Polidor played infield for the Holyoke Millers of the Eastern League (Holyoke, MA) in 1981 and 1982. In 1981 he hit for a batting average of .248.

His best year was 1987 with the Angels, when he hit for a .263 batting average, with 2 homers and 15 RBI in 137 at bats. After dropping off to .148 in 1988 he was traded to the Brewers. Polidor played in a career-high 79 games in 1989 and was later a member of the Marlins in their 1993 inaugural season.

Polidor made a brief comeback attempt as a replacement player with the Montreal Expos in spring training of 1995. Less than a month later, he was murdered in Caracas as he tried to protect his son from two men who were trying to steal his car.[1] He was 33 years old.