ß-globin, a subunit of hemoglobin, is a small protein
(146 amino acids) that transports oxygen throughout our bodies. This
protein has a ring-like heme group, which contains an iron atom that
binds the oxygen. This subunit also contains the glutamic acid at
position 6 that, when changed to valine, results in the sickle cell
mutation. Other changes to the β-globin subunit may also result in human
disease. Varying severities of betathalassemia can develop as a result
of a damaged or completely missing β-globin.

The 1962 Nobel Prize in Chemistry
was awarded jointly to Max Ferdinand Perutz and John Cowdery Kendrew
"for their studies of the structures of globular proteins". Max
Ferdinand Perutz solved the structure of hemoglobin in 1959.

Both 4'' models are made of plaster by rapid prototyping and should be
handled with care. They will break if dropped, held tightly or handled
roughly. Its PDB file is 2HHB.pdb.

4'' models are made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly.

3D Molecular Designs and the Milwaukee School of Engineering Center for
BioMolecular Modeling continually develop and update lesson plans and
other resources for our educational products. Teacher notes, student
handouts and other supporting documents vary based on the applications
and activities of the kit or model. We appreciate your feedback and
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