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Yes, prices on Tobacco are different in every state.

Right, due to individual state taxes, which range from $0.17/pack in Missouri to $4.35/pack in NY. Massachusetts is currently at $3.51. But the most expensive places are some of the big cities that add another local tax on top of the state tax. E.g.: Philly has its own $2.00/pack tax on top of PA's $2.60 state tax. And all of this is on top of a $1.01/pack federal tax.

Just for contrast, it costs me about $1.25 to mix up a week's worth of e-liquid, while a week's worth of cigs would cost me close to $100 now.