Background

Suicide affects people from different backgrounds, ethnical groups, socio-economic status and geographical locations. In Latin America, suicide reports arescarce, specially in Andean countries. In Ecuador, very few reports have partially described this phenomenon, nonetheless, estimation of the burden of disease (BoD) hasnever been reported in the country.

Methods

A country-wide comparison was performed using the Ministry of Public Health’s national databases of overall mortality, Hospital Discharges Database, and the Population Census of the National Institute of Census and Statistics (INEC). The study variables analyzed were age, geographical distribution to provincial level, sex, means of suicide, educational attainment, marital status and mortality. Linear Regression and relative Risk analysis were used to predict outcome and the likelihood that suicide occur among study variables.

Results

In the last 15 years, 13,024 suicides were officially reported. Men were 3 times more likely than women to die by suicide. The overall age-adjusted suicide ratio in Ecuador corresponds to 7.1 per 100,000 per year. The sex-specific rates were 5.3 in women and 13.2 in men. The primary mean of suicide was hanging X70 (51.1%), followed by self-poisoning X68-X69 (35.2%) and firearms X72-X74 (7.6%). Provinces located at higher altitude reported higher rates than those located at sea level (9 per 100,000 vs 4.5 per 100.000). The total economic loss due to suicide was estimated to be $852.6 million during the 15 years’ analysis.

Conclusions

This is the first geodemographic study exploring the complete burden of suicide in Ecuador and one of the very few in Latin-America. In the last 15 years of available data, Ecuador ranks above the regional average with an adjusted suicide rate of 7.1 per 100,000 inhabitants. An important finding is that Suicide affects rather younger populations, adding more than 10,000 years of premature years of life lost (YYL) between 2001 and 2015, becoming the first and fourth leading cause of death among adolescent women and men respectively.

Suicide affects people from different backgrounds, socioeconomic status and educational attainment. The mean of suicide changed over time showing that gun and pesticides related deaths decreased significantly since 2001, while hanging and suffocation increased in more than 50%.

Suicide affects people from different backgrounds, ethnical groups, socio-economic status and geographical locations [1–3]. Suicide can be defined as any deliberated act by which an individual’s death results directly or indirectly from a self-inflicted injury or poisoning [4, 5]. Suicide is a global health problem, ranking between 4th to 20th cause of mortality for any given region in the world [6, 7]. According to the World Health Organization (WHO),a person commits suicide every 40 s [1]. In 2012, suicide accounted for 1.4% of all deaths worldwide, the majority occurring in low- and middle-income countries [8, 9].

Suicide rates vary across countries, ranging from less than 1 per 100,000 deaths in Saudi Arabia and Belize to more than 40 per 100,000 deaths per year in Guyana or Lithuania [1, 10]. The Global Burden of Disease Group (GBD) reported that in 2013, more than 840,000 people died from self-harm worldwide [7]. According to this report, suicide was the 14th leading cause of years of life lost in the world [7].

Several risk factors for suicide have been clearly documented, e.g. male sex, younger age, having a psychiatric disorder such as depression and schizophrenia, hopelessness, marital status, white race, low income, owning firearms, incarceration, job loss and drug abuse [12–18]. Recently, a positive association between altitude gradient and suicide has been described [19].

It is estimated that about 30% of suicides in the world are committed by poisoning with pesticides, hangings or firearms, and the means of suicide depend greatly on the availability and access to the lethal object used by the person [20, 21].

In Latin America, the highest mortality rate comes from Uruguay; a small country with a little more than three million people reported more than 15 per 100,000 deaths per year from suicide in 2012 [6, 22]. Other countries like Guatemala (2.5/100.000), Venezuela (3/100.000) or Peru (5.8/100.000), reported more lower rates, averaging 3.7 per 100,000 deaths in 2012 [6].

In South America suicide rates change according to cultural, behavioral and socioeconomic factors, however, data availability and under-ascertainment might also contribute to these differences. Adding up all the regional reports, it was estimated that more than 45,800 people commit suicide every year in this region [23].

Data about suicide is still scarce in Latin America, especially in smaller countries like Ecuador. In the last 20 years just very few reports have partially described this phenomenon in the country [24–26].

The Observatory for Citizen Security in Quito carried out a study on the subject and determined that in 2014 in Ecuador there were 9 suicides per 100,000 inhabitants with similar results in 2015 [27]. The most recent scientific reports on Ecuadorian suicide epidemiology comes from 2011, with two descriptive analyses that offer an interesting demographic analysis of the problem, however, none of those reports included a detailed geodemographic and economic analysis of suicide, years of life lost, disability-adjusted life years (DALY) or risk analysis [24, 26].

In this sense, this document responds to the lack of data about the economic and public health impact of suicide in Ecuador, adding new insights about a problem that has been poorly described in Latin American countries will improve the capacity of policy makers to correctly approach this health problem.

Study design and population

The present study is an observational cross-sectional analysis of suicide data and the burden of disease in Ecuador in the last 15 years of available data, from 2001 to 2015.

Ecuador is situated in South America and according to national census data, the total population surpassed 16.4 million people in 2015 [28].

A country-wide comparison of the data from the 24 provinces was performed using the complete dataset from the Ministry of Public Health’s national databases on overall mortality and hospital discharge data from 2001 to 2015, as well as 2010 population census data from the National Institute of Census and Statistics (INEC). The study variables analyzed were age, geographical distribution at the provincial level, sex, means of suicide, educational attainment, marital status, mortality and high altitude exposure.

Data sources and description

All cases of suicide were classified according to the International Classification of Diseases 10th Revision (ICD-10). ICD-10 codes reflecting intentional self-harm (X60-X84) were identified through autopsy reports provided by INEC. Data on demographic variables such as sex, province elevation, educational attainment and marital status for all cases of suicide were included.

The burden of disease attributable to deaths by suicide in Ecuador was measured in disability-adjusted life years, or DALYs. [29]. DALYs are the sum of years lived with disability (YLDs) and years of life lost due to premature mortality (YLLs). In the case of suicide, only YLLs were considered for the calculations. YLLs were computed as the number of deaths multiplied by life expectancy at the age of death for specific age and sex strata considering a life expectancy at birth of 80 years for men and 82.5 years for women. A standard time discounting of 3% without age weighting was used. All calculations were made in the “DALY” package for R [30].

Data analysis

The demographic variables, suicide method (X60-X84), place and date of suicide as well as the DALY data was analyzed using descriptive statistics. Data are presented as mortality rates, absolute values and proportions. The mortality rate was adjusted by age, sex and geographic location. Linear Regression and relative Risk analysis were used to predict outcome and the likelihood that suicide occur among variables. The calculations were completed using the IBM SPSS statistics version 24.0. References, citation and retrieval were managed by Zotero Open Source Software version 4.0.11. Spatial analysis was performed using QGIS 2.8 and the graphics were designed using the Piktochart infographic online app.

Ethical considerations

According to the international guidelines of good clinical practices (GCP) and the Helsinki Declaration, anonymous databases can be used when no harm or confidentiality can be guaranteed [31]. According to the national guidelines we have complied and met the criteria described above and the study approval was exempted by the BioEthics Committee for Human Research at Universidad de las Americas (CEISH-UDLA) [32]. The de-identified non- biological data is freely available to the public at the following link www.inec.gob.ec and is owned by the Government of Ecuador, through the National Institute of Statistics and Census of Ecuador (INEC).

In Ecuador, over a period of 15 years from 2001 to 2015, a total of 13,024 deaths were attributed to self-inflected injuries. Over this time period, suicide rate fluctuated between 4.3 to 7.1 per 100.000. The overall national suicide mortality rate in private and public healthcare systems averaged 7.5 per 100,000 deaths. Men were 3 times more likely than women to die by suicide. The highest rate of suicide was recorded in Carchi province (12.7 per 100,000) and the highlands provinces had higher rates than those located at sea level (9 vs 4.5 per 100.000). For the first time in history, the rate of suicide in 2015 (7.9 per 100,000) surpassed the homicide rate (6.3 per 100,000).

Age distribution

Suicide in Ecuador affects all age groups, but adolescents and young adults are the most likely group to commit suicide (Fig. 1). During the 15 years of analysis, 262 children younger than 12 years old committed suicide; Azuay province had the highest cumulative percentage reported for this group (4%).

Fig. 1

Suicide rate per 100.000 by age in Ecuador from 2001 to 2015 Source INEC

Among adolescents, suicide ranked first among all the causes of death in women aged 13 to 20 years old and 4th in men in the same age group, accounting for more than 17% and 10% of mortality, respectively (Table 1.).

Table 1

Main causes of mortality among men and women adolescents between 2004 and 2015

Adolescent Men 13–20 years

Adolescent Women 13–20 years

Cause of death

N

%

Cause of death

N

%

096 Road traffic injuries

3376

22%

101 Intentionally Injured Injuries

1217

17%

102 Aggression

2564

17%

096 Road traffic injuries

788

11%

103 All other external causes

1574

10%

103 All other external causes

541

7%

101 Intentionally Injured Injuries

1501

10%

094 Other findings not elsewhere classified

511

7%

098 Accidental drowning and submersion

776

5%

102 Aggression

352

5%

094 Other findings not elsewhere classified

702

5%

061 Rest of diseases of the nervous system

290

4%

045 Leukemia

465

3%

045 Leukemia

288

4%

061 Rest of diseases of the nervous system

407

3%

074 pneumonias

271

4%

074 pneumonias

397

3%

089 Other direct obstetric deaths

252

3%

068 Other heart diseases

322

2%

068 Other heart diseases

215

3%

Other causes

3197

21%

Other causes

2872

36%

Total

15,224

100%

Total

7365

100%

The proportion of suicide by age groups in relationship with all other causes of death from 2001 to 2015 was 2.9% in children (6–12 years), 12.0% in adolescents (13–20 years), 5.8% among young adults (21–39 years) 1.5% in adults (40–65 years) and 0.2% among the elderly (>65 years old).

Sex differences

In Ecuador, men account for a majority of suicides, 71.5%. The overall sex-specific rates in Ecuador is 5.3 for women and 13.2 for men (Fig. 2) and the men to women ratio is 3:1. The proportion of suicide in comparison with all other causes of death is 1.9 in men and 1.0 in women.

Fig. 2

Sex Distribution of suicide in Ecuador from 2001 to 2015 Source INEC

Means of self-inflicted injury

The means used by persons who committed suicide in Ecuador differs according to sex and location of the victim. The principal means of self-inflected injury reported in the last 15 years is the X70: Intentional self-harm by hanging, strangulation and suffocation (ICD-10 X70), followed by Intentional self-poisoning by exposure to pesticides (ICD 10 X68) and then firearms (ICD 10 X72–74). (Fig. 3).

Fig. 3

Means of Self-inflected injury from 2001 to 2015 Source INEC

Women are more likely to use less violent means, such as poisoning and drug abuse, while men are more likely to use hanging, firearms or intentional self-harm with sharp objects (Fig. 4).

Fig. 4

Means of Self-inflected injury from 2001 to 2015 Source INEC

Self-inflicted deaths by firearms accounted for almost 15% of the of means of suicide s in 2001 and 5% in 2015. Hanging increased from 33% in 2001 to 69.3% in 2015 and pesticide self-poisoning decreased from 43% to 20% in the same time period (Fig. 5).

Fig. 5

Cumulative percentage of the mean of suicide in Ecuador in the last 15 years 2001–2015

Geographical differences

The provinces with the highest suicide rate per 100.000 in Ecuador are Carchi (12.7/100,000), Napo (11.6/100,000), Cañar (11.3/100,000) and Azuay (11.0/100,000) (Fig. 6).

Fig. 6

Geographic distribution of suicide rate in Ecuador from 2001 to 2015 Source INEC

The lowest recorded suicide rate was reported in the coastal province of Santa Elena with 1.4 per 100.000. The highlands region of the country had the highest suicide rate (9 per 100,000), followed by the Amazonian region (8.1 per 100,000), the insular region of Galapagos (5.6 per 100,000) and finally the coastal region (4.5 per 100,000).

When the average elevation was analyzed, higher altitude locations (>2500 m) had a rate of 9.4 per 100,000 while lower altitude locations (<2500 m) had a rate of 6.3 per 100,000) (Table 2). We performed a logistic regression and a relative risk analysis for elevation (in meters) and suicide. The results show that living at high altitude has a very low chance to predict the occurrence of suicide (R2 = 0.0232, p = 0.477), however the relative risk (RR) analysis showed a slightly high increment in the risk of committing suicide when living above 2500 m (RR = 1.545, 95% CI: 1.4890 to 1.6055, p < 0.0001).

Table 2

Suicide Rate by province, region and elevation from 2001 to 2015 * deaths per 100,000

Suicide rate

Region

Average Elevation/m

Altitude Classification

Azuay

11.0

Highlands

*9/100,000

2560

High altitude > 2500 m

*9.4/100,000

Bolívar

8.9

2668

Cañar

11.3

2518

Carchi

12.7

2980

Cotopaxi

8.5

2800

Chimborazo

8.3

2754

Pichincha

5.9

2800

Tungurahua

8.6

2577

Imbabura

8.6

2225

Low Altitude < 2500 m

*6.3/100,000

Loja

5.8

2060

El Oro

5.4

Coast

*4.5/100,000

6

Esmeraldas

5.6

15

Guayas

4.1

4

Los Ríos

6.2

8

Manabí

4.7

6

Santo Domingo de los Tsáchilas

4.2

635

Santa Elena

1.4

45

Morona Santiago

6.8

Amazonia

*8.1/100,000

940

Napo

11.6

598

Pastaza

6.1

790

Sucumbíos

9.6

297

Orellana

9.7

300

Zamora Chinchipe

5.1

920

Galápagos

5.6

Galapagos *5.6/100,000

6

DALYs and YLLs analysis

During the period 2001–2015 in Ecuador there were 13,024 deaths registered as self-inflected injuries causing death. These deaths are equivalent to 135,731 years of life lost due to premature mortality. 93% of YLLs are attributable to deaths in the economically active population. 73.6% of the burden generated by premature mortality occurred in men (Table 3).

Table 3

Years Life Lost (YLL) due to suicide in Ecuador, years 2001–2015*

Year

YLL Males

YLL Females

Total YLL

per 10,000 pop.

2001

4306.62

1927.21

6233.82

4.86

2002

4332.90

1853.19

6186.10

4.72

2003

4975.93

2249.54

7225.47

5.42

2004

6069.33

2379.26

8448.59

6.23

2005

7430.72

2669.09

10,099.81

7.36

2006

6564.18

3057.33

9621.51

6.89

2007

7939.52

2826.75

10,766.27

7.57

2008

7248.46

2676.84

9925.30

6.86

2009

7834.41

2542.20

10,376.62

7.04

2010

7173.49

2627.56

9801.06

6.53

2011

7108.09

2707.92

9816.01

6.43

2012

7657.87

2734.28

10,392.15

6.70

2013

5207.05

1903.13

7110.18

4.51

2014

6322.19

1787.59

8109.78

5.06

2015

8784.75

2834.24

11,618.99

7.14

Total

98,955.53

36,776.12

135,731.65

6.22 (±1.03)**

*Years Life Lost computed as the number of deaths times the life expectancy at the age of death for specific age and sex strata, considering a life expectancy at birth of 80 years for males and 82.5 years for females. A standard time discounting of 3% without age weighting was used

**Average YLL rate per 10,000 population (±SD)

Sociodemographic characteristics

In Ecuador, the majority of people committing suicide are single, followed by married and common law couples. Educational attainment was found to be another important factor related with suicide in Ecuador. In the last 15 years, people who did not finish primary or high school had the highest suicide rates among Ecuadorians. Urban communities have almost triple the suicide rates of rural communities. The overall suicide rate by race shows that mestizos or mixed race has the highest rate (9/100.000), followed by indigenous (7/100.000) and all the other ethnic groups (2/100.000). Suicide rates tend to be higher during January, March and October as described in Table 4.

Table 4

Sociodemographic and monthly variation of suicide in Ecuador from 2001 to 2015

The results from this investigation demonstrate that suicide is one of the most important health issues in Ecuador. Adequate public policy needs to be pursued in order to generate effective public health prevention programs. The results in Ecuador accompany and support the WHO global epidemics [10, 33]. Nearly 13,500 deaths were attributed and officially reported as suicide in the last 15 years in Ecuador, averaging almost 890 deaths per year, with an average suicide rate of 7.1 per 100,000. In Ecuador, men are three times as likely to commit suicide than women; this relationship of 3:1 seems to be within the range described worldwide [10, 22, 34].

Suicide rates vary from region to region, affecting provinces located in the Andean region of Ecuador more than those located at lower altitudes. It is not well understood why this relationship is present in Ecuador, however, other reports have also suggested the positive relationship between altitude and suicide rates [19, 35].

The differences between highland and lowland communities have been well documented and include cultural, physical or socioeconomic variances [27, 36]. Although there is not much research on this subject it is speculated that altitude can increase psychiatric disorders, mood changes, risk of depression and risk to develop stroke [37–40]. Greater access to firearms, isolation or reduced income have also been implicated as possible causes [35]. In Ecuador, high altitude provinces have more presence of indigenous groups than those provinces located at the coast. According to the latest National Census, this vulnerable population has less access to proper housing, education and health care [41]. The World Report on Violence and Health in 2002 found that suicide rates have increased among indigenous people [42]. Among the proposed risk factors, cultural differences, discrimination, poor adaptation to urban lifestyles, poverty and limited health access were identified [42, 43]. In this sense, Carchi and Azuay, two of the provinces with the highest suicide rates experienced a massive emigration from their young adults to the US and Europe in the year 2000 [44]. Immigration patterns are variables that increase the risk of suicide due to the apparition of broken families and children that were raised alone, make this group particularly vulnerable to depression, drug abuse and probably higher risk of suicide [45–47]. On the other hand our results might indicate that living at high altitude could be considered a non-traditional risk factor, although the effect of hypoxia on suicidal thoughts or behavior has not been demonstrated yet, a slightly higher relative risk of committing suicide was demonstrated among high altitude dwellers when compared to those located at lower altitudes [19, 35].

Among Andean countries, Ecuador has the second highest suicide rate, ahead of Colombia (6.1/100.000) and Peru (5.8/100.000) and behind Bolivia (18.7/100.000) [6, 22]. The reasons of this situation are not well understood; multifactorial risk factors might contribute to these differences among similar countries, and there may also be methodological differences in data collection and registering death causes.

It is not clear why some countries within the same region have significantly different suicide rates [6]. The World Health Organization reports that from the 800,000 people committing suicide each year, 50% are from China and India, and the highest rates reported were from Guyana, Lithuania, Hungary and South Korea [21, 33, 48]. Other countries including Saudi Arabia, Syria, Jordan, Nepal and Jamaica reported some of the lowest rates worldwide [49, 50].

The data from rural and urban areas showed different characteristics regarding the means of the suicidal act [51]. The incidence of suicide between rural and urban areas varies around the world due to their cultural, socioeconomic and geographical particularities [52]. In Ecuador, most of the reports come from the cities, more than doubling the cases from rural communities. Social stress factors such as high unemployment rates, social isolation, divorce, drug abuse, excessive working and negative chronobiological or physical working conditions have been identified as risk factors in the urban area [53–56]. Emotional conflicts occur in both rural and urban areas, but due to cultural and economic features, divorce as a reason for suicide is less frequent among the rural communities [57]. It has also been hypothesized that longer night shifts and busier lifestyles in urban areas can increase the risk of suicide [58]. There has been very little research on the effect of urbanization on the incidence of suicide. It has been identified that women perform more suicidal acts in urban areas than men, which may be due to job-related factors (quality, opportunity for promotions, etc.) and also vulnerability living in large cities [59].

It is not yet clear why men commit suicide more than women, despite knowledge that suicidal thoughts are more common in women than men, this proportion is observed across cultures. Certain factors have been identified that influence the suicide rate in men [60, 61]. For instance, the gender gap and the social pressure that is exerted on men because the image is generally linked to family support, which can cause economic failure to have a stronger negative impact on men. In Ecuadorian culture, men are commonly perceived or expected to be the primary head of household or even the family’s unique livelihood. They are expected to earn more than women counterparts so often times economic failure and feelings of inability to support one’s family can create an insurmountable pressure [62].

According to available literature, the means by which a man takes his own life appear to be more violent than those means utilized by women [17, 63]. In Ecuador, men use more violent methods than women, including death by firearms, hanging and sharp objects (Fig. 4). Interestingly, the landscape of means of suicide in Ecuador have changed in the last 15 years. Firearms used to account for 15% of the total causes of suicide in 2001, however in 2015, this number dropped to 5% (Fig. 5). This important reduction might be a consequence of better gun control and stronger national safety policy in Ecuador in the last 10 years [64]. For the first time ever in 2015 homicide rate dropped below the suicide rate, This trend might also be related with an important reduction in crime reported in Ecuador in the last years since suicide did not changed dramatically in the last 15 years. [65, 66].

An alarming discovery is that among adolescent women, suicide is the main cause of death, including all violent and non-violent causes. In the last years suicide has become a major public health problem among adolescents, specially in developed countries like the US [67]. Data from other countries shows that men adolescents are 2.6 times more likely to commit suicide than adolescent women [68]. In Ecuador, the proportion of suicide among adolescents account for more than 12% of the total causes of deaths, being this number higher in women (17%) than in men (10%). Similar reports have been published in other countries, showing that proportions are useful tools when estimating the impact of suicide among all other causes of the unnatural Death [69].

Suicide is usually preventable, especially in health systems where mental health services are readily available [70]. These preventable deaths need to be addressed to public health policy makers in order to plan and implement suicide prevention programs with a special focus on high-risk groups such as young adolescents women and single young men. Despite the fact that from 2001 to 2015 suicide rates in Ecuador were fairly stable, the health system and economic impacts are highly concerning due to premature mortality. Ecuador reported 4421 deaths registered as suicide, and the total years of healthy life lost exceeded 135,731 years. Using the human capital method, in 2001–2015 period, the total economic loss due to suicide was estimated to be $852.6 million international dollars (year 2010 base), almost 1% of the Ecuadorian gross domestic product (GDP) for 2015 [65].

Limitations

The main limitation of our study is that data from suicide attempts was not available. In addition, the lack of data to assess confounding factors in order to better understand some of the observed associations and the possible causes of suicide is inexistent.

This geodemographic study is the first of its kind in exploring the complete burden of suicide in Ecuador and its economic impact over the local health and productive system. In the last 15 years of available data, nearly 13,500 deaths were officially registered as suicide, putting the country above the regional average with a suicide rate of 7.1 per 100,000. Suicide largely is taking the life of younger people; especially adolescent women signifies that gender inequality may be a contributing factor. Some of the possible causes of higher suicide rate among younger people can be explained by chronic stressors such as family dysfunction, school failure, sexual abuse, alcohol, drug use and immigration patterns.

Despite the fact that some of the means of suicide has changed over time, the annual rate of suicide has not varied significantly in the last 15 years. In fact, while other means like firearms and pesticide consumption decreased in the last few years, hangings have increased over time.

Suicide seems to be more prevalent in high altitude provinces when compared to provinces at lower altitudes, however, this relationship does not demonstrate causality and further research is needed. Although this data is important, the analysis of risk factors and behavioral problems need to be addressed at a deeper level future studies.

The results of this study will provide an insight into the needs of authorities with regard to prevention programs and contributed to our understanding of suicide in Andean countries where information is scarce. Furthermore, it contributes to create the baseline data in order to publish guidelines for those involved in the medical practice of suicide specially those who are in charge of adolescents’ school-based education programs and gender inequality policies.

Acknowledgements

The authors wish to thank Dr. Jorge Gabela from the faculty of Medicine of Universidad de Las Americas in Quito for his constant support and his comments related to this manuscript.

Funding

This work did not receive financial support of any kind.

Availability of data and materials

All the datasets analyzed during the current study are available from the INEC repository and the online tool Redatam. The data is freely available to any scientist wishing to use it for non-commercial purposes, without breaching subject confidentiality.

Authors’ contributions

EOP designed methodology and collected all the data. He is responsible for the acquisition of information and interpretation. He is the primary author of the manuscript and is fully responsible for this work. KS and LGB were fully responsible for acquiring the data in XLS format and transformed into CVS format for all the descriptive statistical analysis. They have also collaborated to write with the results section of the manuscript. AHT was fully responsible for the DALY and burden of disease analysis and provided a critical analysis of our manuscript prior to submission. FCL a well-known psychiatrist, added his expertise within the discussion section and throughout the entire manuscript during final revision and approval. EV and DC were fully responsible for downloading the data from INEC and performing the first descriptive analysis of the full data set. GV added a very important point of view regarding high altitude and suicide. He also critically reviewed the entire manuscript and produced several comments prior to submission. All authors read and approved the final manuscript.

Ethics approval and consent to participate

The data was collected from the National Institute of Statistic and Census of Ecuador (INEC) database. According to the international guidelines of good clinical practices (GCP) and the Helsinki Declaration- anonymous, non-biological databases can be used when no harm and full confidentiality can be guaranteed. The de-identified information is freely available to the public and it is owned by the Government of Ecuador and accessed through the INEC database.

According to the national guidelines we have complied and met the criteria described above and the study approval was exempted by the BioEthics Committee for Human Research at Universidad de las Americas (CEISHUDLA).

Consent for publication

Not Applicable.

Competing interests

The authors declare that they have no competing interests.

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