Quality by design is a standout amongst the most techniques which go about as a piece of current methodology to pharmaceutical industry. This paper gives thought regarding the Pharmaceutical Quality by Design (Qbd) and depicts utilization of Quality by design to guarantee quality of pharmaceuticals. The idea advances industry's understanding of the product and manufacturing process with product development, fundamentally constructing quality in, not testing it. It incorporates the Quality Target product profile ,critical quality attributes and key parts of Quality by Design .It likewise gives examination between product quality by end testing and product Quality by Quality by Design. The establishment of Quality by Design is ICH Guidelines. It is focused around ICH Guideline Q8 for pharmaceutical development, Q9 for quality risk management, Q10 for pharmaceutical quality system. It additionally gives application of Quality by Design in pharmaceutical development and manufacturing of pharmaceuticals.