An action-packed horror adventure, "B.P.R.D.: Hell On Earth: The Transformation of J.H. O'Donnell" focuses on a lost mission from Hellboy's past that comes back to haunt the Bureau of Paranormal Research And Defense.

Angel resists Drusilla's tempting offer to rid himself of sadness and the obligation that comes with it, meanwhile Faith doesn't even attempt to resist rekindling her relationship with her father, a (former) drunk who abandoned her as a child.