Broadening the Vaccines Portfolio

At Pfizer, we believe in the promise and value of vaccines to improve people's lives. Leveraging leading technology in vaccine design and
conjugation, we are pursuing preventative solutions to complex, difficult-to-treat bacterial pathogens — across the lifespan. We are also
exploring the power of novel therapeutic vaccines to treat chronic conditions, and diseases such as cancer.

We're working on bringing our vaccines to more people everywhere they are needed. When I envision our world in 2030, I imagine
one in which everyone — no matter where they're born — has access to vaccines that help prevent illnesses and save lives.

– Susan SilbermannPresident, Pfizer Vaccines

Taking on Meningococcal Meningitis

Trumenba® is the first vaccine approved in the United States to protect against meningococcal meningitis serogroup B,
and we are in the process of filing with regulatory authorities in other countries around the world.

Building Out Our Meningitis Vaccines Portfolio

During 2015, we acquired from GlaxoSmithKline two quadrivalent (ACWY) meningitis vaccines, Nimenrix® (meningococcal serogroups A, C, W-135 and Y conjugate vaccine)
and Mencevax® (meningococcal polysaccharide serogroups A, C, Y and W-135 vaccine), currently marketed in a number of countries
outside the U.S. In 2014, we acquired NeisVac-C® (meningococcal group C-TT conjugate vaccine, adsorbed) from Baxter, a vaccine
for protection against serogroup C meningococcal disease, marketed primarily in Europe. With the addition of these complementary vaccines, we
have created a comprehensive portfolio that is focused on helping to prevent meningococcal disease and for controlling outbreaks.

Trumenba® Supplied in Campus Outbreaks

In Trumenba's first year of availability, we have already helped respond to outbreaks of serogroup B meningococcal meningitis at colleges
and universities within the U.S. Following a public announcement by the Rhode Island State Department of Health that two students at Providence
College contracted the disease, Pfizer worked with the college's officials to supply the vaccine for the on-campus vaccination clinic. We delivered
the doses in less than a day and supported more than fifty health care providers who administered them. At the University of Oregon, when four
students were confirmed to have contracted the disease, it took us only one day to put together a unique partnership with two local pharmacy
chains to ultimately supply mass vaccination events targeting more than 22,000 students.

Pfizer colleagues jumped in at a moment's notice to respond to these urgent public health situations. Thanks to the team's
focused actions, we helped to protect thousands of students from this rare but devastating disease.

– John SchuttaPediatric and Adolescent Lead, U.S. Vaccines

4,000Doses

were delivered to Providence College in less than 24 hours.

22,000

Students

Pfizer responded quickly to supply mass vaccination events targeting more than 22,000 students at the University of Oregon.

Prevnar 13® Reaching Across the Lifespan

Our Prevnar franchise (known as Prevenar outside the U.S.) continues to expand. We recently manufactured
our billionth dose. And with Prevnar 13® (pneumococcal 13-valent conjugate vaccine [diphtheria
CRM197 Protein]) we are reaching more people, at more stages of life,
around the world.

In 2014, the U.S. Centers for Disease Control and Prevention recommended Prevnar 13 for routine use to help protect adults age 65 and over
against pneumococcal disease. Additional adult recommendations are under consideration by health authorities in countries around the world.
We continue to work in close collaboration with global partners, such as the International Federation on Ageing, to raise awareness of the
importance of adult vaccination.

Global Efforts to Reach People

We have pledged to supply up to 740 million doses of Prevenar 13® (pneumococcal polysaccharide conjugate vaccine, 13-valent, adsorbed) through 2025 to infants and young children throughout the developing world
at a non-commercial price, through Gavi, the Vaccine Alliance.

Multi-Dose Vial for Prevenar 13®

To help address the practical constraints experienced by health workers operating in many Gavi countries, Pfizer has developed
Prevenar 13® in a multi-dose vial (MDV) presentation and added the preservative 2 phenoxy ethanol to reduce vaccine wastage. The MDV presentation
will contain four doses of Prevenar 13, and will be the same size as the current single dose vial. This will result in a smaller environmental
footprint with a 75 percent reduction in cold chain and shipping material requirements. The dossier for the new MDV presentation is subject
to approval by the European Medicines Agency and WHO prequalification. Pfizer's ongoing investments to ensure high quality vaccines in adequate
and reliable supply, as well as the first preserved PCV multi-dose vial presentation, will help ensure more children have access in communities whose health care systems are still developing.

Investigational Vaccines Advancing in Pipeline

We have two prophylactic vaccines for hospital-acquired infections in Phase 2 trials, one to help prevent Clostridium difficile
(C. difficile) disease and one to help prevent Staphylococcus aureus (S. aureus) infections. Both of these investigational vaccines have
been granted Fast Track status by the U.S. Food and Drug Administration.

C. difficile is a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. Pfizer is currently
investigating a vaccine that targets the two main disease-causing toxins produced by C. difficile (Toxin A & B) and initiated a Phase 2
clinical trial to investigate the safety, immunogenicity and tolerability of Pfizer's C. difficile vaccine in healthy older adults.

S. aureus infections persist as a major cause of life-threatening hospital-acquired infections. To date, there is no licensed vaccine
available to prevent invasive S. aureus disease. Our new investigational, multiantigen S. aureus vaccine is uniquely designed to help prevent
a wide range of clinical disease manifestations by potentially facilitating pathogen killing at early stages of invasive infection.

The development of the C. difficile and S. aureus vaccines has real potential to reduce the suffering and mortality
associated with bacterial infections contracted in health care settings. If successful, these vaccines would provide additional tools to positively
impact human health.

– William Gruber, M.D.Senior Vice President, Vaccine Clinical Research and Development

Selected Vaccine Candidates in Clinical Development

11,000

According to the U.S. Centers for Disease Control and Prevention, S. aureus results in nearly 700,000 hospitalizations and 11,000 deaths annually.

Maternal Vaccination

To deliver on our promise to bring immunizations to people across all stages of life, we are exploring the development of
maternal vaccination candidates to protect newborns from dangerous infections such as Group B streptococcus, respiratory syncytial
virus, and cytomegalovirus (CMV), a herpes virus. Our acquisition of Redvax GmbH, a spin-off from Redbiotec AG, a privately held
Swiss biopharmaceutical company, provides access to a preclinical human cytomegalovirus vaccine candidate, as well as intellectual
property and a technology platform related to another vaccine program. The CMV vaccine program will complement our robust research
portfolio of investigational vaccines and help place Pfizer among the leaders in CMV research and development.

The Institute of Medicine has ranked the development of a CMV vaccine as the highest priority because of the lives it would save
and the disabilities it would prevent. A large segment of young adults, especially women of childbearing age who remain CMV negative,
are at high risk of CMV infection during pregnancy and of passing the infection on to the unborn child (congenital infection). There
are potentially serious and lifelong consequences for babies born with the disease. More children have disabilities due to congenital
CMV than other well-known infections and syndromes, including Down syndrome, fetal alcohol syndrome, spina bifida and pediatric HIV/AIDS.

We are dedicated to developing innovative vaccines that help prevent and treat serious diseases. Through the acquisition
of Redvax, we obtained an innovative CMV vaccine platform and expertise to develop a vaccine to prevent a difficult disease that can
have a devastating and lifelong impact on young children.

– Kathrin U. Jansen, Ph.D.Senior Vice President, Head of Vaccine Research Development

I'm Working On...

Kena Swanson

Senior Principal Scientist, Vaccine Research and Development

Watch Video

I'm Working On...

Kena Swanson

Senior Principal Scientist, Vaccine Research and Development

Watch Video

~5,000

Children

each year in the U.S. develop lasting health problems caused by CMV, such as hearing or vision loss, and severe neurologic disorders.

2B Babies

will be born between now and 2030 worldwide.

Infographic

The Value of Vaccines

Infographic

The Impact of Vaccines on Infectious Disease Morbidity in the United States, Pre-vaccines – 2014