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If someone is sneezing you have to say "salud" or "Jesus". Jesus if you are a kind of religious person and salud if you aren't this kind of person.But if you mean "God bless you" in Spanish would be "Que Dios te bendiga"Many years ago grandparents used to say "con Dios" instead of goodbye. In fact some of this old people still saying this expression "Con Dios" something in English like "With god" or "Go with God"