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A chronic and progressive autoimmune disease characterized by arthritis, inflammation, and eventual immobility of a number of joints.

Description

A chronic and progressive autoimmune disease characterized by arthritis, inflammation, and eventual immobility of a number of joints. The disease usually involves the spine and surrounding spinal structures. Its principal location is in the spine and sacroiliac joints. In the spine, the small synovial joints and the margins of the intervertebral disks are both involved. These structures become bridged by bone, and the spine is accordingly rigid. Ankylosing spondylitis is a disease of men, but there is disagreement among authors as to the male/female sex ratio, varying from 3:1 to 8:1. Onset usually between the ages of fifteen and thirty-five years. Symptoms of the disease are generally milder among females. This disorder is seen rarely in people of colour. An autosomal dominance has been recorded.

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