Meyssen started playing football with his local team Stokkem, but was discovered there by First division side FC Liège. Not achieving a breakthrough there, he signed for SK Tongeren, playing in second division. It would eventually be with Eendracht Aalst that Meyssen promoted to the Jupiler League. Meyssen would stay there for 6 seasons.

He then went to Austrian side SV Casino Salzburg, where he would stay for only one season. He returned to Belgium, signing for Standard Liège, the biggest club in Meyssen's career. After 3 seasons, Meyssen's role was played out, and he then chose the newly promoted Cercle Brugge to continue his career.