This symposium in Amsterdam will be dedicated to some general developments in modern Medicinal Chemistry. The symposium is organised to celebrate the fact that on June 17 this year it will be the 100th anniversary of Wijbe Nauta's birthday, the founder of our department at the VU University Amsterdam. Professor Nauta has been instrumental to introduce Medicinal Chemistry as an independent branch of chemistry in The Netherlands and subsequently in Europe. His special contributions to Medicinal Chemistry concern especially the classical antihistamines. He was an advocate of the idea that Medicinal Chemistry can only flourish when it is executed in what he called an integrated way. As an eye-catching result of this approach in the sixties he suggested that "receptors" could be "proteins in a helix shape". Most likely his paper (1968) in which he proposed this, has been the first in which a receptor was presented as such, complete with an imaginative drawing.