really hoping someone may be able to help me as I'm really struggling with this.

mid November I'm staying a night in Tsumago and then travelling on to Takayama. However, I'm having trouble finding out the best route to get there.
Any help would be much appreciated.
Thanks in advance.

The simplest and fastest way is to use car. It will take two and half hours and will cost you over 30,000 JPY if you use taxi.

To take trains, you must walk or take taxi to JR station "MINAMI-KISO" (2 km). Then you should go Nagoya to take another train or bus. It will take over four hours and cost you 6,000 to 7,000 JPY according to the course you take.

You can also take bus from TSUMAGO to GERO (pronounce like GUERO or GWERO). You need to take two bus: ONTAKE-KOTSU and KITA-ENA-KOTSU and exchange at MAGOME. It will take four hours on bus and one hour on train. Train fee is 1,620 JPY and Bus fee is unknown.