I've been looking for the same answer for a few days. Whew, it's disturbing... I almost thought I would have to return this device. I did find one answer that was fruitful for myself. I'm hooked into a home pc with several connections for usb; somewhere around 10. You'd think one of them would work properly. I guess they do, but... anyway, I had the Audiobox iTwo plugged into the usb connections on the front port of the pc case... they are supposedly both 3.0 and 2.0 compliant... yeh, whatever.. I found the manual to my motherboard and found out exactly what usb was what... I have 2 dedicated to 2.0 on the back. Plugged it in and was very tickled that I heard nothing but crisp and clean sound. I was getting a static noise before. I even noticed static while not recording and just speaking through the mic. ... sounded exactly like playing an old record. The sound the needle makes ... anyway, hope this helps someone... I changed every setting I could possibly change in Studio One and Sonar X3 before finally simply changing placement of the usb cable. Like I said, nothing but crisp clean sound....

Its your CELL PHONE!!!!! I tried everything and put my phone close to my microphone and it got stronger. TURN OFF YOUR PHONES!!!! I know its inconvenient but one less distraction while making music. TRY IT!! IT WORKED!!

Check your USB cable I used my old USB cable that worked for my Old audio card and got NOISE total not useable..switched to the Cable that come with the Audio Box 96 and worked Straight away !?!!? first time ever a changing a cable fixed the issue on a computer !?! but Had to post for others that may run into the same issue

"Its your CELL PHONE!!!!! I tried everything and put my phone close to my microphone and it got stronger. TURN OFF YOUR PHONES!!!! I know its inconvenient but one less distraction while making music. TRY IT!! IT WORKED!!"

helped my problem!! I tried numerous things that this thread recommended and have a furman m-8Dx but nothing seemed to help. I put my cellphone in the next room and the noise immediately decreased. I even bought two Himalayan salt lamps that are good for helping to block radiation and placed them on each side of my interface. the static decreased even more afterward and is now basically 100% gone.

The issue I have encountered is similar to the original poster's issue. In addition, I have interference when I move my mouse in any application as well as with the DAW I'm working in. With any click or movement of the mouse, the interference sound was amplified through the Audiobox headphone output.

A powered USB 2.0 hub solved it for me. Apparently it wasn't getting enough power, which makes sense. That has been the issue with other USB powered devices I've had problems with in the past (external hard drives, etc.) I tried two different models. One of them didn't solve the issue, but one did (this is not a plug for Macally, only my own findings). I've read elsewhere that the ports must be 2.0 compatible, which is why I opted for 2.0 models.