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Angel Beats!
Nyan Koi. This one is tagged by MAL as a harem, but I don't remember there being one at all. I don't even remember there being that many female characters...
Full Metal Panic! is a great comedy and it does have romance, although it's not very pronounced. Has action too. Probably not your tastes but worth mentioning.
Kaichou wa Maid-sama. Very fitting as a romance/comedy.
Kamisama Kazoku wasn't too bad.
Lamune. This was, I think, the second anime I watched on my computer so my memory is fuzzy. I don't think it had a lot of comedy, but it did have a lot of romance and was a wee bit serious about it.
Mamoru-kun ni Megami no Shukufuku wo!
Nogizaka Haruka no Himitsu.
If you like a lot of comedy, School Rumble is pretty great.
Hayate no Gotoku does have some romantic elements in it, but it's mostly comedy. A lot of the romance is limited to very specific episodes and is a bit better in manga format. It is a favorite of mine though.
Obligatory The World God Only Knows mention. I really wouldn't call it a harem, especially if you only watch the anime. It has lots of good comedy and it's centered around romance. The heroine changes repeatedly because of the context, but that doesn't cause any issues except that there's not much length. It's my favorite.

I suspect Tasogare is a bit out of his interests, but he's welcome to try it.

Nyan Koi~ seen it,
Kaichou wa Maid-sama ~ seen it,
Full Metal Panic! ~ hate mecha,
Kamisama Kazoku ~ idk how much production value they put into this one, the drawing look like crap, and the voice acting was pretty bad, i gave it a try a long time ago, and disliked it, the low production value they put into it.
Lamune ~ isnt this a harem,
Mamoru-kun ni Megami no Shukufuku wo! ~ this one look interesting, i'll look into it,
School Rumble ~ nope
Hayate no Gotoku ~ drop it, cause it too long and it just mindless comedy, the story never move on, it feel like every episodes is a filler with mindless comedy.
The World God Only Know ~ i gave it a try, cant move past episode 7, I dislike almost everything about it.
Tasogare ~ this may be too creepy and scary for my taste,

Quote:

Originally Posted by Kurohane

My mistake, its name is Sola, give it a try.

sorry, not going to try that, i heard it very dramatic and sad. and i had my fair share of crying in clannad afterstory.

Have you seen Steins;Gate ? it's a sci-fi mystery show with some romance and deals with time travel. Beginning seemed a little slow but gets better later on. If you have already seen it, then I would recommend something else.

Quote:

Originally Posted by Trudinh

Lamune ~ isnt this a harem,

Quote:

Originally Posted by Traece

No. Not even close.

Don't judge things by the cover, OP. Just because there's an anime with lot of females doesn't automatically make it harem.

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I will protect you from the darkness and I change my destiny.MyAnimeList