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5-12 and 6-11 matchups

Roughly a third of the time, the underdog will win in these pesky matchups. This year the 5s and 6s look safe for the most part, though the aforementioned Utah State should be able to pull of the first round upset over fifth-seeded Kansas State. Another team to watch out for: Gonzaga (left). It has been known to blow up brackets in past years, but the Bulldogs have a well-balanced team that creates points and possessions and have very few glaring flaws. They could definitely give St. Johns a run for its money.