"Mister and Mississippi" is a popular song, written by Irving Gordon. It was published in 1951. The song was popularized by Patti Page. It was also recorded by Rex Allen, Dennis Day and Johnny Desmond.

The Page recording was issued by Mercury Records as catalog number 5645, and first reached the Billboard chart on May 19, 1951, lasting 15 weeks and peaking at #8.

The recording by Dennis Day was released by RCA Victor Records as catalog number 47-4140. It first reached the Billboard magazine Best Seller chart on June 1, 1951 and lasted 11 weeks on the chart, peaking at #15.

On Cash Box magazine's charts, where all versions were combined, the song peaked at #6 on the chart.

The popularity of this song apparently led Gordon, a number of years later, to create another song with even more puns on state names: "Delaware."