Gliogenesis: Historical Perspectives, 1839 - 1985

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Almost a century and a half of study produced substantial progress in our understanding of glial cells and their development. As in other areas of science, major advances were associated with the discovery of new methods. These are summarized first. Most of this account describes development of glia in the CNS. We begin with astroglia because of their known presence and significance in early embryonic stages. Some of A strApm' s unpublished evidence is included in this section. After consideration of oligodendroglia, microglia and ependymal cells, we describe the development of Schwann cells, the glia found in the PNS. In general, morphological observations of developing mammalian nervous tissues (mostly rodent) are emphasized; we have also tried to include findings relevant to cytodifferentiation, interactions, functions and regulation of developing glia. Of course, much has been learned about glial development by studying other species and a variety of experimental models, such as tissue culture systems, grafts and mouse mutants. Selected aspects of these subjects are also included.Their behavior in vivo was described in detail by Speidel (1932), who later
correlated his own observations with in vitro and electron microscopic findings of
others (Speidel 1964). ... During spreading, they became spindle-shaped and
acquired a basal lamina, a morphological sign, perhaps, of a more ... They are,
however, probably more complex than Speidela#39;s descriptions and diagrams
indicated. Fig.

Title

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Gliogenesis: Historical Perspectives, 1839 - 1985

Author

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Henry Webster, Karl E. Åström

Publisher

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Springer Science & Business Media - 2008-12-17

ISBN-13

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