Laser Manipulation and Cellular Engineering

Objectives

The aims of the RG Cell Surgery and the professorship "Biophotonics" are the study and development of optical tools for the manipulation of cells and cellular functions. Optical techniques allow the achievement of highly localized effects within cells, which can be simultaneously used for high resolution imaging.

Research Focus

The focus of the professorship "Biophotonics" within the RG Cell Surgery are the use of photonic technologies in the field of regenerative medicine and biology. Using linear and nonlinear imaging modalities, like laser microscopy, tissue samples of up to several millimeters thickness can be imaged non-invasively, even in vivo imaging at the subcellular level is possible. By using further (nonlinear) effects a precise manipulation or ablation of cells or tissue structures can be achieved, for example for cell surgery or cell transfection. Using plasmonic effects induced in nanoparticles as gold nanoparticles (GNP) or gold nanorods, markers for higher contrast in diagnostics or biotechnologies or even selective therapy can be employed. Furthermore, the group applies genetic methods, like optogenetic modification of cells, to achieve optically controlled cell function, like contraction, signaling or gene expression.