Background and Aim: Acute bronchodilator response (BDR) during spirometry is very common in clinical studies. The response varies in different groups of participants. The aim of this study was to analyze the distribution of BDR in participants with or without airway obstruction. Methods: A retrospective analytical study of the spirometry results was undertaken. The spirometric values were analyzed for the present study. Among them, 1024 test results were included in our study. The values were estimated by an electronic spirometer, model-RMS Helios-702 in the Department of Physiology, R. G. Kar Medical College, Kolkata on 3200 participants. Results: Acute BDR was higher in chronic obstructive pulmonary disease (COPD) participants (45.4%) compared to other participants. Reversibility test was positive in 41.2% of asthma, 31% of allergic rhinitis, 32% of chronic cough, and 13.6% in apparently healthy participants. Conclusion: A good percentage of positive BDR is found not only in COPD and asthma but also in allergic rhinitis, chronic cough, apparently healthy participants which indicate its wider utility.