Six years after the events of The X-Files series finale, former FBI agent Doctor Dana Scully is now a staff physician at Our Lady of Sorrows, a Catholic hospital, and treating a boy named Christian who has Sandhoff disease, a terminal brain condition.

When Bella Swan moves to a small town in the Pacific Northwest to live with her father, she starts school and meets the reclusive Edward Cullen, a mysterious classmate who reveals himself to be a 108-year-old vampire.