It is a shrub or small tree, reaching a maximum height of 4 m, with thin papery bark.[3] The branches are thorny. The leaves are simple or trifoliate, the leaflets ovate, 1–5 cm long, 0.5–2.5 cm broad, irregularly toothed. It is gynodioecious, with some plants bearing bisexual and male flowers, and others with female flowers. The individual flowers are red to pink, with four small petals. The small round fruit are red when ripe.

Guggul produces a resinous sap known as gum guggul. The extract of this gum, called gugulipid, guggulipid or guglipid, has been used in UNANI & Ayurvedic medicine, a traditional UNANI medicine, for nearly 3,000 years in India.[4] Some of the uses in the traditional medicine have been for reducing obesity, as well as in the treatment of rheumatoid arthritis, osteoarthritis and sciatica.[5] The active ingredient in the extract is the steroid guggulsterone, which acts as an antagonist of the farnesoid X receptor, once believed to result in decreased cholesterol synthesis in the liver. However, several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein ("bad cholesterol") increased in many people.[6][7]

Guggul can be purchased in a loosely packed form called dhoop, an incense from India, which is burned over hot coals. This produces a fragrant, dense smoke. The burning coals which let out the smoke are then carried around to different rooms and held in all corners for a few seconds. This is said to drive away evil spirits as well as remove the evil eye from the home and its family members.

Because of its medicinal properties, guggul has been overharvested in much of its habitat, and has been listed on the IUCN Red List of threatened species.[8] Several efforts are in place to address this situation. India's National Medicinal Plants Board launched a project in Kutch District to cultivate 500 to 800 hectares (1,200 to 2,000 acres) of guggal,[9] while a grass-roots conservation movement, led by IUCN associate Vineet Soni, has been started to educate guggal growers and harvesters in safe, sustainable harvesting methods.[10][11]