Note that the therapeutic range applies to use of aspirin for anti-inflammatory purposes. According to the UpToDate guidelines (accessed May 21, 2012) on "Salicylate poisoning in adults" by Barnett and Boyer, "Therapeutic serum salicylate concentrations fall between 10 to 30 mg/dL (0.7 to 2.2 mmol/L); values above 40 mg/dL are associated with toxicity. Although there is no absolute correlation between plasma salicylate concentration and symptoms, most patients show signs of intoxication when the plasma concentration exceeds 40 to 50 mg/dL. Plasma salicylate concentrations >100 mg/dL in acute intoxication and >60 mg/dL in chronic intoxication are indications for hemodialysis."