Sandostatin is a medicine used to treat acromegaly (a condition involving excessive growth due to increased levels of growth hormone). Sandostatin is also used to treat severe diarrhea and flushing episodes associated with certain cancers. Sandostatin is administered subcutaneously (just below the skin). Sandostatin may also be administered intravenously (directly into a vein) in a hospital setting.

What should I know when beginning and continuing on this medication?

How does this medication work?

Sandostatin works by decreasing the amount of certain natural substances produced by the body, thereby improving your condition.

What are the beneficial effects of this medication and when should I begin to have results?

What: By decreasing levels of growth hormone and other hormones, Sandostatin may help improve acromegaly and symptoms associated with certain cancers.

When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions. It is important that you use Sandostatin exactly as your healthcare provider has prescribed.

How do I know it is working?

You may feel an improvement in your symptoms once you begin using Sandostatin. This is a good indicator that your medication is working. Your healthcare provider may also ask you questions to assess how well your symptoms are controlled.

What are the possible side effects of this medication?

The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

Acromegaly

More common side effects may include: diarrhea, gallstones, abdominal (stomach-area) pain, gas.

Certain Cancers

More common side effects may include: back pain, tiredness, headache, abdominal pain, nausea, dizziness.

Less common side effects of Sandostatin may include:

Sandostatin may cause changes in your blood sugar levels, inflammation of the pancreas, or alter absorption of dietary fats.

Who should not take this medication?

Do not use Sandostatin if you are allergic to it or any of its ingredients.

What should I tell my healthcare provider before I take the first dose of this medication?

Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Sandostatin. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; or gallbladder, heart, kidney, or thyroid problems.

What is the usual dosage?

The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

Acromegaly

Adults: The recommended starting dose is 50 micrograms three times a day.

Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.

If you have kidney impairment, your healthcare provider may adjust your dose appropriately.

How should I take this medication?

Use Sandostatin exactly as prescribed by your healthcare provider. Do not use it more often or stop using it without first talking to your healthcare provider.

Rotate injection sites during treatment with Sandostatin.

It is important to use reliable forms of birth control during treatment with Sandostatin. Discuss with your healthcare provider about appropriate contraception.

Your healthcare provider will teach you how to inject Sandostatin. Do not use Sandostatin without proper training from your healthcare provider.

What should I avoid while taking this medication?

Do not miss any follow-up appointments with your healthcare provider.

What are the possible food and drug interactions associated with this medication?

If Sandostatin is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Sandostatin with the following: blood pressure/heart medications known as beta-blockers (such as metoprolol or propranolol) or calcium channel blockers (such as diltiazem or amlodipidine), bromocriptine, certain diabetes medicines (such as insulin or glipizide), cyclosporine, quinidine, or terfenadine.

May I receive this medication if I am pregnant or breastfeeding?

The effects of Sandostatin during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of this medication?

If you miss a dose of Sandostatin, use it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not use two doses at once.

How should I store this medication?

Store at room temperature for up to 14 days. Protect from light.

For prolonged storage, store in the refrigerator. Protect from light.

Who should I contact in case of emergency or overdose?

In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222

This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

This monograph summarizes the most important information about your
medication and does not cover all the information you may need. If you
have any questions or concerns or want to learn more about your
medication, ask your healthcare provider; he/she will be able to provide
answers to your questions. This medication should only be used by the
patient for whom it was prescribed and should not be shared with other
people.

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