Can counteract the adverse side effects of other acne treatments. (v.26)

Significantly reduces malondialdehydes – a type of compound produced by free radical damage. People with severe acne have high levels of these compounds. (v.27-28)

At 5% concentration, lab tests by one manufacturer show that alpha lipoic acid has antibacterial effects against Propionibacterium acnes . Alpha lipoic acid may also help strengthen skin's natural antibacterial barriers. Although P. acnes are a helpful type of bacteria found on the skin, high levels of it in pimples can generate free radicals. This can lead to oxidative stress which aggravates acne. (v.24, 29-32)

Although some experts note that there may be some difficulty in alpha lipoic acid penetrating the skin due to the size of its molecules, there may be a solution. Research studies demonstrate that patches containing alpha lipoic acid cream help to improve how much of it is absorbed by the skin. (v.24-25, 33)

The Bottom Line

Alpha lipoic acid may be helpful in reducing pimples – especially severe acne. It has powerful anti-inflammatory effects in the skin. Studies suggest its antioxidant benefits would help reduce oxidative byproducts linked to severe acne more than mild or moderate acne. (v.27-28)

Recent lab studies show that the skin benefits of alpha lipoic acid may be enhanced if combined with other supplements. These include: (v.31, 34)