this study provides vigorous evidence that ZBP-89 was significantly downregulated in clear cell renal cell carcinoma (show MOK Proteins)(CCRCC) and could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC.

Colony formation was reduced dramatically in those hepatocellular carcinoma cell lines in which ZBP-89 overexpression was demonstrated; this appeared to correlate with increased apoptosis.

ZBP-89 is required for expression of the Tph1 (show TPH1 Proteins) gene and subsequent production of 5HT (show DDC Proteins) in response to bacterial infection in mice. Reductions in epithelial ZBP-89 increase susceptibility to colitis and sepsis after infection with S. typhimurium.

identify ZBP-89 as being a novel transcription factor involved in erythroid and megakaryocytic development and suggest that it serves a cooperative function with GATA-1 (show GATA1 Proteins) and/or FOG-1 (show ZFPM1 Proteins) in a developmental stage-specific manner

the G(5) string is necessary for Gata1 (show GATA1 Proteins) gene expression in vivo and ZBP-89 is the functional trans-acting factor for this cis (show CISH Proteins)-acting region.

Zebrafish Zinc Finger Protein 148 (ZNF148) interaction partners

identify ZBP-89 as being a novel transcription factor involved in erythroid and megakaryocytic development and suggest that it serves a cooperative function with GATA-1 (show GATA1 Proteins) and/or FOG-1 (show ZFPM1 Proteins) in a developmental stage-specific manner

Zinc Finger Protein 148 (ZNF148) Protein Profile

Protein Summary

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.