INTRODUCTION: The purpose of the study is to compare the refractive error measurements of pediatric patients performed with PlusOptix A09 photorefractor (PO), Retinomax K-plus 3 (RTX) and the new autorefractokeratometer Nidek HandyRef-K (HDY) handheld autorefractokeratometer and to evaluate the intermethods agreement. METHODS: One hundred and ninety four eyes of 194 children were included in the study. All children underwent refraction measurement with the PlusOptix before cycloplegia and two different autorefractors were used after cycloplegia: Retinomax and HandyRef-K, respectively.RESULTS: The mean age of the patients was 16.65±10.04 months (range, 3 to 34 months). There were not statistically significant differences in spherical values (SV), cylindrical axis values (CAV) between the PO (SV: 1.61±1.79, CAV: 94.25±72.47), RTX (SV: 1.91±2.06, CAV: 94.3±73.44), and HDY (SV: 1.89±2.04, CAV: 93.55±73.71) respectively (p˃0.05).There was a statistically significant difference for cylindrical values (CV) between RTX (CV: -0.97±0.75) and HDY (CV: -1.11±0.76)(p=0.003); HDY and PO (CV: -0.92±0.68)(p=0.002) while there was no statistically significant difference between RTX and PO (p˃0.05) respectively. Statistically significant differences were demonstrated for spherical equivalent values (SEV) between RTX (SEV: 1.43±1.97) and PO (SEV: 1.15±1.74); HDY (SEV: 1.34±1.95) and PO (p=0.02, p=0.03, respectively) but no significant difference was found between RTX and HDY (p˃0.05). DISCUSSION AND CONCLUSION: According to SEV, no significant difference was found between RTX and HDY but PO was significantly less hyperopic than RTX and HDY. CV measured by HDY was higher than other devices. These devices can be used for screening in crowded pediatric ophthalmology clinics and may be an easier way of measuring refractive errors in children younger than 3 years but especially high SEV and CV should allert the physicians. It should be kept in mind that cycloplegic retinoscopy is still the gold standard and these alternative methods can only be used for screening. Prescription of spectacles should not be made without cycloplegic retinoscopy.