The Higgs boson mass spectrum and couplings of the neutral Higgs bosons to the fermions are worked out in a CP spontaneously broken two-Higgs doublet model in the large tan beta case. The differential branching ratio, forward-backward asymmetry, CP asymmetry and lepton polarization for B --> X(s)l(+)l(-) are computed. It is shown that the effects of neutral Higgs bosons are quite significant when tan beta is large. Especially, the CP violating normal polarization P-N can be as large as several percents.