Well, I'm unsure as to whom is correct here, but I know for me personally, that I wanted to attempt that, so I went to go to play Cherokee and the game said I must complete the game on Normal first, to unlock Cherokee mode. Perhaps it is already because I had started the game in Normal mode - maybe if you pick Cherokee mode from the get-go it works. Not really sure, but I had to play through normal first.

I just started playing the game and had to choose NORMAL SKILL level. I tried to choose CHEROKEE SKILL level but it said that you must first complete the game on NORMAL SKILL. Not sure what 'Cazx27' has been drinking but i can assure you all that he/she is definetely mistaken.

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100% Completed Retail Games (111) - Including all DLC

First one Ive got so far is Poker Face, got many pair's and a lucky triple at the end. Now to finish the rest of the game.. I didn't try cherokee though it was selectable when I started, oh well. But like others stated it needs normal play through first to unlock it, right?