Reduced ambulatory activity has been shown to effect the response to a high fat tolerance
test (HFTT) after acute exercise. This study will evaluate the effect of varying levels of
daily ambulation on response to a HFTT after an acute aerobic exercise bout.

Cerebral palsy (CP) affects the motor function but also the cognitive function of the child.
Physical activity brings motor and cognitive benefits and appears as an important aspect of
the therapy that is offered to them.
The child is seating in front of a computer, seatting comfortably on a chair during 1 hour.
The experimental task consists in learning a sequence of taps on "Serial reaction time task"
type buzzers (SRTT) in which the child must press a buzzer corresponding t...

This pilot study has a sequential design involving three groups to ensure appropriate
development and evaluation of the optimal procedural steps of the D-UAO device and to
confirm that those steps are reproducible in the hands of multiple surgeons.

The study is designed to validate the accuracy of steps detected by a commercially available
smartwatch in persons with multiple sclerosis. Specifically, the investigators examine
whether a smartwatch can detect steps accurately during slow, comfortable and fast overground
walking. The total steps counted by the smartwatch will be compared to those counted by an
accelerometer commonly used in clinical studies and the actually walked steps.

Accelometers enhance physical activity. Nevertheless, their validity (ability to accurately
count steps) is not known in an elderly frail population ready for discharge from a
rehabilitation unit. Our objective was to assess accelometers' validity for counting steps
(10 meters), in comparison with the gold standard: steps counted by 2 physicians blind to
accelometers data, over a filmed 10-meter walk (minimal capacity to walk inside their own
living place). Our second objective...

This is a formative study, designed to provide information required to tailor Life-Steps for
Pre-Exposure Prophylaxis (PrEP), an evidence-based cognitive behavioral adherence
intervention, to enhance PrEP uptake and adherence in high risk young men who have sex with
men (YMSM) and young transgender women who have sex with men (YTWSM).
Life-Steps for Pre-exposure prophylaxis (PrEP) is a manualized modular adherence intervention
based on principles of cognitive-behavioral therap...

The proposed project will leverage two programs of research at UPenn and CHOP that are
delivering technology-based interventions to adolescent and young adult (AYA) cancer
survivors.
In the proposed study, all AYA survivors will receive a care plan via a tool (Smart-ALACC).
They will then be randomized to receive (or not) a mobile health application (AYA STEPS) that
will provide tailored messages to enhance uptake of their care plan.

Manufacturer's diagrams showing defibrillation pad positioning (as used on public access
defibrillators) are anatomically incorrect and are likely to lead to poor position of
defibrillation pads, with reduced defibrillation efficacy.
We will ask untrained members of the public to observe the diagrams and place pads as
indicated on the diagram. We will asses the accuracy of pad placement and repeat the study
using an anatomically correct diagram to see if we can improve the acc...

To determine the maximal safe daily dose of BG8962 (rCD4) which can be administered by
continuous subcutaneous infusion (CSCI) over 24 hours; to determine the pharmacokinetics of
BG8962 when it is administered by intramuscular and subcutaneous routes; and to look for
dose related antiviral activity determined by quantitation of infectious HIV peripheral
blood leukocytes (PBLs) and plasma, and by monitoring the blood levels of viral p24 antigen
(when present), CD4+ T-cells, and ...

This is a prospective randomized controlled trial in which patients with previous breast
cancer will be randomized into two treatment arms:
1. Control Group of Usual Physical Activity
2. Intervention Group of Increased Physical Activity
No specific intervention will be performed In the patients randomized in the control group.
Patients randomized in the Intervention group will receive a program of increased physical
activity starting from 5000 steps/day up to 1200...

This pilot pharmacokinetic study is designed to exclude a large difference (>40%) in
pharmacokinetics (esp. AUC) between two new Lopimune formulations and the branded
formulation. The formal bioequivalence study with adequate power will be conducted by the
manufacturer. In order to get data independently from the manufacturer and to have this
information in an earlier phase, this small pilot study is initiated.
The initial study showed a declined bioavailability of the granule...

A high physical fitness can prevent cardiovascular disease. Which form of exercise training
is efficient at improving fitness is well known. The challenge is to get people to do it.
Personal activity intelligence (PAI) is an algorithm developed for this challenge. It gives a
score that tells the users whether they are active enough to achieve the maximum health
benefit of exercise based on their heart rate. It has been shown that people who obtain 100
PAI a week have less cardi...

In this study, we measured the number of steps, blood pressure, blood glucose, and weight in
daily life through the smartphone personal health record app for patients with type 2
diabetes. The efficacy of text message intervention, which encourages an increase in the
number of steps per week for 12 weeks, on an increase in the number of daily steps and
changes in glucose levels, weight, and blood pressure will be investigated. Also, the
durability of intevention will be checked...

Previous Biogen studies have provided experience with the tolerability, immunogenicity, and
efficacy of a single and multiple 12-week courses of therapy of alefacept. At this stage,
experience in larger studies, as well as the FDA-approved labeling, is confined to treatment
courses of 12 weeks. The purpose of the present study is to offer an extended course of
therapy with alefacept.

Anxiety problems are a major concern of youth mental health given that the prevalence of
anxiety disorders in Dutch adolescents aged 12 to 18 is approximately 10 percent. In this
group, specific phobias are among the most common. Cognitive Behavioral Therapy (CBT) with
exposure as its key ingredient, takes a prominent place in national guidelines for the
treatment of anxiety disorders. These guidelines are based on empirical support that exposure
is effective in the treatment o...

The overall, broad objective of this study is to pilot the BSD technique. The specific
purpose of this particular study is to generate pilot data to validate several crucial steps
of the BSD technique, in particular steps 1, 2, and 4. Radiation treatments will proceed
per standard of care, and will not be modified in any way during this protocol. This study
is a non-treatment protocol.

The aim of the present study was to investigate the potential factors that determine
preschool obesity in Al Ain, United Arab Emirates, and assess the effectiveness of a simple
healthy lifestyle tool: Eat Right Emirates (ERE) adapted from the Ten Steps for Healthy
Toddlers, produced in the UK by the Infant and Toddler Forum.

This study assesses the effectiveness of a nutrition advice programme - The ten steps for
healthy feeding of children under than two years - on nutritional status and morbidity
history of children. This is a randomized controlled trial in mostly socioeconomic deprived
families (intervention=200; controls=300). Mother's of the intervention group received
dietary counseling in the first year of life. Both groups received routine care by their
paediatricians and research assessme...

- Steps in short: Undergoing the conventional steps of maxillary single denture
construction till the step of framework construction that will be designed and
constructed using CAD/CAM after optical scanning of the master cast ( 2 frameworks to
cover the palate and crest of the ridge : one made of titanium and the other made of
cobalt/chromium) then conventional steps will be undergone including bite, Try-in and
delivery ending by measuring the denture...