Hillary Clinton's last day as secretary of state on Friday seemed to be a microcosm of her four globe-trotting years as America's top diplomat.

The former first lady had a full schedule, as usual, meeting in private with President Barack Obama at the White House and then attending the send-off ceremony with clapping, cheering workers at the agency she led.

Those events were clouded by a suicide bombing earlier in the day in Ankara that killed the attacker and a Turkish security guard at the embassy. No Americans were killed or injured.

Clinton traveled nearly 1 million miles and visited 112 countries in her quest as secretary to promote better understanding of the United States and its role in the world.

Photos:Hillary Clinton's life in the spotlight

Photos:Hillary Clinton's life in the spotlight

Hillary Clinton accepts the Democratic Party's nomination for president at the Democratic National Convention in Philadelphia on July 28. The former first lady, U.S. senator and secretary of state was the first woman to lead the presidential ticket of a major political party.

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Photos:Hillary Clinton's life in the spotlight

Before marrying Bill Clinton, she was Hillary Rodham. Here she attends Wellesley College in Massachusetts. Her commencement speech at Wellesley's graduation ceremony in 1969 attracted national attention. After graduating, she attended Yale Law School.

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Rodham was a lawyer on the House Judiciary Committee, whose work led to impeachment charges against President Richard Nixon in 1974.

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In 1975, Rodham married Bill Clinton, whom she met at Yale Law School. He became the governor of Arkansas in 1978. In 1980, the couple had a daughter, Chelsea.

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Arkansas' first lady, now using the name Hillary Rodham Clinton, wears her inaugural ball gown in 1985.

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The Clintons celebrate Bill's inauguration in Little Rock, Arkansas, in 1991. He was governor from 1983 to 1992, when he was elected President.

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Bill Clinton comforts his wife on the set of "60 Minutes" after a stage light broke loose from the ceiling and knocked her down in January 1992.

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In June 1992, Clinton uses a sewing machine designed to eliminate back and wrist strain. She had just given a speech at a convention of the International Ladies' Garment Workers Union.

Clinton accompanies her husband as he takes the oath of office in January 1993.

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The Clintons share a laugh on Capitol Hill in 1993.

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Clinton unveils the renovated Blue Room of the White House in 1995.

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Clinton waves to the media in January 1996 as she arrives for an appearance before a grand jury in Washington. The first lady was subpoenaed to testify as a witness in the investigation of the Whitewater land deal in Arkansas. The Clintons' business investment was investigated, but ultimately they were cleared of any wrongdoing.

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The Clintons hug as Bill is sworn in for a second term as President.

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The first lady holds up a Grammy Award, which she won for her audiobook "It Takes a Village" in 1997.

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The Clintons dance on a beach in the U.S. Virgin Islands in January 1998. Later that month, Bill Clinton was accused of having a sexual relationship with former White House intern Monica Lewinsky.

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Clinton looks on as her husband discusses the Monica Lewinsky scandal in the Roosevelt Room of the White House on January 26, 1998. Clinton declared, "I did not have sexual relations with that woman." In August of that year, Clinton testified before a grand jury and admitted to having "inappropriate intimate contact" with Lewinsky, but he said it did not constitute sexual relations because they had not had intercourse. He was impeached in December on charges of perjury and obstruction of justice.

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The first family walks with their dog, Buddy, as they leave the White House for a vacation in August 1998.

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President Clinton makes a statement at the White House in December 1998, thanking members of Congress who voted against his impeachment. The Senate trial ended with an acquittal in February 1999.

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Clinton announces in February 2000 that she will seek the U.S. Senate seat in New York. She was elected later that year.

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Clinton makes her first appearance on the Senate Environment and Natural Resources Committee.

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Sen. Clinton comforts Maren Sarkarat, a woman who lost her husband in the September 11 terrorist attacks, during a ground-zero memorial in October 2001.

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Clinton holds up her book "Living History" before a signing in Auburn Hills, Michigan, in 2003.

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Clinton and another presidential hopeful, U.S. Sen. Barack Obama, applaud at the start of a Democratic debate in 2007.

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Obama and Clinton talk on the plane on their way to a rally in Unity, New Hampshire, in June 2008. She had recently ended her presidential campaign and endorsed Obama.

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Obama is flanked by Clinton and Vice President-elect Joe Biden at a news conference in Chicago in December 2008. He had designated Clinton to be his secretary of state.

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Clinton, as secretary of state, greets Russian Prime Minister Vladimir Putin during a meeting just outside Moscow in March 2010.

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The Clintons pose on the day of Chelsea's wedding to Marc Mezvinsky in July 2010.

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In this photo provided by the White House, Obama, Clinton, Biden and other members of the national security team receive an update on the mission against Osama bin Laden in May 2011.

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Clinton checks her Blackberry inside a military plane after leaving Malta in October 2011. In 2015, The New York Times reported that Clinton exclusively used a personal email account during her time as secretary of state. The account, fed through its own server, raises security and preservation concerns. Clinton later said she used a private domain out of "convenience," but admits in retrospect "it would have been better" to use multiple emails.

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Clinton arrives for a group photo before a forum with the Gulf Cooperation Council in March 2012. The forum was held in Riyadh, Saudi Arabia.

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Obama and Clinton bow during the transfer-of-remains ceremony marking the return of four Americans, including U.S. Ambassador Christopher Stevens, who were killed in Benghazi, Libya, in September 2012.

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Clinton ducks after a woman threw a shoe at her while she was delivering remarks at a recycling trade conference in Las Vegas in 2014.

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Clinton, now running for President again, performs with Jimmy Fallon during a "Tonight Show" skit in September 2015.

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Clinton testifies about the Benghazi attack during a House committee meeting in October 2015. "I would imagine I have thought more about what happened than all of you put together," she said during the 11-hour hearing. "I have lost more sleep than all of you put together. I have been wracking my brain about what more could have been done or should have been done." Months earlier, Clinton had acknowledged a "systemic breakdown" as cited by an Accountability Review Board, and she said that her department was taking additional steps to increase security at U.S. diplomatic facilities.

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U.S. Sen. Bernie Sanders shares a lighthearted moment with Clinton during a Democratic presidential debate in October 2015. It came after Sanders gave his take on the Clinton email scandal. "The American people are sick and tired of hearing about the damn emails," Sanders said. "Enough of the emails. Let's talk about the real issues facing the United States of America."

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Clinton is reflected in a teleprompter during a campaign rally in Alexandria, Virginia, in October 2015.

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Clinton walks on her stage with her family after winning the New York primary in April.

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After Clinton became the Democratic Party's presumptive nominee, this photo was posted to her official Twitter account. "To every little girl who dreams big: Yes, you can be anything you want -- even president," Clinton said. "Tonight is for you."

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Obama hugs Clinton after he gave a speech at the Democratic National Convention in Philadelphia. The president said Clinton was ready to be commander in chief. "For four years, I had a front-row seat to her intelligence, her judgment and her discipline," he said, referring to her stint as his secretary of state.

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Clinton arrives at a 9/11 commemoration ceremony in New York on September 11. Clinton, who was diagnosed with pneumonia two days before, left early after feeling ill. A video appeared to show her stumble as Secret Service agents helped her into a van.

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Clinton addresses a campaign rally in Cleveland on November 6, two days before Election Day. She went on to lose Ohio -- and the election -- to her Republican opponent, Donald Trump.

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After conceding the presidency to Trump in a phone call earlier, Clinton addresses supporters and campaign workers in New York on Wednesday, November 9. Her defeat marked a stunning end to a campaign that appeared poised to make her the first woman elected US president.

"It has been an honor to serve in your administration and to represent our country around the world," the letter said.

"I am proud of what we have accomplished together on behalf of the American people and in pursuit of our interests and values. And I am more convinced than ever in the strength and staying power of America's global leadership and our capacity to be a force for good around the world," she said.

In what was billed as Clinton's farewell speech on Thursday at the Council on Foreign Relations, she said the United States needs to build "smart power" in a world where the levers of influence are changing rapidly.

American diplomats have to work with entrepreneurs and activists, use new technological tools such as social media and update the global and regional institutions that have dominated international affairs since World War II, Clinton said.

"We need a new architecture for a new world -- more Frank Gehry than formal Greek," she said. "Now some of his work at first might appear haphazard, but in fact, it's highly intentional and sophisticated. Where once a few strong columns could hold up the weight of the world, today we need a dynamic mix of materials and structures."

Clinton called the United States "uniquely well-positioned" to help construct that metaphorical global edifice.

"Those things that make us who we are as a nation --- our openness and innovation, our diversity, our devotion to human rights and democracy --- are beautifully matched to the demands of this era and this interdependent world," she said.

Kerry, who served nearly 30 years in the Senate, stepped down Friday ahead of his swearing-in as the nation's 68th secretary of state.

He was chairman of the Senate Foreign Relations Committee and the Democratic nominee for president in 2004, when he lost to incumbent President George W. Bush.

Kerry expects to take his first official overseas trip in coming weeks, according to a U.S. official who said stops would likely include Israel and Egypt.

Clinton, 65, now faces persistent questions about whether she will mount a second White House run in 2016 to break perhaps the highest remaining glass ceiling.

"Well I'm not thinking about anything like that right now. I'm looking forward to finishing my tenure as secretary of state and catching up on 20 years of sleep deprivation," Clinton said Tuesday at a global "town hall" forum in Washington.

Observers note her answer was a less emphatic denial than previous responses that seemed to rule out any possibility of reentering the political fray.

According to a CNN/ORC International poll conducted last month, 85% of Democrats and independents who lean toward the Democratic Party said they would be very or somewhat likely to support Clinton if she sought the Democratic nomination.

Clinton was considered a favorite in 2008, but Obama, who served with her in the Senate, got an early jump in the primaries. Clinton was unable to capture the momentum in a fierce political battle.

Despite the rugged campaign, Obama chose Clinton for his Cabinet and she embraced the role.

In a joint interview with CBS that aired on Sunday, Obama said that he believes Clinton's legacy will rank among the best.

"It has been a great collaboration over the last four years," Obama said. "I'm going to miss her."