Outline

Objective: The mTOR pathway plays a pivotal role in glioma pathophysiology. N-myc downstream regulated gene 1 (NDRG1) represents a mTOR complex2 (mTORC2) downstream target, which is significantly upregulated during hypoxia. Hypoxia represents a driving force in glioma angiogenesis. It was the aim to analyse the role of NDRG1 in glioma angiogenesis and to elucidate its effects on the efficacy of antiangiogenic treatment.