Phil Mickelsons wife, Amy, has been diagnosed with breast cancer, and the three-time major champion said Wednesday he will suspend his PGA Tour schedule indefinitely.

According to a release from Mickelsons management company, his wife was to have more tests but begin treatment with major surgery as early as the next two weeks.

Mickelson, the No. 2 player in the world with 36 career PGA Tour victories, was to play the Byron Nelson Championship this week before defending his title next week at Colonial.

It was not certain if Mickelson would return in time for the U.S. Open on June 18-21 at Bethpage Black in New York, where he was a runner-up in 2002 and is beloved by golf fans in the New York area.

Amy Mickelson is among the most visible wives on the PGA Tour, a former Phoenix Suns cheerleader who regularly walks during the rounds and mingles easily with the gallery.

They met in 1992 when Mickelson was a senior at Arizona State, a year after he won his first PGA Tour event as an amateur. Amy knew nothing about golf at the time.

I grew up in a tennis family, and when he told me he was a pro golfer, I thought he worked in the shop at a golf course, she wrote in Mickelsons book, One Magical Sunday, after he won his first major at the 2004 Masters.

They were married in 1996 and have three children: Amanda, 9, Sophia, 7, and Evan, 6. Their first child was born the day after the 1999 U.S. Open at Pinehurst No. 2., where Mickelson carried a pager and promised to leave if his wife went into labor.

Golfer Phil Mickelson (R) and his wife Amy watch Game 5 of their NBA Western Conference semi-final basketball playoff game between the Los Angeles Lakers and the Houston Rockets in Los Angeles, May 12, 2009.

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