Data show that immune thrombocytopenia (ITP (show ITPA Proteins)) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins.

Data suggest that the ligand AGDV tetrapeptide binds to ITGB3/GPIIIa subunit and induces complete opening of headpiece of integrin alphaIIb/beta3 complex; AGDV appears to have very little contact with ITGA2B/GPIIb subunit.

CD61-overexpressing human umbilical cord mesenchymal stem cell, which had turned into primordial germ-like cells-like cells, could be further differentiated into male germ-like cells.

The frequencies of the rare alleles of CCR2 (show CCR2 Proteins), ITGB3, and 3'UTR of c-fms (show CSF1R Proteins) in the Old Believers are lower than in the sample of Novosibirsk Russians, and the rare allele of DBH (show DBH Proteins) is more frequent

results demonstrate that beta3 integrin expression depends on the source of the fibroblast and that its expression inhibits alphaSMA (show ACTA2 Proteins) expression (and thus the myofibroblast phenotype).

33Leu --> Pro substitution of GPIIIa does not influence the prevalence and extent of angiographically defined coronary artery disease in general population, although apparently playing a role among younger patients.

Pig (Porcine) Integrin beta 3 (ITGB3) interaction partners

The observed effects of shear stress on integrin alpha(v (show ITGAV Proteins))beta(3) and p38 MAPK (show MAPK14 Proteins) activation, as well as on FGF-2 (show FGF2 Proteins) release could be mimicked by application of pancreatic elastase to static endothelial cells.

structure and distribution of the CD61 provides insight into the physiological function of the porcine beta(3) integrins and should be of importance in understanding the role of this integrin family in biological processes

Cow (Bovine) Integrin beta 3 (ITGB3) interaction partners

Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

Integrin beta 3 (ITGB3) Protein Profile

Protein Summary

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.