CD48 on blood leukocytes and in serum of asthma patients varies with severity.

Abstract

BACKGROUND
CD48 is a membrane receptor (mCD48) on eosinophils and mast cells and exists in a soluble form (sCD48). CD48 has a pivotal role in murine asthma and in the proinflammatory interactions of mast cells with eosinophils via its ligand CD244. Thus, CD48 might be important in human asthma.
METHODS
Therefore, two separate cohorts (IL and UK… (More)