Dissolution DNP

A dissolution-DNP experiment is a three step process: first, the sample is polarized via DNP by microwave irradiation at low temperature; second, the sample is dissolved in a hot solvent and transported into the spectrometer or imager magnet by blowing high-pressure gas through a plastic tube; third, the solution is injected into a NMR tube, an animal or a human and data acquisition is launched.
Optimization of protocols that cover this sequence from the first to the last step is of great importance to obtain reliable, reproducible results. This is achieved through computer control of specifically designed hardware for each of the steps.