Mouse Cursor moves without human interaction

I have this very strange problem on one of the PC's on our network whereby the mouse cursor seems to jerk about very slightly and move slowly towards the top left corner of the screen, even when left alone. I'm quite certain that the machine isn't infected with anything as I've run virus scans and a couple of spy/malware scans and all have come up clean and I've made sure there are no processes running in the background that shouldn't be.

I know it's nothing to do with the mouse or the ports (tried USB and PS/2) as it still happens with the mouse completely unplugged... It also continues to happen after a reboot.

Does anyone have any ideas on this as I'm stumped and the user is getting rather frustrated with it.

"it happens after reboot without a mouse plugged in"... i don't think an optical mouse would cause this problem... i've heard of this happening with a shorted ps2 connector... doesn't matter if your using

is it an optical mouse? if so it may be something to do with the surface it's sitting on - my optical mouse does the same thing if it's sat on a glossy surface. try putting a mouse mat orsomething that isn't shiny under the mouse

"it happens after reboot without a mouse plugged in"... i don't think an optical mouse would cause this problem... i've heard of this happening with a shorted ps2 connector... doesn't matter if your using usb or if anything is plugged in or not... the ps2 is still shorting and causing the mouse to move... i would go into control panel.. then system... then device manager... then go to input devices... then click on ps2 mouse... or whatever it says... you know.. then disable it... hook up a usb mouse and restart the computer... see what's movin!

I considered mouse drivers and surfaces (2 different types of mouse mat and just flat on teh desk) when I first started looking at the problem, but as I said in the original post, this is happening even after I've unplugged the mouse completely from the PC and rebooted so it definitely rules surfaces out.

Not sure if a driver would have an effect or not, so probably worth a try...

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