Lakshmi will set all units' MP to 0 after her first turn. To recover from that you can use MP recovering items, such as Greater Scroll of Recovery, in conjunction with MP batteries to sustain your run.

Lakshmi heals 15 million HP every 3 turns, therefore you have to outdamage her. Make use of chainers, imperils, elemental attacks, and Man-Eater/Man-Eater+ (including from Diabolos).

Lakshmi can be blinded, can serve useful if you did not bring in a full evade provoke tank. Utilize the TMR Rikku's Pouch with Chaos Grenade if you have it.

Suggested roles:

Light-resistant magic tank (preferably with 100% resistance)

Provoke tank (preferably with 100% evasion)

ATK/MAG breaker. Although this is not necessary if you use 100% light-resistant magic tank and 100% evasion provoke tank, later on Lakshmi will charm your provoke tank, disabling his evasion.

Charm is used every 10 turns (10, 20,...), so you can ignore all of these by having more damage.

You can dispel charm with dualcast-Dispel trick or damaging dispel like Fingersnap.

Risky way: If you use a 100% evasion provoke tank, you can ignore gearing for HP and instead focus on reraising him, so that when he is killed after being charmed, he will then be auto-revived. Moogle Plushie and other forms of passive provoke, along with DEF buff and ATK break, can be used to reduce incoming damage due to lost of provoke.

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