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Yo its the Danish Panobinostat study. Results are expected in September. I would not expect too much, in other studies HDAC has failed, but Panobinostat is stronger than Zolinza, maybe they have more success. Time will tell.You can read about HDAC a lot here in different threads.

Basically they are reporting on research that is just starting. The tag line of the article makes the statement "a cure for HIV within months."

I think that is a bit deceptive and done to make a headline to get the reader interested in the story.

The science is sound though, there are a few researchers working on this same strategy using hdac inhibitors to try and flush out viral reservoirs and then prime the immune system using a vaccine to clear the virus. If it works (which is a BIG IF) its more likely not going to be in months but more like years or even a decade or more. IMHO

Nonetheless it was an interesting article, here here for the Dutch. I hope they have success in their work. I really do.

That psychedelic illustration is straight out of The Fantastic Journey.http://www.youtube.com/watch?v=-hjiVViMuS4 I saw this movie so many times on "The 4:30 Movie" that my visualisations of the immune system are still based on this film.

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“From each, according to his ability; to each, according to his need” 1875 K Marx

Here is the paragraph from the paper that summarizes Panobinostat, which is mentioned in the article:

Panobinostat has recently displayed considerable potency in reactivating HIV-1 expression in latently infected cell lines and primary resting CD4+ T cells as compared with other HDACi in clinical development.67 In this study, panobinostat reactivated HIV-1 expression at concentrations as low as 8–32nM – well below the levels obtained with oral clinical dosing. Panobinostat is likely one of the most potent pan-HDAC inhibitors in clinical development and as the elimination time of panobinostat is relatively long, prolonged histone hyper acetylation can be observed 7 d after a second dose with this compound.75 This allows for dose reductions or intermittent dosing schedules to diminish the problematic thrombocytopenia seen with all HDAC inhibitors. A clinical trial to investigate the in vivo effect of panobinostat on HIV-1 expression and HIV reservoir size has been initiated by our group at Aarhus University Hospital, Denmark (NCT01680094). This study entails 8 week of cyclic panobinostat therapy with a primary endpoint of change from baseline in cell-associated unspliced HIV-RNA and will also provide a unique opportunity for studying the effect on host immune responses.

That psychedelic illustration is straight out of The Fantastic Journey.http://www.youtube.com/watch?v=-hjiVViMuS4 I saw this movie so many times on "The 4:30 Movie" that my visualisations of the immune system are still based on this film.

Love the announcer saying, "Four men and a beautiful girl...." I guess she couldn't be ugly. And, she seems more like a woman to me. And, that's Dr. Loomis, who was Michael Myers' doctor! I never saw Fantastic Voyage. I did see where Stewie was shrunk down to go inside Peter, in order to kill his brother.

That's not the reporter speaking, that is one of the scientists performing the research. He's basically saying they have demonstrated proof of principle and now they want to perform it in a live human host and eventually if all that works they will be able to bring the cure to market for everyone in 5 years. It's an extremely optimistic view to say the least.

This is really exciting; and of course I hope it works! It seems like a simple strategy, very shock and awe! I find it concerning that not a peep was heard from mainstream media in the US. Big pharma won't like a cure; they want people on expensive mess perpetually.

That's not the reporter speaking, that is one of the scientists performing the research. He's basically saying they have demonstrated proof of principle and now they want to perform it in a live human host and eventually if all that works they will be able to bring the cure to market for everyone in 5 years. It's an extremely optimistic view to say the least.

One thing that's sort of interesting and encouraging to me is that the primary completion date for this study was in March 2013. So if one of the scientists associated with the project is even willing to mention the word cure at this point implies (to me) that they're seeing some reasonable preliminary success.

The Danish scientists want to show their results on a conference in Malaysia in the summer. It seems that they had some kind of success, or they would be unreliable scientists making such announcements in the press.

The Danish scientists want to show their results on a conference in Malaysia in the summer. It seems that they had some kind of success, or they would be unreliable scientists making such announcements in the press.

The posting on the University website is a big deal in my mind - my interpretation of all of the press was that one reporter was being sensationlistic and that was being picked up by the rest of the press. The fact that the University themselves is posting this lends more credibility to the claim.

Obviously the cork is still in the bottle, but perhaps we can think about when it may be appropriate to bring the bottle up from the cellar - recognizing that we may have to cancel the party too.

The Danish scientists want to show their results on a conference in Malaysia in the summer. It seems that they had some kind of success, or they would be unreliable scientists making such announcements in the press.

Reading the part about success may depend on how strong and sensitive a person's immune system got me thinking about something I've thought about previously. Say some cure of some kind is found, but it doesn't work on everyone. I think this will lead to more depression, as well as feelings of resentment. And, what if some cure works on 60% of patients, for example. That would change access to doctors and medications I would think. I know it's putting the cart way before the horse, but many posts here do that. My point is I hope for any cure, but hope it works for everyone.

Reading the part about success may depend on how strong and sensitive a person's immune system got me thinking about something I've thought about previously. Say some cure of some kind is found, but it doesn't work on everyone. I think this will lead to more depression, as well as feelings of resentment. And, what if some cure works on 60% of patients, for example. That would change access to doctors and medications I would think. I know it's putting the cart way before the horse, but many posts here do that. My point is I hope for any cure, but hope it works for everyone.

That's a valid and thoughtful concern but I tend to think that if they're able to come up with a cure that's initially effective for only a part of the population infected, then it would only be a matter of time before it's refined to make it effective for everyone.

Reading the part about success may depend on how strong and sensitive a person's immune system got me thinking about something I've thought about previously. Say some cure of some kind is found, but it doesn't work on everyone. I think this will lead to more depression, as well as feelings of resentment. And, what if some cure works on 60% of patients, for example. That would change access to doctors and medications I would think. I know it's putting the cart way before the horse, but many posts here do that. My point is I hope for any cure, but hope it works for everyone.

Sure we all hope it works for everyone. But 60% cure rate would be fantastic news too, right? If there was some sort of treatment that could cure some HIV+ people and it wouldn't work for my own bug, I would be disappointed. Maybe I would get depressed.... I don't know. I would be happy for the cured!

I don't follow the point about the change to access.

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“From each, according to his ability; to each, according to his need” 1875 K Marx

when some people are cured, or non-infected people are vaccinated, funding and access will decrease in proportion to the need. It'll be tough for those who will still need meds and healthcare as resources will be withdrawn and fewer people will be concerned about the remaining few.

when some people are cured, or non-infected people are vaccinated, funding and access will decrease in proportion to the need. It'll be tough for those who will still need meds and healthcare as resources will be withdrawn and fewer people will be concerned about the remaining few.

This prediction ties into the thread I just opened up asking what the world would be like after HIV is "cured"http://forums.poz.com/index.php?topic=48458.0Thoughts of the future definitely tickles my imagination. "cure" vs "functional cure" vs "vaccine only".

Reading the part about success may depend on how strong and sensitive a person's immune system got me thinking about something I've thought about previously. Say some cure of some kind is found, but it doesn't work on everyone. I think this will lead to more depression, as well as feelings of resentment. And, what if some cure works on 60% of patients, for example. That would change access to doctors and medications I would think. I know it's putting the cart way before the horse, but many posts here do that. My point is I hope for any cure, but hope it works for everyone.

Good point, but they could develop another therapy that could be taken concurrently thus having synergistic properties. For example using Interferon to increase a persons immune system response.

Paul Sax • May 2nd, 2013Categories: Health Care, HIV, Infectious Diseases, Research (2 votes, average: 5.00 out of 5)There it is, right in your daily paper, on your tablet or computer screen, or wherever you get your news today — a headline about a great medical breakthrough everyone’s been waiting for:

Scientists on brink of HIV cureResearchers believe that there will be a breakthrough in finding a cure for HIV “within months”Yes, I read this exact headline recently. Here’s the full article, published in the English newspaper the Daily Telegraph. It details how some Danish researchers have figured out a way for “the HIV virus to be stripped from human DNA and destroyed permanently by the immune system.”

Furthermore, they are “expecting results that will show that finding a mass-distributable and affordable cure to HIV is possible.”

By all means, go ahead and read the full piece; you’ve got 20 free reads on the Telegraph website. As a treat, there’s a colorful stock photo too, showing red blood cells floating through some blood vessels, along with a few HIV virions glowing bright green — it’s very Fantastic Voyage-esque, minus Raquel Welch in her scuba gear.

But return here for a moment, please. I’m going to recommend three simple steps to getting the most from this — and other medical breakthroughs — in the mainstream media.

Step 1: Be a skeptic. As exciting as curing HIV would be, and no matter how much you’d like this to happen, just think for a moment about the plausibility of this story. Are scientists really on the “brink” of curing HIV? If so, why is this only appearing in the U.K. Telegraph? Trust me, this brink-of-cure has not yet appeared in peer-reviewed medical journals or at scientific meetings. And wouldn’t you expect this kind of advance, if real, to show up everywhere in media land? Fire up that Google machine, and see what you can find about it elsewhere — lo, it’s the great following herd, all stampeding after that same U.K. Telegraph story. And importantly, here’s a New York Times piece on the very same general subject — HIV cure — and they don’t even mention these Danish researchers. Sure, the Times misses some stories, but it’s got some pretty impressive Health and Science sections — could they miss this, researchers ON THE BRINK OF CURING HIV, no less? I think not. So perhaps Mr. U.K. Telegraph Science Reporter is exaggerating a bit, for the sake of his story, of course.

Step 2: Don’t be a complete snob — give the story a chance. This is the other side of that same coin. Sure, it’s been a challenge curing HIV, but we’ve got that Berlin patient (now living in Las Vegas, by the way) — he’s cured. And the baby from Mississippi, he/she is cured (sort of). Plus, a whole army of smart HIV researchers actively tackling the problem as we speak. In fact, this very same approach cited by the Danish researchers — stimulating the HIV reservoir with an HDAC inhibitor — is a leading candidate for a viable cure strategy; it’s being looked at by many groups. Hey, why can’t Good Ol’ Ole Søgaard and his team be the first to succeed? The extra funding provided by the Danish government — 12 million Danish kroner! — is further evidence of the soundness of Professor Søgaard’s approach.

Step 3: After all that, land someplace between Steps 1 and 2. Take a deep breath. Read the full piece.Discard the fluff: Brink of cure; 12 million Danish kroner; expect a cure to be available in months; you can distribute it to millions; it’s affordable, too.Focus on the facts: Some Danish researchers have some funding to investigate a potentially promising HIV cure strategy; they are testing it in a small number of people; some European scientists may soon be collaborating; we have no actual results yet to report.

After these three steps, all these medical breakthroughs — on HIV, cancer, Alzheimer’s, weight loss, male-pattern baldness, you-name-it — make a lot more sense.

In 8 weeks we will know the results on IAS 2013. If Panobinostat is not enough, there is still another potent HDAC-I in research from Gilead. They test Romidepsin together with GS-9620 (TLR7 Agonist). Maybe a combo of these 3 drugs will reach the aim in the far future. Time will tell.

In 8 weeks we will know the results on IAS 2013. If Panobinostat is not enough, there is still another potent HDAC-I in research from Gilead. They test Romidepsin together with GS-9620 (TLR7 Agonist). Maybe a combo of these 3 drugs will reach the aim in the far future. Time will tell.

Interesting, is HDAC-I what I'm potentially helping out with? (or one of those others, who knows I guess) Again,(posted earlier) I'm signed up for the Gilead HIV Latency Study​​. I'm told there is no benefit to me, they just want to run external tests on my blood. I go in for apheresis in 2 weeks. Hopefully they continue making progress.

http://www.questclinical.com/#!studies/cjg9"BackgroundHIV (+) volunteers are needed to participate in a two-part research study. The purpose of this Latency study is to harvest a quantity of white blood cells during a three-hour apheresis process."

when some people are cured, or non-infected people are vaccinated, funding and access will decrease in proportion to the need. It'll be tough for those who will still need meds and healthcare as resources will be withdrawn and fewer people will be concerned about the remaining few.

Ok this is being discussed simultaneously in other threads it seems. I understand the logic but I do think this is a US based fear. HIV care seems to have been a "bonus" type funding in the USA, its "exceptionally" funded and there is some reluctance and resentment about that funding and constant fear by HIV+ people about it. Its amazing the whole system got set up, but it comes with a certain mindset. Precarity.

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“From each, according to his ability; to each, according to his need” 1875 K Marx

"During the past week a story originating in the Telegraph entitled "Scientists on brink of HIV cure" has been published in other medias.

The article's title and subtitle suggests that a cure for HIV is expected in months. But this is not the case, according to the Danish researchers from Aarhus University Hospital whose work was cited in the Telegraph.

- We are not on the brink of an HIV cure, says Dr. Ole Søgaard from Aarhus University Hospital.- We have an exciting study in which a potential anti-HIV latency reversing agent is tested in persons with HIV. We are making good progress, but there is still a long way to go."

The authors state that they regret if anyone got the impression from reading the article that there may be a cure for HIV in the immediate future. Like many others, the researchers believe that a cure for HIV is an achievable goal, but most likely it will take many years, numerous basic science discoveries, and several phase 1/2 trials before a HIV cure may actually be reached. "

Ok this is being discussed simultaneously in other threads it seems. I understand the logic but I do think this is a US based fear. HIV care seems to have been a "bonus" type funding in the USA, its "exceptionally" funded and there is some reluctance and resentment about that funding and constant fear by HIV+ people about it. Its amazing the whole system got set up, but it comes with a certain mindset. Precarity.

yes, that other thread just started and after responsing to you here, we probably ought to take any more on this subject over there.

It is an amazing system and it only got funded because pozzies and their friends acted up and fought for it. Other illnesses/drugs don't have this kind of protection/intervention because those affected by those diseases never fought for their own adequate care. Of course, we were dying so had nothing to lose and everything to gain by fighting for extraordinary funding. See "How to Survive a Plague". The American healthcare system is a crazy mess and many HIV positive people are often living on a knife's edge of losing/keeping access to ARVs.

Focus on the facts: Some Danish researchers have some funding to investigate a potentially promising HIV cure strategy; they are testing it in a small number of people; some European scientists may soon be collaborating; we have no actual results yet to report.

don't worry Sensual, there'll be plenty of time to talk about this "cure". If it really is the cure, there's still a long time (ie years) to go before it reaches market

JazJon- You are a cool guy:) I hope You have success with Your CalImmune trial. I would be too scared to do this:).You are also in the Gilead trial? I hope they try Romidepsin. It is a 10.000 fold more potent Histone deacetylases-inhibitor than SAHA or Panobinostat. If it does'nt cure HIV, then nothing will do it.I really wonder why Gilead invests so much money and time to find a cure. They have so much to lose if a cure is found.They earn billions with Truvada and Co.. I don't understand them.

I hope You have success with Your CalImmune trial. I would be too scared to do this:).You are also in the Gilead trial? I hope they try Romidepsin. It is a 10.000 fold more potent Histone deacetylases-inhibitor than SAHA or Panobinostat. If it does'nt cure HIV, then nothing will do it.I really wonder why Gilead invests so much money and time to find a cure. They have so much to lose if a cure is found.They earn billions with Truvada and Co.. I don't understand them.

Yup! With so few initial Calimmune slots, I wanted to continue proving I'm the ideal patient for Calimmune by doing the Gilead Latency study. (and show I can handle aphereses with flying colors) My original interest from the beginning was to be part of a cutting edge Stem Cell/Gene Therapy treatment. I was originally interested in the Zinc finger approach, but the Calimmune research has swayed my vote of confidence their way. 2013/2014 could be big news for everyone, only time will tell. If Calimmune ends up not working, I'm pretty sure it will still "help" boost the immune system for the long run.

This whole latency wake-up and kill all HIV approach sounds great too. (and I'll be signed up! pending my previous trials don't disqualify me) I guess that's the only thing I'm scared of is being disqualified for "the one" treatment that ends up working because of the previous one I tried disqualifying me. I'm not really scared, just thinking out-loud here with the what if game.

-"There is no doubt anymore"&-"It is well tested and ready for mass use soon."

Um yeah, that's a bit over the top, but I like the optimism !

I'm not getting my hopes up, I'm treating it as an experiment and happy either way it goes just knowing I'm helping advance science. Having said that, I have no problem being a poster boy for a success story interview on CNN with Anderson Cooper though in 2016 lol.

Your CalImmune will be a great success. There is no doubt anymore. It is well tested and ready for mass use soon.

No hyperbole there.

That said though, don't forget that the Godfather of this approach / company is Dr. David Baltimore, a guy who won the Nobel prize for his work on reverse transcriptase and retroviruses. He's been talking about gene therapy to cure HIV for many years and this is the culmination of decades of research. There's likely a fair chance he knows what he's doing.

Ok let's stay cautious and not too optimistic. It could give false hopes for people who didn't follow the research for the last decade.Everything is only theoretical and at early stage and can fail, of course.I wish a nice summer, it has finally arrived here

so I ask...please think about the wording and grammar of this story, about what they are actually saying here.

notice the words and grammar, like how the title of that article ("HIV may be curable 'within months': Scientists on brink of AIDS vaccine") doesn't seem to understand the difference between the words "cure" and "vaccine"?? LOL Or how this article's title says "within months" when the article they link to says "five years"?? I guess the single quote marks around "within months" lets us know the writer of this article knows he wrote a lie and jazzed up the title to get more readers. LOL

Doesn't take a lot of bait to attract the slow-swimming fish, does it?

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"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."