Sialic Acid Identification and Quantitation Sialic acids are a family of nine-carbon acidic monosaccharides that occur naturally at the end of sugar chains attached to membrane glycoproteins and secreted glycoproteins... http://www.creative-proteomics.com/application/sialic-acid-identification-and-quantitation.htm

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N-Acetylneuraminic acid (NeuAc) or sialic acid is an acetyl derivative of the amino sugar neuraminic acid. It occurs in many glycoproteins, glycolipids, and polysaccharides in both mammals and bacteria. The most abundant sialic acid, NeuAc, is synthesized in vivo from N-acetylated D-mannosamine (ManNAc) or D-glucosamine (GlcNAc).

Did you know that changes in protein glycosylation are frequently studied in #cancer research to identify potential biomarkers? Factors investigated include differences in overall oligosaccharide (glycan) content, monosaccharide content changes, differences in sialylation amount and sialylation linkages, the degree of fucosylation, and differences in glycan branching. Read this fantastic sialic acid resource on the evaluation of protein #glycosylation by HPAE-PAD.

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A novel discovered peptide as checkpoint inhibitor Scientists from Susavion Biosciences, Inc. recently dentified a unique peptide that mimics the sugar sialic acid and binds with high avidity to inhibitory, sialic acid-binding receptors on immune cells. Administration of the peptide to mice induced dramatic increases in populations of activated immune cells in the peritoneal cavity.