A Mexican woman who allegedly oversaw the finances of El Chapo's billion dollar drugs empire is set to plead guilty in a United States federal court later in May.

Guadalupe Fernández Valencia is alleged to have been the highest-ranking female in Joaquín ''El Chapo'' Guzmán's Sinaloa Cartel.

Fernández Valencia was nicknamed 'La Patrona' - meaning 'The Boss' - and federal investigators allege she was part of the cartel's scheme to use airplanes, submarines, vehicles and tunnels to sneak huge amounts of drugs into the U.S.

The 58-year-old was indicted by a Chicago court in 2014 and charged with trafficking cocaine, heroin, methamphetamines and marijuana. She was also accused of money laundering.

She was arrested in February 2016 in Culiacan, a city in the northwestern Mexican state of Sinaloa, and extradited to the Chicago in November 2017.

Guadalupe Fernández Valencia is said to have been the highest-ranking female in Joaquín ''El Chapo'' Guzmán's Sinaloa Cartel. She is set to appear in a Chicago court on May 25 and plead guilty

Guadalupe Fernández was said to be a top aide of the leader of the Sinaloa Cartel, Joaquín ''El Chapo'' Guzmáns - pictured center after being extradited to the US in 2017

Fernández Valencia fell in the crosshairs of the U.S. government well before the Mexican federal police apprehended her, as she was placed in the notorious 'kingpin' list. That means any assets that she owns in the U.S. territory can be seized.

The Sinaloa Cartel is alleged to have distributed drugs in wholesale quantities in the U.S. through a syndicate operated by Chicago twins, Pedro and Margarito Flores.

The funds were then laundered back across the border to Mexico.

The Flores brothers at one time moved drugs for both the Sinaloa Cartel and the Beltran-Leyva Organization. But they turned on the criminal organizations and worked as key witnesses for the government in bringing down key leaders in both cartels.

A court in Chicago indicted Fernández Valencia (bottom left) for her alleged role in trafficking cocaine, heroin, methamphetamines and marijuana as well as money laundering

Guadalupe Fernández Valencia was arrested in Mexico in February 2016 and extradited to the United States in November 2017

The charges filed against Fernández Valencia also alleged that she was a lieutenant for El Chapo's son, Jesus Alfredo Guzmán Salazar, who took over running the cartel after his father's arrest.

Fernández Valencia is set to appear in court on May 25 for a change of plea hearing at a Chicago district court.

El Chapo was convicted in February of running a criminal enterprise, among other narcotic-related charges, and remains in custody in a federal prison in Manhattan, New York. He is due to be sentenced on June 25.

La Partona's brother, Manuel Fernández Valencia, another alleged member of the Sinaloa Cartel, was sentenced in December 2017 to 27 years behind bars after he pleaded guilty to transporting large amounts of cocaine to the Chicago area.

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El Chapo's female confidant 'La Patrona' is set to plead guilty to overseeing his empire