MY Google Chrome only works in safe mode

The problem I have is when I try to open Chrome Windows informs me it cannot access the specified drive path etc.I can use the properties of the short cut to take me to the exe. file so shortcut should work.I have set permisions to full control but no joy. this was working up until yesterday.I have run Malware Bytes, Spybot 2 and Kaspersky Anti virus. I can access Chrome in safe mode but not in normal windows.