Research Support

Active

5 R37 HL34557

Sherry (PI)

National Institute of Health MERIT Award$250,000 annual direct costTitle: Metabolism in the Heart by NMR
The major goal of this project is to develop hyperpolarized 13C techniques to quantitatively measure flux through specific enzyme catalyzed steps in perfused hearts, livers and cancer cells. 2.40 calendar

2 R01 CA115531

Sherry (PI)

National Institute of Health $168,539 annual direct costTitle: PARACEST Agents for Molecular Imaging of Cancer by MRI
The major goal is to develop applications of paramagnetic chemical exchange saturation transfer imaging agents when bound to macromolecules and as small molecule sensors of hypoxia. 1.20 calendar

5 P41 RR02584

Malloy (PI)

The goal of this project is to develop CEST imaging techniques to image liver glycogen in vivo, to map tissue pH, and to image the distribution of extracellular glucose in tissues in vivo. 0.72 calendar

RP101243-C01

Sherry (PI)

CPRIT $29,338 annual direct costTitle: Novel MRI and MRS Methods for Imaging Cancer Metabolism: C01
The major goal is the development of biomarkers in tumors to study metabolism, MRI and Hypersense substrates.1.20 calendar

AT-584

Sherry (PI)

The major goal is to synthesize a series of new DOTA-tetraamide ligands with variable steric strain, charges, and redox properties and examine the CEST properties of the resulting lanthanide complexes.0.40 calendar

1R01 DK095416-01A1

Sherry (PI)

National Institute of Health $250,000 annual direct costTitle: Imaging Beta Cell Function in Vivo with Zinc Responsive MRI Contrast Agent
The goal is to determine the general utility of a novel Zn2+ sensor molecule, GdDOTA-diBPEN, MRI agent for imaging Beta-cell function in anticipation of translating this technology to clinical imaging.1.20 calendar

2 P01 DK058398-11A1

Sherry (PI)

National Institute of Health/Duke University $100,000 annual direct costTitle: Development of Novel Therapies for NIDDIM: Core A
The goal is to provide NMR and tracer core support for the 4 projects of the PO1 grant.

0.60 calendar

2 P01 DK058398-11A1

Malloy (PI)

National Institute of Health/Duke University $294,209 annual direct costTitle: Development of Novel Therapies for NIDDIM: Project 40.48 calendar

PC110174

Sherry/Khemtong (PI)

US Department of Defense $75,000 annual direct costTitle: Extracellular pH Imaging of Prostate Tumors by Hyperpolarized 15N MRI
The major goal of this award is to explore 15N-enrihed compounds for pH imaging of prostate tumors by hyperpolarized MRI.0.00 calendar

Mentor-Based Predoc Fellowship

Sherry/Anderson (PI)

American Diabetes Association $42,910 annual direct costTitle: In Vivo Imaging of Beta cell Function with Zinc responsive MRI Contrast Agents
To support a postdoc who will test a novel MRI contrast agent sensitive to pancreatic function by researching its effectiveness and then use the agent as a metric for competing beta cell implantation techniques.0.36 calendar

1 R03 NS081584-01A1

Udugamasooriya (PI)

National Institute of Health $150,000Title: Direct Identification of Ready–to-Use Peptoid-DOTA Theranostic Systems
The goal is to identify peptoids capable of being generated into a new class of drugs with the potential to impact treatment of multiple types of cancer.0.60 calendar

RO1 EB004582

Lenkinski (PI)

National Institute of Health NIBIB $207,305Title: PARACEST Agents: Optimization for Human MR Imaging
Major Goal: This is a bioengineering partnership application involving further development of the chemistry of PARACEST agents at UT Dallas, development of optimal pulse sequences for clinical scanners at GE Medical, and imaging of PARACEST agents in large animal models (pigs) at UT Southwestern.1.2 calendar

Completed

1 R13 EB015773

Sherry (PI)

National Institutes of Health $25,000 Title: 2012 Metals in Medicine
This conference grant is to support travel and registration fees for scientists to attend the 2012 Gordon Research Conference on Metals in Medicine. The conference this year will focus on the development of new metal-based drugs for therapy, imaging, and other clinical applications.0.0 calendar

R01 HL34557

Sherry (PI)

National Institutes of HealthTitle: Intermediary Metabolism by 13C NMR
The major goals of this project are to develop novel 13C and 1H NMR techniques for examining intermediary metabolism in intact tissues and to apply such techniques to significant metabolic issues. Current studies involve the kinetics of 13C labeling of glutamate and other intermediates in isolated rat heart mitochondria and indirect 1H detection of 13C labeling in isolated perfuse mouse hearts.

AT-584

Sherry (PI)

The Robert A. Welch FoundationTitle: Lanthanide-based CEST Agents for Molecular Imaging
The major goals of this project are to synthesize a series of new DOTA-tetraamide ligands with variable steric strain, charges, and redox properties and examine the CEST properties of the resulting lanthanide complexes.

RO1 CA115531

Sherry (PI)

National Institutes of HealthTitle: PARACEST Agents for Molecular Imaging of Cancer
The major goals of this project are to develop applications of paramagnetic chemical exchange saturation transfer imaging agents when bound to antibody surfaces and as small molecule sensors of hypoxia.

P01 DK058398

Newgard (PI)

National Institutes of Health (renewal – this application)Title: Development of Novel Therapies for NIDDM
This is a renewal application for a project grant to continue studies of novel targets and imaging agents for imaging pancreatic beta cell function by MRI and PET. Dr. Christopher Newgard of Duke will become the PI of this program project grant involving several scientists at UTSW and at Duke University.

P41 RR02584

Malloy (PI)

National Institute of Health Research Resources grant (renewal application)Title: Metabolic Imaging Agents
The major goals of this project are to develop CEST imaging techniques for determining liver glycogen in animal models, apply glucose sensitive PARACEST agents to image the distribution of glucose in tissues in vivo and to develop new agents for mapping of tissue pH by MRI.

U24 DK-59632

Malloy (PI)

National Institutes of HealthTitle: Metabolic Phenotyping Center for Mouse Models of Diabetes
This project is one element of a national consortium involving three other centers with the shared goal of refining methods for metabolic studies in mice and in providing those methods to the research community.

RO1 EB004582-01

Lenkinski (PI)

National Institutes of HealthPARACEST Agents: Optimization for Human MR Imaging This is a bioengineering partnership application involving further development of the chemistry of PARACEST agents at UT Dallas, development of optimal pulse sequences for clinical scanners at GE Medical, and imaging of PARACEST agents in large animal models (pigs) at the Beth Israel Deaconess Medical Center in Boston, MA.