Deep learning is now more popular research domain in machine learning and pattern recognition in the world. Deep learning is widely success in the in-depth of applications specifically in healthcare, speech recognition, and natural language processing using the absolute amount of data accessible nowadays, big data takes opportunities and transforms possible design for several sectors. Further, it also performs on the unpredictable defies to connecting data and information. The size of the data is getting larger, and deep learning is imminent to perform a vital part in big data predictive analytics. This paper provides an available outline of deep learning and focuses recent exploration in analyze of medical images, diagnose diseases accurately and provide personalized medicines.