Despite Weeden's atrocious play, the Browns managed to hang around in a 17-16 loss to the Eagles. It got a little bit better as the season progressed, but not much. Weeden is now a backup with the Texans.

The No. 1 overall pick struggled mightily in his debut, losing to the Saints 45-27. It didn't get any better over his next nine games, as Stafford won just two while battling injury. He's still leading the Lions and was selected to the Pro Bowl in 2014.

The Texans rudely introduced Tannehill to the pros by sacking him twice and picking him off three times. The Dolphins lost 30-10 and finished the season 7-9 with the rookie starting all 16 games. Tannehill has not missed a game since being drafted by the Dolphins in 2012.

Another No. 1 pick that struggled. Luck's turnover woes cost the Colts in a 41-21 loss to the Bears. Despite playing behind a rickety offensive line, Luck led the Colts to the playoffs and was named to the Pro Bowl.

Bradford aired it out a whopping 55 times in his debut. He was sacked twice and picked three times in a 17-13 loss to the Cardinals. The team remained middling throughout the year, finishing 7-9. Bradford is now in Minnesota backing up veteran Shaun Hill.

Wilson had Seattle up until Arizona scored with 5 minutes left, and he wound up taking a 20-16 loss. Everything turned out fine for Wilson though, as he guided Seattle to an 11-5 record and earned a spot in the Pro Bowl. Wilson led the Seahawks to a Super Bowl win in 2013.

The first quarterback on this list to taste victory in his NFL debut, Flacco was underwhelming but avoided costly mistakes in a 17-10 win over the Bengals. His season was much the same as he played the role of game manager, relying on the Ravens' defense to decimate opponents on a weekly basis. Flacco won a Super Bowl in 2012.

The No. 1 overall pick was upstaged by another rookie (who we'll get to later) in this one. The Buccaneers were shredded by the Titans, 42-14. Winston began flashing the promise that led the Bucs to take him first as the season went on, and he's already off to a terrific start in 2016 after throwing for four touchdowns in a Week 1 win.

Precott's steady debut put the Cowboys in a position to win late, but Terrence Williams' inability to get out of bounds denied kicker Dan Bailey a shot. The 20-19 loss is a painful one to open with, but Prescott proved the game isn't too big for him.

Getting the ball down two with under 40 seconds to go, Smith led the Jets into Bucs territory to set Nick Folk up for a game-winning 48-yard field goal. Smith is still with the Jets, but he's backing up Ryan Fitzpatrick these days.

Another Jets prospect that didn't pan out, Sanchez led the Jets to a 24-7 win over the Texans in Week 1. New York seemed to win almost in spite of Sanchez at times as the Jets' stifling defense pushed the team all the way through to the AFC Championship. Sanchez is now in Dallas backing up Prescott.

Carr's opening-day numbers look decent thanks to a garbage-time touchdown in a 19-14 loss to the Jets. He had a strong rookie season on a bad team, but has transformed into one of the league's most promising his third year.

Sure, it's the Browns, but a win is a win. This year's second-overall pick dissected the Browns' defense in a 29-10 victory and, in the process, probably made more than a few Rams fans jealous as they had to endure the Case Keenum experience while No. 1 pick Jared Goff sat in street clothes on Monday night.

Dalton was rolling before exiting after one half due to injury. Still, the Bengals defeated the Browns 27-17 to give the Red Rifle his first NFL victory. Dalton has twice been a Pro Bowler in his career and has accumulated a 51-26-1 record as a starter.

Manuel nearly led the Bills to an upset of the Patriots on the road, but had his moment ruined by Tom Brady and kicker Stephen Gostoswki in a 23-21 loss. Manuel injured his right knee in October, causing him to miss more than a month of the season. Still with the Bills, Manuel is currently Tyrod Taylor's backup.

There was nothing quiet about SuperCam's introduction to the NFL: The No. 1 pick threw for 422 yards in a 28-21 loss to the Cardinals, the most ever by a rookie in Week 1. Newton broke numerous records during his Rookie of the Year campaign and was named NFL MVP in 2015.

Ryan wasn't asked to do too much in a 34-21 win over the Lions. Instead he handed off to Michael Turner and Jerious Norwood 36 times -- they finished with 318 yards on the ground. Ryan's season played out in similar fashion as the Falcons finished 11-5, earning a Wild Card berth.

Griffin set the league on fire in his debut, going punch-for-punch with Drew Brees and emerging the victor in a 40-32 win over New Orleans. Griffin was named the Rookie of the Year, but his season ended on a sour note as he tried to play through an LCL sprain in a Wild Card loss to the Seahawks. He hasn't been the same force since.

Mariota was literally perfect in his debut against Winston and the Buccaneers. He had twice as many touchdowns (4) as incompletions (2) in a 42-14 win. Mariota never reached those heights again, but turned in a strong rookie season that was cut a bit short by a knee injury.