It took Chuck Pagano less than nine months to instill his fighter's mentality and hopeful spirit in the Colts.

He will need both to survive the biggest fight of his life - against leukemia.

In a somber news conference Monday, the Colts announced that their head coach had been hospitalized for cancer treatment and probably will not return to full coaching duties this season. He will be replaced on an interim basis by offensive coordinator Bruce Arians.

"He will do fine," Arians said, his voice cracking as he recalled his own fight with prostate cancer in 2007. "I know him. He's a fighter. He's survived tough times already in his life. As a cancer survivor myself, I know that these first few days are really hard on you, but as he and I talked yesterday, it's just a matter of time."

The news hit hard in all corners of the team complex.

Team owner Jim Irsay, who began his career as a Colts ball boy in the early 1970s, said the only comparison he could come up with was Vince Lombardi's cancer diagnosis during the summer of 1970.

New general manager Ryan Grigson read stoically from his prepared notes, and Arians struggled to hold back tears.

After practice, players signed a get-well card that read in part, "We are in your corner 100 percent. Get rest, but we can't wait to get our leader back."

The usually jovial comments were replaced by concerned looks and serious discussion about life - not football.

"When I first heard about it, my heart dropped," cornerback Jerraud Powers said. "You think about your family members or someone that's actually been affected by it. But Chuck will fight this thing and he will beat this thing, there's no doubt in my mind."

Holmes out: X-rays were negative on Santonio Holmes' left foot, but the Jets' receiver is expected to be sidelined at least a few weeks.

Briefly: The Titans say Jake Locker has no structural damage to his left, non-throwing shoulder and is day-to-day. ... The Jets signed cornerback Aaron Berry, who was arrested twice this summer and cut by the Lions. ... The Broncos placed center J.D. Walton on injured reserve with a broken and dislocated left ankle, sustained Sunday. ... The Chiefs say Matt Cassel will remain the team's starting quarterback. ... The Jets say they'll stick with Mark Sanchez at quarterback. ... The Seahawks are sticking with Russell Wilson at QB.