29 Cards in this Set

This model of schizophrenia is flawed because it produces hallucinations that are pleasant and visual.

The LSD model.

PCP causes dysfunction at this receptor, leading to a state that is highly similar to schizophrenia

NMDA receptor (glutamate receptor)

This treatment can be given in addition to an antipsychotic medication in order to treat the negative and cognitive symptoms of schizophrenia

glycine

List some of the positive symptoms in schizophrenia.

Delusions, hallucination, through disorders that revovles around religion, illusion of grandeur, paranoia.
Hallucinations are typically olfactory and auditory. Hearing things that are bad about them, or commands.

Thorazine was used to treat schizophrenia, and it is a DA antagonist. therefore, schizophrenia might be caused by excessive DA in system. causes positive symptoms as seen in cocaine and amphetamine abuse.

Abuse of amphetamine induces postive symptoms and symptoms can be alleviated by antipsychotics. If schizophrenic patients take amphetamine, it exacerbate symptoms. It increases the norepinephrine, serotonin and opamine neurotransmitter in the brain.

What is the draw back of the amphetamine model of schizophrenia?

Amphetamine does not induce negative symptoms that are often found in Schiphrenia. it only explain positive symptoms.

Describe the LSD model of schizophrenia.

LSD is a serotonin agonist, specifically 5-HT agonist. It is very potent and induces pleasant visual hallucination.

What are the draw backs of the LSD model?

The hallucination induced by LSD is unlike those observed in schizophrenia.
LSD: visual, pleasant
Schizo: auditory, olfactory, unpleasant
LSD abusers are highly suggestible while Schizo are highly resistant to suggestions.

What is use to block serotonin?

Clozapine is a 5-HT2a antagonist, it blocks it. Does not cause extrapyramidal side effects but increase chances of agranulocytosis as a side effect