Angiogenesis

Angiogenesis, the process of forming new blood vessels, is a hallmark in the pathology of many diseases, including cancer, ischemia, atherosclerosis, and inflammatory diseases. Inducers of angiogenesis include members of the vascular endothelial growth factor family, angiopoietins, and members of the fibroblast growth factor family. Angiogenesis inhibitors include some thrombospondins, and cytokines such as CCL2 and CXCL10. Angiogenesis is essential for normal development and physiology, including processes such as wound healing and tissue regeneration. Proteins involved in the development of new blood vessels, such as cytokines, adhesion molecules, proteases, and transcription factors, alter their expression during both normal and disease states. Cancerous growths often release angiogenic factors to continue proliferation. However, anti-angiogenic drugs have not been as promising a chemotherapeutic option as anticipated. The mechanisms of angiogenic response during oncogenesis must be fully elucidated to identify new potential drug targets. ...

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Angiogenesis, the process of forming new blood vessels, is a hallmark in the pathology of many diseases, including cancer, ischemia, atherosclerosis, and inflammatory diseases. Inducers of angiogenesis include members of the vascular endothelial growth factor family, angiopoietins, and members of the fibroblast growth factor family. Angiogenesis inhibitors include some thrombospondins, and cytokines such as CCL2 and CXCL10. Angiogenesis is essential for normal development and physiology, including processes such as wound healing and tissue regeneration. Proteins involved in the development of new blood vessels, such as cytokines, adhesion molecules, proteases, and transcription factors, alter their expression during both normal and disease states. Cancerous growths often release angiogenic factors to continue proliferation. However, anti-angiogenic drugs have not been as promising a chemotherapeutic option as anticipated. The mechanisms of angiogenic response during oncogenesis must be fully elucidated to identify new potential drug targets.