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Abstract:

In Brief:

The development of scoliosis after pinealectomy in chicken may be caused by the relative over activity of calmodulin. This study investigated the effect of calmodulin inhibitors and demonstrated that Tamoxifen is effective in decreasing the incidence as well as the magnitude of scoliosis at a certain time point.

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Overfilling a bony defect with rhBMP-2/ACS or hyperconcentrating the rhBMP-2 solution on an absorbable collagen sponge led to concentration-dependent osteoclastic resorption of peri-implant bone in an ovine corticocancellous defect model. The osteoclastic effect was transient with progressive bony healing taking place over the 8-week survival period.

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The efficacy of prostaglandin E1 derivative limaprost alfadex for patients with cervical spinal canal stenosis was evaluated by objective scoring/grading and stabilometry. The patients showed significant improvement of the symptoms and the effects were confirmed by objective data.

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This study confirms that porous coated motion disc replacement adjacent to a prior anterior cervical decompression and fusion is associated with retained motion and excellent clinical outcomes with significant improvement in clinical symptoms and Neck Disability Index. The extent of improvement is comparable with that seen in patients undergoing porous coated motion disc replacement as a primary procedure.

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To provide initial estimates of the frequencies and magnitudes of neck motion during inartificial daily activities, 10 healthy young adults wore a portable motion measurement device for a 5-day period. Subject activity logs were used to calculate hourly rates of motion for specific activities.

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We evaluated and compared the pre and postoperative neurostatus of 194 patients who underwent surgical decompression of the spine due to neurodeficit present in metastatic disease. The analysis of the results showed that patients with neurologic deficit due to spinal bone metastases benefit from early operative intervention.

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Clinical outcome was significantly improved after both a standard open posterior lumbar interbody fusion and after a less invasive PLIF (LI-PLIF). However, clinical outcome, duration of hospital stay, and number of complications were significantly better still after LI-PLIF than after standard posterior lumbar interbody fusion. LI-PLIF is therefore recommended for the treatment of intractable low back pain.

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Outcomes of 16 patients with deep wound infection were compared to 16 matched controls as measured by SF-36 physical domains. No significant differences in SF-36 scores were found at a mean follow-up of 62 months.

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An objective statistical tool (cluster analysis) of spinal shape parameters revealed 4 groupings of patients in a clinic population. The groups differed according to the 4 permutations of positive or negative rotation of the plane of maximum curvature in the 2 scoliosis curve regions, but this information alone should not determine patient management.

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Actual spine flexibility tests evaluate reducibility instead of flexibility since the forces involved in the movement are not known. The suspension test allows estimating the forces involved in addition to reducibility. The aim of this study is to verify whether suspension is a better method than side-bending to estimate curve reducibility.

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This study shows scoliotic women shrink faster than nonscoliotic women. Curve progression is highly related to shrinkage, and can be predicted from the self-reported decrease in body height. This simple method could help clinicians predict the evolution of curvature and choose the most appropriate treatment in patients without documented radiograph follow-up.

Abstract:

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Rotatory subluxation is a hallmark of adult scoliosis. We tested the inter- and intraobserver reliability of 3 specific measurement methods. The centroid method was most reliable; however, all 3 measures demonstrated good-excellent reliability, but yielded different values for the same level. Thus, use one of these methods and remain consistent. Increased >3 mm measured by the endplate or centroid method suggest progression of rotatory subluxation.

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We retrospectively reviewed the results of an immediate preprocedure imaging protocol for patients scheduled for vertebroplasty or kyphoplasty. In carefully selected patients, MRI often demonstrated compression fractures that were not present previously. This imaging protocol can provide valuable information that substantially alters patient treatment.

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In Brief:

Measurement of axial rotation by computed tomography was compared with biomechanical testing in human lumbar cadaver spines. Computed tomography was shown to be accurate and precise and maybe a useful clinical tool.

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We aimed to describe organizational characteristics of spine and pain clinics (N = 46). The majority were free-standing and physician-owned, offered epidurals and/or trigger point injections, and medication prescription. Many had anesthesiologists but less than one third had mental health providers. Few offered exercise instruction and most were not multidisciplinary in nature.

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In Brief:

The French version of the Scoliosis Research Society Outcome Questionnaire showed satisfactory reliability, factorial structure, concurrent validity, and discriminant capacity. This study provides scores in a group of healthy adolescents and demonstrates a clear gradient in response between subjects with adolescent idiopathic scoliosis, non clinically significant scoliosis, and healthy controls.

Abstract:

In Brief:

Translation and adaptation of the Turkish validation of the Quebec Back Pain Disability Scale was performed. Visual Analog Scale, Schober test, and scores of the Quebec Back Pain Disability Scale and Oswestry Disability Index were evaluated twice. The authors found it to have excellent reliability and adequate validity.