Persistent pathogens in the parenchyma of the brain

Persistent pathogens in the parenchyma of the brain

Persistent pathogens in the parenchyma of the brain

It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from
the brain parenchyma is distinct from that documented for soluble proteins. A persistent pathogen in the brain parenchyma can become a target for the immune system following peripheral sensitisation, and this may lead to bystander tissue damage. These observations may have consequences for
vaccination of persons with central nervous system HIV infection.

brain, antigen presenting cell, pathogen, dendritic cell

1355-0284

S86-S89

Perry, V. Hugh

8f29d36a-8e1f-4082-8700-09483bbaeae4

May 2000

Perry, V. Hugh

8f29d36a-8e1f-4082-8700-09483bbaeae4

Perry, V. Hugh(2000)Persistent pathogens in the parenchyma of the brain.Journal of NeuroVirology, 6(Supplement 1), S86-S89.

Record type:
Article

Abstract

It has recently been shown that bacteria and viruses can be delivered to the brain parenchyma without evoking an immune response. These experiments demonstrate that there are no cells within the brain parenchyma that can initiate a primary immune response, and that the drainage of pathogens from
the brain parenchyma is distinct from that documented for soluble proteins. A persistent pathogen in the brain parenchyma can become a target for the immune system following peripheral sensitisation, and this may lead to bystander tissue damage. These observations may have consequences for
vaccination of persons with central nervous system HIV infection.