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Claims for Patent: 5,478,847

Claims for Patent: 5,478,847

Title:

Methods of use for inhibiting bone loss and lowering serum cholesterol

Abstract:

A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompased by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.

Inventor(s):

Draper; Michael W. (Carmel, IN)

Assignee:

Eli Lilly and Company (Indianapolis, IN)

Application Number:

08/205,012

Patent Claims:

1. A method of inhibiting bone loss or bone resorption comprising administering to a human in need thereof a compound of formula I ##STR3## or a pharmaceutically acceptable salt or
solvate thereof, in an amount of about 50 to 150 mg/day.

2. A method of claim 1 wherein the human has been diagnosed as suffering from osteoporosis.

3. A method of claim 1 wherein the human is a post-menopausal female.

4. A method of claim 1 wherein the human is a male.

5. A method of claim 1 wherein the compound is administered prophylactically.

6. A method of claim 1 wherein the compound of formula I is administered in an amount of about 60 to about 150 mg/day.

7. A method of claim 1 wherein the compound of formula I is administered in an amount of 60 mg/day.

8. A method of claim 1 wherein the compound of formula I is administered in an amount of 75 mg/day.

9. A method of claim 1 wherein the compound of formula I is administered in an amount of 100 mg/day.

10. A method of claim 1 wherein the compound of formula I is administered in an amount of 125 mg/day.

11. A method of claim 1 wherein the compound of formula I is administered in an amount of 150 mg/day.

12. A method of claim 1 wherein the compound is the hydrochloride salt.

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