Clinical illness due to parvovirus B19 infection after infusion of solvent/detergent‐treated pooled plasma

Clinical illness due to parvovirus B19 infection after infusion of solvent/detergent‐treated...
Koenigbauer, Ulrike F.; Eastlund, Ted; Day, John W.
2000-01-01 00:00:00
BACKGROUND: Lipid‐enveloped viruses such as HIV, HBV, and HCV can be inactivated by treatment with solvents and detergents. HAV and human parvovirus B19 lack lipid envelopes and are not inactivated. Solvent/detergent‐treated pooled plasma (S/D plasma) contains neutralizing antibodies, but it is not known whether the parvovirus B19 antibody content is sufficient to prevent transmission of the disease. A patient is described who developed a clinical illness due to parvovirus B19 infection after the infusion of S/D plasma.
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Clinical illness due to parvovirus B19 infection after infusion of solvent/detergent‐treated pooled plasma

Abstract

BACKGROUND: Lipid‐enveloped viruses such as HIV, HBV, and HCV can be inactivated by treatment with solvents and detergents. HAV and human parvovirus B19 lack lipid envelopes and are not inactivated. Solvent/detergent‐treated pooled plasma (S/D plasma) contains neutralizing antibodies, but it is not known whether the parvovirus B19 antibody content is sufficient to prevent transmission of the disease. A patient is described who developed a clinical illness due to parvovirus B19 infection after the infusion of S/D plasma.

Journal

Transfusion
– Wiley

Published: Jan 1, 2000

Keywords: ; ; ; ;

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References

Role of parvovirus B19 in human disease.

Anderson, LJ

Detection of antibodies and antigens of human parvovirus B19 by enzyme‐linked immunosorbent assay.