Metronidazole (Flagyl)

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Comparative study of the vigor and safety of ceftazidime/avibactam more metronidazole versus meropenem in the management of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-eyeless, Phase II trial.

Avibactam, a unusual non-β-lactam β-lactamase inhibitor, restores the in vitro action of ceftazidime against class A, C and more class D β-lactamase-producing pathogens, including those commonly associated with complicated intra-abdominal infections (cIAIs). This randomized, in actual process-controlled, double-blind, Phase II vexation (NCT00752219) aimed to evaluate the preservation and efficacy of ceftazidime/avibactam more metronidazole compared with meropenem in hospitalized patients through cIAI.

METHODS:

Adults with confirmed cIAI requiring surgical interference and antibiotics were randomized 1:1 to embrace intravenously either (i) 2000 mg of ceftazidime in addition 500 mg of avibactam plus a unconnected infusion of 500 mg of metronidazole or (ii) 1000 mg of meropenem plus placebo every 8 h for a least part of 5 days and a maximum of 14 days. The primary effectiveness endpoint was the clinical response in microbiologically evaluable (ME) patients at the experiment-of-cure (TOC) visit 2 weeks afterward the last dose of study therapy.

RESULTS:

Overall, 101 patients received ceftazidime/avibactam plus metronidazole; 102 admitted meropenem. The median duration of method of treating was 6.0 and 6.5 days, particularly. Favourable clinical response at the TOC survey in the ME population was observed in 91.2% (62/68) and 93.4% (71/76) of patients in the ceftazidime/avibactam more metronidazole and meropenem groups, respectively (observed bickering: -2.2%; 95% CI: -20.4%, 12.2%). The incidence of management-emergent adverse events was similar conducive to ceftazidime/avibactam plus metronidazole (64.4%) and meropenem (57.8%).

CONCLUSIONS:

Ceftazidime/avibactam in addition metronidazole was effective and generally well tolerated in patients with cIAI, with a favourable clinical replication rate in the ME population of >90%, homogeneous to that of meropenem.