Social Media & Mailings – JAD is on Facebook and Twitter, so be sure to follow us and be part of the conversation! JAD also issues regular newsletters; not signed up yet? You can do so here: tiny.cc/JADsignup. Read the recent newsletter here.

Discover our fully open access Alzheimer's journal – Perhaps you are also interested in JAD's sister journal, the open access Journal of Alzheimer's Disease Reports? See the contents here, and click here to view the newsletter with highlights of JADR Volume 2.

Celebratory Issue Online – JAD's 20th anniversary issue (JAD 62:3) is available online. All articles are open access and freely available to read for all. Featuring 35 review articles covering 20 years of Alzheimer's disease research, plus personal perspectives from researchers in the field, this is one informative issue of JAD. Read more about the content here, or skip directly to the articles via: tiny.cc/JAD-anniv.

JAD turns 20! – During 2018, the Journal of Alzheimer's Disease (JAD) celebrates its 20th anniversary and a celebratory issue of the journal will be published in vol.62, iss.3 (view here). To read our special commorative publication (PDF), click here. If you would like a print copy of this brochure, please get in touch by email: market@iospress.nl

For all our 20th anniversary news, please see the relevant section on this page of the JAD website

The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer’s disease.

In association with JAD, a number of book titles relating to Alzheimer's disease are published by IOS Press. These include the book that was published to commemorate the centennial in 2006 of Alois Alzheimer's discovery of what would become to be known as Alzheimer's disease, as well as the book series 'Advances in Alzheimer's Disease' (AIAD), which currently has five titles. A new, forward-looking book in the AIAD series is now also published (July 2018). To read more and order your copy, click here.

Editor-in-ChiefGeorge Perry, PhD
College of Sciences
University of Texas at San Antonio
One UTSA Circle
San Antonio, Texas 78249, USA
Email: george.perry@utsa.edu
Tel: +1.210.458.4450
Fax:+1.210.458.4445

12 Nov 2018 - Morgantown, WV, USA – A research team led by Dr. Kim Innes, a professor in the West Virginia University School of Public Health, has found that a simple meditation or music listening program may alter certain biomarkers of cellular aging and Alzheimer’s Disease in older adults who are experiencing memory loss. ...

05 Nov 2018 - San Antonio, TX, USA – To expand the understanding and explanation of Alzheimer’s disease, United States businessman James Truchard has given a $5 million USD gift to The University of Texas at San Antonio (UTSA) College of Sciences to establish the Oskar Fischer Project. ...

25 Oct 2018 - San Francisco, CA, USA – UC San Francisco researchers, in collaboration with the unique Brazilian Biobank for Aging Studies (BBAS) at the University of São Paulo, have shown that the earliest stages of the brain degeneration associated with Alzheimer’s disease (AD) are linked to neuropsychiatric symptoms including anxiety, depression, loss of appetite, and sleep disturbances. ...

22 Oct 2018 - Pittsburgh, PA, USA – For older adults, it may seem as though the die is already cast regarding their odds of developing dementia, but new research from the University of Pittsburgh has identified a dementia risk factor among older adults that should be modifiable even well into old age....

19 Oct 2018 - Manchester, UK – A hypothesis which has been the standard way of explaining how the body develops Alzheimer’s disease for almost 30 years is flawed, according to a University of Manchester biologist....

12 Oct 2018 - Gurgaon, India – In a breakthrough human study published in the Journal of Alzheimer's Disease, anti-oxidant, glutathione (GSH), which protects the brain from stress, has been found to be significantly depleted in Alzheimer's patients compared to normal subjects. ...

03 Sep 2018 - Amsterdam, NL – Every year in September across the globe, efforts are made to increase awareness of AD and dementia – and the ongoing research into the disease – during World Alzheimer's Month (WAM). Join with the Journal of Alzheimer's Disease in supporting WAM this year, by spreading awareness of the impact JAD has and what our journal achieves in terms of advancing knowledge in the field, and you could be enter a draw to win a copy of our latest book!
...

21 Aug 2018 - Costa Mesa, CA, USA – In the largest known brain imaging study, scientists from Amen Clinics (Costa Mesa, CA), Google, John’s Hopkins University, University of California, Los Angeles and the University of California, San Francisco evaluated 62,454 brain SPECT (single photon emission computed tomography) scans of more than 30,000 individuals from 9 months old to 105 years of age to investigate factors that accelerate brain aging. SPECT tomography) evaluates regional cerebral blood flow in the brain that is reduced in various disorders....

20 Aug 2018 - Frankfurt, Germany – Osteoporosis is estimated to affect 200 million women across the world. In Germany, the prevalence of this chronic disease among people aged 50 years and older is around 15%. In recent decades, several authors have analyzed the impact of osteoporosis on the risk of cognitive decline, but most of these studies have been conducted outside Europe. ...

27 Jul 2018 - Lyon, FR – Driving is a complex task that involves perceptual, motor and cognitive abilities. These abilities may be affected in early Alzheimer's disease (AD) patients. Nevertheless, they continue to drive for more years than people with other dementia syndromes perhaps because of a deficit in self-awareness that prevents them from perceiving their driving difficulties and adapting accordingly. The purpose of the present pilot study was to closely examine the self-regulation behavior of older individuals with AD using a naturalistic driving approach. ...

16 Jul 2018 - Amsterdam, NL – The Journal of Alzheimer’s Disease (JAD) is pleased to announce that Greg Kennedy, a PhD candidate at the Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia, has been chosen as the recipient of the 2018 Alzheimer Award....

20 Jun 2018 - Waterford, Ireland – Ground-breaking new research has identified a unique combination of nutrients to slow the progression of Alzheimer’s disease (AD), which affects over 520,000 people in the UK and represents a burden on the struggling NHS of over £26 billion per year. ...

12 Jun 2018 - Melbourne, Australia – The rate of decline in certain aspects of memory may be explained by a combination of overall physical fitness and the stiffness of the central arteries, researchers from Swinburne’s Centre for Human Psychopharmacology have found....

08 May 2018 - Newcastle, UK – Body-worn sensors used at home and in clinic by people with mild Alzheimer’s to assess walking could offer a cost-effective way to detect early disease and monitor progression of the illness. A pilot study involving Newcastle University has revealed low-cost wearable devices could improve clinical trial efficiency and encourage research investment....

01 May 2018 - Amsterdam, NL – IOS Press is pleased to announce that 2018 marks the 20th anniversary of the Journal of Alzheimer’s Disease (JAD). One of the many events celebrating this milestone is the publication of an open access issue (JAD 62:3) looking back at 20 years of Alzheimer’s disease (AD) research, which is now available online....

24 Apr 2018 - Lisbon, Portugal – Researchers from the Lisbon School of Medicine, University of Lisbon found that, in some mild cognitive impairment patients, real neuropsychological stability over a decade is possible and that long-term stability could be predicted based on neuropsychological tests measuring memory and non-verbal abstract reasoning, according to a study published in the Journal of Alzheimer’s Disease....

23 Apr 2018 - Essen, Germany – In a large population-based study of randomly selected participants in Germany, researchers found that participants aged 65–74 years with olfactory dysfunction showed impaired cognitive performance. Interestingly, this strong association was not present in younger (55–64 years) or older (75–86 years) participants. Additionally, the effect was more present in women than men. The study was led by Sarah Tebruegge and is published in the Journal of Alzheimer’s Disease....

28 Mar 2018 - Columbia, US – The sense of smell is one of the first things to change as Alzheimer’s disease takes root, even before other symptoms appear. That’s raised the idea that a scratch-and-sniff test that rates an individual’s ability to identify odors could potentially detect the disease early – allowing patients to begin treatment before symptoms become harder to treat. Columbia neurologist William Kreisl, MD, has been studying a smell identification test and explains what it can – and can’t – say about Alzheimer's. ...

27 Mar 2018 - Sheffield, UK – A new link between diminished input from dopamine-firing cells deep inside the brain and the ability to form new memories could be crucial in detecting the earliest signs of Alzheimer's disease....

20 Mar 2018 - Costa Mesa, US – New research from the Amen Clinics shows that brain SPECT (single photon emission computed tomography) imaging, a study that measures blood flow and activity patterns, identifies who is likely to get better from depression and who is not. The study is published in the Journal of Alzheimer's Disease, because depression is a highly treatable risk for cognitive decline and Alzheimer's disease....

13 Mar 2018 - Thessaloniki, Greece – Although the general public and mental health professionals seem to disregard incapacity regarding financial issues and relevant decision making in mild cognitive impairment (MCI), and focus only on severe dementia cases, a PhD study in Greece reveals that noticeable deficits do exist in the handling of financial issues in elders suffering from MCI. The results are published in the Journal of Alzheimer’s Disease....

12 Mar 2018 - Barcelona, Spain – The ability to generate spoken verbs in infinitive in a given time begins to worsen in the early stages of Alzheimer's disease (AD). Thus, the verb fluency test has been found to be a suitable neuropsychological tool for the detection of healthy aging people at risk of developing cognitive impairment, according to a recent research of the Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, UIC-Barcelona, Spain (fundacioace.com)....

07 Mar 2018 - Roscoff, France – A new study led by Laurent Meijer of ManRos Therapeutics shows that some pyrazole insecticides, of which fipronil is an archetype, trigger enhanced in vitro production of Aβ42/Aβ43 over Aβ40 amyloid peptides in a cell-free, highly purified preparation of γ-secretase, in various cell lines and in neurons differentiated from human-induced pluripotent stem cells (iPSCs) from a healthy or a familial Alzheimer’s disease (AD) patient with the APP K724N mutation. Findings are published in the Journal of Alzheimer’s Disease....

21 Feb 2018 - Atlanta, US – The mass pursuit of a conspicuous suspect in Alzheimer’s disease may have encumbered research success for decades. Now, a new data analysis that has untangled evidence amassed in years of Alzheimer’s studies encourages researchers to refocus their investigations....

20 Feb 2018 - Kuopio, Finland – An innovative e-health solution, based on an interactive internet platform, has been developed to support senior citizens in improving their lifestyle to prevent cardiovascular disease, cognitive decline and dementia....

06 Feb 2018 - Gainesville, US – A new University of Florida (UF) study finds that 23 percent of adults age 60 and older who underwent a total knee replacement experienced a decline in activity in at least one region of the brain responsible for specific cognitive functions. Fifteen percent of patients declined across all brain networks the team evaluated....

06 Feb 2018 - Aurora, US – An association between inflammation biomarkers in both blood plasma and cerebrospinal fluid (CSF) and markers of Alzheimer’s disease (AD) associated pathology, has been found by researchers at the University of Colorado Anschutz Medical Campus working with the University of Wisconsin Alzheimer’s Disease Research Center and the University of California San Francisco Memory and Aging Center....

30 Jan 2018 - Columbus, US – While most treatments for Alzheimer’s disease focus on improving memory, researchers at The Ohio State University Wexner Medical Center conducted a study aimed at slowing the decline of problem solving and decision-making skills in these patients. Findings of the study are published in the Journal of Alzheimer’s Disease....

15 Jan 2018 - London, UK – A new multi-centre study published in the Journal of Alzheimer's Disease, led by researchers from King’s College London (KCL) and UCL, has found that people with Down syndrome (DS) develop earlier onset of Alzheimer’s disease (AD), with an average age of diagnosis between 55 and 56....

28 Nov 2017 - Aberdeen, UK – TauRx Therapeutics Ltd reported the full results from its second Phase 3 clinical study of LMTM (registered name: LMTX), the first tau aggregation inhibitor in Alzheimer’s disease, which has been published online in the Journal of Alzheimer’s Disease....

28 Nov 2017 - Boston, USA – Researchers from the Harvard affiliated Hebrew SeniorLife Institute for Aging Research (IFAR), in collaboration with scientists from Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School (HMS), and Brown University, have found increasing evidence that the level of delirium in post-surgical patients is associated with the level of later cognitive decline in those same patients. Findings from this study were published today in the Journal of Alzheimer’s Disease....

13 Nov 2017 - Toulouse, France – A new study in the Journal of Alzheimer's Disease by researchers at the Paul Sabatier University in Toulouse identifies a 5-item version of the McNair and Kahn Scale for predicting cognitive decline....

15 Sep 2017 - Obu, Japan – A new study from the multimodal neuroimaging for AD diagnosis (MULNIAD) study, which is a prospective study implemented at the National Center for Geriatrics and Gerontology (NCGG), provides that hypometabolism in the medial prefrontal areas is specifically associated with Alzheimer’s disease-related nutritional problems, and decrease in fat mass may have a key role. This study is published in the Journal of Alzheimer’s Disease....

28 Aug 2017 - Stockholm, Sweden – A new study from the FINGER trial team shows that participants with shorter leukocyte telomere length (LTL) had more pronounced benefits on cognition following the multidomain lifestyle intervention....

04 Aug 2017 - Toronto, CA – A new study from Sunnybrook researchers provides evidence that a specific type of treatment for hypertension, or high blood pressure, appears to protect against brain degeneration associated with Alzheimer’s disease, and preserve cognition when compared to other classes of anti-hypertensive medications....

02 Aug 2017 - San Diego, US – Older adults who consume alcohol moderately on a regular basis are more likely to live to the age of 85 without dementia or other cognitive impairments than non-drinkers, according to a University of California San Diego School of Medicine-led study.
...

01 Aug 2017 - Bergen, Norway – Rare mutations in the amyloid precursor protein (APP) have previously been shown to be strongly associated with Alzheimer’s disease (AD). Common genetic variants in this protein may also be linked to intelligence (IQ) in children, according to recent research performed at the University of Bergen, Norway....

01 Aug 2017 - Ancona, Italy – Currently, no possibility exists to reliably quantify the risk of Alzheimer’s disease (AD) onset in the general population and in subjects with mild cognitive impairment. Metabolic and genetic factors involved in increasing the probability of developing dementia have already been identified. Some vascular risk factors, as hypertension, dyslipidaemia, diabetes or smoking can cause a derangement in extra or intracranial vessels architecture, which can be responsible for an early aging of the brain. However, reliable tools for early identification of subjects at greater risk of evolution from mild cognitive impairment to AD are not available....

29 Jun 2017 - Boston, USA – In the last decade, mounting evidence has linked seizure-like activity in the brain to some of the cognitive decline seen in patients with Alzheimer’s disease. Patients with Alzheimer’s disease have an increased risk of epilepsy and nearly half may experience subclinical epileptic activity – disrupted electrical activity in the brain that doesn’t result in a seizure but which can be measured by electroencephalogram (EEG) or other brain scan technology. ...

27 Jun 2017 - Amsterdam, NL – The Journal of Alzheimer’s Disease (JAD) is pleased to announce that Shi-Jiang Li, PhD, Professor of Biophysics, Radiology, and Psychiatry and Behavioral Medicine at the Medical College of Wisconsin, has been chosen as the recipient of the 2017 Alzheimer Award. It has been presented by the journal in recognition of his outstanding work on the development of the CARE index, potentially a significant new tool in the battle against Alzheimer’s disease (AD) that can be used to characterize risks associated with AD stages and quantify disease severity on an individual subject basis....

16 Jun 2017 - Stockholm, Sweden – The patients who live alone do not receive the same extent of diagnostic investigations and anti-dementia treatment as those who are co-habiting. On the other hand, they were treated more frequently with antidepressants, antipsychotics and sedative drugs....

06 Jun 2017 - San Diego, USA – A phase 2 clinical trial in young adults with Down syndrome of a drug being investigated for the treatment of Alzheimer’s disease supports further investigation of its potential. Results of the four-week trial of scyllo-inositol, also known as ELND005, have been published in the Journal of Alzheimer’s Disease....

22 May 2017 - Amsterdam, NL – The incidence of Alzheimer’s disease (AD) is expected to triple in the coming decades and no cure has been found. Recently, interest in dietary approaches for prevention of cognitive decline has increased. In particular, the omega-3 fatty acids have shown anti-amyloid, anti-tau and anti-inflammatory actions in the brains of animals. In a new article published in the Journal of Alzheimer’s Disease, researchers have found that for patients with high omega-3 levels, blood flow in specific areas of the brain is increased....

07 May 2017 - Houston, USA – Predicting the timing of Alzheimer’s disease (AD) conversion for individuals with mild cognitive impairment (MCI) can be significantly improved by incorporating longitudinal change information of clinical and neuroimaging markers, in addition to baseline characteristics, according to projections made by investigators from The University of Texas Health Science Center at Houston....

30 Mar 2017 - Winnipeg, USA − 3D Signatures Inc. (TSXV:DXD; OTCQB:TDSGF; FSE:3D0) (the
"Company" or "3DS"), is pleased to announce clinical study results which confirm that based on a
swab from the inside of a patient’s cheek, its proprietary TeloViewTM software platform has the ability
to identify patients with Alzheimer’s disease (“AD”) and, furthermore, distinguish between mild,
moderate, and severe forms of the disease. The results of this confirmatory study have been
accepted for publication in the peer-reviewed Journal of Alzheimer’s Disease....

21 Mar 2017 - Tel Aviv, Israel – A new Tel Aviv University study published in the Journal of Alzheimer's Disease finds that insulin resistance, caused in part by obesity and physical inactivity, is also linked to a more rapid decline in cognitive performance. According to the research, both diabetic and non-diabetic subjects with insulin resistance experienced accelerated cognitive decline in executive function and memory. ...

17 Mar 2017 - Los Angeles, USA – A new study published in the Journal of Alzheimer's Disease shows Donepezil, a medication that is approved to treat people with Alzheimer’s disease, should not be prescribed for people with mild cognitive impairment without a genetic test. UCLA School of Nursing researchers discovered that for people who carry a specific genetic variation — the K-variant of butyrylcholinesterase, or BChE-K — donezpezil could accelerate cognitive decline. ...

16 Feb 2017 - Madrid, Spain – It has been proposed that somatic gene variations (SNV) present in few brain cells could facilitate the development of neurodegenerative disorders like Alzheimer’s disease. Testing that hypothesis requires DNA sequencing directly in brain cells or tissue rather than in blood cells. However, the identification of SNV by standard and reliable sequencing procedures does not work well when the number of cells bearing the specific SNV (or mutation) is very low within the tissue. In this way, another techniques, such as high-throughput methods, could be used. However, those methods can introduce errors in reading sequence alignments that can interfere with the identification of true somatic variations....

15 Feb 2017 - Amsterdam, NL – Does a patient have depression or a cognitive disorder (CD) such as Alzheimer’s disease or both? Since both disorders have overlapping symptoms, how can a clinician tell them apart to make an appropriate diagnosis? In a new article published in the Journal of Alzheimer’s Disease, researchers have found that single photon emission computed tomography, or SPECT, can help to distinguish between these diagnostic categories....

30 Jan 2017 - Philadelphia, USA – Promising, early studies of deep brain stimulation (DBS) for the treatment of Alzheimer’s disease have paved a path for future clinical trials, but there are unique ethical challenges with this vulnerable population regarding decision making and post-study treatment access that need to be addressed as they ramp up, Penn Medicine researchers argue in a new review in the Journal of Alzheimer’s Disease....

23 Jan 2017 - Morgantown, USA – In a recent study of adults with early memory loss, a West Virginia University research team lead by Dr. Kim Innes found that practice of a simple meditation or music listening program may have multiple benefits for older adults with preclinical memory loss. ...

23 Dec 2016 - Bordeaux, France – A French observational study in real life showed that dementia patients benefiting from occupational therapy sessions report relevant clinical benefits over the intervention period, according to a research study published in the Journal of Alzheimer’s Disease this month. The research suggested the influence of occupational therapy on reducing behavioral troubles, caregivers’ burden and amount of informal care over the intervention period and a stabilization over the 3-months period thereafter....

22 Dec 2016 - Tests that measure the sense of smell may soon become common in neurologists’ offices. Scientists have been finding increasing evidence that the sense of smell declines sharply in the early stages of Alzheimer’s, and now a new study from the Perelman School of Medicine at the University of Pennsylvania published in the Journal of Alzheimer’s Disease confirms that administering a simple “sniff test” can enhance the accuracy of diagnosing this dreaded disease....

22 Dec 2016 - An enzyme found in the fluid around the brain and spine is giving researchers a snapshot of what happens inside the minds of Alzheimer’s patients and how that relates to cognitive decline. ...

20 Dec 2016 - Antipsychotic drug use is associated with a 60 percent increased risk of mortality among persons with Alzheimer's disease, shows a recent study from the University of Eastern Finland. The risk was highest at the beginning of drug use and remained increased in long-term use. Use of two or more antipsychotic drugs concomitantly was associated with almost two times higher risk of mortality than monotherapy. The results were published in the Journal of Alzheimer’s Disease....

19 Dec 2016 - The Journal of Alzheimer’s Disease (JAD) is pleased to announce that its Alzheimer’s Funding Analyzer (AFA) now includes all Alzheimer’s Association (AA) grants in addition to grants from other funding bodies. AFA is a free service that is part of a suite of online features integrated into the JAD site to meet the needs of the Alzheimer disease (AD) research community....

12 Dec 2016 - Overweight and obesity in adolescents have increased substantially in recent decades, and today affect a third of the adolescent population in some developed countries. While the dangers posed by high adult BMI on cognitive function in later life have been documented, the association of adolescent BMI with cognitive function in midlife has not yet been reported. (BMI, or Body Mass Index, is a calculation of a person’s weight in kilograms divided by the square of their height in meters.)...

12 Dec 2016 - A machine learning method analyzing large amounts of health information has potential in assessing the risk of cognitively healthy older people for later dementia, according to research published in the Journal of Alzheimer’s Disease. The new risk assessment tool also presents the individual risk profile in a quickly interpretable visual form....

28 Nov 2016 - Aurin Biotech (aurinbiotech.com), announced that it has developed a simple saliva test that can diagnose Alzheimer’s disease, as well as predict its future onset, allowing individuals to take preventive measures before the disease takes hold. ...

28 Nov 2016 - As the U.S. races to legalize marijuana for medicinal and recreational use, a new, large scale brain imaging study gives reason for caution. Published in the Journal of Alzheimer’s Disease, researchers using single photon emission computed tomography (SPECT), a sophisticated imaging study that evaluates blood flow and activity patterns, demonstrated abnormally low blood flow in virtually every area of the brain studies in nearly 1,000 marijuana compared to healthy controls, including areas known to be affected by Alzheimer’s pathology such as the hippocampus....

24 Nov 2016 - A new study from The University of Texas Medical Branch at Galveston offers important insight into how Alzheimer’s disease begins within the brain. The researchers found a relationship between inflammation, a toxic protein and the onset of the disease. The study also identified a way that doctors can detect early signs of Alzheimer’s by looking at the back of patients’ eyes....

31 Oct 2016 - Greek researchers demonstrated the potential use of assistive technologies for people with dementia, to fulfill an important need: the improvement of clinical diagnosis and decision making meeting individual needs. ...

12 Oct 2016 - A peer reviewed study led by Proteome Sciences plc (“Proteome Sciences”), in conjunction with a group of highly respected universities and hospitals, demonstrates the ability of an innovative mass spectrometry (MS) workflow to dramatically improve the ability to detect tau-derived peptides that are directly related to human Alzheimer’s pathology as early stage biomarkers of the disease....

15 Sep 2016 - A new study led by Laurent Meijer, at ManRos Therapeutics, and collaborators shows that some herbicides (triazines) trigger enhanced in vitro production of the Aβ42 over Aβ40 amyloid peptides in various cell lines. This suggests that some products from the ‘human chemical exposome’ (HCE) (estimated to be over 85,000 products) may contribute to the increased production of Aβ42 over Aβ40 characteristic of Alzheimer’s disease (AD). In addition, some of these products might be turned into pharmacological tools to develop a chemically-induced animal model of AD (in contrast with the currently used genetic, recombinant mice models). Publication of these findings is scheduled in the Journal of Alzheimer's Disease, vol. 54(4) issue. This work is now continuing with special focus on (1) Persistent Organic Pollutants (POPs) and (2) defining conditions under which such products could trigger in vivo Aβ42 production in mice....

12 Sep 2016 - A new study by researchers at the Universities of Montana, Valle de México, Boise State, Veracruz University, Médica Sur, Centro de Ciencias de la Atmósfera, UNAM, Hospital Regional de Alta Especialidad, Ciudad Victoria, Hospital de Especialidades #14, IMSS, Centre Hospitalier Universitaire, Hôpital de Hautepierre and AJ Roboscreen GmbH heightens concerns over the detrimental impact of fine particulate matter PM2.5 on CSF markers associated with Alzheimer and Parkinson’s diseases in children ages 11.9±4.8 years. These findings are published in the Journal of Alzheimer’s Disease....

12 Sep 2016 - Greek researchers and clinicians demonstrated the potential of Crocus Sativus L. (saffron) as a therapeutic pharmaceutical natural compound for older adults with amnestic Mild Cognitive Impairment (aMCI). MCI is a condition that often predates Alzheimer’s disease (AD) and is characterized by memory loss and inability to execute complex Activities of Daily Living. While there is no treatment for MCI and symptomatic only treatment for AD, the global effort against cognitive disorders is focused on early detection and management of AD at the stage of MCI....

12 Sep 2016 - A long-term follow-up study of 3050 twins from the Finnish Twin Cohort has shown that midlife, moderately vigorous physical activity is associated with better cognition at old age. The association was statistically independent of midlife hypertension, smoking, education level, sex, obesity and binge drinking. This suggests that the beneficial influence of physical activity on the brain and cognition is not solely based on decreasing vascular risk factors. ...

07 Sep 2016 - A new study, based on longitudinal data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe), suggests that temporal stability versus instability of an individual’s report of subjective worsening of cognition over time plays an important role with regard to whether such experiences are associated with future dementia risk. These findings, which will be published in the Journal of Alzheimer's Disease 54(3), add to a constantly growing strand of research on the phenomenon of “Subjective Cognitive Decline” (SCD) in Alzheimer’s Disease (AD). ...

25 Aug 2016 - A new study, based on data from the Framingham Heart Study (FHS) suggests a simple test of physical functioning may be able to help physicians identify individuals who are at a higher risk for developing Alzheimer’s disease and stroke....

02 Aug 2016 - Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer’s disease or another type of dementia....

21 Jul 2016 - New findings published today by a team of researchers led by Dr. Andres Lozano at the Krembil Neuroscience Centre (KNC) of Toronto Western Hospital (TWH) have provided further insight into the effects of Deep Brain Stimulation (DBS) in the treatment of Alzheimer’s disease....

19 Jul 2016 - No single assessment tool is able to consistently determine driving ability in people with Alzheimer’s disease and mild cognitive impairment, a St. Michael’s Hospital research review has found....

15 Jul 2016 - The Journal of Alzheimer’s Disease (JAD) is pleased to announce that Mark W. Bondi, PhD, ABPP/CN, Professor of Psychiatry at UC San Diego and Director of the Neuropsychological Assessment Unit at the VA San Diego Healthcare System, has been chosen as the recipient of the 2016 Alzheimer Award presented by the journal in recognition of his outstanding work on the development of a novel and promising method of staging preclinical Alzheimer’s disease (AD) based on number of abnormal biomarkers that is predictive of progression to mild cognitive impairment (MCI) and AD....

14 Jul 2016 - Can estrogen preserve brain function and decrease the risk of Alzheimer’s disease when given early in menopause? Newly postmenopausal women who received estrogen via a skin patch had reduced beta-amyloid deposits, the sticky plaques found in the brains of people with Alzheimer’s disease, a Mayo Clinic study published this month in the Journal of Alzheimer’s Disease found. Ultimately, these deposits harm neurons, leading to cognitive problems. ...

14 Jun 2016 - Neurocentria, Inc. announced today the publication of a scientific paper showing how its candidate drug, L­-Threonic acid Magnesium salt (L-TAMS), reverses cognitive impairment in humans, as previously demonstrated. The paper titled "Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration" was published in the medical journal Neuropharmacology. The drug's discovery is based on more than a decade of research at Stanford, Tsinghua University, and MIT....

30 May 2016 - A team of investigators at Midwestern University, an affiliate institution of the Arizona Alzheimer’s Consortium, now report that young adult brain donors who carried a common genetic risk factor for Alzheimer’s disease showed large changes in pathways involving the uptake and use of sugars and ketone bodies — the primary sources of energy for the brain. The average age of the donors was approximately 30, well before any sign of the microscopic abnormalities commonly associated with the disease commonly appear, and almost five decades before the age at which they might develop symptoms....

26 Apr 2016 - The discovery of brain pathology through autopsy in former National Football League (NFL) players called chronic traumatic encephalopathy (CTE) has raised substantial concern among players, medical professionals, and the general public about the impact of repetitive head trauma. Using sophisticated neuroimaging and analytics, researchers have now identified abnormal areas of low blood flow in living professional football players. These findings, published in the Journal of Alzheimer’s Disease, raises the potential for better diagnosis and treatment for persons with football related head trauma....

26 Apr 2016 - Lead investigator Kim Innes, PhD, Associate Professor in the Department of Epidemiology in the WVU School of Public Health, and her team have published a new study in the Journal of Alzheimer’s Disease....

26 Apr 2016 - Long before Alzheimer’s disease can be diagnosed clinically, increasing difficulties building cognitive maps of new surroundings may herald the eventual clinical onset of the disorder, finds new research from Washington University in St. Louis....

12 Apr 2016 - In a new paper published by The Journal of Alzheimer’s Disease, Professor Melissa Schilling, a strategy and innovation expert at the NYU Stern School of Business, uncovers a surprising new connection between diabetes and Alzheimer’s disease: hyperinsulinemia, which is most often caused by prediabetes, early or undiagnosed diabetes, or obesity, is responsible for almost half of all cases of Alzheimer’s disease....

12 Apr 2016 - Alzheimer’s not only steals people’s memories but also their ability to recognize faces, which widens the gulf between people with this disease and their loved ones. A recent study has demonstrated that, beyond causing memory problems, Alzheimer’s disease also impairs visual face perception. This finding may help families better understand their loved one's inevitable difficulties and lead to new avenues to postpone this painful aspect of the disease. Research in this area by the team of Dr. Sven Joubert, PhD, a researcher at the Centre de recherche de l'Institut universitaire de gériatrie de Montréal of the CIUSSS du Centre-Sud-de-l’Île-de-Montréal and a professor with the Department of Psychology at Université de Montréal, has just been published in the Journal of Alzheimer’s Disease. ...

17 Mar 2016 - A landmark Editorial issued by 33 senior scientists and clinicians from a dozen countries across the world has been published in the highly regarded peer-reviewed journal, Journal of Alzheimer's Disease. This major call for action is based on substantial evidence indicating that some microbes – a specific virus and particular bacteria – are likely major causes of the disease....

17 Mar 2016 - Researchers from Charité – Universitätsmedizin Berlin were able to show that omega-3 fatty acid supplementation improves memory function in humans. They studied the effects of supplementation with natural omega-3 fatty acids in healthy older adults over a period of six months. Results from the study, which show that supplementation leads to significant improvements in memory function, have been published in the current issue of the Journal of Alzheimer's Disease....

03 Mar 2016 - According to a community-based longitudinal study in Japan, researchers found that depressive symptoms increased the risk of Alzhemer’s disease (AD) in an amnestic mild cognitive impairment (aMCI) group, but not in a non-amnestic mild cognitive impairment (naMCI) group. Likewise, depressive symptoms increased the risk of aMCI but not naMCI in a cognitively normal group. Depressive symptoms might be a clue to finding prodromal AD in patients with a certain type of MCI....

12 Feb 2016 - Medical professionals have to conduct a long series of tests to assess a patient's memory impairment and cognitive skills, functional abilities, and behavioral changes to accurately diagnose Alzheimer's disease. They also have to execute costly brain imagining scans and even, sometimes, invasive cerebral spinal fluid tests to rule out other diseases. The process is laborious at best -- and subjective at worst....

11 Feb 2016 - The Journal of Alzheimer’s Disease (JAD) is proud to announce the launch of the Alzheimer’s Funding Analyzer (AFA) on the JAD website. It is a free service that is part of a new suite of online features that have been designed to serve the needs of the Alzheimer disease (AD) research community....

09 Feb 2016 - Australian researchers have found biochemical changes occurring in the blood, in the rare inherited form of Alzheimer’s disease. Changes in these fat-like substances, may suggest a method to diagnose all forms of Alzheimer’s disease before significant damage to the brain occurs....

21 Jan 2016 - Correctly diagnosing Alzheimer’s disease remains a challenge for medical professionals. Now, a new study published in the current issue of the Journal of Alzheimer’s Disease reveals a new clue to possible misdiagnosis. The study found that older adults with a history of reading problems perform similarly on some neuropsychological tests to those who show signs of mild cognitive impairment (MCI) associated with early Alzheimer’s disease. The finding, based on the results of a Stony Brook University-led research team in collaboration with Boston University School of Medicine, emphasizes the need for professionals to take into account developmental history and have a broad understanding of neuropsychological testing when interpreting the meaning of low memory test scores....

19 Jan 2016 - While research has already established that B vitamin supplements can help slow mental decline in older people with memory problems, an international team have now found that having higher levels of Omega-3 fatty acids in your body could boost the B vitamins’ effect....

16 Dec 2015 - In a large population-based study of randomly selected participants in Germany, researchers found that participants with anemia, defined as haemoglobin <13 g/dl in men and <12 g/dl in women, showed lower performances in verbal memory and executive functions. Furthermore, mild cognitive impairment (MCI) occurred almost twice more often in participants diagnosed with anemia. This study is published in the Journal of Alzheimer’s Disease....

16 Dec 2015 - New research has identified changing levels of proteins in the blood which are associated with increasing mental impairment over time in people with Alzheimer's disease. The findings could ultimately help develop new drugs for the condition, by allowing better monitoring of the effects of drugs and improvements in clinical trials....

10 Dec 2015 - A new epidemiologic study showed that patients with early stage dementia, who had been referred to a specialist, have twice the risk of institutionalization compared to those who are not, according to a research study published in the Journal of Alzheimer’s Disease this month. The research suggested the influence of early specialist referral for dementia patients on institutionalization risk and demonstrated that the benefits of early dementia diagnosis may lead to challenging issues....

10 Dec 2015 - Researchers led by Dr. Teppo Särkämö at University of Helsinki, Finland have revealed that caregiver-implemented musical leisure activities, particularly singing, are cognitively and emotionally beneficial especially in the early stages of dementia. The findings could help improve dementia care and better target the use of music in different stages of dementia. The research was published today in the Journal of Alzheimer's Disease....

12 Nov 2015 - Researchers led by Professor Jun-Fen Lin at Zhejiang Provincial Center for Disease Control and Prevention have found that reproductive history, an important modifier of estrogen exposure across women’s lifetime, is associated with risk of cognitive impairment in postmenopausal women. These findings are published in the Journal of Alzheimer’s Disease....

12 Nov 2015 - Researchers at University College London (UCL) have revealed that a change in sense of humour could be an early sign of dementia. The findings could help improve dementia diagnosis, by highlighting changes not commonly thought to be linked to the condition. The study was funded by Alzheimer’s Research UK, the Wellcome Trust, Medical Research Council (MRC) and NIHR Queen Square Dementia Biomedical Research Unit. The research was published in the Journal of Alzheimer’s Disease on 10 November 2015. ...

11 Nov 2015 - A new and comprehensive study by investigators at the Celiac Disease Center at Columbia University Medical Center has found that celiac patients are at no increased risk for dementia before or after their diagnosis of celiac disease. ...

03 Nov 2015 - Chemical changes in brain cells caused by disturbances in the body’s day-night cycle may be a key underlying cause of the learning and memory loss associated with Alzheimer’s disease, according to a University of California, Irvine study....

03 Nov 2015 - Neurocentria Inc., a clinical-stage biopharmaceutical company developing therapeutics to enhance brain function and correct cognitive impairment, announced the successful completion of a human study demonstrating that the company’s lead compound significantly reversed cognitive impairment in subjects 50 to 70 years old. The results have been published in the peer-reviewed Journal of Alzheimer's Disease....

22 Oct 2015 - Benzodiazepines and related drugs are initiated frequently in persons with Alzheimer's disease already before the diagnosis, and their use becomes even more common after the diagnosis, shows a recent study from the University of Eastern Finland. Benzodiazepines and related drugs are used as a sleep medication and for anxiolytic purposes. These drugs were initiated more frequently in persons with Alzheimer's disease than in persons not diagnosed with AD. Compared to persons not diagnosed with AD, it was three times more likely for persons with Alzheimer's disease to initiate benzodiazepine use after the diagnosis, and benzodiazepines were most commonly initiated six months after the diagnosis. ...

21 Oct 2015 - A new neuroimaging software, Neuroreader, was shown to be as accurate as traditional methods for detecting the slightest changes in brain volume, and does so in a fraction of the time, according to a research study published in the Journal of Alzheimer’s Disease this month. The research validates the software program that can be used for measuring hippocampal volume, a biomarker for detecting Alzheimer’s Disease. ...

06 Oct 2015 - Brooklyn, NY – Researchers led by Deborah Gustafson, PhD, MS, professor of neurology at SUNY Downstate Medical Center, have shown that women with a gene variant (APOEe4 allele) associated with Alzheimer’s disease experience a steeper decline in body mass index (BMI) after age 70 than those women without the version of the gene, whether they go on to develop dementia or not. The finding adds to a body of evidence suggesting that body weight change may aid in the diagnosis and management of Alzheimer's disease.
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24 Sep 2015 - Framingham State Professor Ruth Remington, her colleague Tom Shea from UMass Lowell, and members of their research team, have published findings from a study that add to a growing body of evidence that lifestyle modification can help maintain brain power as we age....

24 Sep 2015 - A new study by researchers at the Universities of Montana, Valle de México, Boise State, and North Carolina, the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Instituto Nacional de Pediatría, and Centro Médico Cozumel heightens concerns over the detrimental impact of air pollution on hippocampal metabolites as early markers of neurodegeneration in young urbanites carrying an allele 4 of the apolipoprotein E gene (APOE). This is associated with the risk for Alzheimer disease (AD) and a susceptibility marker for poor outcome in traumatic brain injury (TBI) recovery. These findings are published in the Journal of Alzheimer’s Disease....

21 Sep 2015 - How the brain progresses from mild cognitive impairment (MCI) to Alzheimer's-type dementia has been an enigma for the scientific community. However, a recent study by the team of Dr. Sylvie Belleville, PhD, Director of the Research Centre at the Institut universitaire de gériatrie de Montréal (Montreal Geriatric Institute) and Professor of Psychology at Université de Montréal, has shed light on this progression by showing the typical patterns of the brain's progression to dementia. ...

15 Sep 2015 - The potential benefits of dietary cocoa extract and/or its final product in the form of chocolate have been extensively investigated in regard to several aspects of human health. Cocoa extracts contain polyphenols, which are micronutrients that have many health benefits, including reducing age-related cognitive dysfunction and promoting healthy brain aging, among others....

10 Sep 2015 - Today, more than 5.1 million Americans live with Alzheimer’s disease, a devastating type of dementia that plagues memory and thinking. That number is expected to triple in the coming decades. Moreover, according to a 2012 survey, Americans fear Alzheimer’s more than any other disease....

25 Aug 2015 - Ongoing European Research Council-funded research at Waterford Institute of Technology’s (WIT) Macular Pigment Research Group (MPRG) is investigating the potential link between cognitive function and levels of a vital eye pigment linked to diet. The study suggests that measuring macular pigment offers potential as a biomarker of cognitive health. The results of this study are highlighted to a global audience through the prestigious international medical journal, the Journal of Alzheimer’s Disease. ...

06 Aug 2015 - Researchers at the UW Medicine, Veteran's Administration Puget Sound and Saint Louis University have made a promising discovery that insulin delivered high up in the nasal cavity goes to affected areas of brain with lasting results in improving memory....

27 Jul 2015 - Meditation and spiritual fitness are key components in reducing the risk of Alzheimer’s disease according to a new article, “Stress, Meditation, and Alzheimer’s Prevention: Where the Evidence Stands”, published in an early online version of the Journal of Alzheimer’s Disease 48(1). The print edition is scheduled to be published in August....

23 Jul 2015 - In a large population-based study of randomly selected participants in Germany, researchers found that mild cognitive impairment (MCI) occurred significantly more often in individuals diagnosed with a lower ankle brachial index (ABI), which is a marker of generalized atherosclerosis and thus cumulative exposure to cardiovascular risk factors during lifetime. Interestingly, this strong association was only observed in patients with non-amnestic MCI, but not amnestic MCI. There also was no independent association of MCI and intima media thickness (IMT) or coronary artery calcification (CAC), two other surrogate markers of cardiovascular risk. Examination of differences by gender revealed a stronger association of a decreasing ABI with non-amnestic MCI in women. This study is published in the Journal of Alzheimer’s Disease....

17 Jul 2015 - Individuals with amnestic mild cognitive impairment (aMCI) are at twice the risk of others in their age group of progressing to Alzheimer’s disease. Although no conclusive test exists to predict who will develop Alzheimer’s, new research from the Center for BrainHealth at The University of Texas at Dallas is attempting to identify a potential biomarker that could offer a more complete picture of who is most at risk....

30 Jun 2015 - The amyloid cascade hypothesis of Alzheimer’s disease (AD) posits that sticky aggregations or plaques of amyloid-beta peptides accumulate over time in the brain, triggering a series of events that ultimately result in the full-blown neurodegenerative disorder. The hypothesis has been a major driver of AD research for more than 20 years. ...

26 Jun 2015 - The Journal of Alzheimer’s Disease is proud to announce that Hartmuth Kolb, PhD, Head of Neuroscience Biomarkers, Johnson & Johnson, San Diego, CA, has been chosen as the recipient of the 2015 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on the importance and imaging of neurofibrillary tangles (NFTs) and Alzheimer’s disease (AD)....

11 Jun 2015 - A new study from The University of Texas Medical Branch at Galveston has revealed that a treatment taken daily by people who have had organ transplants to prevent organ rejection protects against Alzheimer’s disease. An early online version of this paper detailing the findings has been published and is scheduled for publication in the July 7 issue of the Journal of Alzheimer’s Disease....

26 May 2015 - In a new study published in the Journal of Alzheimer’s Disease, Dr Rebekah Ahmed and colleagues found that patients with dementia show a decrease in sexual relations with their partners. ...

06 May 2015 - According to the National Institutes of Health (NIH), Alzheimer’s disease (AD) may affect as many as 5.5 million Americans. Scientists currently are seeking treatments and therapies found in common foods that will help stave off the disease or prevent it completely. Now, University of Missouri researchers have determined that a compound found in green tea, and voluntary exercise, slows the progression of the disease in mice and may reverse its effects. Further study of the commonly found extract could lead to advancements in the treatment and prevention of Alzheimer’s disease in humans....

14 Apr 2015 - A team from the Vision Research Centre at Waterford Institute of Technology has discovered that patients with Alzheimer’s disease have significantly worse vision than others in their age group and are more likely to be seriously deficient in carotenoids, key nutrients in the eye....

02 Apr 2015 - In their latest brain imaging study on women at risk for Alzheimer’s disease, York University researchers have found deterioration in the pathways that serve to communicate signals between different brain regions needed for performing everyday activities such as driving a car or using a computer....

02 Apr 2015 - Researchers at the Blanchette Rockefeller Neurosciences Institute (BRNI) and the Marshall University Joan C. Edwards School of Medicine announced their findings from a new study entitled, "PSEN1 Variant in a Family with Atypical AD." An Alzheimer patient with very severe disease, genetically confirmed to have a known variant of PSEN1, showed promising benefits during treatment with the drug Bryostatin 1. Genetically confirmed Alzheimer’s patients as severely advanced as patient IV-18 have not shown this level of clinical improvement previously with other treatment(s). ...

03 Feb 2015 - A new study by researchers at the Universities of Montana, Carleton, and North Carolina, and the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, heightens concerns over the detrimental impact of the apolipoprotein E (APOE) ε4 allele -- the most prevalent genetic risk for Alzheimer’s disease -- upon cognition, olfaction, and metabolic brain indices in healthy urban children and teens. These findings are published in the Journal of Alzheimer’s Disease....

03 Feb 2015 - New paper published in the Journal of Alzheimer's Disease provides evidence that cooking foods at high temperatures increases the risk of Alzheimer's disease. This study looked at the content of advanced glycation end products (AGEs) in national diets and clinical studies comparing and compared total AGEs to Alzheimer's disease rates....

22 Jan 2015 - Women with Alzheimer’s disease showed stable cognition for a year when a drug that is more commonly used to treat advanced prostate cancer was added to their drug regimen, according to a new study from researchers at the University of Wisconsin-Madison....

20 Jan 2015 - The Journal of Alzheimer’s Disease has published today the results of the first clinical trial of a Tau Aggregation Inhibitor (TAI) in Alzheimer’s disease (AD).1 This Phase II clinical trial, conducted by TauRx Therapeutics Ltd (a Singapore incorporated spinout from the University of Aberdeen), provided the basis and rationale for subsequent Phase III clinical trials of a TAI in AD currently in progress. ...

13 Jan 2015 - Greek researchers demonstrated the potential of a virtual supermarket cognitive training game as a screening tool for patients with mild cognitive impairment (MCI) among a sample of older adults. MCI is a condition that often predates Alzheimer’s disease (AD) and is characterized by memory loss and inability to execute complex activities such as financial planning. ...

09 Jan 2015 - A man-made form of insulin delivered by nasal spray may improve working memory and other mental capabilities in adults with mild cognitive impairment and Alzheimer’s disease dementia, according to a pilot study led by researchers at Wake Forest Baptist Medical Center....

16 Dec 2014 - An estimated 5 million Americans aged 65 and older have Alzheimer’s disease. As drug companies struggle to find a cure, new research from the National Runners’ and Walkers’ Health Study suggests that exercise earlier in life may substantially reduce Alzheimer’s disease mortality. The study, which appeared in an online prepublication from the Journal of Alzheimer’s Disease, involved over 154,000 runners and walkers who were followed for 11.6 years. There were 175 deaths where Alzheimer’s disease was diagnosed as an underlying or contributing cause of death during follow-up....

05 Dec 2014 - Detection, prevention, and preclinical treatment are three key areas that may make a difference in the battle to reduce the rapid rise of new Alzheimer’s disease (AD) cases every year. These three topics are the focus of an important new supplement to the Journal of Alzheimer’s Disease....

19 Nov 2014 - Researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London have proposed that repetitive negative thinking (RNT), a common symptom of many psychological disorders, may increase the risk of developing Alzheimer’s disease....

22 Oct 2014 - A new animal study published in the Journal of Alzheimer’s Disease indicates that a diet including walnuts may have a beneficial effect in reducing the risk, delaying the onset, slowing the progression of, or preventing Alzheimer’s disease. ...

08 Oct 2014 - Before there are any telltale behavioural signs of dementia, a simple test that combines thinking and movement could point to those with a heightened risk of developing Alzheimer’s disease and who are already having visuomotor difficulties, according to new research out of York University....

07 Oct 2014 - A study coordinated by the University of Barcelona (UB) has described a mechanism that plays a key role in the evolution of Alzheimer’s disease. According to the paper published in the Journal of Alzheimer’s Disease, the activation of the protein Sirtuin 1 in a murine model with familial Alzheimer’s disease has neuroprotective effects. The study, based on the PhD thesis developed by the researcher David Porquet (UB), first describes Sirtuin 1 pathway in this murine model. Mercè Pallàs, from the Department of Pharmacology and Therapeutic Chemistry at the Faculty of Pharmacy of UB, coordinates the study. The Bellvitge Biomedical Research Institute (IDIBELL) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) also collaborate in the study. ...

30 Sep 2014 - Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease, a recent study from neuroscientists at the University of South Florida shows....

17 Sep 2014 - Findings by researchers at the School of Public Health of Tianjin Medical University suggest that in a survival analysis of the cohorts, Type 2 diabetes mellitus with mild cognitive impairment (T2DM-MCI) accelerated the median progression to dementia by 2.74 years. ...

17 Sep 2014 - Pollution in many cities threatens the brain development in children. Findings by University of Montana Professor Dr. Lilian Calderón-Garcidueñas, MA, MD, Ph.D., and her team of researchers reveal that children living in megacities are at increased risk for brain inflammation and neurodegenerative changes, including Alzheimer’s or Parkinson’s disease.
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03 Sep 2014 - Essen, Germany, September 2, 2014 – In a large population-based study of randomly selected participants in Germany, researchers found that mild cognitive impairment (MCI) occurred twice more often in individuals diagnosed with diabetes mellitus type 2. Interestingly, this strong association was only observed in middle-aged participants (50-65 years), whereas in older participants (66-80 years) the association vanished. This study is published in the Journal of Alzheimer’s Disease....

01 Sep 2014 - Tampa, FL -- Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease, a recent study from neuroscientists at the University of South Florida shows....

28 Aug 2014 - Research published in the Journal of Alzheimer’s Disease this week suggests healthy older adults are less capable of observing their own cognitive decline over an 18 month period than Cogstate’s computerized brief battery (CBB). The study, conducted by neuropsychologists, also indicated that close family members were unable to perceive decline in the cognitive behavior of their partner and trial participant in social settings. ...

20 Aug 2014 - Today, researchers at the Blanchette Rockefeller Neurosciences Institute (BRNI) announced findings from a new study entitled, “PKCe Deficits in Alzheimer’s Disease Brains and Skin Fibroblasts.” These new findings offer significant promise for a new therapeutic and diagnostic approach to Alzheimer's disease (AD) that has remained so refractory to effective and early drug treatment. This approach is now the major focus of ongoing clinical trials being conducted by at BRNI/Neurotrope, Inc. collaboration. In contrast to past strategies, this new therapeutic strategy now being clinically tested, not only removes the precursors to amyloid plaques and tangles, it also induces the growth of new synapses and prevents neuronal death. ...

14 Aug 2014 - Alzheimer’s disease (AD) and vascular dementia (VaD) are the most common forms of dementia. Traditionally, these illnesses have been treated as separate clinical syndromes. But new research led by Drexel University College of Medicine suggests that AD and VaD have much more in common than diagnostic guidelines currently allow. The study is set for publication in the September edition of the Journal of Alzheimer’s Disease....

12 Aug 2014 - Decline in daily functioning associated with Alzheimer’s disease is related to alterations in activity in certain regions of the brain, according to a study published in the August 2014 issue of the Journal of Alzheimer’s Disease. ...

07 Aug 2014 - In a long-term, large-scale population-based study of individuals aged 55 years or older in the general population researchers found that those diagnosed with mild cognitive impairment (MCI) had a four-fold increased risk of developing dementia or Alzheimer’s disease (AD) compared to cognitively healthy individuals. Several risk factors including older age, positive APOE-ɛ4 status, low total cholesterol levels, and stroke, as well as specific MRI findings were associated with an increased risk of developing MCI. The results are published in a supplement to the Journal of Alzheimer’s Disease. ...

06 Aug 2014 - There have been several studies mapping out Alzheimer’s disease (AD) research using bibliometrics. One of these studies was instrumental in building the Top 100 Most Prolific AD Investigators and Top 100 Most Cited AD Investigators lists that you’ll find on the JAD website....

17 Jul 2014 - People who develop a combination of mild cognitive problems and depressive symptoms in old age are more likely to develop Alzheimer’s than are their age peers with mild cognitive disorders and no symptoms of depression. This was the conclusion of a study conducted at the University of Antwerp, in which scientists followed a large group of elderly people with mild cognitive impairment. The study is appearing in a leading publication, the Journal of Alzheimer’s Disease....

25 Jun 2014 - A specific preparation of cocoa-extract called Lavado may reduce damage to nerve pathways seen in Alzheimer’s disease patients’ brains long before they develop symptoms, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published June 20 in the Journal of Alzheimer’s Disease (JAD). ...

28 May 2014 - We are proud to announce that Bob Olsson, PhD, has been chosen as the recipient of the 2014 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on microglia markers and Alzheimer’s disease....

21 May 2014 - A molecular compound developed by Saint Louis University scientists restored learning, memory and appropriate behavior in a mouse model of Alzheimer’s disease, according to findings in the May issue of the Journal of Alzheimer’s Disease. The molecule also reduced inflammation in the part of the brain responsible for learning and memory....

09 Apr 2014 - Two studies published in the Journal of Alzheimer’s Disease indicate that some of the pathologic changes associated with Alzheimer’s disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease. In the first study, no differences were found in hippocampal volume or asymmetry between cognitively normal adolescent carriers and non-carriers of the ApoE ɛ4 or ɛ2 allelles. The second study reports no differences in plasma concentrations of amyloid-β peptides among young adult ɛ4, ɛ3 or ɛ2 carriers....

19 Mar 2014 - A team of scientists from the University of California, San Diego School of Medicine, the Medical University of South Carolina and San Diego-based American Life Science Pharmaceuticals, Inc., report that cathepsin B gene knockout or its reduction by an enzyme inhibitor blocks creation of key neurotoxic pGlu-Aβ peptides linked to Alzheimer’s disease (AD). Moreover, the candidate inhibitor drug has been shown to be safe in humans....

21 Feb 2014 - Researchers studying peptides using the Gordon supercomputer at the San Diego Supercomputer Center (SDSC) at the University of California, San Diego (UCSD) have found new ways to elucidate the creation of the toxic oligomers associated with Alzheimer’s disease. ...

19 Feb 2014 - Investigators at the University of Amsterdam, The Netherlands, have shown that progression of disease in memory clinic patients can be tracked efficiently with 45 minutes of neuropsychological testing. MRI measures of brain atrophy were shown to be less reliable to pick up changes in the same patients. ...

02 Jan 2014 - A team of Stony Brook University researchers led by William Van Nostrand, PhD, Professor in the Department of Neurosurgery, has discovered in a model of Alzheimer’s disease that early accumulation of a small protein, known as amyloid β, in the blood vessels of the brain can drive early cognitive impairment. The findings, published in the current online edition of the Journal of Alzheimer’s Disease, suggest that targeting early buildup of amyloid in brain blood vessels could be a potential treatment strategy in early stage disease. ...

03 Dec 2013 - At the first signs of memory loss, most people start worrying and wonder, “What if I have Alzheimer's disease?” And yet, the disease is often diagnosed late in its development and sometimes up to ten years after the first pathological changes have affected the brain. A major goal in the treatment of Alzheimer's disease has been to provide earlier diagnosis so that patients can receive treatment as early as possible. A study by Sylvie Belleville, PhD, Director of Research at the Institut universitaire de gériatrie de Montréal, an institution affiliated with Université de Montréal, has shown a way to do just that. In their study, Sylvie Belleville and her team accurately predicted (at a rate of 90%) which of their research subjects with mild cognitive impairment would receive a clinical diagnosis of Alzheimer's disease within the following two years and which subjects would not develop this disease. The study was published in Volume 38, Issue 2 of the prestigious Journal of Alzheimer's Disease. ...

15 Nov 2013 - In France prescription of drugs for Alzheimer’s disease (AD) is strictly regulated. The Department of Public Health and the Memory Clinic of Nice University Hospital have explored real world prescriptions of anti-AD medications in patients with mild cognitive impairment (MCI) not AD. A national survey [1] was set up from the data of the French National Alzheimer Databank (BNA) and shows that off label prescriptions are not frequent and concern 6.1% of MCI patients (versus a quarter of MCI patients in the US [2]). French physicians seem to limit this kind of prescription to MCI patients at risk of conversion to AD: more aged, with a more important quantitative cognitive impairment and with a memory predominant form. In a context of low efficacy of the available medications against AD this study emphasizes the need to develop more preventive drugs....

08 Nov 2013 - A Columbia University Medical Center-led research team has clinically validated a new method for predicting time to full-time care, nursing home residence, or death for patients with Alzheimer’s disease. The method, which uses data gathered from a single patient visit, is based on a complex model of Alzheimer’s disease progression that the researchers developed by consecutively following two sets of Alzheimer’s patients for 10 years each. The results were published online ahead of print in the Journal of Alzheimer's Disease....

08 Nov 2013 - As the population of older adults continues to grow, researchers at the University of Kentucky Sanders-Brown Center on Aging are engaged in work to understand the mechanisms of a variety of diseases that predominately affect those of advanced age....

08 Oct 2013 - Alzheimer’s disease (AD) affects millions of people worldwide. As a result of an increase in life expectancy, the number of patients with dementia is expected to increase dramatically. Due to the lack of effective treatments that can slow down or reverse the progression of AD, preventive measures to lower the prevalence rate of AD by means of managing potential or actual risk factors is a reasonable clinical strategy. In this respect, identifying treatable factors which are able to promote cognitive deterioration would have important practical implications....

08 Oct 2013 - The projected substantial increase in Alzheimer’s disease due to the higher life expectancy in modern societies is one of the great future challenges of health care systems worldwide. Alzheimer’s disease leads to significant changes in the temporal structure of activities that impair everyday activities. Abnormal motion behavior and degeneration of the sleep-waking cycle are among the most severe behavioral symptoms. An early detection and even a prediction of these behaviors would allow a timely onset of interventions that aim to delay the manifestation or exacerbation of symptoms and reduce the need of institutionalized care....

25 Sep 2013 - In a paper just published electronically in the Journal of Alzheimer’s Disease, dramatic increases in Alzheimer’s disease (AD) in Japan and significant increases in developing countries are linked to changes in national diets....

08 Aug 2013 - Mothers who breastfeed their children may have a lower risk of developing Alzheimer’s Disease, with longer periods of breastfeeding also lowering the overall risk, a new study suggests....

07 Aug 2013 - New research out of the University of Maryland School of Public Health shows that exercise may improve cognitive function in those at risk for Alzheimer’s by improving the efficiency of brain activity associated with memory. Memory loss leading to Alzheimer’s disease is one of the greatest fears among older Americans. While some memory loss is normal and to be expected as we age, a diagnosis of mild cognitive impairment, or MCI, signals more substantial memory loss and a greater risk for Alzheimer’s, for which there currently is no cure. ...

People with poor oral hygiene or gum disease may be at a greater risk of developing Alzheimer’s disease, a new study led by The University of Central Lancashire (UCLan) School of Medicine and Dentistry suggests.

The research, which has received international collaboration, and led by Professor Stjohn Crean and Dr Sim Singhrao from UCLan, examined brain samples donated by ten patients without dementia and ten patients suffering from dementia. The research demonstrated the presence of products from Porphyromonas gingivalis in brains from patients suffering from dementia.

This bacterium is commonly associated with chronic periodontal (gum) disease. These bacteria enter the bloodstream through daily activities such as eating, chewing, tooth brushing but especially following invasive dental treatment, and from there, potentially enter the brain on a regular basis. The researchers propose that every time they reach the brain, the bacteria may trigger immune system responses by already primed brains cells, causing them to release more chemicals that kill neurons. This could be one mechanism that leads to changes in the brain, which is typical of Alzheimer’s disease, and could be responsible for causing symptoms such as confusion and deteriorating memory.

The research benefited from donated brain samples, provided by Brains for Dementia Research, a brain donation scheme supported by Alzheimer’s Research UK and Alzheimer’s Society. Finding P. gingivalis in the brains from dementia sufferers compared to those without dementia is significant as its presence in Alzheimer’s diseased brains has not been documented previously and at the same time adds to a growing body of evidence that suggests an association between poor oral health and dementia.

These published research findings from human brain specimens are further supported by recent (as yet unpublished) research from the same group, on periodontal disease, using animal models, which has been carried out in collaboration with the University of Florida. This animal work has confirmed that P. gingivalis in the mouth finds its way to the brain once the periodontal disease becomes established.

Professor Stjohn Crean, Dean, School of Medicine & Dentistry said:

“Whereas previous studies have indicated a link between dementia and other bacteria and viruses such as the Herpes simplex virus type I, this new research indicates a possible association between gum disease and individuals who may be susceptible to developing Alzheimer’s disease, if exposed to the appropriate trigger! Research currently underway at UCLan is playing an active role in exploring this link, but it remains to be proven whether poor dental hygiene can lead to dementia in healthy people, which obviously could have significant implications for the population as a whole. It is also likely that these bacteria could make the existing disease condition worse.”

Dr. Sim K. Singhrao, Senior Research Fellow at UCLan said: “We are working on the theory that when the brain is repeatedly exposed to bacteria and/or their debris from our gums, subsequent immune responses may lead to nerve cell death and possibly memory loss. Thus, continued visits to dental hygiene professionals throughout one’s life may be more important than currently envisaged with inferences for health outside of the mouth only. To help us prove our hypothesis we are hoping to use the Brains for Dementia Research tissue resource to examine brain tissue from people with both intact and compromised memory who have relevant dental records. The future of the research aims to discover if P. gingivalis can be used as a marker, via a simple blood test, to predict the development of Alzhiemer’s disease in at risk patients.”

Notes to editors:

The University of Central Lancashire (UCLan), with Professor Lakshmyya Kesavalu who specialises in animal models of periodontal disease (Department of Periodontology and Oral Biology, College of Dentistry, University of Florida, USA).

The University of Central Lancashire (UCLan) has developed an enviable reputation as an institution that innovates, evolving its course portfolio to over 500 undergraduate programmes and 180 postgraduate courses. The University has an established research reputation within the areas of Business, Health, Humanities and Science. In the recent Research Assessment Exercise, all 17 subject areas submitted were rated as containing research of international excellence while 11 areas were assessed to be undertaking research which is world-leading. With approximately 32,000 students, the University indirectly contributes close to £250 million into the regional economy every year. UCLan is currently in the process of spending more than £120 million on new buildings and facilities to support teaching, learning and leisure activities.

Brains for Dementia Research is a partnership between the Alzheimer’s Research UK and Alzheimer’s Society to promote brain donation and develop a network of brain tissue banks in England and Wales for dementia research. The project is being run in association with the Medical Research Council. The Brains for Dementia Research coordinating centre is based at King’s College London and there are six assessment and donation centres based at the Universities of Cardiff, London, Manchester, Newcastle, Oxford and Bristol.

01 Jul 2013 - Ineke van Rossum, MD, has been chosen as the recipient of the 2013 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of her outstanding work that implicates a different role for biomarkers in the diagnosis and prognosis of subjects with mild cognitive impairment due to Alzheimer’s disease....

26 Jun 2013 - For years, Alzheimer's researchers have focused on two proteins that accumulate in the brains of people with Alzheimer's and may contribute to the disease: plaques made up of the protein amyloid-beta, and tangles of another protein, called tau....

29 May 2013 - Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important health benefit? The common baking spice might hold the key to delaying the onset of — or warding off — the effects of Alzheimer’s disease....

05 Mar 2013 - People with probable amnestic mild cognitive impairment (MCI) have the most and closest risk of conversion to dementia, mainly Alzheimer’s disease (AD), according to a recent research of Fundació ACE, Barcelona Alzheimer Treatment and Research Center (www.fundacioace.com). That is, amnestic MCI subjects without any comorbidity that could explain their cognitive deficits have 8.5 times more risk to convert to dementia than people with non-amnestic MCI caused by cerebrovascular pathology or psycho-affective symptoms. Furthermore, a storage pattern of memory impairment, the multiple domain condition, and the presence of at least one ε4 allele increase the risk of conversion to dementia in MCI subjects. ...

14 Feb 2013 - A large majority of the nation's top neurologists say they would use a recently approved amyloid detection brain scan to evaluate their patients for Alzheimer's disease if the scan was paid for by health insurance, according to a survey recently published in the Journal of Alzheimer's Disease....

07 Feb 2013 - A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system's ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer's disease. ...

28 Jan 2013 - Keeping active can slow down the progression of memory loss in people with Alzheimer’s disease, a study has shown. A team of researchers from The University of Nottingham has identified a stress hormone produced during moderate exercise that may protect the brain from memory changes related to the disease. The work, funded by Research into Ageing (Age UK) and the University and published in the Journal of Alzheimer’s Disease, may also explain why people who are susceptible to stress are at more risk of developing the disease.
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05 Dec 2012 - A software tool called PredictAD developed by VTT Technical Research Centre of Finland promises to enable earlier diagnosis of the disease on the basis of patient measurements and large databases. Alzheimer’s disease currently takes on average 20 months to diagnose in Europe. VTT has shown that the new method could allow as many as half of patients to get a diagnosis approximately a year earlier....

06 Nov 2012 - Over the last 15 years, researchers have found a significant association between vascular diseases such as hypertension, atherosclerosis, diabetes type 2, hyperlipidemia, and heart disease and an increased risk of Alzheimer’s disease. In a special issue of the Journal of Alzheimer’s Disease, leading experts provide a comprehensive overview of the pathological, biochemical, and physiological processes that contribute to Alzheimer’s disease risk and ways that may delay or reverse these age-related abnormalities....

30 Aug 2012 - Alzheimer’s disease (AD) is one of the most common brain disorders, with an estimated 35 million people affected worldwide. In the last decade, research has advanced our understanding of how AD affects the brain. However, diagnosis continues to rely primarily on neuropsychological tests which can only detect the disease after clinical symptoms begin. In a supplement to the Journal of Alzheimer’s Disease, investigators report on the development of imaging-based biomarkers that will have an impact on diagnosis before the disease process is set in motion. ...

20 Jun 2012 - Scientists from the University of South Florida and Fudan University in Shanghai found increases in brain volume and improvements on tests of memory and thinking in Chinese seniors who practiced Tai Chi three times a week, reports an article published today in the Journal of Alzheimer’s Disease. ...

15 Jun 2012 - No effective treatments are currently available for the prevention or cure of Alzheimer’s disease (AD), the most frequent form of dementia in the elderly. The most recognized risk factors, advancing age and having the apolipoprotein E Ɛ4 gene, cannot be modified or treated. Increasingly, scientists are looking toward other risk factors to identify preventive and therapeutic strategies. Much attention recently has focused on the metabolic syndrome (MetS), with a strong and growing body of research suggesting that metabolic disorders and obesity may play a role in the development of dementia. ...

Alzheimer's disease (AD) is a major neurodegenerative disorder that affects millions of people worldwide. New and accurate techniques for early diagnosis are critical. Pravat K. Mandal, PhD, and his colleagues have developed a completely non-invasive brain imaging technique to measure specific brain chemical changes. This provides a signature of the early stages of AD from the hippocampal region of the brain. Their work is reported in the Journal of Alzheimer’s Disease.

“Alzheimer’s disease has become a silent tsunami in the aging population,” says Dr. Mandal, who is associated with the National Brain Research Center, Gurgaon, India, and Johns Hopkins University School of Medicine. “This discovery of a diagnostic technique that requires no blood work or radiation, and that can be conducted in less than fifteen minutes, may offer hope to Alzheimer’s disease patients and their families.”

Dr. Mandal and his co-investigators studied the brains of normal controls, AD patients, and patients with mild cognitive impairment (MCI) using multi-voxel 31P magnetic resonance spectroscopy (MRS) imaging, along with an advanced analytical tool, to assess brain chemistry in the hippocampal regions. They observed during the course of their study that the left hippocampus becomes alkaline in AD patients, which is in contrast to the normal aging process in which the brain tends to be more acidic.

Dr. Mandal and his colleagues also identified four brain chemicals that change significantly in pre-Alzheimer and Alzheimer disease patients compared to normal subjects. They are phosphomonoester (PME), the building block of neuronal membrane; phosphodiester (PDE), the membrane degradation product; phosphocreatine (PCr), stored energy for brain functioning; and adenosine triphosphate (-ATP), the source of brain energy. The level of PME is significantly decreased in the left hippocampal areas of these patients, and the levels of PDE, PCr, and -ATP are increased.

“In the left hippocampus the increase in pH to the alkaline range, along with statistically significant increases in PDE, PCr, and y-ATP and decreases in PDE, serve as a promising new biomarker for AD,” notes Dr. Mandal. He and his colleagues plan to conduct longitudinal studies with Alzheimer and Parkinson patients with larger sample sizes to investigate specificity of their test. “It is our hope that such clinical research, using state-of-the-art technology, may give new hope to cognitively impaired patients for an earlier and more predictable AD diagnosis.”

These clinical studies were performed in collaboration with Dr. Manjari Tripathi, MD, DM, Department of Neurology, All India Institute of Medical Sciences, New Delhi. This study was made possible through the research funding, to Dr. Mandal, from the Department of Biotechnology, Government of India.

Anders Lönneborg, PhD, has been chosen as the recipient of the 2012 Alzheimer Award presented by the Journal of Alzheimer’s Disease in recognition of his outstanding work on the detection of early Alzheimer’s disease.

“My co-authors and I are extremely pleased to have been chosen by a distinguished group of peers as the recipients of this year’s Journal of Alzheimer’s Disease award for our work on the development of ADtect®, the 96-gene expression test for detection of early Alzheimer’s disease,” said Dr. Lönneborg, Research Director, DiaGenic, Oslo, Norway.

Each year the more than 500 Associate Editors of the Journal of Alzheimer’s Disease vote to select an outstanding article published the previous year to receive this prestigious award, which is made possible by support from IOS Press and Elan Pharmaceuticals. Dr. Lönneborg will be presented with the bronze Alzheimer Medal featuring the likeness of Alois Alzheimer. The winning paper is entitled, “A Novel Blood Test for the Early Detection of Alzheimer’s Disease" (J Alzheimers Dis 23, 121-129, 2011), by A. Lönneborg et al.

The team behind the paper, led by Dr. Lönneborg, investigated the diagnostic value of a 96-gene expression array for detection of early AD. A disease classification algorithm was developed and was validated in two steps using an independent initial test set and another second test set. A similar accuracy (72%), sensitivity (72%) and specificity (71%) were achieved both in the initial analysis and in the two independent test sets. When compared with available CSF biomarker data high agreement (80%) was found.

“Although further studies are needed to confirm these findings, they suggest that the gene expression test using a convenient blood sample can aid the diagnosis of mild to moderate AD,” adds Dr. Lönneborg.

Anders Lönneborg, PhD, received his degree in molecular plant physiology from the University of Umeå, Sweden in 1986. After a postdoctoral fellowship in molecular plant biology at Michigan State University under the mentorship of Prof. Chris Somerville, and working as Research Scientist at the Norwegian University of Life Sciences and as Senior Scientist at the Norwegian Forest Research Institute, Dr. Lönneborg was acknowledged competence as professor in 1995. In 1998 he founded DiaGenic with Dr. Praveen Sharma, where he has served as Research Director since the company’s inception and CEO from 2003-2007.

DiaGenic’s focus has always been to develop blood-based tests based on gene expression to aid the diagnosis of important diseases, primarily neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease. The company aims to develop companion diagnostics and biomarkers to aid the development of novel treatments for Alzheimer’s disease.

18 Apr 2012 - Michel Baudry, PhD, dean of the Graduate College of Biomedical Sciences at Western University of Health Sciences, will publish his research on the critical role of oxidative stress in Alzheimer’s disease and a potential treatment....

10 Apr 2012 - Alzheimer’s disease (AD) is now the sixth leading cause of death among Americans, affecting nearly 1 in 8 people over the age of 65. There is currently no treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals like copper and zinc may start years before the onset of AD symptoms. A new study shows that reducing iron levels in blood plasma may protect the brain from changes related to AD. ...

10 Apr 2012 - Researchers at the University of California, San Diego and Veterans Affairs San Diego Healthcare System have shown that elevated pulse pressure may increase the risk of cerebrovascular disease (CVD) in older adults with Alzheimer’s disease (AD). Their study has been published in the early online edition of Journal of Alzheimer's Disease in advance of the June 5 print publication....

02 Apr 2012 - Investigators from the University of Amsterdam, Netherlands, have shown that in most elderly patients invasive and expensive techniques, i.e. lumbar puncture and PET scan, are not useful to establish the diagnosis of Alzheimer’s disease. They arrived at this conclusion after analysis of data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a large collaborative research project of medical centers in the USA and Canada. ...

27 Mar 2012 - Researchers from the Alzheimer Center, VU University Medical Center in Amsterdam, the Netherlands, have found a way to predict clinical progression of Alzheimer’s disease in subjects in the predementia stage. Patients with mild memory problems, who had brain atrophy on MRI scan or a high level of tau protein in cerebrospinal fluid showed more rapid cognitive decline than subjects without this shrinkage of the brain. The study is published in The Journal of Alzheimer’s Disease 29:2....

27 Mar 2012 - Alzheimer’s disease is the sixth leading cause of death in the United States and the only cause of death among the top 10 in America without a way to prevent, cure or even slow its progression, according to the Alzheimer’s Association. Today, 5.4 million Americans are living with the disease, and another American develops it every 69 seconds....

26 Mar 2012 - Associate Professor Kevin Barnham from the Mental Health Research Institute has recently finished a report that highlights both the need for standard blood collection and processing methods in Alzheimer’s disease research, and a way forward. ...

26 Mar 2012 - An international team of researchers have developed a new method for measurement of aggregated beta-amyloid – a protein complex believed to cause major nerve cell damage and dysfunction in Alzheimer’s disease. The new method might facilitate diagnosis and detection as well as development of drugs directed against aggregated beta-amyloid....

26 Mar 2012 - Both subjective and objective cognitive impairment are highly common among non-demented elderly Swedes, with an overall prevalence of 39 percent and 25 percent respectively, according to a nation-wide twin-study by researchers at the Aging Research Center of Karolinska Institutet, Sweden. The study confirms higher education as a major protective factor and stresses the importance of environmental aspects over genes in mild cognitive disorders in old age. ...

21 Mar 2012 - New research in humans published today reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer’s drugs and for detecting the disease before the onset of clinical symptoms....

06 Mar 2012 - A team of academic researchers has identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer's disease. ...

01 Mar 2012 - Do you recall what you ate for breakfast today or dinner last night? According to new research, you may have a better chance remembering if you had included walnuts. Recent findings published in the Journal of Alzheimer’s Disease report walnut consumption in a Mediterranean diet is associated with better memory scores and cognitive function. The results suggest that antioxidants present in walnuts and other Mediterranean dietary pattern may help counteract age-related cognitive decline and reduce the incidence of neurodegenerative diseases, including Alzheimer's disease. ...

07 Feb 2012 - Scientists in Nottingham have found abnormal levels of seven different proteins in spinal fluid could act as markers for detecting Alzheimer’s disease. The study, which was part-funded by Alzheimer’s Research UK, the UK’s leading dementia research charity, could lead to the development of a new test to detect the disease in its early stages....

07 Nov 2011 - Amsterdam, NL, 7 November 2011 – Impacting millions of families and devouring billions of dollars globally, Alzheimer’s disease is the focus of exhaustive research to find a cure. Although intensely investigated over the last three decades using cutting-edge technologies, the “pathogenic cause” of Alzheimer’s disease has not been found. While many research “breakthroughs” have been claimed and high-profile drugs trials carried out, why does the promised “cure” still seem to elude scientists? ...

19 Oct 2011 - Within the next 20 years it is expected the number of people with Alzheimer’s disease (AD) will double from its current figure of half a million to one million. A new study has looked at whether certain types of drugs used to treat high blood pressure, also called hypertension, might have beneficial effects in reducing the number of new cases of Alzheimer’s disease each year. ...

11 Oct 2011 - Alzheimer’s disease (AD) is a common problem that is becoming progressively burdensome throughout the world. A new supplement to the Journal of Alzheimer’s Disease, Imaging the Alzheimer Brain, clearly shows that multiple imaging systems are now available to help understand, diagnose, and treat the disease. ...

04 Oct 2011 - A team of scientists, led by Johns Hopkins researchers, say they may have found a way to predict how quickly patients with
Alzheimer’s disease (AD) will lose cognitive function by looking at ratios of two fatty compounds in their blood. The finding, they say, could provide useful information to families and caregivers, and might also suggest treatment targets for this heartbreaking and incurable neurodegenerative disorder....

07 Sep 2011 - UK scientists have uncovered how a known risk gene for Alzheimer’s might play a role in the development of the disease. The study – which was funded by Alzheimer’s Society and Alzheimer’s Research UK – provides an exciting new area of investigation for researchers developing treatments and ultimately a cure for the disease. It is being published in the current issue of the Journal of Alzheimer’s Disease....