Rasagiline Side Effects

It is possible that some side effects of rasagiline may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to rasagiline: oral tablet

As well as its needed effects, rasagiline may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking rasagiline, check with your doctor immediately:

Less common

Abdominal or stomach pain

arm, back, or jaw pain

black, tarry stools

chest pain or discomfort

chest tightness or heaviness

chills

cloudy urine

cough

diarrhea

difficulty swallowing

dizziness

fainting

fast or irregular heartbeat

fever

hives, itching, or skin rash

loss of appetite

nausea

painful or difficult urination

persistent, non-healing sore

pink growth on the skin

puffiness or swelling of the eyelids or around the eyes

reddish patch or irritated area

redness, blistering, peeling, or loosening of the skin

seeing, hearing, or feeling things that are not there

shiny bump

sore throat

sores, ulcers, or white spots on lips or in mouth

sweating

swollen glands

tests that show problems with the liver

tightness in the chest

unusual bleeding or bruising

unusual tiredness or weakness

weakness

white, yellow or waxy scar-like area

Some rasagiline side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

runny nose

sensation of spinning

shivering

sneezing

stuffy nose

swelling or redness in the joints

thinning of the hair

tiredness

trouble concentrating

trouble sleeping

vomiting

weight loss

For Healthcare Professionals

Applies to rasagiline: oral tablet

Cardiovascular

When used as an adjunct to levodopa, the risk for developing posttreatment high blood pressure, combined with a significant increase from baseline was higher for rasagiline (2%) compared to placebo (1%).

Clinical trial data suggest that orthostatic hypotension occurs more frequently during the first 2 months of rasagiline treatment and tends to decrease over time.

Postmarketing reports of elevated blood pressure, including rare incidents of hypertensive crisis associated with the ingestion of unknown amounts of tyramine-rich foods, have been reported in patients taking recommended doses of rasagiline.[Ref]

Dyskinesia or exacerbation of dyskinesia has been reported when rasagiline is used as an adjunct to levodopa. A dose reduction of levodopa may mitigate this effect.

Cases of patients treated with rasagiline and other dopaminergic medications falling asleep while engaged in activities of daily living including the operations of motor vehicles, have been reported and sometimes resulted in accidents. Some of these cases of somnolence have been reported more than 1 year after initiation of treatment.

The postmarketing reports of serotonin syndrome, associated with agitation, confusion, rigidity, pyrexia, and myoclonus have been reported by patients treated with antidepressants/SNRI concomitantly with rasagiline.

When studied as an adjunct to levodopa, the incidence of hallucinations was approximately 5% at a rasagiline dose of 0.5 mg per day, 4% at 1 mg per day, and 3% with placebo. Dose reduction or treatment discontinuation should be considered if hallucinations or psychotic-like behaviors develop.

Reduced impulse control or increased compulsive behaviors include intense urges to gamble, increased sexual urges, intense urges to spend money, and binge eating. Patients may not recognize these behaviors as abnormal. Dose reduction or treatment discontinuation should be considered if such urges develop.[Ref]

Consumer resources

Professional resources

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