Vardhman Mahavir Medical College was established at Safdarjung Hospital by the Government of India in November, 2001. Its inauguration was done by the then Honourable Prime Minister Sh. Atal Bihari Vajpayee on 17th December, 2001 in presence of Sh.L.K.Advani, Sh. C. P. Thakur and Founder Principal Dr. Jagdish Prasad. The College building was dedicated to the Nation by the Vice President Sh. M. Hamid Ansari on 20th Nov. 2007 in the presence of Honourable Health Minister Dr. Anbumani Ramadoss. The first batch of MBBS students was admitted in February, 2002. Post-graduate courses (MD/MS) in clinical subjects were running at Safdarjung Hospital even before the establishment of VMMC. The (MD/MS) course in Pre and Para clinical subjects were started in year 2011. Over the period of time, the numbers of MD/MS seats have been increased. The College also is running super specialization (Mch/DM).

VMMC is affiliated to Guru Gobind Singh Indraprastha University; New Delhi. Over a decade the VMMC College has established itself as a prominent medical institution in India. (A Medical marvel by as India Today Aspire August 2013.)

Safdarjung Hospital is the largest hospital under the Ministry of Health and Family Welfare and is well known for its quality of services to all strata of society since pre-independence days. As on date, it has more than 1550 beds including bassinets. It has an annual OPD attendance of more than 10 lakh patients. Vardhman Mahavir Medical College in association with Safdarjung Hospital provides modern facilities in all kinds of investigations and patient care. This medical college & hospital has speciality and super speciality departments like Dept. of Cardiac Surgery (CTVS), Cardiology, Neurology, Urology, Nephrology, Respiratory Medicine, Burns & Plastic, Paediatric Surgery, Gastroenterology, etc. It has modern facilities for angiography, angioplasty, valve replacement and repairs, coronary artery bypass grafting, lithotripsy, sleep laboratory, endoscopies, arthroscopies, video EEG, dialysis, spiral CT, MRI, automated blood Test analyzers etc.

The Office of the Principal is located on the ground floor of the College building. For all matters related to admission, examination, fee, certificates, degrees, hostel, scholarship etc, the Academic Section which is also on the ground floor, can be contacted.