Ibogaine is metabolized in the human body by cytochrome P450 2D6, and the major metabolite is noribogaine (12-hydroxyibogamine). Noribogaine is most potent as a serotonin reuptake inhibitor and acts as…

Ibogaine first appeared in popular culture in the writings of Hunter S. Thompson. While covering the Wisconsin primaries of the 1972 Presidential primaries for Rolling Stone magazine, Thompson claimed that…

In Bwiti religious ceremonies, the rootbark is pulverized and swallowed in large amounts to produce intense psychoactive effects. In Africa, iboga rootbark is sometimes chewed, which releases small amounts of…