I have an Exchange Server running Exchange 2010. I have one specific user who we just migrated over to Windows 7 x64 an he is also running Microsoft Outlook 2010 x86. Our exchange mailboxes are tied directly to their Active Directory accounts, so they do not need a password to open Outlook.

Now the problem that only one of my users is running in to. Every 30 minutes or so he gets a notification down in the status bar at the bottom of Outlook that Outlook needs his password. He clicks on the notification button and his mailbox updates. I have no idea what is causing this.

I have tried renaming the profile under:
%userprofile%\AppData\Roaming\Microsoft\Protect but this did not resolve my issue.

I have searched high and low for a solution and nothing seems to be relevant.

Disabling it does not fix the issue, as you obviously have problems with HTTP sessions not being transparent/keepalived. It does however "fix" the problem for the end user.
– pauskaFeb 1 '12 at 17:13

I'm all open for a better solution. I tried playing with auth on IIS, like every blog talks about, nothing worked.
– SirberFeb 1 '12 at 17:26

Changing the auth method to Windows Integrated on the RPC vdir should stop the prompting for your users. However there are many considerations you need to take into account before doing this. It may not be an option for you. TMG/ISA frontends need special consideration/setup when attempting this. Also, this will change how your users use Outlook Anywhere, I.E. a domain will be required when logging in. Etc.
– TatasFeb 1 '12 at 17:37

that didn't fix the problem for me. Outlooks acts the same (randomly asking password)
– SirberFeb 1 '12 at 17:52

1

You lead me down the right path that fixed my issue. You do not need to use a GPO to disable Outlook anywhere though, you can just disable it from the EMC.
– Nic YoungFeb 6 '12 at 15:01

This may be totally unrelated, but we had a similar issue that I will share. Maybe it will help someone else anyway. A user was frequently asked for her credentials when Outlook (2007) was open, but it was more random than every 30 minutes, not consistent. This went on for months before I realized that she had been issued an Android phone that was set to automatically check her mail. When her desktop and the phone tried to talk to the server at the same time the issue would occur. We set the phone to not sync automatically during business hours and havent had the problem since.