It is not surprising that the interactivity affects radio and its applications. Besides, after radio began its first broadcasting, new inventions affected its development two ways: 1) the first one was the technological developments of sciences. For instance, the invention of transistors made it possible to create very small radio machines, and also the use of FM broadcastings were able to deliver the first stereo programs, and 2) the last one is the program dimensions of radio broadcastings. The various program styles and formats of radio have been broadcasted gradually for many years, such as countless music, drama, entertainment, culture, documentary, sporting events, news or education programs. Both the technical dimensions and program producing processes of radio can affect the use of interactive educational radio programs. Accordingly, the main purpose of this article is to explain the infrastructure of interactive educational radio programs, and to introduce a framework about how to develop interactive educational radio programs in e-learning systems. (Contains 2 tables.)