TARGET applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. Investigators form a collaborative network to facilitate discovery of molecular targets and translate those findings into the clinic. TARGET is managed by NCI’s Office of Cancer Genomics and Cancer Therapy Evaluation Program.

Kidney Tumors

Pediatric kidney tumors fall into four primary categories: Wilms Tumors (~85% of all cases), Clear Cell Sarcomas of the Kidney (~5%), Congenital Mesoblastic Nephromas (~4%), and Rhabdoid Tumors of the Kidney (~3%). The TARGET initiative is investigating three of these tumor types.