Used when someone is talking, there is too much noise or when someone is talking shit. It is the upgrade of "shut up" and is used mainly when you are angry and annoyed to the extent the you could lose it at any moment.

"Why don't you go into the kitchen,and open the fridge. Look in the back, all the way back. There's a can of soda, cold chillin'. I want you to reach back there and take it. Open it up and take a nice long drink. MMM, was good, wasn't it? Now i want you to look at the can and make sure its a twelve ounce can, of Shut The Fuck Up.