In bodybuilding, Nolvadex (Tamoxifen
Citrate) is used as both an anabolic steroid cycle ancillary drug and
as recovery or as a post anabolic steroid cycle therapy drug.

Nolvadex is an oral anti-estrogen/estrogen antagonist
prescription drug. Nolvadex is commonly referred to as an
anti-estrogen, but technically it is more of an estrogen antagonist. An
estrogen antagonist has a unique way of preventing estrogen activity.
What it does is to compete with estrogen at the receptor sites,
occupying it so that estrogen cannot bind with it.

Nolvadex is an anticancer drug which is reportedly effective
in treating breast cancer, particularly the kind that is induced by
estrogen. Its other therapeutic uses include reduction of the risk of
invasive breast cancer following surgery and radiation therapy for
ductal carcinoma in situ. Nolvadex is also used as preventive drug. It
is prescribed in women who are at high risk of developing breast cancer
(genetic disposition).

Why is there a need for Nolvadex

During a steroid cycle, Nolvadex is used by bodybuilders
who are sensitive to estrogen buildup. Estrogen buildup can lead to
many concerns, foremost of these is the occurrence of gynecomastia
(growth of breast tissues in men) and subcutaneous fat and water
retention.
During PCT, Nolvadex is effective in averting the dreaded effect when
coming off a steroid cycle – the post-cycle crash. This is basically
losing what you have gained when you’re on a cycle. Bodybuilders, in
general, use Nolvadex to block this from taking place.

Here’s the scenario. When a bodybuilder is taking anabolic steroids,
the body ceases its production of androgens. When he stops taking them,
the body does not immediately resume its normal production of these
hormones, resulting to depressed androgen level. When this happens the
body compensates by overproducing estrogen. The excess estrogen, in
turn, results to can increase the production of SHBG and blocks
testosterone-receptor sites. SHBG or sex hormone-binding globulin is a
glycoprotein that binds to sex hormones, including testosterone. And
so, if there’s an increase in the amount of SHBG in the system it
translates to lesser amount of free or unbound testosterone. This means
there are two mechanisms by which excess estrogen interferes with the
normalization of androgen level in the body.

Furthermore, a depressed androgen level can lead to catabolism. There
are many signals that induce catabolism and this includes cortisol,
which is considered to be one of the ‘classic’ catabolic hormones.
Cortisol plays a great role in protein catabolism, which is the
breakdown of macromolecules. Macromolecules include proteins and lipids
(fat). When protein catabolism takes place, there is a subsequent loss
in muscle gains and strength. Your muscles get leaner because fat,
water, and protein substrates break down. However, this is not to say
that this is a completely negative effect as some bodybuilders prefer
leaner muscles. But for those who are after bulk or mass this poses a
problem. This is why Nolvadex is not advised for those whose aim is to
gain mass.

Nolvadex vs aromatase inhibitors

Nolvadex is usually compared to aromatase inhibitors like Arimidex;
however, there is a distinct difference between these two classes of
drugs. Estrogen agonists or anti-estrogens (also classified as
triphenylethylenes) do not halt the production of estrogens whereas
aromatase inhibitors do quite effectively.

Aromatase blockers or inhibitors halt the natural production of
estrogen and therefore tend to completely suppress estrogenic activity,
including its beneficial roles in body (metabolism, lipid profile,
protein synthesis). This is why many still opt for Nolvadex as an
ancillary and recovery drug.

Further, Nolvadex exerts its effects faster
vis-à-vis an aromatase inhibitor. Thus, when bodybuilders experience
the symptoms of gynecomastia while they are on steroid cycle, they rely
on Nolvadex to immediately counter the problem. However, a drawback of
this drug is that it exhibits only short-term effects, which means that
once Nolvadex intake is discontinued,
the same problems can possibly rebound sooner than later. To prevent
this rebound, Nolvadex
is generally use in conjunction with aromatase inhibitor. Nolvadex can
deal with the problem right away while an aromatase inhibitor like
Arimidex can work for the long-term results as it reduces the
production of estrogen.

Nolvadex is recommended to be
stacked with highly aromatizable steroids like Dianabol and
testosterone.

It is important to start a PCT once you finished a steroid cycle to
avoid a dramatic loss of the mass gained. The question on how soon to
initiate a PCT depends on the kind of steroids you used. If your cycle
is comprised of orals, which have relatively the shortest effect on the
body, it is advised to start immediately. Some say PCT can begin as
early as the last day of the steroid cycle. If short-acting esters or
water-based injectables, PCT is recommended 4-7 days after the last
injection. In the case of long-acting esters, it should be around 10-14
days after the last injection.

Side effects are reportedly few and mild with this drug. Nausea,
vomiting and hot flashes can be experienced by users of Nolvadex.
High dosage can prevent natural testosterone production by the testes.
Further, high dosage can be counter-productive; that instead of
lowering estrogenic levels, it increases the levels. This is a
consequence when the adrenal glands are overly stimulated to produce
the prohormone dehydroepiandrosterone or DHEA. DHEA converts to
estrogen.

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