Supplementary Material for: Responsiveness of Infrapatellar Fat Pad Volume Change to Body Weight Loss or Gain: Data from the Osteoarthritis InitiativeSteidle-Kloc E.Dannhauer T.Wirth W.Eckstein F.10.6084/m9.figshare.5840832.v1https://figshare.com/articles/Supplementary_Material_for_Responsiveness_of_Infrapatellar_Fat_Pad_Volume_Change_to_Body_Weight_Loss_or_Gain_Data_from_the_Osteoarthritis_Initiative/5840832<p>Obesity is a potent risk factor for knee osteoarthritis (OA) that is
driven by mechanical and potentially endocrine mechanisms, and it
affects women more frequently than men. The infrapatellar fat pat (IPFP)
represents a potential link between obesity, intra-articular
inflammation and structural pathology. Here we investigate whether the
IPFP is responsive to body weight loss/gain in women and how its
responsiveness to weight change compares to that of subcutaneous fat
(SCF) of the thigh. All female participants of the Osteoarthritis
Initiative (OAI) with ≥10% weight loss/gain between baseline and a
2-year follow-up were included. Within-subject changes in IPFP volume
and SCF cross-sectional areas (CSA) were determined from 3-T magnetic
resonance imaging. Linear regression was used to assess the association
between change in weight, IPFP volume, and SCF CSA. In the 38
participants with ≥10% weight loss over 2 years (age 59.3 ± 9.1 years,
mean loss = 15.9%), there was a significant reduction in IPFP volume
(-2.2%, <i>p</i> = 0.02) as well as in SCF CSA (-22%, <i>p</i> <
0.001). In the 34 participants with ≥10% gain (age 61.5 ± 8.7 years,
mean gain = 15.9%), there was a significant increase in SCF CSA (+26%, <i>p</i> < 0.001) but not in IPFP volume (0.2%, <i>p</i> = 0.87). Weight change was significantly associated with SCF CSA change (<i>r</i> = 0.76, <i>p</i> < 0.001) but not with IPFP volume change (<i>r</i> = 0.11, <i>p</i>
= 0.37). In this first longitudinal, observational study investigating
the responsiveness of IPFP and SCF to weight change, IPFP morphology was
found responsive to weight loss but not to weight gain. Overall, the
responsiveness of the IPFP was substantially less than that of the SCF.</p>2018-01-31 09:59:16Body mass indexHoffa’s fat padKneeOsteoarthritis InitiativeMagnetic resonance imaging