Then Click Edit and remove ";C:\Windows\Microsoft.NET\Framework\v4.0.30319".

Retry and it no longer produces the error (Error 0# when calling C:\Windows\System32\cmd.exe;C:\Windows\Microsoft.NET\Framework\v4.0.30319 /D /C Update.cmd /verify in C:\temp\w61-x64.Server2008R2x64) and starts to patch the server!