STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Acin_1469

Malolactic enzyme (542 aa)

Predicted Functional Partners:

Acin_2290

Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1167 aa)

0.975

Acin_2032

Pyruvate-ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1178 aa)

0.975

Acin_1089

Hypothetical protein; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1168 aa)

0.975

Acin_0057

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1134 aa)

0.975

fumC

Fumarate hydratase (464 aa)

0.961

Acin_1468

Malate transporter (328 aa)

0.960

Acin_2417

L-lactate dehydrogenase (317 aa)

0.955

Acin_0505

L-lactate dehydrogenase (319 aa)

0.955

pyk

Pyruvate kinase (611 aa)

0.947

pyc

Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (1143 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

Acin_0057

Acin_0505

Acin_0057

Acin_0505

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

L-lactate dehydrogenase

0.985

Acin_0057

Acin_1089

Acin_0057

Acin_1089

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

Hypothetical protein; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

0.999

Acin_0057

Acin_1469

Acin_0057

Acin_1469

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

Malolactic enzyme

0.975

Acin_0057

Acin_2032

Acin_0057

Acin_2032

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

Pyruvate-ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

0.999

Acin_0057

Acin_2290

Acin_0057

Acin_2290

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

0.999

Acin_0057

Acin_2417

Acin_0057

Acin_2417

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

L-lactate dehydrogenase

0.985

Acin_0057

fumC

Acin_0057

Acin_2402

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

Fumarate hydratase

0.558

Acin_0057

pyc

Acin_0057

Acin_0904

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second

0.975

Acin_0057

pyk

Acin_0057

Acin_1656

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

Pyruvate kinase

0.975

Acin_0505

Acin_0057

Acin_0505

Acin_0057

L-lactate dehydrogenase

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

0.985

Acin_0505

Acin_1089

Acin_0505

Acin_1089

L-lactate dehydrogenase

Hypothetical protein; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

0.985

Acin_0505

Acin_1469

Acin_0505

Acin_1469

L-lactate dehydrogenase

Malolactic enzyme

0.955

Acin_0505

Acin_2032

Acin_0505

Acin_2032

L-lactate dehydrogenase

Pyruvate-ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

0.985

Acin_0505

Acin_2290

Acin_0505

Acin_2290

L-lactate dehydrogenase

Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

0.985

Acin_0505

Acin_2417

Acin_0505

Acin_2417

L-lactate dehydrogenase

L-lactate dehydrogenase

0.840

Acin_0505

fumC

Acin_0505

Acin_2402

L-lactate dehydrogenase

Fumarate hydratase

0.790

Acin_0505

pyc

Acin_0505

Acin_0904

L-lactate dehydrogenase

Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second

0.967

Acin_0505

pyk

Acin_0505

Acin_1656

L-lactate dehydrogenase

Pyruvate kinase

0.985

Acin_1089

Acin_0057

Acin_1089

Acin_0057

Hypothetical protein; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

Pyruvate ferredoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

0.999

Acin_1089

Acin_0505

Acin_1089

Acin_0505

Hypothetical protein; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin

L-lactate dehydrogenase

0.985

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: