Twenty-Two years after the mysterious death of his mother, Sam Winchester in is college and has not spoken to his brother or father in two years. That is until his brother, Dean Winchester, shows up at his door saying their father is missing. On the search for him, the boys discover a 'woman in white', the spirit of a cheated wife who killed her kids before committing suicide. Her ghost haunts the roads, looking for and murdering unfaithful men, and Sam and Dean must stop her.