Abstract:The UNAIDS Fast-Track approach to end AIDS epidemic by 2020, assumes 90% of people living with HIV know their status, 90% of them are accessing treatment and 90% of those receiving treatment have suppressed viral loads (90-90-90).However, there are no specific targets for people living with HIV who have already met these criteria. Therefore, adding the fourth „90” is being proposed: to ensure that 90% of people with virally suppressed will present a good health related quality of life. Hundreds oftools have been developed recently to assess the health-related quality of life (HRQoL), giving the opportunity to choose the disease-specific instrument. The PROs (Patient related outcomes) are gaining an importance covering a whole range of potential measurements based on general and specific questionnaires.Their application in everyday practice translates into improvement of the quality of healthcare, improves communication between the physician and the patient, helps to adapt treatment plansto meet the patient’s preferences and needs. The purpose of this article is to explain the concepts related to quality of life, review the available, most commonly used HRQoLtools in people living with HIV, and provide evidence for the utility of PROs in everyday clinical practice.

Key words: Quality of Life, people living with HIV, EQ5-D, PRO, fourth 90

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