In summary, we show that Pten loss per se in Lgr5 (zeige LGR5 Proteine)+ intestinal stem cells is not required either as a tumor suppressor or for maintaining intestinal homeostasis when Apc is functional, even when combined with obesity.

In this study, the effect of deficiency of OPN (zeige SPP1 Proteine) on intestinal tumor development in Apc-deficient Min mice was investigated.At 16 weeks of age, the number of small intestinal polyps in Min/OPN (zeige SPP1 Proteine)(+/-) and Min/OPN (zeige SPP1 Proteine)(-/-) mice was lower than that of Min/OPN (zeige SPP1 Proteine)(+/+) mice. Colorectal tumor incidences and multiplicities in Min/OPN (zeige SPP1 Proteine)(+/-) and Min/OPN (zeige SPP1 Proteine)(-/-) mice were significantly lower than those in Min/OPN (zeige SPP1 Proteine)(+/+) mice

The results indicate that C-terminal domain of APC has a role in the regulation of intestinal epithelium homeostasis.

we provide mechanistic insight into the role of APC mutations and Wnt (zeige WNT2 Proteine) signaling in hematopoietic stem cells (HSC (zeige FUT1 Proteine)) biology. As Wnt (zeige WNT2 Proteine) signals are explored in various in vivo and ex vivo expansion protocols for HSCs, our findings also have clinical ramifications.

Human Adenomatous Polyposis Coli (APC) Interaktionspartner

Because of low sensitivity, APC gene promoter methylation in serum was not suitable for breast cancer (BC) screening. However, as specificity was very high, detection of serum APC gene promoter methylation could be used as tool to confirm BC.

A novel APC frameshift mutation has been identified in a large Chinese family with familial adenomatous polyposis.

In the two wild type (WT) cases, two novel alterations were detected: a complex deletion of APC and a pathogenic mutation of LAMTOR2 (zeige LAMTOR2 Proteine). Focusing on WT DT subtype, deep sequencing of CTNNB1 (zeige CTNNB1 Proteine), APC and LAMTOR2 (zeige LAMTOR2 Proteine) was conducted on a retrospective series of 11 WT DT using a targeted approach

This study demonstrates a prognostic role for APC.

There is a certain correlation between the APC gene and ovarian tumors, and the APC gene mediates the apoptosis of tumor cells through the MDR-1/CLCX-1 signaling pathway.

We have investigated if the initial source of intratumoral heterogeneity is consequent to multiple independent lineages derived from different crypts harboring distinct truncal APC and driver KRAS mutations, thus challenging the prevailing monoclonal monocryptal model.

methylation-dependent silencing of the APC gene promoter 1A is a mechanism that contributes to the activation of Wnt (zeige WNT2 Proteine) signaling pathway in cervical cancer cells infected by high risk HPV16.

depletion of APC from cystostatic factor (CSF (zeige CSF2 Proteine)) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin (zeige TUBB Proteine) distribution in spindles and asters formed in such extracts

Adenomatous Polyposis Coli (APC) Protein Überblick

Protein Überblick

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.