This 2011 paper by Dr DePinho builds on previous papers and his theory of the “telomere-p53-PGC axis”. This is a big reason along with the work of Dr Michael Fossel I believe telomerase therapy is probably the best chance of radical life extension in the near future. This is one of a number of papers that implicate dysfunctional telomeres in a cascade that causes mitochondrial dysfunction and various other aging consequences.

- PhD student researching Aging, Mitochondria, and Regenerative Medicine -
I currently write for The Conversation (http://bit.ly/13WVyUW) and I have
written for The Guardian (http://bit.ly/13WVtRh) - Ringleader of the Oxford
University Scientific Society - Co-conspirator at the Oxford Transhumanism
and Emerging Technologies - Designing exciting events with the British
Science Association Oxford - Advisory Board member at Lifeboat Foundation's
Life Extension Board, and the Sustainability Board - Also, I am an Ultimate
(frisbee) enthusiast - Yes, unfortunately that's me trying to catch the
frisbee