Mr. Ellison's comments about the books of Hatecraft earned him an attack by one of its characters, Char Gar Gothakon.

Later he and Hatecraft decided to collaborate on a book about fans and how monstrous they are.

Later, it was revealed that Mr. Ellison had become a teacher at Darrow University. He was absent at a misanthrope convention at the time of the Obliteratrix attack.

Post-Nibiru

After Mystery Incorporated destroyed the Evil Entity during Nibiru and reset the timeline, Harlan Ellison was the only one besides them that remembered what happened and became the new "Mr. E". He enrolled the gang (even Scooby-Doo) at Miskatonic University on the East Coast, with the gang deciding to take the Mystery Machine across the country and solving mysteries along the way.