Suzuki was appointed Prime Minister following the sudden death of Masayoshi Ōhira, who died of a heart attack during a general election campaign. The sympathy vote generated by Ohira's death resulted in a landslide for the ruling LDP, handing Suzuki the largest parliamentary majority any Prime Minister had enjoyed for many years. He chose not to run for reelection to the presidency of the LDP in 1982, and was succeeded by Yasuhiro Nakasone.

He served during a period of instability; cabinet members frequently changed, and parties were often split by fractional politics. His diplomatic skills allowed him to chair his party's executive council ten times, winning him support in his early career. Despite his foreign policy gaffes as prime minister, he later helped further foreign relations with the United States, during a 1988 summit with Ronald Reagan.