A painter for 47 episodes of The Simpsons from 1992 to 1995, she also was a cel painter for TV’s Denver, the Last Dinosaur (1988).

Clayton was a key cel painter for the 1992 video The Kingdom Chums: Original Top Ten and a model painter for the 1993 TV-movie Nick & Noel (TV movie).

In theatrical films, Clayton was a Xerox checker for American Pop (1981); did ink and paint special effects for Pinocchio and the Emperor of the Night (1987), BraveStarr: The Legend (1988) and Happily Ever After (1990); was an ink artist for Cool World (1992); and was a color modeler for Tom and Jerry: The Movie, also a 1992 release.

For TV series, she was an ink and paint artist for Widget, the World Watcher (1991), a color designer for The Critic (1994), and a color stylist for The What a Cartoon Show (1995) and Dexter’s Laboratory (1996).

Additionally, Clayton was an ink and paint artist for the 1995 TV-movie Jonny Quest Versus the Cyber Insects.