(Cat? OR feline) AND NOT dog?
Cat? W/5 behavior
(Cat? OR feline) AND traits
Cat AND charact*

This guide provides a more detailed description of the syntax that is supported along with examples.

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Concept Search - What can I type?

For a concept search, you can enter phrases, sentences, or full paragraphs in English. For example, copy and paste the abstract of a patent application or paragraphs from an article.

Concept search eliminates the need for complex Boolean syntax to inform retrieval. Our Semantic Gist engine uses advanced cognitive semantic analysis to extract the meaning of data. This reduces the chances of missing valuable information, that may result from traditional keyword searching.

Disclosed herein after is an impurity in the synthesis of ( (S)-2-((2-oxo-3-(4-(3- oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione (Compound I) having the following structure:

2,2'-(((4-(3-oxomorpholino)phenyl)azanediyl)bis(2-hydroxypropane-3,1- diyl))bis(isoindoline-1,3-dione) (Compound A) which was identified as a process intermediate (IPCOM000233194D) can react further to form diethyl (((4-(3- oxomorpholino)phenyl)azanediyl)bis(3-(1,3-dioxoisoindolin-2-yl)propane-1,2-diyl)) bis(carbonate) (Compound B).

Compound B can be obtained by a process as shown in the scheme below:

Example:

A reactor of 1L was loaded with Compound A (10 g, 0.017 mol), N, N'- carbonyldiimidazole (97% assay, 5.6 g, 0.034 mol) and toluene (300 ml). The suspension was heated and stirred at 114 °C (Tj) for ~5h. The reaction mixture was then cooled to 60 °C (Tj) and abs. EtOH (100 ml) was added followed by cooling to 25 °C (Tj). The mixture was concentrated under reduced pressure and the residue was