

Purchase

5,140

42.5750 GBP

5p ordinary

Purchase

5,730

42.4733 GBP

ADR

Purchase

6,332

168.4534 USD

5p ordinary

Purchase

9,077

42.4291 GBP

5p ordinary

Purchase

12,381

42.4552 GBP

5p ordinary

Purchase

14,426

42.5985 GBP

5p ordinary

Purchase

14,846

42.6000 GBP

ADR

Purchase

19,625

168.6154 USD

5p ordinary

Purchase

65,318

42.5603 GBP

5p ordinary

Purchase

71,128

42.4577 GBP

5p ordinary

Purchase

264,567

42.4820 GBP

ADR

Sale

5

168.1800 USD

ADR

Sale

21

168.7000 USD

5p ordinary

Sale

22

42.4025 GBP

ADR

Sale

30

168.0500 USD

5p ordinary

Sale

73

42.4625 GBP

5p ordinary

Sale

74

42.4450 GBP

5p ordinary

Sale

89

42.4250 GBP

5p ordinary

Sale

90

42.4850 GBP

5p ordinary

Sale

98

42.6600 GBP

ADR

Sale

100

167.7500 USD

ADR

Sale

100

168.4000 USD

ADR

Sale

100

168.4400 USD

ADR

Sale

100

168.5043 USD

ADR

Sale

100

168.6000 USD

ADR

Sale

100

168.9800 USD

ADR

Sale

100

169.1000 USD

5p ordinary

Sale

118

42.4160 GBP

5p ordinary

Sale

177

42.6994 GBP

ADR

Sale

200

167.7400 USD

ADR

Sale

229

168.0400 USD

ADR

Sale

252

168.2883 USD

ADR

Sale

300

168.3700 USD

ADR

Sale

300

168.3675 USD

ADR

Sale

310

167.8012 USD

ADR

Sale

400

168.8150 USD

ADR

Sale

500

168.4600 USD

ADR

Sale

500

168.0620 USD

5p ordinary

Sale

556

42.6036 GBP

5p ordinary

Sale

571

42.6630 GBP

ADR

Sale

660

168.6400 USD

ADR

Sale

800

168.5306 USD

ADR

Sale

1,000

168.7100 USD

5p ordinary

Sale

1,189

42.5070 GBP

ADR

Sale

1,484

168.0300 USD

ADR

Sale

1,700

168.1198 USD

5p ordinary

Sale

1,853

42.5484 GBP

ADR

Sale

2,201

168.5612 USD

ADR

Sale

2,400

168.1718 USD

5p ordinary

Sale

3,310

42.6417 GBP

ADR

Sale

4,442

168.6871 USD

5p ordinary

Sale

5,146

42.4265 GBP

ADR

Sale

5,531

168.3722 USD

5p ordinary

Sale

5,592

42.4722 GBP

5p ordinary

Sale

10,950

42.4708 GBP

5p ordinary

Sale

12,381

42.4552 GBP

ADR

Sale

13,423

168.6315 USD

5p ordinary

Sale

16,538

42.5705 GBP

5p ordinary

Sale

28,398

42.6000 GBP

5p ordinary

Sale

31,580

42.5546 GBP

5p ordinary

Sale

37,472

42.6039 GBP

5p ordinary

Sale

51,101

42.4387 GBP

5p ordinary

Sale

91,139

42.5615 GBP

5p ordinary

Sale

182,885

42.4310 GBP

(b)Cash-settled derivative transactions

Class of

Product

Nature of dealing

Number of

Price per

relevant

description

reference

unit

security

securities

5p ordinary

CFD

Long

118

42.4161 GBP

5p ordinary

SWAP

Long

420

42.5035 GBP

5p ordinary

CFD

Long

709

42.6429 GBP

5p ordinary

SWAP

Long

2,306

42.5435 GBP

5p ordinary

CFD

Long

3,310

42.6417 GBP

5p ordinary

SWAP

Long

17,320

42.3971 GBP

5p ordinary

SWAP

Long

35,340

42.5761 GBP

5p ordinary

CFD

Long

37,472

42.6039 GBP

5p ordinary

SWAP

Long

41,556

42.6000 GBP

5p ordinary

SWAP

Short

100

42.6043 GBP

5p ordinary

SWAP

Short

300

42.5326 GBP

5p ordinary

SWAP

Short

436

42.4503 GBP

5p ordinary

SWAP

Short

752

42.5153 GBP

5p ordinary

SWAP

Short

927

42.4842 GBP

5p ordinary

CFD

Short

1,271

42.5305 GBP

5p ordinary

CFD

Short

1,524

42.3403 GBP

5p ordinary

CFD

Short

2,587

42.6618 GBP

5p ordinary

CFD

Short

2,709

42.6996 GBP

5p ordinary

CFD

Short

3,343

42.4004 GBP

5p ordinary

SWAP

Short

7,700

42.6004 GBP

5p ordinary

SWAP

Short

20,736

42.4889 GBP

5p ordinary

SWAP

Short

42,371

42.5485 GBP

5p ordinary

CFD

Short

47,826

42.6038 GBP

(c)Stock-settled derivative transactions (including options)

(i)Writing, selling, purchasing or varying

Class

Product

Writing,

Number

Exercise

Type

Expiry

Option

of

description

purchasing,

of

price

date

money

relevant

selling,

securities

per unit

paid/

security

varying etc

to which

received

option

per unit

relates

ADR

Put Options

Selling

1,000

115 USD

American

20 Jul 2018

0.1000 USD

(ii)Exercise

Class of relevant security

Product description

e.g. call option

Exercising/ exercised against

Number of securities

Exercise price per unit

(d)Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

4.OTHER INFORMATION

(a)Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement
or understanding, formal or informal, relating to relevant
securities which may be an inducement to deal or refrain from
dealing entered into by the person making the disclosure and any
party to the offer or any person acting in concert with a party to
the offer:

Irrevocable commitments and letters of intent should not be
included. If there are no such agreements, arrangements or
understandings, state “none”

(b)Agreements, arrangements or understandings relating to
options or derivatives

Details of any agreement, arrangement or understanding, formal or
informal, between the person making the disclosure and any other
person relating to:

(i) the voting rights of any relevant securities under any
option; or

(ii) the voting rights or future acquisition or disposal of any
relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or
understandings, state “none”

(c)Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

5 Jul 2018

Contact name:

Femi Badmos

Telephone number:

020 3555 1125

Public disclosures under Rule 8 of the Code must be made to a
Regulatory Information Service.

The Panel’s Market Surveillance Unit is available for consultation in
relation to the Code’s disclosure requirements on +44 (0)20 7638 0129.