Total parenteral nutrition versus early enteral nutrition after cystectomy: a meta-analysis of postoperative outcomes

Abstract

Background

This study aimed to systematically summarize and analyze the current evidence regarding the effect of total parenteral nutrition (TPN) versus early enteral nutrition (EEN) on postoperative outcomes of cystectomy.

Methods

A comprehensive search of online databases was conducted to identify comparative studies on the postoperative outcomes of patients receiving TPN and EEN after cystectomy. Our subsequent meta-analysis followed the PRISMA Protocol and the Cochrane Handbook.

Conclusion

EEN was found to have a significant effect on reducing infectious complications and costs compared with TPN treatment after cystectomy. Remarkably, EEN had no significant impact on mortality incidence, postoperative ileus, length of hospital stay, or the time to resumption of full diet.

Keywords

Cystectomy Parenteral nutrition Enteral nutrition Meta-analysis

Shuxiong Zeng, Yongping Xue, and Junjie Zhao have contributed equally to this paper.

Notes

Acknowledgements

This research was financed by grants from Shanghai Sailing Program (Grant No. 18YF1422700), Starting Foundation for Young Scientists of Second Military Medical University (Grant No. 2017QN11), National Natural Science Foundation of China (Grant No. 81802515), Natural Science Foundation of Shandong Province (Grant No. ZR2016HL36), and the Medical Science and Technology Development Project of Shandong Province (Grant No. 2016WS0703).

Compliance with ethical standards

Conflict of interest

The authors declare they have no conflicts of interest.

Ethical approval

This study was a meta-analysis based on the existing published data, and therefore did not require the approval of an institutional review board.