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ZytoLight ®SPEC NTRK1 Dual Color Break Apart Probe

The ZytoLight ® SPEC NTRK1 Dual Color Break Apart Probe is designed to detect translocations involving the chromosomal region 1q23.1 harboring the NTRK1 gene. NTRK1 rearrangements were shown to be involved in thyroid carcinogenesis. Various inhibitors targeting the NTRK1-derived fusion proteins were shown in vitro to inhibit proliferation of cells expressing the fusion genes. This indicates that these fusion genes are potential therapeutic targets.

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