The aim of this study was to determination and comparison of echocardiographic profile of elite Iranian weightlifters with non-athletes. Sample of research included 10 elite weightlifters with mean age of /2±1/218 years old and 10 non-athletes with mean age of 8/3±1/19 years old that As subjects participated in this study. The subjects were tested by one and two-dimensional echocardiography to determine cardiac structure (Left ventricular mass (TLVM), Left ventricular end-diastolic diameter (LVDD), Left ventricular end-systolic diameter (LVSD), End-diastolic inter ventricular septal size (DVS), End-systolic inter ventricular septal size (SVSS)) after complete of consent form and medical history questionnaire. For comparison of data in two groups, all data recorded digitally according basic data analysis was calculated by expert echo cardiographer. Findings of the research were analyzed by independent samples t test. Results show that the mean left ventricular structural variables of the elite Iranian weightlifters are more than non-athletes. Except in left ventricular end-diastolic and systolic size (P>0.05), there were significant differences in other cardiac structural variables between the two groups (P< 0.05). These results are consistent with the Morgan Roth hypotheses (1997) and follow the pattern of concentric hypertrophy.