Furosemide

An event is serious (based on the ICH definition) when the patient outcome is:

* death

* life-threatening

* hospitalisation

* disability

* congenital anomaly

* other medically important event

A 70-year-old woman developed polyarticular gout and encephalopathy during treatment with furosemide for a right heart failure.

The woman had a history of alcohol-induced liver cirrhosis, chronic kidney disease, portopulmonary hypertension and paroxysmal atrial fibrillation requiring anticoagulation [specific drug not stated]. She was hospitalised in Australia for treatment of symptomatic iron deficiency anaemia, rectal bleeding, marked-dependent oedema and worsening exertional dyspnoea. During the hospitalisation, she was diagnosed with a right heart failure and transfused with two units of packed RBCs and also started receiving treatment with ferric carboxymaltose and IV infusion of furosemide [frusemide; dosage not stated]. The anticoagulation was stopped. She was started on...