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For seizure patients, the goal is a trough concentration of 50 to 100 micrograms per milliliter. After the starting dosage, Depakote is increased by 5 to 10 milligrams per kilogram of body weight per week for seizure patients, explains the prescribing information on Drugs.com. There are no strict guidelines for up-titration for people with mania. The prescribing doctor monitors the patient closely to determine an individual therapeutic dosage once plasma concentrations are within range.

However, the prescribing information notes the benefits of Depakote plateau at 60 milligrams per kilogram of body weight per day, according to Drugs.com. This is the maximum recommended daily dose for both mania and seizure patients.