The Framingham Heart Study

Table 4

Adjusted Odds Ratios and 95% CIs of Prevalent or High CAC or AAC across Quartile Categories of Energy-Adjusted Self-Reported Total (Dietary and Supplemental) Magnesium Intake

Quartile 1(n = 673)

Quartile 2(n = 674)

Quartile 3(n = 674)

Quartile 4(n = 674)

p Value

Magnesium intake, mg/day

p Linear trend

Median

258.8

303.6

351.1

427.4

Range

159.8–283.9

284.0–325.4

325.5–383.6

383.9–669.4

CAC >0

Model 1

1 (Ref)

0.95 (0.73–1.23)

0.79 (0.60–1.03)

0.60 (0.45–0.81)

<0.001

Model 2

1 (Ref)

0.93 (0.71–1.23)

0.79 (0.60–1.05)

0.58 (0.43–0.79)

<0.001

Model 3

1 (Ref)

0.84 (0.63–1.11)

0.65 (0.47–0.89)

0.42 (0.29–0.62)

<0.001

CAC ≥90th

Model 1

1 (Ref)

1.20 (0.89–1.62)

0.94 (0.68–1.29)

0.71 (0.50–1.02)

0.02

Model 2

1 (Ref)

1.26 (0.92–1.72)

0.99 (0.71–1.38)

0.71 (0.49–1.03)

0.02

Model 3

1 (Ref)

1.20 (0.87–1.64)

0.92 (0.64–1.32)

0.63 (0.40–0.98)

0.01

AAC >0

Model 1

1 (Ref)

0.99 (0.75–1.30)

0.71 (0.54–0.94)

0.70 (0.51–0.95)

0.01

Model 2

1 (Ref)

1.07 (0.80–1.44)

0.76 (0.56–1.02)

0.77 (0.55–1.06)

0.03

Model 3

1 (Ref)

1.02 (0.75–1.37)

0.69 (0.49–0.95)

0.66 (0.44–0.98)

0.01

AAC ≥90th

Model 1

1 (Ref)

0.75 (0.57–0.99)

0.62 (0.46–0.83)

0.73 (0.54–0.99)

0.05

Model 2

1 (Ref)

0.80 (0.59–1.08)

0.65 (0.48–0.90)

0.79 (0.57–1.10)

0.17

Model 3

1 (Ref)

0.76 (0.56–1.04)

0.61 (0.43–0.86)

0.70 (0.47–1.05)

0.10

Any calcification defined as AS 0 versus >0; high calcification as AS < versus ≥90th percentile for age and sex on the basis of a healthy reference population. For AAC, n = 2,681. Models adjusted for as in Table 2.