I have a face GUI, it's a camera basically, high up in the scene away from the character meshes, looking at a bunch of curves that are hooked up to drive the face rig.
If I reference another copy of the same rig into the scene though I'll end up with two GUI cameras right on top of each other in world space which means the animator can't select the curves for one character cleanly anymore.

Edit - I found a simple solution, just build a check for multiple GUIs into the GUI script itself.. obvious really..d'oh

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