MEDICAL
REVIEW AND CLINICAL STUDY

MEDICAL
REPORT ON EFFICACY AND SAFETY STUDIES
PERFORMED ON THE PRODUCT WONDERUP, A
NATURAL FORMULA FOR BREAST ENHANCEMENT

by Dr.
Benigno Bartoletti, MD

20
September 1999

STUDY
OVERVIEW: As regards the product
Wonderup, on the basis of my professional
medical review of the clinical study and
of my own preliminary medical studies, I
can state that it is effective and safe.
The product has been tested on a sample
of 140 women from 17 to 65 years of age
for a year, with positive responses in
more than 90% of cases. All
experimentation has been performed with
control groups; therefore I can confirm
that the claims about breast size
increases ranging from a minimum of 2 cm
(0.7 in) to a maximum of 8 cm (3.14 in)
in 90 days are truthful and confirmed by
facts. The final results do vary
individually according to constitutional
and metabolic factors but are confirmed
in the vast majority of cases after
regular and constant use. As a medical
professional with years of experience in
nutritional sciences, I therefore
consider Wonderup a complete product and
most of all entirely natural in its
formulation. The secret of the product
consists in the accurate selection of
dosages and in the focus on the positive
synergistic effects of the ingredients.

PRODUCT
BACKGROUND: Wonderup is a
nutritional product, generally described
as a herbal formula for breast
enhancement.

STUDY
OBJECTIVES: The objectives of
the clinical study on Wonderup were to
assess the efficacy of the product for
breast enhancement and the safety of the
product for daily use.

ACTIVE
PRINCIPLES: The reason for the
choice of these ingredients for the
product is their high content in
phytoestrogens (isoflavones,
isoflavonoids, lignans, coumestans,
bioflavonoids and similar, also referred
to as phytosterols or phytochemicals) and
their associated galactogogue property
(their estrogenic effects indeed include
increased lactation in pregnancy), which
accounts for the traditional use in
popular herbal medicine for stimulating
the production of mother's milk in
lactating women. According to medical
sources and recent studies,
phytoestrogens are in fact hormone-like
substances contained in plants - they're
similar in structure to human estrogens
naturally produced by the female body but
1/1000 weaker in potency.

HOW
THE PRODUCT WORKS: The apparent
action of phytoestrogens on the breasts
is related to their influence on hormone
metabolism - a mildly stimulating and
balancing action on the female hormonal
system. Indeed, due to their structural
similarity with body estrogen, they bind
to the estrogen receptor cells in the
breast, and also have an effect on growth
factor molecules (which are released from
cells in response to estrogen and affect
neighbouring cells) - thus they can
influence the natural growth process of
the breast tissue similarly to what
occurs during puberty.

HEALTH
CONSIDERATIONS: It must be noted
that phytoestrogens are not hormones and
therefore not to be confused with
synthetic hormones or even human hormones
- and they do not overstimulate the
hormonal system, since they only balance
it and favour the absorption of naturally
produced estrogen into the breast's
receptor cells. Therefore they do not
present any of the health risks
associated with synthetic hormonal
treatments - in fact, recent research has
demonstrated that phytoestrogens hold a
great potential for disease prevention
and many health benefits specifically
associated with the wellbeing of women.
Even if the product is not specifically
aimed at these effects and is not
intended as therapeutic or preventive, an
overview of the medical literature on the
topic helps confirm the safety for daily
use of plants and herb extracts
containing phytoestrogens. It is also
important to note that because
phytoestrogens have a balancing action on
the hormonal system, they can therefore
function both as estrogen agonists and
antagonists, which is why they do not
overstimulate the hormonal system.

STUDY
PREMISES: Women with abnormally
low levels of estrogen in their blood can
benefit from the estrogenic effect of
phytoestrogens, which will raise their
hormone levels with consequent overall
beneficial effects upon them. In short,
they will stimulate natural estrogen
production only when needed and in
specific areas such as the breasts, where
estrogen receptors respond to the
estrogenic effect of the phytochemicals.
Based on these premises, the study
examined the incidence of these possible
effects of the active principles in the
product's ingredients on a sample of
women.

STUDY
OUTLINE: The study was of the
product's effects on 140 volunteers -
women aged 17 to 65 - over a period of 12
months. The study method was double-blind
with placebo-control.

REQUIRED
CONSUMPTION: The study was based
on test subjects consuming the usual
amount of the Wonderup formula, which is
2 tablets 3 times daily.

STUDIES
PERFORMED: The tests were aimed
at measuring the efficacy of the product
in relation to:
- increase in cup size and/or size in cm
of the breast circumference.
- firming and toning of the breast with
reduction of "sagging" effect.
The tests did not take into consideration
any therapeutical or nutritional
properties of the product, which is in
fact not to be intended as a medicinal or
therapeutic product. The only criterion
taken into consideration has been its
efficacy at an aesthetic level. The study
also evaluated the product's safety for
daily intake by examining the possibility
of side effects, and, as noted above, by
overviewing the medical literature on the
product's active ingredients.

DATA
ANALYSIS: The data were
collected at the beginning and at the end
of the testing periods and measured with
these methods:
- measurement (by means of a body
caliper) of the mass of the breast,
before and after test.
- measurement (by means of a tape
measure) of the breast tissue under
mammary gland aureole, before and after
test.
- measurement (by means of
tensiometer/densitometer) of the density
and consistency of the breast tissue,
before and after test.
The study also collected personal
feedback from the volunteers about their
degree of satisfaction with the product's
effects.

STUDY
RESULTS: After an initial 3
month testing period, the measurements
taken from the group which received the 6
tablets daily of Wonderup show that more
than 90% of the volunteers experienced a
positive response. 75% of the women
studied experienced a breast size
increase of at least 2 cm (0.7 in)
ranging to a maximum of 8 cm (3.14 in).
The measurements taken from the group
which received the 6 tablets daily of a
placebo show that none of the subjects
experienced a change in their breasts.

SIDE
EFFECTS: No significant or
medically relevant side effects were
observed. 55% of women in the Wonderup
group reported tingling and/or aching
sensations in the breast area and/or a
feeling of tenderness in the breasts.
However, these sensations tended to
subside quite quickly and are therefore
not regarded as significant. No other
side effects were reported.

FINAL
ASSESSMENT: After the initial 3
month testing period, the level of
personal satisfaction with the product of
the individuals in the Wonderup group was
taken into consideration, with the
following results:
- 55% reported that they were very
satisfied with the product.
- 30% reported that they were satisfied.
- 15% reported that they had experienced
little or no effect.
At the end of the full 12 months study
period, the level of personal
satisfaction with the product was again
taken into consideration, with the
following results:
- 75% reported that they were very
satisfied with the product.
- 20% reported that they were satisfied.
- 5% reported that they had experienced
little or no effect.
Taking into consideration the fact that
the ingredients are common plants and
foods considered completely safe and used
for centuries both in nutrition and
herbal tradition worldwide, and
considering also the favourable
prevailing scientific opinion on their
active ingredients (phytoestrogens), the
study found that the product has no
significant side effects and presents no
health hazards for users. In fact, recent
research has indicated that
phytoestrogens hold great potential for
health benefits.

STUDY
CONCLUSIONS: The study concluded
that Wonderup is effective for breast
enhancement and is safe for daily use,
having no significant side effects.