The Odeon closed in February of 1990, a few months after a five screen Cineplex-Odeon multiplex opened in Stone Road Mall. A ten screen Galaxy multiplex opened in 2004 and the Stone Road mall cinemas closed in 2005. As of this writing (Sept. 2012), a second eight screen Galaxy theatre is currently under construction.

According to this 2002 online Guelph history, the Odeon was built on the site of Guelph Royal Opera House (later the Capitol Theatre) and became a nightclub called Club Denim (which appears to be still in operation): View link
However, as noted above, the Odeon opened in 1947, and the Opera House had an even-numbered address which would have placed it on the other side of the street.

An item in Boxoffice of October 19, 1946, about delays in construction on various theater projects in Canada said that the Odeon at Guelph was an exception, and that it was expected to be completed soon. They should have knocked on wood. The house was not opened for another year.

Boxoffice of November 8, 1947, said that the Odeon Theatre at Guelph had opened on October 31. The item also said that architect Leslie Kemp had been “interested in the design” of the theater. Kemp was an English theater architect who had come to Canada to oversee the completion of the various Odeon theater projects designed by the late Jay English, who had drowned that August.

The long-delayed date of opening indicates that the Guelph house was designed by Jay English, and that Kemp only oversaw the later period of its construction and took care of any minor design changes that might have been made while the project was being completed. Kemp’s arrival in Canada was announced in the October 11, 1947, issue of Boxofffice, though he probably had been in the country for some days before the item appeared.

The precise address is/was 161 Wyndham. It was a part of the Odeon (Canada) circuit well before the creation of Cineplex Odeon, having opened in 1949 (if the information on the Rivest List is accurate). I would imagine that most locals referred to it simply as the Odeon right up until its closing, which appears to have occurred in the early 1990s.