Magnetite iron oxide nanoparticle is one of the most applied nanostructure in the field of physiological and pharmaceutical which have wide applications in medical sciences. Despite the advantages of these nanoparticles, they have some disadvantages. For example, uncoated iron oxide nanoparticles in aqueous solution create ions that are harmful to the body and are toxic in high dosage. In addition, due to the magnetism property of these particles, they agglomerate in solution and create sediment. Therefore, improving the surface structure of the nanoparticles is essential to overcome the mentioned problems. In this study, different mechanisms for coating the nanoparticles surface by using fatty acids which is extaracted from vegetable oils have been discussed. Not only these fatty acids could improve the disadvantage properties of magnetic nanoparticles, but also they have medicinal and therapeutic properties which can be used as a medicinal and nutritional complementary.