Recent Submissions

Introduction: In South Africa, breast cancer has the highest prevalence with a life time risk of
1 in every 9 women being diagnosed annually. There are four sub-types of breast cancer and
according to the stage of the ...

Parkinson’s disease (PD) is an incurable, progressive disease characterised by loss of dopaminergic
neurons in the substantia nigra of the brain. The main cause of dopaminergic neuron loss is attributed to
oxidative ...

Malaria is a major public health problem that affects millions of lives globally. The increased
burden of malaria requires new interventions that will address the eradication of the disease.
Current interventions include ...

Plasmodium falciparum is a protozoan parasite responsible for causing the most severe form of
malaria in humans. This species is responsible for over 90% of malaria mortalities which occur
predominantly in Africa. An ...

This dissertation describes the elucidation and implementation of derivatisation
in the quantification of biologically active vitamin D metabolites in limited volume
serum and dry blood spot samples (DBS) using the liquid ...

Malaria is a global pandemic that affects millions of people each year. It is a parasitic
infection caused by the Plasmodium family, with Plasmodium falciparum being the most
virulent strain. Malaria is transmitted to ...

Scientifically credible and valid biological systems are essential in pharmaceutical research and development. Standardizing in vitro preclinical hepatotoxicity is confounded by the diversity of origin of cells and the ...

Context: The association between long-term metformin use and low vitamin B12 levels has been proven. However, the prevalence estimates of metformin-induced vitamin B12 deficiency showed considerable variation among the ...

Background: Carbohydrate derived fulvic acid (CHD-FA) is a synthetic heavy metal free
fulvic acid. Although CHD-FA has been suggested as a nutritional supplement and even a
medication, there is currently no data available ...

Herbal remedies are an important and often-used commodity in developing countries,
such as those in Africa. There is a long-standing belief that these medicinal
preparations are more effective and safe than allopathic ...

Introduction: Biogenic amines are a group of endogenous compounds which play an important role in maintaining homeostasis. These compounds are produced from amino acid precursors and exert strong physiological effects ...

Cancer is one of the most life-threatening groups of diseases that affect humanity. Current treatment options include surgery, radiation treatment as well as chemotherapeutic agents such as alkylating agents, antimetabolites ...

Most successful treatment strategies for neosplasms comprise combinations of anti-cancer
drugs with different mechanisms of action and side effect profiles. This strategy allows for the
use of anti-cancer agents at the ...

A wound occurs when the integrity of the tissue is compromised, resulting in the breakdown of its protective functions. Wound healing is a complex sequential overlapping process. The progression of the wound healing process ...

Resident skin flora are usually non-pathogenic and prevent colonization of
harmful microbes by competing for nutrients and stimulation of the immune
system. However, these resident microbes can enter the bloodstream ...

The most severe form of malaria in humans is caused by the intracellular parasite Plasmodium falciparum. The African continent bears the greatest burden of malaria with 90% of all malaria deaths occurring in sub-Saharan ...

Introduction: Plasmodium falciparum is the dominant cause of severe malaria in humans, with the highest number of global deaths occurring in Africa and Southeast Asia. Even though artemisinin-derivative combination therapies ...

Humic substances, such as the closely related humic and fulvic acids are ubiquitous, naturally occurring organic macromolecules of complex but undefined structure. These compounds are known complexing agents due to their ...

Malaria is a disease caused by the protozoan parasite Plasmodium where the species that causes the most severe form of malaria in humans is known as Plasmodium falciparum. At least 40% of the global population is at risk ...

Type 2 diabetes mellitus (T2DM) is an increasing global health concern, currently affecting an estimated 382 million individuals. There is no cure for T2DM and the search for new and improved treatments is ongoing. Presently, ...