Study Sheds Light on How to Mend a Broke Heart

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A molecule that converts stem cells into heart cells has been discovered by researchers. This finding could help in formulating methods to replace diseased or damaged tissue in patients suffering from heart disease.

Study Sheds Light on How to Mend a Broke Heart

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Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham), the Human BioMolecular Research Institute, and ChemRegen, Inc. have been searching for molecules that convert stem cells to heart cells for about eight years-and now they've found one.

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In the new study, the researchers have described how they sifted through a large collection of drug-like chemicals and uncovered ITD-1, a molecule that can be used to generate unlimited numbers of new heart cells from stem cells.

"Heart disease is the leading cause of death in this country. Because we can't replace lost cardiac muscle, the condition irreversibly leads to a decline in heart function and ultimately death. The only way to effectively replace lost heart muscle cells-called cardiomyocytes-is to transplant the entire heart," Mark Mercola, senior author of the study, said.

"Using a drug to create new heart muscle from stem cells would be far more appealing than heart transplantation," he said.

Stem cells are important because they do two unique things - self-renew, producing more stem cells and differentiate, becoming other, more specialized cell types.

To obtain a large number of a certain cell type, such as heart cells, the hard part is figuring out the signals that direct them to become the desired cell type.

Mercola's group has been hunting for heart-inducing signals for 15 years-in embryos and in stem cells.

To find a synthetic molecule that might one day lead to a drug therapy to regenerate the heart, they joined forces with a team of medicinal chemists at the Human BioMolecular Research Institute led by John Cashman, Ph.D.

With funding from the California Institute for Regenerative Medicine, they used sophisticated robotic technology to methodically test a large collection of drug-like chemicals, looking for that needle in a haystack that, when added to stem cells, results in cardiomyocytes.

The winning compound was ITD-1.

There's no shortage of therapeutic possibilities for ITD-1.

"This particular molecule could be useful to enhance stem cell differentiation in a damaged heart," Erik Willems, first author of the study, said.

"At some point, it could become the basis for a new therapeutic drug for cardiovascular disease-one that would likely limit scar spreading in heart failure and promote new muscle formation," he added.

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