Journal of Clinical Investigation

The Journal of Clinical Investigation is a monthly open access biomedical scientific journal, with a 2010 impact factor of 14.152. It was established in 1924. The editorial board is unusual in that its members are located chiefly at a single academic medical center and are predominantly members of the American Society for Clinical Investigation. Its leadership changes every five years: As of March 2007, it is located at the University of Pennsylvania and the current editor-in-chief is Laurence A. Turka (Harvard University). From March 2002 to March 2007, the board was located at Columbia University, with Andrew Marks as editor-in-chief.

Antibodies derived from a type of immune cell found in unusually high numbers in HIV-infected individuals with chronically uncontrolled virus levels are less effective at neutralizing HIV than antibodies derived from a different ...

With the help of a computer program called "Rosetta," researchers at Vanderbilt University have "redesigned" an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency ...

National Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice with a rare disease similar to one in humans, hoping ...

People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin-producing pancreatic beta cells.

Parkinson's disease is the second most common neurological disorder, affecting almost 10 million people worldwide. While there is no cure for this disease, many patients are able to successfully manage their symptoms. Surgical ...

Doxorubicin is a widely used as a component of chemotherapy regimes; however, the use of doxorubicin is associated with severe cardiotoxicity. It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been ...

Currently, opioids are the standard treatment for chronic pain. Patients on opioids for long periods of time become desensitized to these drugs or become paradoxically hypersensitive to pain (hyperalgesia); however, the adaptive ...

An arrest in cell proliferation, also referred to as cellular senescence, occurs as a natural result of aging and in response to cellular stress. Senescent cells accumulate with age and are associated with many aging phenotypes, ...

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