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If Jones-Drew is ready to go in this impossible matchup, we know his ankle is feeling reasonably healthy. There's no way he would suit up at too far less than 100 percent while in a contract year. Expect 12-16 touches for Jones-Drew, but production will be difficult to come by. The Jags are 19-point underdogs. The Jags inactives: QB Blaine Gabbert, WR Mike Brown, DB Winston Guy, CB Alan Ball, DB Dwayne Gratz, TE Marcedes Lewis and DL Abry Jones.

Updating an earlier report, Tyrod Taylor (knee) is practicing in full for Week 15 against the Dolphins.

He'll be back under center after sitting out Sunday's game with a bruised patellar tendon. Taylor's fantasy results have been all over the map this year but his scrambling ability (he ranks third among quarterbacks with 334 rushing yards) keeps him in the streaming conversation this week.

Marcus Mariota (knee) is practicing in full for Week 15 against the 49ers.

He suffered a minor knee injury in Sunday's loss to Arizona but didn't miss a snap and saw his usual reps when the Titans returned to practice on Wednesday. Mariota has thrown eight interceptions over his last four games and won't be more than a QB2 for the fantasy semifinals, even in a great matchup.

Alvin Kamara (concussion) said he's "good to go" for Week 15 against the Jets.

Kamara was concussed early in Thursday night's loss to Atlanta but returned to a full practice on Wednesday and should be ready to roll Sunday against the Jets. The steal of the 2017 draft, Kamara has scored 11 touchdowns this year and leads all running backs in receiving yards with 639. Consider him an RB1 for the fantasy semifinals.

Manning was shaping up as a lock to be released, but his status has changed with Ben McAdoo gone. Even with New York in position for a top-five pick, it's possible they give Manning another year with an improved supporting cast. There should be more clarity with the Giants expected to interview general manager candidates next week. Manning has two years and $22 million guaranteed remaining on his deal.

Coach Bruce Arians said he has "no idea" if Adrian Peterson (neck) will play again this season.

That's not very encouraging news. Peterson has missed the past two games and again missed practice Wednesday. The Cardinals are out of it, and there's a real chance we saw the last of Peterson playing in the NFL if he doesn't suit up the rest of this season. Peterson turns 33 in March, and there wasn't a hot market for his services last offseason. Kerwynn Williams and D.J. Foster will continue to fill in as the Cardinals' running backs in Peterson's absence.

It's a new issue for Bernard after he played a season-high in snaps and turned 17 touches into 130 yards. Perhaps it's more of a maintenance day after the big workload. Joe Mixon (concussion) remains in the protocol.

Cooper played 14 snaps last week against the Chiefs before aggravating his ankle issue. The Raiders were aggressive to play him through the high-ankle sprain. Cooper is unlikely to be a factor the rest of the fantasy season.

He was riding the stationary bike off to the side. The knee issue is new for Norman, and he played every snap last week. Norman has been relatively average this season as he approaches his 30th birthday Friday. Norman likely isn't going to see much of Larry Fitzgerald in the slot anyway this week.

Cannon hasn't played since Week 8, and the Patriots finally decided to throw in the towel for the rest of the season. Cannon's loss will be felt and already has at times with La'Adrian Waddle and Cameron Fleming trying to fill in the last several weeks. Cannon signed a five-year, $32.5 million extension last November.

Coach Sean McDermott didn't mention McCoy in the morning as someone who would be limited in Wednesday's practice, but we'll side with it being a precaution for now. Coming off a huge game against the Colts when he saw 32 carries in the blizzard, it may just be a way to get McCoy some rest ahead of another smash spot this week against Miami. McCoy is a locked-in elite RB1.