..01; effect sizes d 1.0-1.8), as did quality of life (p < 0.02). Four of the 11 achieved remission. These improvements from nightly adjunctive eTNS in treatment-resistant depression merit replication under double-blind conditions...

Trigeminal nerve stimulation in major depressive disorder: first proof of concept in an open pilot trial

..This novel neuromodulation approach may have use as an adjunct to pharmacotherapy in major depressive disorder. Additional larger trials are needed to delineate efficacy and tolerability with greater reliability...

A lack of effect from transcranial magnetic stimulation (TMS) on the vagus nerve stimulator (VNS)