No real reason why it shouldn't work, they have to be building the hardware in a way that would take full advantage of an SSD.

Only problem is the price. A 512gb SSD costs about the same as the console itself. Not sure how practical that is. They better also offer usb 3.0 external hdd compatibility like the xbox one. Obviously not as fast, but you can get 1-4TB drives for a fraction of the cost of an SSD and you don't have to sacrifice the internal drive.

Seems like some improvements can be seen but nothing to brag about. Seems like games are likely to load up slightly faster and installing should be faster then that but is it worth the upgrade? Also seems like it might fix some of Rage's texture problems.

I've noticed loading times for Last Of Us are really short with an SSD. I did bought the digital version so no reading from the disc. I can imagine it has the same sort of impact on the PS4. It'll be a bit more smoother and faster overall, but the biggest win for me is no HDD read/write noise but pure silence. The original 80GB HDD in my PS3 was very loud.

-TRIM or garbage collection would be nice to have, but SSD hardware manufacturers have built in to firmware

-Even on the PS3, load times on hard drive heavy games were cut down significantly and a lot of issues have been solved gameplay wise

I use a hybrid on my PS3 since the SATA speed is too slow, still was enough to improve performance on Rage, BF3 multiplayer. Nothing like loading first in a multiplayer game and getting to the enemy side flags. The next gen games are going to be using the hdd even more than now, even disc games. Everything that needs to be loaded quickly will be installed and we are look at tens of GB installs. I would recommend at least a 480-512gb SSD for a PS4 though, to match the stock drive size. I'm probably going to put that 960gb Crucial M500 that came out recently.

Edit: Lifetime writes for the drive I mentioned is pegged at 72tb, not something I'm ever going to hit.