The 2000 strangulation murder of Florida resident Isabelle Pedroza is recalled. The victim's daughter, Linda, confessed to her role after her boyfriend, Antoine L. Wright, agreed to testify against her. The pair killed Pedroza because she disapproved of the couple's relationship.

The case of Georgia resident David Nemeth, who was shot to death in 1999. Michael Graham confessed to killing Nemeth during an argument over Jayna James McDonald, who was later convicted of concealing the victim's death.

The murder of Yemassee, S.C., resident James Dillard, who was shot to death in a wooded area in 2000. Ajanae Roach testified against Shameen Coker, his codefendant in the case, claiming that Coker shot the victim. Roach was convicted of voluntary manslaughter, and Coker was found guilty of murder.

A woman vanishes while driving across a rural stretch of a Wyoming highway. Weeks after her disappearance, the woman's body is found along the banks of a secluded river. With no leads or prime suspects, Dayle Hinman, a criminal profiler, joins the hunt for the killer.

The case of Kacy Ray, a schoolteacher who was left on the side of a road stabbed and beaten, with no motive for the investigators to work with. She may have been a victim of a random crime, and their only witness may be the victim's dog.

An elderly woman and her mattress are found hundreds of miles away in a remote field. Strange evidence and no witnesses to the brutal crime, leaves the investigators baffled on who could have viciously killed such a sweet woman.

A recollection of the 1995 murder of Charles Godley, a South Carolina resident who was bludgeoned to death inside his home during a robbery. A homeless man, Richard Simmons, Jr. confessed to the crime and was convicted and sentenced to life in prison.

Re-examination of a crime scene leads to a shocking discovery after the investigators first search turned up a dead end, when a husband and wife are shot by an intruder in which the man dies and his wife survives.