The most common mutation in Hutchinson-Gilford progeria syndrome (HGPS) is caused by a de novo dominant mutation on a paternal inherited allele. There has been one case reported of a somatic mosaicism in an asymptomatic mother carrying the G608G mutation.

Affected children’s parents are not affected.

Does not increase the risk for other siblings or family members.

Current record have only indicated two sets of identical twins with HGPS.

Families with more than one sibling with classic HGPS are extremely rare.

Individuals with HGPS do not reproduce.

Strong evidence indicate that only one mutated allele is required to cause the disease.

Compound heterozygous mutations have also been reported, which may result in atypical HGPS