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Written informed consent must be obtained for each patient, either from the patient himself or from the patient's legal guardian.

No prior systemic antifungal therapy for cryptococcosis.

Relapse after prior therapy.

Success of prior therapy must have been documented by negative cerebrospinal fluid (CSF) culture at the end of therapy. Following prior therapy, such patients may not have received more than 1 mg/kg/wk amphotericin B in the 4 weeks before entry into study.