ribonucleotide reductase

ri·bo·nu·cle·o·tide re·duc·tase

a protein complex that converts ribonucleotide diphosphates (NDPs) such as ADP and CDP to 2'-deoxyribonucleotide diphosphates (dNDPs) such as dADP and dCDP. This complex requires thioredoxin, thioredoxin reductase, and NADPH. It is crucial for DNA synthesis.

The two components of ribonucleotide reductase, R1 and R2, are integral to our antisense technology platform and are being used to develop very promising anticancer drugs that are currently in clinical trials," said Dr.

Extensive published research on enzyme active site structures such as those found in hemerythrin, ribonucleotide reductase, methane monooxygenase and many other enzymes reveals the presence of binuclear metallic cores, many of which are carboxylate-bridged (refs.

Bergeron reported in an earlier study that iron chelators -- molecules that tightly bind iron--prevent it from being incorporated into ribonucleotide reductase, an iron-dependent enzyme that catalyzes a step of DNA synthesis.

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