Eosinophil-Related Disease and the SkinPublication date: Available online 12 June 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kristin M. Leiferman, Margot S. PetersAbstractEosinophils are bone marrow-derived cells that infiltrate skin and mucous membrane in a broad spectrum of primary and reactive inflammatory diseases and malignancies. The eosinophil has potent proinflammatory activities, particularly, through the effects of its toxic granule proteins. In addition, eosinophils have prothrombotic and profibrotic activities. Eosinophil participation in the pathogenesis of certain diseases without identifiable intact eosinoph...Source: The Journal of Allergy and Clinical Immunology: In Practice - July 10, 2018 Category: Allergy & Immunology Source Type: research

Drug-induced Anaphylaxis Documented in Electronic Health RecordsPublication date: Available online 30 June 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Neil Dhopeshwarkar, Aziz Sheikh, Raymond Doan, Maxim Topaz, David W. Bates, Kimberly G. Blumenthal, Li ZhouAbstractBackgroundAlthough drugs represent a common cause of anaphylaxis, few large studies of drug-induced anaphylaxis have been performed.ObjectiveTo describe the epidemiology and validity of reported drug-induced anaphylaxis in the electronic health records (EHRs) of a large United States healthcare system.MethodsUsing EHR drug allergy data from 1995-2013, we determined the population prevale...Source: The Journal of Allergy and Clinical Immunology: In Practice - July 10, 2018 Category: Allergy & Immunology Source Type: research

Chronic Spontaneous Urticaria: The Devil's ItchPublication date: July–August 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 4Author(s): Sarbjit S. Saini, Allen P. KaplanChronic urticaria is defined as the presence of urticaria for a period exceeding 6 weeks, assuming symptoms for most days of the week. It is divided into chronic inducible urticarias and chronic spontaneous urticaria, previously termed chronic idiopathic urticaria. The latter designation emphasizes that patients can experience urticaria independent of any exogenous stimulus even if one can define circumstances that may worsen symptoms. A search for such an...Source: The Journal of Allergy and Clinical Immunology: In Practice - July 10, 2018 Category: Allergy & Immunology Source Type: research

Emerging Biomarkers and Therapeutic Pipelines for Chronic Spontaneous UrticariaPublication date: July–August 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 4Author(s): Gustavo Deza, Peter A. Ricketti, Ana M. Giménez-Arnau, Thomas B. CasaleChronic spontaneous urticaria (CSU) is defined as the appearance of evanescent wheals, angioedema, or both, for at least 6 weeks. CSU is associated with intense pruritus and poor quality of life, with higher odds of reporting depression, anxiety, and sleep difficulty. As of yet, the assessment of the activity and course of the disease along with the response to several treatments in CSU are based purely on the p...Source: The Journal of Allergy and Clinical Immunology: In Practice - July 10, 2018 Category: Allergy & Immunology Source Type: research

Angioedema Due to Bradykinin DysregulationPublication date: July–August 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 4Author(s): Marco Cicardi, Bruce L. ZurawAngioedema is an acute swelling of the deeper layers of the skin or mucosa resulting from a transient increase in vascular permeability. Angioedema can occur in the absence or presence of hives, be hereditary or acquired, and be caused by various potential mediators, including histamine and bradykinin. Bradykinin-mediated angioedema can be difficult to diagnose but is responsible for a disproportionate percentage of the serious morbidity and mortality associat...Source: The Journal of Allergy and Clinical Immunology: In Practice - July 10, 2018 Category: Allergy & Immunology Source Type: research