To make matters worse, leading rusher Rex Burkhead injured his left knee early in the third quarter after rushing for 119 yards on 14 carries, but did not return.

The Huskers also gave up points on offense - Bradley Roby had two interceptions for Ohio State (6-0, 2-0), including one he brought back 41 yards for a touchdown - and on special teams. Corey Brown returned a punt 76 yards for a score.

Pelini was bewildered by all the breakdowns.

"I don't know, I wish I knew," he said when asked for a reason for all the missed assignments and missed tackles. "It doesn't happen at home. We practice with crowd noise every day, every single day. It hurts us."

It was the most points given up by the Cornhuskers since a 65-51 loss at Colorado in the final game of the 2007 season - also the last game of the Bill Callahan era.

The weird part is that the Huskers had things going their way early. They led 17-7 early in the second quarter and, at that point, had held the Buckeyes without a first down.

But then everything that could go wrong, did.

Down by 11 points at the half, the cut the lead to 35-31 on Martinez's 3-yard pass to tight end Ben Cotton.

But just as quickly, the Buckeyes countered on Hyde's third TD run and Brown's lightning-fast burst through traffic on the punt return. All of a sudden, it was 49-31 and the end was in sight.

"It's the whole thing. You just can't point at one play here or there," Cotton said. "It's the game as a whole. We made too many mistakes to win the game."

Burkhead, averaging 91 yards rushing a game, injured a knee on a 24-yard gain on the fourth play of the second half. He spent much of the third quarter pedaling away on a stationary bike on the Nebraska sideline.

Pelini said Burkhead's injury was not "a long-term thing."

He had rushed for 119 yards on 14 carries before being sidelined.

The game, played before 106,102, the largest crowd ever at Ohio Stadium, was a dramatic change from a year ago. In Nebraska's first Big Ten home game ever, the Huskers fell behind by 21 points before coming back to beat the Buckeyes 34-27 in the greatest comeback in school history.

But not this time.

"You've got to execute. You can talk about it all you want," Pelini said. "Like I said, what just happened, happened. What I'm worried about is we have six weeks. We need to win the next six football games to get us to Indianapolis."