Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in early December 2019 in Wuhan, China. It has since spread throughout the world.

One measure of viral spread is the R0, the expected number of secondary infectious cases produced by a primary infectious case. This calculation is used to determine the potential for epidemic spread in a susceptible population. The effective reproduction number, Rt, determines the potential for epidemic spread at a specific time t under the control measures in place (Figure 1). To evaluate the effectiveness of public health interventions, the Rt should be quantified in different settings, ideally at regular and frequent intervals (eg, weekly).

In an article published in JAMA, Pan and colleagues1 evaluated the association of public health interventions with the epidemiological features of the COVID-19 outbreak in Wuhan by 5 periods, according to key events and interventions, including cordons sanitaire, traffic restriction, social distancing, home confinement, centralized quarantine, and universal symptom survey.

In their study, Pan et al1 determined the Rt as an indicator to measure the transmission of SARS-CoV-2 before and after the interventions. In a figure in their article, the authors show the extraordinary change in the rate of transmission of SARS-CoV-2 associated with reducing social interaction (Figure 2). In early through mid-January 2020, the SARS-CoV-2 epidemic in Wuhan had an Rt of 3 to 4. In other words, each case spread to an average of 3 to 4 others. That is a striking number: compare it to the Rt of 1.4 to 1.7 for influenza, which is a disease that spreads widely around the world every year. Couple that with the fact that each new generation of SARS-CoV-2 cases occurs every 5 days, and it is clear to see how this epidemic was spreading out of control.

The effective reproduction number Rt is defined as the mean number of secondary cases generated by a typical primary case at time t in a population, calculated for the whole period over a 5-day moving average. Results are shown since January 1, 2020, given the limited number of diagnosed cases and limited diagnosis capacity in December 2019. The darkened horizontal line indicates Rt = 1, below which sustained transmission is unlikely so long as antitransmission measures are sustained, indicating that the outbreak is under control. The 95% credible intervals (CrIs) are presented as gray shading.

On January 23, a series of major actions were taken by the Chinese government, including a city lockdown and home and centralized quarantines. Some of the measures put in place in Wuhan would not be deemed either societally acceptable or practically feasible in many parts of the world; eg, complete control of movement for months or compulsory isolation in facilities. Other measures put in place at that time (not shown in this figure but widely reported elsewhere) included business closures, school closures, and cancellation of gatherings, which also contributed to substantially lowering social interaction. Those measures have become the core of social distancing interventions taken around the world to control the spread of SARS-CoV-2.

When all those measures were taken collectively in Wuhan, the Rt of the epidemic declined to below 1 within weeks. When an Rt decreases below 1 for a given disease in a given place, disease spread slows and the epidemic has the potential to be controlled in that area.

Figure 2 illustrates what the goal must be now around the world. Until a safe and effective vaccine is developed and globally disseminated, countries need to use some combination of social distancing measures to work to bring their Rt below 1. Hopefully, countries will find strategies to implement social distancing in ways that allow economies to come back and society to resume some normalcy. Given the severe economic and societal consequences of these strategies, continued efforts should be made to study the need for and effectiveness of social distancing measures as they are put in place and relaxed in the time ahead. Beyond the larger measures of business and school closures and cancellation of gatherings, individual actions to keep physical distances of at least 6 feet, wear cloth masks in public, and telecommute to work will help reduce the Rt. Absent any social distancing at all, SARS-CoV-2 would likely revert to its pattern of spread as it was back in early January, with an Rt in the 2 to 4 range and doubling in size every 5 days, until a substantial portion of the population develops immunity through infection and recovery, or through vaccination.

The US Centers for Disease Control and Prevention (CDC) should regularly report on the Rt for the US and for each of the 50 states so that political and public health leaders can gauge how well the combined organizational and individual social distancing measures in place around the country are working to diminish transmission of this virus. The CDC should then communicate this transparently to the public to increase public buy-in and understanding of the actions being taken to slow the spread of COVID-19.

Dr Inglesby very clearly explains how to calculate and how to monitor viral spread and the effectiveness of containing measures. The author also comments on the work done by authorities in Wuhan to reduce the rate of transmission.

We know that Chinese scientists were the first to identify and isolate the causative agent of an increasing number of atypical pneumonias observed in the province of Hubei beginning early in December (1-3). Chinese scientists (1) also sequenced the large-RNA-genome and made the nucleotide sequence available to the rest of the world. An oligonucleotide sequence could be generated from that viral sequence which could be used to perform PCR-analysis of the RNA extracted from patient's samples.

An increase of „interstitial“ pneumonia cases of unknown origin has been observed in several emergency rooms not only in northern Italy but also in New York, in Ireland, and also in other countries as reported by the Italian journalist Sigfrido Ramucci (4).

This infomation could support the hypothesis that the virus had been „around“ for some time before
the nucleotide sequence of the viral genome became available (5).

It has not yet been demonstrated that the virus originally might have „spread“ from Wuhan throughout the world.

Dr. Inglesby certainly provides food for thought regarding the R(0) or R(t) for SARS-CoV-2. That number will vary considerably among different locations of the country. This is especially true because the current lack of adequate testing for active and past infection make the true R(t) difficult to determine. It is, thus, likely higher than any calculated value. All this makes successful contact-tracing difficult or impossible in hard-hit areas.

The work of Pan, et al, is remarkable given the sheer size and ferocity of Wuhan's (then) epidemic. It would be interesting if the individual contributions of the six public health interventions that were studied could have been determined for their roles in lowering Wuhan's R(t). Such data would better inform national and local decisions on how best to proceed as the United States seeks a path forward.