Constructed in 1922, the house is significant as one of the few pre-1941 building in Tempe; less than two-hundred such buildings are believed to predate the Guthrie House. It is in the upper 99th percentile of all Tempe buildings in terms of age (p%=0.998). The Guthrie House is significant as a rural farmhouse originally surrounded by an extensive agricultural landscape. It is also significant as a local variant of Bungalow-style residential architecture.