The airport is easily accessible from most areas in Northeast Texas via major highways and Interstate 20.

From Dangerfield:

Take 259 South to Longview. Proceed on 259 South, which is also known as Eastman Road to Hwy 149. Proceed South on Hwy 149 taking Hwy 322 West. East Texas Regional Airport entrance is two miles from intersection on the left.

From Mt. Pleasant / Pittsburgh:

Take Hwy 271 South to Hwy 300. Proceed on Hwy 300 into Longview then go West on Loop 281 to Estes Parkway, which is also known as Hwy 149. Go South on Estes Parkway to Hwy 322. Continue West on Hwy 322, and East Texas Regional Airport is two miles down on the left.

From Gilmer:

Take Hwy 300 South to Longview. Follow West Loop 281 to Estes Parkway, which is also known as Hwy 149. Proceed South on Estes Parkway to Hwy 322 West. Continue West on Hwy 322, and East Texas Regional Airport is two miles down on the left.

From Nacogdoches:

Take 259 North through Henderson to Hwy 322. Proceed East on Hwy 322, and East Texas Regional Airport is 17 miles on the right. FROM MARSHALL: Take Interstate 20 West to Exit 595. Go South on Hwy 149 to Hwy 322. Proceed West on Hwy 322, and East Texas Regional Airport is two miles down on the left.

From Carthage:

Take Hwy 149 North to Hwy 322. Proceed West on Hwy 322, and East Texas Regional Airport is two miles down on the left.

From Henderson:

Take Highway 259 North to Highway 322. Proceed East on Texas Highway 322 for approximately 17 miles. East Texas Regional Airport will be on your right.