A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans.

@article{Petrascheck2009AHS,
title={A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans.},
author={Michael Petrascheck and Xiaolan Ye and Linda B. Buck},
journal={Annals of the New York Academy of Sciences},
year={2009},
volume={1170},
pages={698-701}
}

One long-term goal of aging research is to find drugs that can delay aging and the onset of age-associated diseases. With this in mind, we screened 88,000 chemicals for the ability to increase the lifespan of Caenorhabditis elegans nematodes. We found that mianserin, a serotonin receptor antagonist used as an antidepressant in humans, can increase C. elegans lifespan when given only during adulthood. This effect is reduced or abolished by mutations that affect serotonin synthesis or serotonin… CONTINUE READING