Stratified Medicine in primary Sjögren’s syndrome

Objectives of the Project

The proposal aims to further characterise the clinical significance and the underpinning pathotypes of 4 PSS subtypes. The specific objectives are:

1. To understand the natural history of the different PSS subtypes.

2. To validate the transcriptomic signatures of the PSS subtypes and re-calibrate (if necessary) for non-UK cohorts.

3. To further characterise the underpinning pathobiological profiles of the four PSS subtypes

4. To explore whether the four subtypes respond differently to treatments by reanalysing data from two clinical trials (JOQUER (hydroxychloroquine) and TRACTISS (Rituximab)

Facts and Figures

Project lead
Prof. W-F Ng
Newcastle University

FOREUM research grant: € 600.000

2018, Duration 3 years

Meet the Team

Mr. D Lendrem
Newcastle University

Prof. J-E Gottenberg
Strasbourg University

Prof R Seror
Université Paris Sud INSERM U1184

Prof. V Devauchelle-Pensec
Brest University

Prof. A Saraux
Brest University

Hon Prof. S Bowman
University of Birmingham

Dr. F Barone
University of Birmingham

Dr. B Fisher
University of Birmingham

Assoc. Prof. G Nordmark
Uppsala University

Prof. U Landegren
Uppsala University

Prof. R Omdal
Stavanger University Hospital

Dr. M Bombardieri
Queen Mary University London

Patient Voice

We will invite two patient research partners from each participating country to advise on what information to collect that will best describes the burden that PSS brings to their daily lives. It will involve an initial face-to-face meeting followed by two video-conferences. We will also invite two of them to join our steering committee to provide guidance and oversight of the whole proposal.

FOREUM is devoted to promote research in rheumatic and musculoskeletal diseases (RMDs)