It further relates to a new externally applicable, for application to the skin suitable khellin-preparation and to their use for the treatment of psoriasis psoriasis. Psoriasis is one of the most common skin Psoriasis begrenzte stationäre Phase with a severe psychosocial stress for the patients concerned. The disease is characterized by sharply demarcated erythematous, covered with silvery white scales, sometimes itchy patches of different size and shape.

Different genetic predispositions along with initiating trigger factors such as bacterial infections, stress and drugs lead to a wide spectrum of clinical manifestations. Die Erkrankung weist in der Regel einen chronisch-rezidivierenden Verlauf auf. The disease usually has a chronic relapsing course. The treatment of psoriasis aims to draw sion with a long-lasting as possible from Release freedom.

Because of the accompanying nausea oral therapy often Psoriasis begrenzte stationäre Phase not be applied. In addition, the treatment is accompanied by a very high phototoxicity and requires extreme safety precautions and intensive cooperation of the patient.

The carcinogenicity of these photo chemo therapy seems to be more favorable than that of Psoriasis begrenzte stationäre Phase PUVA therapy. Sichere Daten liegen noch nicht vor.

Secure data are not yet available. The bath PUVA therapies require expense a considerable time, cause huge logistical diffi culties as bath unit and irradiation unit must be located in the neighborhood and are therapeutically difficult to control because they are associated stability with a very pronounced Photo Sensi account which are easily phototoxic reac caused can be.

Currently there are no satisfactory for the treatment Sign Symptome der Psoriasis der Gelenke took psoriasis. Ekzeme entstehen entweder endogen, so das atopische Ekzem, oder durch die akute bzw. Eczema caused either endogenously as atopic dermatitis, or by acute or chronic exposure to specific allergen or nonspecific mechanical irritation, pressure, chemicals, frequent cleaning of the skin stimuli on the skin.

To analyze the effectiveness of KUVA therapy, we have studied an example of the effectiveness of Psoriasis begrenzte stationäre Phase treatment at Palmoplantarekzem. The invention is therefore based on the object set bereitzu a medicine used to treat psoriasis, which overcomes the disadvantages of previous preparations.

It should also be suitable for long-term therapy and gentle young patients can be administered satisfactorily. Surprisingly, it has now been found that the furanone chromone khellin and its derivatives, leading to monoadducts, particularly when formulated Psoriasis begrenzte stationäre Phase a suitable on the skin for application of preparation, topically can be used to photo chemotherapeutic treatment of psoriasis, without harmful side effects were observed. It also includes the use of this preparation for topical photo chemotherapeutic treatment of psoriasis and palmoplantar eczema.

There were no long this time late follow. In contrast to 8-methoxypsoralen, a commonly used photosensitizer, which is used for PUVA photochemotherapy, khellin has only a very limited ability to form diadducts.

In dermatology khellin tablets for oral khellin UVA phototherapy of vitiligo Psoriasis begrenzte stationäre Phase spots disease can be used Dermatologica, In addition, recent case reports that khellin can be used in a cream base in combination with a subsequent UVA irradiation in alopecia areata and vitiligo with moderate success. Bei diesen Indikationen sollen die Ergebnisse denen der oralen PUVA-Behandlung vergleichbar sein.

In these indications, the go here of which oral PUVA treatment should be comparable.

Khellin has not previously been used for the topical treatment of psoriasis. The experience of the conventional treatment of psoriasis with 8-MOP and subsequent UVA irradiation has suggested that a phototoxic irritation or treat- ment near the phototoxic threshold is necessary to treat Psoriasis begrenzte stationäre Phase successfully as possible by means of photo chemo therapy PUVA.

This is not true for the treatment of vitiligo. Since the treatment described in vitiligo with khellin and subsequent UVA irradiation does not cause Psoriasis begrenzte stationäre Phase visible phototoxic reactions, it Psoriasis begrenzte stationäre Phase previously unlikely that topical therapy with khellin and subsequent UVA irradiation would be suitable for the treatment of psoriasis.

It could be shown now that, surprisingly, psoriasis, including psoriasis and eczema Palmo Psoriasis begrenzte stationäre Phase can be successfully treated with khellin. In combination with a subsequent UVA or UVA1 irradiation, this preparation is suitable with good success for topical use in phototherapeutic treatment of psoriasis.

Psoriasis begrenzte stationäre Phase drug was well tolerated and resulted when used with a subsequent phototherapy no adverse local and systemic reactions. It has a very good local anti-inflammatory effect and leads to a rapid involution of the skin manifestations of psoriasis. Die Remission wurde histologisch gesichert. The remission was confirmed histologically. Khellin has the advantage that after recent Detects ratios no phototoxic reactions occur and that it only has a low potential photomutagenes - especially in comparison with 8-MOP.

One of Psoriasis begrenzte stationäre Phase reasons for the low photomutagenic potential, the very poor ability of khellin be to train diadducts that are seen in connection with carcinogenic properties of photosensitizers. Thus, no significant mutagenicity in green algae and only a small photomutagenicity was observed in bacteria.

Psoriasis begrenzte stationäre Phase studies have shown that a UVA phototherapy with khellin a significantly lower carcinogenic risk than has been usual photochemotherapy with 8-MOP. Furthermore, a khellin UVA therapy does not lead to the known, above partially mentioned, systemic side effects of oral phototherapy with 8-MOP there is no Psoriasis begrenzte stationäre Phase was observed and is logistically much easier and less time-consuming than the previously known alternative, the bathing PUVA therapy.

Which may be in form of an ointment, a cream, a gel, a lotion, a spray, a bath additive or a paste. It is present as a cream, so the amount of khellin and its derivatives 0. Kohlen wasserstoffgrundlage wie Vaselin, Triglyceride, Wachse oder ein Polyalkylsiloxan.

The basis of the formulation, a Psoriasis begrenzte stationäre Phase ambi hydrophilic cream or ointment base to be such. As coal hydrogen basis such as Vaseline, triglycerides, waxes or polyalkylsiloxane.

Examples of a hydrocarbon base Psoriasis begrenzte stationäre Phase natural and Kunstvaseline, Plastibase and thick- and thin liquid paraffins. Examples of Triglyceridgrundlage are natural or synthetic triglyceride oils such as olive oil, groundnut and castor oil or neutral oils. Preferably, the preparation comprises an aqueous phase and is in the form of a cream, a gel, a lotion, a spray, a bath additive or a paste before. Fettalkohole wie Cetyl alkohol und Stearylalkohol, Wollwachs Psoriasis begrenzte stationäre Phase Wollwachs alkohole.

In accidental exposure to the sun or incorrect application no burns were observed. The amount of each applied amount of khellin depends on the condition of the patient, the severity of the condition, the duration of treatment, etc. Average treatments are needed. The invention is further illustrated by the following examples. Die Psoriasis-Plaques werden mit der Khellin-Zubereitung behandelt, die Khellin-Zubereitung wirkt eine Stunde ein. Psoriatic plaques are treated with the http://festival-celle.de/luiza-hey-und-psoriasis.php, the khellin-preparation causes an hour.

There was a treatment with the invention khellin cream in combination with UVA irradiation. Durchschnittlich erhielten die Patienten 23,2 Behand lungen. On average, the patients received After treatment with khellin UVA phototherapy according to please click for source invention, a substantial normalization of the entire structure of the epidermis in all patients showed cytes with decrease in proinflammatory Lymphoma.

This success of the therapy click here comparable with results that can be achieved with the conventional PUVA therapy with 8-MOP. The efficacy of phototherapy using the khellin cream according to the invention was compared with the bath-PUVA and UVB nm phototherapy, two recognized effective therapies for psoriasis analyzed.

In particularly severe forms of psoriasis, UVB nm phototherapy was performed in combination with topical therapy such as Psoriasis begrenzte stationäre Phase. Such combination Psoriasis begrenzte stationäre Phase usually requires hospitalization, as treatment with anthralin at home can not be performed.

The bath PUVA therapy is based on the principle of photo-sensitization by 8-MOP and UVA irradiation followed. The UVBnm UVB Psoriasis begrenzte stationäre Phase uses in the wavelength of nm proportion as this was superior in the study compared to UVB broad-spectrum treatment.

Dargestellt sind im Vergleich die "Psoriasis Activity and Severity Index" PASI -Scores. Shown are compared to "Psoriasis Activity and Severity Index" PASI credit scores. This is a clinically documented history parameter, the severity of psoriasis and treatment effectiveness over time.

In summary, the cream KUVA therapy proves to be an at least equally fast and as efficient form of treatment of psoriasis as the two established forms of therapy. The efficacy of phototherapy using the khellin cream according to the invention was investigated in comparison with bath PUVA phototherapy for psoriasis of the hands and feet, including pustular forms. It was found that the average patient responded faster in contemporary fiction, khellin cream phototherapy and total required a lower number therapy.

The cumulative UVA dose was average in the inventive khellin-cream phototherapy higher, due to the possibility of a faster increase due to the lack of phototoxic reactions http://festival-celle.de/plantar-psoriasis-behandelt-1.php therapy. The proportion of complete remissions, so total clearance, were similar in both treatment methods. The efficacy of phototherapy using the khellin cream according to the invention was investigated in comparison with bath PUVA phototherapy for chronic eczema here please click for source an example Psoriasis begrenzte stationäre Phase the hands and feet.

It was found that the patients required an average of less therapies in khellin cream phototherapy according to the invention. The cumulative UVA dose was higher on average in the inventive khellin-cream phototherapy, due to the rapid increase due to the lack of phototoxic reactions in therapy. Brushable or spreadable composition A for application to the skin comprises khellin I; Psoriasis begrenzte stationäre Phase 3,2-g 1 benzopyranoneor its derivatives or related furanochromones such as angelicin and 7-methylpyrido 3,4-c pyridine that produce click at this page and a dermatological base Salbe Psoriasis the new Google Patents, with machine-classified Google Scholar results, and Psoriasis begrenzte stationäre Phase and South Korean patents.

Topical composition containing khellin or its derivatives, useful for phototherapy of psoriasis and eczema, has low mitogenic potential DE A1. Brushable or spreadable composition A for application to the skin comprises khellin I; 4,9-dimethoxymethyl-5H-fura 3,2-g 1 benzopyranoneor its derivatives or related furanochromones such as angelicin and 7-methylpyrido 3,4-c pyridine that produce photo-monoadducts and a dermatological base containing appropriate auxiliaries or additives, is new.

Preparation according to claim 1, characterized in das Nano-Gels für Psoriasis it comprises 0. Preparation according to one of claims 1 to 3, characterized in that it is in the form of a cream, an ointment, a gel, a lotion, a spray or a bath additive or a paste.

Use of a khellin-preparation according to one of claims 1 to 4 for the topical Psoriasis begrenzte stationäre Phase as a photo-chemotherapy for psoriasis, its sub-types and special forms, including psoriasis and as Palmoplantar- photochemotherapy of eczema. Use of khellin for topical photo chemotherapeutic treatment of psoriasis, its sub-types and special forms, including palmoplantar psoriasis, and for the treatment of eczema. Verwendung nach Anspruch 7, wobei die Verwendung in Form einer Creme, einer Salbe, eines Gels, einer Lotion, eines Sprays, eines Badezusatzes oder einer Paste vorliegt.

Use according to claim 7, wherein the use is in the form of a cream, an ointment, a gel, a just click for source, a spray, a bath additive or a paste. Beschreibung der Behandlung Description of the treatment Die Psoriasis-Plaques werden mit der Khellin-Zubereitung behandelt, die Khellin-Zubereitung wirkt eine Stunde ein.

On Thursday morning, Psoriasis-Arthritis, after living in the U.S. for 21 years, became one of the first people deported under Trump’s executive orders on immigration.

In a 2008 immigration raid at the water park where she worked, Lupita was arrested for using a forged social security number to gain employment. After spending months in a county jail and then an immigration center, she was ordered to be deported back to Mexico, however federal authorities under the Obama administration decided not to act on her deportation, which effectively put her case on hold. As a result of her arrest, she was Psoriasis bei schwangeren Frauen, wie sie zu behandeln

On Thursday morning, Würmer bei Psoriasis, after living in the U.S. for 21 years, became one of the first people deported under Trump’s executive orders on immigration.

Last week we saw a truly incredible outpouring of protest against Trump’s unconstitutional immigration bans.

We saw Muslim Americas stand up for their communities and we saw thousands of non-Muslim people stand in solidarity with their neighbors, strangers, and friends. These protests offer hope for the long fight ahead. They also offer an opportunity for non-Muslim Americans to challenge the roots of Islamophobia in our politics and culture—not only within the rightwing, but within “progressive” politicians and ourselves. We know that Trump’s anti-Muslim policies aren’t a radical break from, but rather an extension of, Democrats’ escalation of the War on Terror under Obama. Even the irrational singling out of these seven countries isn’t unprecedented: Obama

Last week we saw a truly incredible outpouring of protest against Trump’s unconstitutional immigration bans.

We saw Muslim Americas stand up for their communities and we saw thousands of non-Muslim people stand ...

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