In 1808 he entered the Imperial University of Dorpat, where he first studied philology, but soon turned his attention to astronomy. From 1813 to 1820, he taught at the university and collected data at the Dorpat Observatory, and in 1820 became a full professor and director of the observatory. His teachings have had strong effect that is still felt in at the university.[3][4][5]

Struve's name is best known for his observations of double stars, which he carried on for many years. Although double stars had been studied earlier by William Herschel and John Herschel and Sir James South, Struve outdid any previous efforts. He discovered a very large number of double stars and in 1827 published his double star catalogue Catalogus novus stellarum duplicium.[5]

Since most double stars are true binary stars rather than mere optical doubles (as William Herschel had been the first to discover), they orbit around one another's barycenter and slowly change position over the years. Thus Struve made micrometric measurements of 2714 double stars from 1824 to 1837 and published these in his work Stellarum duplicium et multiplicium mensurae micrometricae.[5]

In an 1847 work, Etudes d'Astronomie Stellaire: Sur la voie lactee et sur la distance des etoiles fixes, Struve was one of the first astronomers to identify the effects of interstellar extinction (though he provided no mechanism to explain the effect). His estimate of the average rate of visual extinction, 1 mag per kpc, is remarkably close to modern estimates (0.7-1.0 mag per kpc).[5]