Nature of the Analyte

The majority of analytes imprinted to date have been low molecular weight organic compounds of molecular mass 200-300 Da, but with appropriate modification of the imprinting conditions much larger analytes can also be imprinted. Various chemical and physical properties of the analyte are of considerable importance; besides having a suitable chemical handle for interaction with a functional monomer, an analyte must be compatible with the functional monomers and crosslinkers used, it must be soluble in the solvent(s) used for imprinting, and it must be stable and inert under the polymerization conditions employed.

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