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2019-02-21 Sponsored Conferences: VAAM 2019 and FASEB NAD+ Conference

BIOLOG sponsors the upcoming annual Conference 2019 of the Association for General and Applied Microbiology (VAAM 2019) which will take place in Mainz, Germany, March 17-20, 2019, and the bi-annual FASEB Science Research Conference on NAD+ Metabolism and Signaling to be held in Dublin, Ireland, June 23-28, 2019.

2019-02-20 Rp,Rp-2'3'-c-diAMPSS - Price cut!

We are pleased to announce a significant price reduction for our product Rp,Rp-2'3'-c-diAMPSS (syn. c[A(2',5')pS[Rp]-A(3',5')pS[Rp]], Cat. No. C 224). Please follow the link to the product detail page for further information.

Rp,Rp-2'3'-c-diAMPSS is a synthetic cyclic dinucleotide with improved stability against degradation by phosphodiesterases and enhanced binding affinity to STING. The related structure c[A(2',5')pS[Sp]-A(3',5')pS[Rp]], Cat. No. C 223 is also available.

2018-08-20 New category "Future Products" introduced!

"Future Products" list structures which are nearly ready for commercialisation. The list will be permanently updated and contains already > 80 items at the moment.

2018-07-02 Linear metabolites available related to 2',3'-cGAMP and 3'3'-cGAMP, respectively.

pppG(2',5')pA is considered to be the linear catalytic intermediate in the enzymatic production of 2',3' - cGAMP (aka c[G(2',5')pA(3',5')p], BIOLOG Cat. No. C 161) by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). According to Hall e t al. (2017) human stimulator of interferon genes STING 155 - 341 does not bind pppG(2',5')pA at concentrations of up to 50 μM.

2018-06-26 New products added: Rp-2'-F-dATP-α-S, Sp-2'-F-dATP-α-S and a new NIR fluorescent 2',3'-cGAMP analogue

With Rp-2'-F-dATP-α-S (Cat. No. D 220) and Sp-2'-F-dATP-a-S (Cat. No. D 219) the sulfur-modified analogues of 2'-deoxy-2'-fluoro-ATP (Cat. No. D 074), which are considered to be metabolically more stable, have been added to our product list. In addition, c[3'-[sCya7]-AHC-G(2',5')pA(3',5')p], (Cat. No. C 240), a new NIR fluorescent 2',3'-cGAMP analogue has joined the cyclic dinucleotide tools set.

2018-06-08 New product: 8-Br-2',3'-cAMP

8-Br-2',3'-cAMP (Cat. No. B 280) is now available from Biolog. This compound is considered to be a membane-permeable analogue of 2',3'-cAMP (Cat. No. A 307) and was recently used by Kosmacz et al. (2018) to study the role of 2',3'-cAMP in the formation of stress granules in Arabidopsis thaliana (Reference: Kosmacz et al., Plant Physiol., 177, 411 - 421 (2018): "Interaction of 2',3'-cAMP with Rbp47b Plays a Role in Stress Granule Formation").

2018-01-31 DEACM-caged cAMP available again

Our product DEACM-caged cAMP (Cat. No. D 042) which was temporarily out of stock, is available again. DEACM-caged cAMP is a caged precursor of the second messenger cAMP and releases both cAMP and a fluorescent coumarin analogue upon irradiation.

2018-01-18 Conference update: DGHM and DGPT 2018

Biolog is pleased to be one of the sponsors of the upcoming 70th Annual Meeting of the German Society for Hygiene and Microbiology e. V. (DGHM, February 19-21, 2018, Bochum, Germany, www.dghm-kongress.de) and of the 3rd German Pharm-Tox Summit (DGPT, February 26-March 1, 2018, Göttingen, Germany, www.gpts-kongress.de).

2017-09-29 ISO 9001:2015 certification

Biolog's Quality Management System certification has been upgraded to the new ISO 9001:2015 standard. Please click here to download a PDF of our updated certificate.

2017-08-22 New bacterial second messenger: c-hexaAMP

The newly discovered bacterial second messenger c-hexaAMP (syn.: cyclic hexaadenylate / c-A6 / cA6) is now available from Biolog. c-hexaAMP was recently reported by Niewoehner et al. (2017) and Kazlauskiene et al. (2017) to be a signalling molecule in prokaryotes, involved in the Type III CRISPR-Cas-associated detection and degradation of invasive genetic elements.

2017-06-23 New 8-modified and "clickable" analogues of NAD+

We have added a number of new NAD+ analogues, mostly modified at the 8-position of the adenine ring, to our product catalogue. Many of these structures are described in a collaborative paper recently published in Science: Gibson et al., Science, 353, 45 - 50 (2016): "Chemical Genetic Discovery of PARP Targets Reveals a Role for PARP-1 in Transcription Elongation".

2017-06-14 8th International Conference on cGMP

Biolog is one of the sponsors of the upcoming 8th International Conference on cGMP - cGMP: Generators, Effectors and Therapeutic Implications. The conference will take place June 23-25, 2017 in Bamberg, Germany.

Visit the meeting website at www.cyclicgmp.net for further information on this event.

2017-02-13 Microbiology and Infection 2017 Meeting

Biolog sponsors Microbiology and Infection 2017, the 5th Joint Conference of the DGHM (German Society for Hygiene and Microbiology) & VAAM (Association for General and Applied Microbiology), which will be held March 5-8, 2017 in Würzburg, Germany.

2016-10-26 International Signal Transduction Meeting

Biolog sponsors the 20th Joint Meeting of the Signal Transduction Society (STS) "Signal Transduction – Receptors, Mediators and Genes" which will be held November 9-11, 2016 in Weimar/Germany. Visit the homepage of the Signal Transduction Society at https://sigtrans.de/index.html.

2016-08-17 Welcome to Biolog's new website

We are happy to introduce the new www.biolog.de to you. Our website has been completely revised to offer a fresh look, an extended search function for our products, and an improved online shop system.

If you are a registered user of www.biolog.de, please note that for the purpose of data protection, your address details and login information have not been transferred to the new website. We would therefore like to ask you to create a new online account.

2016-07-06 IRT 2016 Paris

2016-01-29 Conference update

Biolog sponsors the upcoming German Pharm-Tox Summit 2016 (DGPT) (Berlin/Germany, February 29 - March 3, 2016) and the Annual Conference of the Association for General and Applied Microbiology (VAAM) (Jena/Germany, March 13 - 16, 2016).

2015-08-10 2'3'-cGAMPSS / 2'3'-cGsAsMP

Biolog now offers a set containing 0.1 µmol each of c[G(2',5')pS-A(3',5')pS], isomer 1 and c[G(2',5')pS-A(3',5')pS], isomer 2 which are isomeric di-thiophosphate analogues of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] (aka 2'3'-cGAMP, Cat. No. C 161). Please visit the product detail page for further information on the set.

2015-05-15 pApA and pGpG - Price cut

We are pleased to announce a significant price reduction for our products pApA (Cat. No. P 033) and pGpG (Cat. No. P 023). These products are now sold in 1 µmol vials instead of 0.1 µmol vials at unchanged prices. Please visit the product detail pages for pApA and pGpG for further information.

The linear dinucleotides pApA and pGpG were found to be metabolic degradation products of the bacterial second messengers c-diAMP (Cat. No. C 088) and c-diGMP (Cat. No. C 057), respectively.

Together with academic collaborators, Biolog has developed new EPAC agonists that discriminate between the isoforms EPAC1 and EPAC2. Two of the cyclic AMP-based structures described are now exclusively available from Biolog: