Introduction: The influence of statins and antioxidants administration on patients with familial dyslipidaemia (phenotypes IIa and IIb) was the aim of the study.Methods: Forty-four patients (pts) (M=34, F=10, mean age 48?7.2 years) with dyslipidaemia were divided randomly in two groups. Simvastatin (40mg daily) was administered as monotherapy in Group A (M=18, F=4) and vitamin E was administered also as monotherapy (150mg daily) in Group B (M=16, F=6). The levels of hemoglobin, hematocrit, glucose, cholesterol (total, LDL, HDL), triglycerides, cardiac enzymes (SGOT, SGPT, CPK) and free oxygen radicals (FOR) were estimated at baseline and four months later. Pts with coronary artery disease, arterial hypertension, diabetes mellitus and severe valvular disease were excluded from the study. The statistical analysis was performed using the statistical software package SPSS v 10.Results: In Group A the FOR levels were decreased significantly (285.81? 20.4 U Carr - 240.69 ?18.74 U Carr, p< 0.001) and the lipidaemic profile was also improved significantly. In Group B there was not any significant alteration in the estimated values.Conclusion: In pts with familial dyslipidaemia the statins expect their favorable effect on lipidaemic profile have overt antioxidant action.