Police have criticised US television series Breaking Bad for romanticising the methamphetamine trade, after seizing nearly $15 million worth of ice and chemicals in the wake of a crystal meth lab bust in Sydney's north-west.

Detectives arrested 35-year-old Jamie Tallarida from Bondi and 24-year-old Joshua Ciampi from Cranebrook on Wednesday night after stopping a car at Box Hill.

Officers said they found a large-scale drug lab while searching a nearby property, seizing one kilogram of ice and three litres of methylamphetamine oil.

A short time later, police raided an apartment in Bondi, where they found 70,000 ecstasy tablets, four kilograms of MDMA, four kilograms of ice and a ballistics vest.

The two men were charged with a string of offences and were remanded in custody until August.

"The scale of the lab ... we'll allege, is one of the largest that we've seen," he said.

"You'll see from some of the footage that we've got there that, we see shows like Breaking Bad that romance this a little bit, [but] you can see the filth that this is manufactured in."

Superintendent Cook says the reality of the drug manufacturing trade is nothing like that portrayed in the television series, which sees chemistry teacher Walter White cooking crystal methamphetamine to fund his cancer treatment.

"Cooks aren't out there concerned about how they're making this. It's full of garbage, manufactured in places like this which are dangerous," he said.

"There's no Walter Whites out there, and the best thing about this is that Hank got his man."

Superintendent Cook said the laboratory, which police believe had been in operation for some time, had the capacity to "churn out multiple kilograms of drugs".

And he said its closure had prevented "hundreds of thousands of doses" reaching the street.

The discovery of the Box Hill laboratory brings the number shut down by police in New South Wales to 44 so far this year.

"This stuff goes on in premises, in homes, in units, in factories," Superintendent Cook said.

"We very clearly rely on the public to give us what information they can so if anyone sees anything unusual, hears anything unusual, smells that emanate from these places and they do stink, please call Crime Stoppers."

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