Project: Optimization and validation of an alternative mucosal irritation test.

project duration

01-OCT-01 – 30-SEP-03

abstract

In the lab. of pharmaceutical technology an alternative mucosal irritation test was developed using the slug Arion lusitanicus as test organism. With this test it is possible to screen the irritation potency of chemicals based on the amount of mucus produced by the slugs and the release of proteins and enzymes from the body wall after treatment with the test substance. The test need to be further optimized and validated with reference standards. Additionaly, the possible use of other slugs species as test organism will be investigated.