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In Ghost Fight at the O.K. Corral, in the small town of Tombstone, Arizona, the spirits of Doc Holliday and the Earps materialize, intent on recreating the gunfight at the O.K. Corral. The Ghostbusters may soon get caught in one of the greatest showdowns the west has ever seen.[2]

The Mayor of Tombstone addressed a crowd in front of Boot Hill Cemetery. Dewey Lamort made a generous investment to create "Six Guns Over Tombstone," the greatest Western theme park in southeastern Arizona. Dewey greeted the crowd as the Mayor also introduced Dewey's wife, Dorothy. The Mayor then presented Dewey with a pair of boots that once belonged to Wyatt Earp. A photographer in the crowd suggested Dewey put the boots on. Ectoplasm seeped out of the boots and a ghost manifested - Wyatt Earp. Earp wasted no time and shot ectoplasmic bullets after forming one of his hands into a make believe gun. Once everyone was gone, Earp turned to the Six Guns banner and shot it off the Boot Hill sign.

In the Firehouse, Egon was ready to test out a new Ghost Trap with twice the psychokinetic energy suction of the older model. Slimer donned a helmet and volunteered to help test the trap. It appeared to work but the trap also took a chunk of the ceiling with it. However, it then sucks in its remote pedal then itself...disappearing altogether. Slimer then fell back down from the second floor and teared up as Ray, Winston, and Egon stated more tests were needed.

Janine answered a phone call from none other than Dewey Lamort. Peter's head popped out from the new hole in the ceiling and he rushed down to take the call. Peter made an agreement and announced the Ghostbusters were heading to Tombstone, Arizona. Everyone else was still not sure who Lamort was so Peter revealed he is the greatest Western writer. Peter then started citing off titles of Lamort's books as everyone walked away. As the Ghostbusters departed a West Air airplane at Tucson Airport, Peter still cited more book titles. Unbeknownst to them, Slimer stowed away on the exterior of the airplane.

The guys traveled in a rental car as Peter still talked about westerns. The radiator overheated and they were forced to pull over. Slimer stumbled out of the exhaust. Egon spotted a limo in the distance. They attempted to wave down the limo but its driver, Lamort, just waves at them and drove off. The second car behind him stopped and the Ghostbusters met Boris Mealey, the photographer from earlier. As Boris drove the guys to Boot Hill, he revealed Lamort had to fly to New York for a luncheon and was asked to show them around instead. Boris hated it in Tombstone but he worked for Random Choice Publishing and was tasked with getting publicity shots for Lamort's new book "Earpo." Slimer stowed away on the car bumper.

The Ghostbusters went to work. Only Ray noticed Slimer and he advised the spud to lay low. Egon took out his P.K.E. Meter and the ectoplasmic trail led to Tombstone. Earp's set of footprints suddenly became four sets. Peter declared they must belong to Virgil and Morgan, Wyatt's brothers, and their friend Doc Holliday. When everyone laughed at Egon's jab at westerns, Peter is annoyed. Egon then suggested they split up. Boris went with Winston and saw a Foto-Fast. He decided to get more film as Winston investigated Tombstone Epitaph. Virgil Earp appeared and printed out a bunch of newspapers that landed on Winston. Ray and Slimer looked around in a dental office. Sure enough, Doc Holliday appeared and tried to perform a check up on Ray. Slimer helped out and Ray escaped the office.

At the General Store, Egon ran into Morgan Earp and the store was leveled. The Earp Gang reunited at a saloon. A short time later, Peter spotted the saloon and entered. He went up to the bar and did a bad John Wayne impression. Peter is surprised when someone answered him. The Earp Gang was playing Poker at a table. They invited Peter to join in. Everyone had Aces and Eights, the Dead Man's Hand. Peter revealed four Aces. The Earp Gang accused Peter of cheating and shot at him. Slimer threw down a welcome sign to distract the ghosts while Peter ran off back to Boot Hill and met up with the others. Winston handed out a newspaper from his encounter in town. Egon realized it was a challenge and the ghosts wanted to reenact their battle with Clanton Gang. The Ghostbusters eventually agreed to the challenge. They marched into town and confronted the Earp Gang. Things didn't go well and the guys are forced to run for it.

Peter was temporarily blinded by a splash of water from a trough and Slimer took up his Particle Thrower. Peter then tripped and discovered 16 horse shoes. He came to a revelation and hid nearby. The Earp Gang soon arrived and boarded their Ghostly Horses. Peter activated the four Ghost Traps underneath and captured them all. The Ghostbusters returned to Boot Hill and Boris took a photograph. As they departed, Slimer took a well deserved nap on the bumper.

Peter: (shuffles) "Seven card high-low stud, draw, roll your own deuces sevens, twos wild, lavos us manos, and full steam ahead. (the ghost cowboys point their gun fingers at him) Or whatever. (deals cards) So, does anybody need any more?"Cowboy Ghosts: (drop their cards to the table, revealing they all have exactly the same hand of 2 aces, 2 eights, and a six) "Aces to Eights. Dead Man's Hand."