Many side effects from these drugs, they can be different for each one of us. I think Omeprazole actually lowered my blood pressure as it made me a bit dizzy every time I stood up. I also felt achy on it. The only way you will know is to move to another PPI like Nexium or Prevacid and see what goes away.

I know at times when I've been in flare with my reflux my pulse has been higher. I don't know if it is the medication or not. I usually put it down the the stress on my body from dealing with the symptoms.

I've been on all of the PPI's. Nexium was the one I had awful side effects with. For me, it caused lots of GI problems. I ended up having to switch to another. I'd say if you continue to have the side effects it might be worth calling your doctor to discuss whether or not it would be better to try something else.