Fig. 2

Different strategies of CRISPR-Cas system for targeting lncRNA. a Removing the entire locus of an lncRNA gene via sgRNA-mediated cleavage by Cas9. b Solely deleting the promoter region of an lncRNA gene by CRISPR-Cas9. c Silencing an lncRNA gene by knocking-in transcription termination signal. d Suppressing or enhancing lncRNA expression by CRISPRi/a. e Cleaving lncRNA transcripts by CRISPR-Cas13 system