Many breast cancer patients can skip chemo, new study finds

Dr. Otis Brawley, chief medical and scientific officer for the American Cancer Society said that he was "delighted" by the study and anxious about unnecessary cancer treatment and the side effects that come from chemotherapy.

"You shouldn't do chemo unless you have to", added Dr. Jack Jacoub, medical oncologist and medical director at the MemorialCare Cancer Institute at the Orange Coast Medical Center in California.

Proceeds from the U.S. Postal Service's breast cancerstamp helped fund this important study.

Dr. Steven Rosenberg, chief of surgery at the National Cancer Institute, was stunned by the response shown by Perkins' body, who had resigned herself to what she thought would be her inevitable end. "With your help, we can continue to support a better informed local community and a healthier democracy for another 30 years". To conduct the study, women in the intermediate groups were either prescribed chemotherapy or given treatment absent of the use of chemotherapy.

The treatment involves a highly personalized approach and a patient's tumor is genetically analyzed to "identify the rare changes that might make the cancer visible to the immune system".

These mid-range women were randomly assigned to either receive hormone therapy alone, or hormone therapy and chemotherapy. "If we are going to take a step back" from chemotherapy, he said, "we really had to be sure". Now they can have confidence in those decisions, experts said. The test looks for 21 specific genes associated with breast-cancer remission.

"We have been waiting for these results for years", said Allison Kurian, an oncologist at Stanford University who wasn't involved in the trial.

In Canada, where one in eight women will develop breast cancer, many doctors are hoping to use the study's findings to change how they treat the disease.

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The study enrolled 10,273 women, of whom 9719 with follow-up data were included in the main analysis set; 6711 women (69%) had an intermediate recurrence score of 11-25, while 1619 (17%) had a low recurrence sore of 10 or less and 1389 (14%) had a recurrence score of 26 or higher.

For many patients, it's a hard choice to decide whether to go through chemotherapy.

"Tumors grow more aggressively in premenopausal women, not just women under 50", Brawley said. Another 16 per cent had very low risk scores and were told they could skip chemo.

The team of doctors complemented the cell treatment with "a range of new immunotherapy drugs called "checkpoint inhibitors", Sky Newsreports, "designed to overcome a cancer's ability to shield itself from the immune system".

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Not only will they be able to dodge the side-effects of chemotherapy but they'll also feel more confident in their decision. The rate that women who had also received chemotherapy was more than 84 percent, a statistically insignificant difference.

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