Psycho-Babble Alternative Thread 1096138

Hello So I have been taking Progesterone cream for 3 days. My question is I heard Progesterone increases MAO. How long will it take for me to recover from Low MAO due to stress? I have had Low MAO-A for 10 years .But I wanna increase by MAO-A to reduce neurontransmitters. Anyone know anything about this? Are there any info on increasing MAO or something?

In reply to Increase MAO-A to reduce Neurontransmitters?, posted by farshad on December 2, 2017, at 6:14:04

> Hello So I have been taking Progesterone cream for 3 days. My question is I heard Progesterone increases MAO. How long will it take for me to recover from Low MAO due to stress? I have had Low MAO-A for 10 years .But I wanna increase by MAO-A to reduce neurontransmitters. Anyone know anything about this? Are there any info on increasing MAO or something?

In reply to Re: Increase MAO-A to reduce Neurontransmitters?, posted by SLS on December 2, 2017, at 16:41:11

> > Hello So I have been taking Progesterone cream for 3 days. My question is I heard Progesterone increases MAO. How long will it take for me to recover from Low MAO due to stress? I have had Low MAO-A for 10 years .But I wanna increase by MAO-A to reduce neurontransmitters. Anyone know anything about this? Are there any info on increasing MAO or something?> > Look into valbenazine (Ingrezza). It's a VMAT2 antagonist.> > > - Scott

In reply to Re: Increase MAO-A to reduce Neurontransmitters?, posted by farshad on December 3, 2017, at 5:54:12

Oh I'm sorry. I am not a diagnostician, but you seem to want one who doesn't ask questions?

The MAO variants that are reported by common genetic tests are only weakly associated with functional brain MAO levels.

Also, in many cases, higher MAO levels are associated with depression and social stress induced anhedonia (remarkably reversed by MAO inhibitors).

Mood stabilizers (lithium, valproate) and other GSK3 inhibitors may increase monoamine oxidase levels, over time, through downstream interactions with per2.

However, genetic tests are only in their infancy. The actual functional level of brain serotonin depends on the activity of likely hundreds of receptors, enzymes, neurotransmitters etc. Tryptophan hydroxylase, SERT, 5-ht1a, 5-ht1b, GSK3, just to scratch the surface.

Also, increasing MAO-A may leave you with lower levels of norepinephrine and dopamine (in addition to serotonin) as this enzyme catabolizes all three.

In reply to Re: Increase MAO-A to reduce Neurontransmitters?, posted by linkadge on December 3, 2017, at 13:07:45

> Oh I'm sorry. I am not a diagnostician, but you seem to want one who doesn't ask questions?> > The MAO variants that are reported by common genetic tests are only weakly associated with functional brain MAO levels.> > Also, in many cases, higher MAO levels are associated with depression and social stress induced anhedonia (remarkably reversed by MAO inhibitors). > > Mood stabilizers (lithium, valproate) and other GSK3 inhibitors may increase monoamine oxidase levels, over time, through downstream interactions with per2.> > However, genetic tests are only in their infancy. The actual functional level of brain serotonin depends on the activity of likely hundreds of receptors, enzymes, neurotransmitters etc. Tryptophan hydroxylase, SERT, 5-ht1a, 5-ht1b, GSK3, just to scratch the surface.> > Also, increasing MAO-A may leave you with lower levels of norepinephrine and dopamine (in addition to serotonin) as this enzyme catabolizes all three. > > > Linkadge

yeah I know it increasing MAO will decrease dopamine also.Progesterone increases both MAO a and B from what I have read.Progesterone also increases COMT which I think also reduces neurontransmitters? not sure. Anyway ... I just want this to work. I just wanna reduce my serotonin levels. Progesterone also increases GABA which decreases neuron firing so less active serotonin.Well im like on day 3 now on progesterone cream applying it on my skin.. I do feel the effect somewhat. Do you know if it takes time when you introduce something that increases MAO for the neurontransmitters to start depleting hard?

In reply to Re: Increase MAO-A to reduce Neurontransmitters?, posted by farshad on December 4, 2017, at 4:17:50

Hi.

> oh and I tried nardil didnt work so im pretty sure my MAO is low..

Perhaps MAO is not involved at all in your case.

> Low MAO is a lot worse than fast MAO.

Your statement is interesting, although counterintuitive. What is your evidence for saying this?

Which neurotransmitters do you feel are important in your case?

> I like how you automatically assumed my MAO is fast.

Linkadge is only trying to help. He is being generous with his time and knowledge. Everyone wants to see you succeed and feel better.

I mentioned VMAT2. Blocking this vesicular transporter reduces the amount of neurotransmitter in the synaptic cleft. Valbenazine (Ingrezza) is a drug that has recently been approved for the treatment of neuroleptic-induced dyskinesia. The idea is to offset postsynaptic supersensitivity by reducing dopamine release.

In reply to Re: Increase MAO-A to reduce Neurontransmitters? » farshad, posted by SLS on December 4, 2017, at 6:17:33

> Hi.> > > oh and I tried nardil didnt work so im pretty sure my MAO is low..> > Perhaps MAO is not involved at all in your case.> > > Low MAO is a lot worse than fast MAO. > > Your statement is interesting, although counterintuitive. What is your evidence for saying this?> > Which neurotransmitters do you feel are important in your case?> > > I like how you automatically assumed my MAO is fast.> > Linkadge is only trying to help. He is being generous with his time and knowledge. Everyone wants to see you succeed and feel better.> > I mentioned VMAT2. Blocking this vesicular transporter reduces the amount of neurotransmitter in the synaptic cleft. Valbenazine (Ingrezza) is a drug that has recently been approved for the treatment of neuroleptic-induced dyskinesia. The idea is to offset postsynaptic supersensitivity by reducing dopamine release.> > > - Scott

how am I gonna get Valbenazine ? its not even made in sweden and even if it was what am I gonna say. I belive I have a low mao pls give me Valbenazine . they are gonna laugh in my face . most docs not up to date to this stuff.

In reply to Re: Increase MAO-A to reduce Neurontransmitters?, posted by farshad on December 4, 2017, at 7:55:02

> > Hi.> > > > > oh and I tried nardil didnt work so im pretty sure my MAO is low..> > > > Perhaps MAO is not involved at all in your case.> > > > > Low MAO is a lot worse than fast MAO. > > > > Your statement is interesting, although counterintuitive. What is your evidence for saying this?> > > > Which neurotransmitters do you feel are important in your case?> > > > > I like how you automatically assumed my MAO is fast.> > > > Linkadge is only trying to help. He is being generous with his time and knowledge. Everyone wants to see you succeed and feel better.> > > > I mentioned VMAT2. Blocking this vesicular transporter reduces the amount of neurotransmitter in the synaptic cleft. Valbenazine (Ingrezza) is a drug that has recently been approved for the treatment of neuroleptic-induced dyskinesia. The idea is to offset postsynaptic supersensitivity by reducing dopamine release.> > > > > > - Scott> > how am I gonna get Valbenazine ? its not even made in sweden and even if it was what am I gonna say. I belive I have a low mao pls give me Valbenazine . they are gonna laugh in my face . most docs not up to date to this stuff.> > https://neuroendoimmune.wordpress.com/2013/11/21/progesterone-and-the-neurotransmitters-the-under-recognized-relationship/> > I wanna use progesterone to increase mao. im asking if its sufficient enough to do it.