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Articles

Cavinton in the treatment of ischemic cerebral stroke. Clinical and computerized-tomographic evaluation

Author

Domzal T, Kozlowski P, Zaleska B

Date

1986

Journal

Neurol Neurochir Pol

Abstract

Intravenous Cavinton (ethyl ester of apovincaminic acid) was given to
27 patients with acute ischaemic stroke, while 30 patients were given
aminophylline twice daily during 10 days. The results of this
treatment was compared on the basis of clinical manifestations and
changes in computerized tomograms (CT) before and after the
treatment. It was found that Cavinton gave similar results as
aminophylline and other vasoactive preparations studied by other
authors. In the group of severe strokes better results were observed
after Cavinton, --out of 14 patients 2 died and 12 improved. In the
aminophylline group 5 out of 10 patients died, and in 2 no
improvement was observed. Clinical improvement was not correlated
with CT improvement, while a significant correlation was observed
between the state of the patient during admission and the size of the
focus in CT. Cavinton had a significantly greater effect on the
regression of CT changes.