Areas of Interest

Our laboratory currently focusses on three different areas of hematopoiesis. We are investigating how transcription factors GATA2 and GATA3 regulate hematopoietic stem cell function and maintenance, how T cells develop in the thymus, and how specific enzymatic inhibitors inactivate epigenetic modifying enzymes in erythroid progenitors leading to induced synthesis of fetal hemoglobin as a treatment for sickle cell disease and beta-thalassemia, the world's most common inherited diseases.