Microarrays are the platform of choice for detecting DNA structural variants (SV) such as chromosome insertions, duplications and deletions. In addition to these copy number variations (CNVs), whole-genome arrays that cover not-only polymorphic (SNP) but also non polymorphic regions can additionally detect chromosomal imbalances and allelic imbalance indicative of absence of heterozygosity (AOH), loss of heterozygosity (LOH), or long contiguous stretches of homozygosity (LCSH).

Microarray based assays advantages:

Whole-genome coverage covering genes established as significant today as well as those with emerging evidence

Featured products

Application areas

Reproductive Health

Compromising on genomic coverage, content, or resolution by using traditional methods such as karyotyping, fluorescent in situ hybridization (FISH), and low-resolution arrays leads to significant aberrations being missed, which necessitates further analysis, delaying results and increasing costs. Whole-genome microarrays that cover both polymorphic (SNPs) and non-polymorphic regions of the genome can be used to assess DNA copy number alterations at a much higher resolution than those older conventional methods.

Neurodevelopmental and Genetics Research

Most CNVs found in the human genome do not cause an effect in human health, however, hundreds of CNVs have been associated to neurological disorders such as schizophrenia, autism, attention deficit hyperactivity disorder (ADHD), intellectual disability and bipolar disorder. Several well known studies using high resolution whole-genome microarrays reported that CNVs in the same genes might be implicated across these neurodevelopmental disorders.

Custom High-Throughput Applications

Create your own high throughput 96- or 384-panel with the most relevant markers for your own custom applications as well as genome-wide association, replication, fine mapping, and candidate gene studies combined with the capability of CNV elucidation.

Instruments and software

Low- to Medium-Throughput Instrument

The GeneChip™ Instrument System is a fully integrated platform for conducting your research using GeneChip-brand cartridge arrays. We offer three versions of this system and accessories for low- to medium-throughput array processing.

Software

Chromosome Analysis Suite (ChAS) provides a free-of-charge intuitive and flexible workflow for accurate analysis. ChAS was developed with input from leading experts and is tailored for copy number and cytogenetics research analysis and reporting. ChAS enables you to view and summarize chromosomal aberrations across the genome. Chromosomal aberrations may include copy number gain or loss, mosaicism, or loss/absence of heterozygosity (LOH/AOH). The latest ChAS 3.1 includes the addition of a powerful database and the unique automatic diploid-centering algorithm for oncology applications.

CytoScan HD suite

Coverage without compromise

The CytoScan™ array was designed by empirically selecting probes from a pool of over 20 million probes and then further screening them with over 3,000 samples to choose those that performed best for whole-genome Copy Number applications.

The design is optimized for balanced whole-genome coverage, enabling high-resolution DNA copy number analysis with precise breakpoint accuracy, as well as high-density SNP coverage for LOH/AOH and LCSH that can lead to uniparental disomy (UPD) detection.

Our proprietary manufacturing technology produces arrays that are highly reproducible between each batch.

Exceptional performance: high specificity, sensitivity, dynamic range, and resolution across the genome

Designed to evolve with your applications: covers all 36,000 RefSeq genes, including 14,000 OMIM, all ClinGen (formerly ICCG and ISCA) and Decipher constitutional regions, and Sanger cancer genes.