The National Institute of Neurological Disorders and Stroke (NINDS) requests applications for clinical centers to collaborate
on a large, double-blind randomized trial of two or more potential neuroprotective agents in patients early in the course
of Parkinson's disease (PD).* The intent of this request for applications (RFA) is to solicit applications from qualified
investigators proposing to serve as clinical centers in order to conduct a large, collaborative randomized double-blind trial
testing neuroprotective agents in patients with early PD. A clinical center is an institution that is actively involved with
the recruitment, evaluation, treatment, and follow-up of study participants. It will consist of a team of researchers with
the neurological skills to apply diagnostic criteria for PD and criteria for study selection, and to deliver medical care
to PD patients. Optimally, the team will also have experience in collaborative clinical studies. The center(s) may have agreements
with other nearby institutions to recruit and treat patients for this study. APPLICATION RECEIPT DATE: November 15, 2001.
For more information, potential applicants should contact Dr. Bernard Ravina, Program Director, Clinical Trials Cluster, NINDS,
Neuroscience Center, 6001 Executive Boulevard, Room 2225, Bethesda, MD 20892; telephone: (301) 496-9135; fax: (301) 480-1080;
e-mail: ravinab@ninds.nih.gov.