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Breaking a bone and waiting for it to heal correctly is a long process that takes patience. Research shows that cannabinoids, including CBD, increase the bone growth
but also bone density. Rodent with broken limbs healed much faster when treated with cbd. This is all because of the endocannabinoid system. Cannabinoids work on
receptors in the endocannabinoid system to produce bone formations. Research even shows that we have a skeletal endocannabinoid system that works directly with our bones.

Bone fractures are one of the leading injuries today. Both men and women of all ages experience bone fractures throughout their life. As a child our bones are
stronger but as we get older, they can start to degenerate. Sometimes we’ll fall out of a tree while climbing, over extend your leg while achieving a game-winning point,
or twist your ankle in a pair of heels. No matter how you fractured your bone, making sure it heals correctly is extremely important to your health.

Bone fractures heal on their own, It is important to keep a balanced diet and stay healthy while your bones are repairing. Various minerals and vitamins are
found in foods that will help promote bone growth. Once the fracture has occurred one will experience a inflammation stage where a blood clot will form. Cytokines then
begin to repair cells into the fracture gap. These cells will turn into specialized cells to create osteoblasts which produce new cells that lay down new bone and
cartilage. These osteoblasts produce protein to create a soft callus which will harden over time. Finally as the bone fully heals osteoblasts and osteoclasts will weave
the bone with bone formation cells and bone resorption cells. During this process the bone will rebuild itself. A 2009 study concludes that in age-related osteoporosis,
cannabinoid receptors will increase peak bone mass and bone marrow. Osteoporosis is defined as the loss of bone mass and bone tissue, creating weak bones. It is
oftentimes in older people, specifically women due to smaller bones and menopause.

Observations throughout the study demonstrate that the CB1 receptor regulates peak bone mass through effects of osteoclasts, bone resorption and age-related bone
loss. This means that the administered CBD helped to strengthen the fracture callus; the cartilage which mends the fracture. The CB1 receptor is therefore unique in that
it regulates peak bone mass through an effect on osteoclast activity, but protects against age-related bone loss by regulating bone cells. In one of the most recent
studies, results show that CBD alone specifically helps with healing bone fractures. Tel Aviv University specifically examined the bone health with isolated CBD or a
combination with THC; a group of mice were administered CBD or THC and CBD. Results concluded that isolated CBD has better effects than when the two cannabinoids were in
combination.

During this study the results concluded that CBD alone enhanced the biochemical properties of healing in a fracture. CBD involves changes to the organic matrix
of bones that affects the flexibility and toughness. Multiple experiments were complete to isolate the various effects of how CBD helps with bone growth. Findings show
the callus has an increase in strength and toughness from CBD which is explained by osteoblastic bone formation. Most of us are familiar with the endocannabinoid system
but there is also a skeletal cannabinoid system that works with your bones. Some of the key components found in the endocannabinoid system are also located in our
bones. Anandamide and 2AG are believed to be sourced in the skeleton and produced by osteoblasts and osteoclasts. CBD interacts with these cannabinoid receptors to
return back to homeostasis.

Anandamide: an endocannabinoid neurotransmitter that regulates pain, sleep, memory, reproduction, movement and cognition. 2AG: a main endocannabinoid that reacts
on the CB receptors in the central and peripheral nervous system. 2AG regulates appetite, pain management and the immune system. These studies demonstrate how CBD and
bone growth relate. Due to our skeletal endocannabinoid system, CBD is able to send signals to our bone cells. It is important to maintain a healthy lifestyle while your
bones are healing so they can heal properly. CBD helps with bone growth to strengthen the bone by triggering osteoblasts.

Once you get older your bone will begin to deteriorate causing your bones to become brittle, making it easier to fracture. Old age can also come with bone
diseases that create a block in bone growth. Getting through life with a bone disease like osteoporosis typically means relying on medications to provide relief.
Prescription medications can come with harsh side effects that make you feel even worse. Turning to a natural cannabinoid will eliminate having to take medications that
provide poor side effects. Research shows direct correlation in CBD and bone growth.

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Cbd together with trpv-1 antagonist, reduces dyskinesia by acting on cb1 and ppar gamma receptors and reducing the expression of the inflammatory markers COX-2 and
NF-KB. Many individuals have reported the benefits of cannabis mostly the CBD cannabinoid in it, for treating anxiety, insomnia, pain, spasticity and a whole host of
other ailments. It’s believed to be effective in treating epilepsy and acts as a wonderful muscle relaxant. Many Parkinson’s disease patients swear by its ability to
reduce tremors. So, where do medical marijuana and tardive dyskinesia (TD) stand, then? First, you should know a little more about TD itself.

What Is Tardive Dyskinesia?TD is a side effect antipsychotic medications cause. Doctors prescribe these medicines to help treat mental health disorders, mainly schizophrenia. Tardive dyskinesia
causes uncontrollable stiff, jerky movements of your body and face. It may cause you to stick out your tongue, blink an eye or wave your arms without you even intending
on doing so. Not all individuals taking antipsychotic medications will experience this side effect. However, it does occur, and in some cases, it’s permanent. Therefore,
if you’re taking an antipsychotic drug and notice any uncontrollable movements, let your doctor know immediately. They can lower the dose of your medication or switch it
entirely to alleviate your symptoms.

Causes of TDAntipsychotic medications treat brain conditions, such as bipolar disorder and schizophrenia. They also go by the name of neuroleptic drugs. They block the dopamine
chemical in your brain, helping cells communicate to one another and your muscles to move smoothly. When you lack dopamine, your movements may become out of control and
jerky.

You can develop tardive dyskinesia if you’ve been taking an antipsychotic medication for more than three months. However, in rare cases, even one dose of this
type of drug can cause TD. The older medications are most likely to lead to TD than the newer ones. But, research has shown a risk from both newer and older medications
of these types.

Neuroleptics are the most likely to cause TD. These are also called dopamine receptor antagonists. They treat psychosis-related conditions which can alter your
view of reality. With a psychotic condition, you may experience one or both of the following. Hallucinations: Seeing or hearing things that aren’t thereDelusions:
Persistent beliefs that are not reality-based Some psychosis-related conditions include: SchizophreniaSevere depressionBipolar disorderDrug abuse Older neuroleptic
medications are called “typical” or first-generation neuroleptics and are most likely to lead to TD. These medications can cause TD in a little over 32 percent of the
individuals who use them long-term. Neuroleptic medications in the first-generation category include: Fluphenazine, Chlorpromazine, Perphenazine, Haloperidol.
Second-generation neuroleptic medications, or “atypical” medications, are newer drugs with less risk of causing TD. One review showed long-term users only had a 13.1
percent risk of developing the condition. Common second generation neuroleptic medications include: Olanzapine, Risperidone, Paliperidone, Quetiapine, Lurasidone,
Aripiprazole.

Several drugs physicians prescribe for use as a digestive condition treatment along with psychosis also seem to have an association with TD, including the
following. Prochlorperazine: Some patients use this medication to treat severe nausea and vomiting. Doctors also prescribe it for severe anxiety and schizophrenia.
Metoclopramide: This drug helps heal ulcers or sores in the stomach or throat, while it also aids the stomachs of diabetics. How and Why Marijuana and CBD Can Be an
Effective Treatment for TD.

The basal ganglia contain an abundance of CB1R and CB2R endocannabinoid receptors, which implies they have something to do with normal motor function and medical
marijuana formulations. As agonists at both areas, they could ease movement disorder symptoms.

Tardive dyskinesia symptoms are similar to the symptoms of Parkinson’s disease. Studies suggest medical cannabis can help certain patients effectively manage
their symptoms, according to the National Parkinson’s Foundation. However, you shouldn’t replace approved TD treatments with medical weed. And there still needs to be
more research into how using the herb long-term can affect the condition and confirm its results.

Many researchers started showing enthusiasm in studying medical marijuana about Parkinson’s disease after Parkinson’s patients began providing anecdotal reports
on how the herb helped reduce their tremors. Some researchers believe medical pot could be neuroprotective — in other words, it saves neurons from Parkinson’s-related damage.

The digestive imbalance and endocannabinoid system play significant roles in Parkinson’s. THC, CBD and THCV research has shown medical marijuana is helpful in managing
Parkinson’s disease symptoms.

In Kentucky, University of Louisville School of Medicine scientists have found cannabidiol (CBD) could have substantial therapeutic implications for PD.

The CBD cannabinoid activates the brain’s GPR6, a G-coupled protein receptor in the brain’s basal ganglia region. Since researchers can’t find the main endogenous
compound binding to the GPR6 receptor, they consider it to be an “orphan receptor.”Research shows a GPR6 depletion results in a dopamine increase, and GPR6 could
potentially treat Parkinson’s. As you may know, Parkinson’s is a long-term, neurodegenerative condition impairing motor control due to a progressive loss of
dopamine-producing neurons. CBD increases dopamine levels.

This information is not provided by medical professionals and is intended only to complement, and not to replace or contradict, any health or medical advice
or information provided by healthcare professionals. If you have any questions, please contact your doctor or other healthcare professional.

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Research suggest taking CBD before bed improves sleep in people with insomnia. Preliminary research into cannabis and insomnia suggests that cannabidiol (CBD) may
have therapeutic potential for the treatment of insomnia. Delta-9 tetrahydrocannabinol (THC) may decrease sleep latency but could impair sleep quality long-term. Novel
studies investigating cannabinoids and obstructive sleep apnea suggest that synthetic cannabinoids such as nabilone and dronabinol may have short-term benefit for sleep
apnea due to their modulatory effects on serotonin-mediated apneas.

CBD may hold promise for REM sleep behavior disorder and excessive daytime sleepiness, while nabilone may reduce nightmares associated with PTSD and may improve
sleep among patients with chronic pain. The effects of cannabis extracts on nocturnal sleep, early-morning performance, memory, and sleepiness were studied in 8
healthy volunteers (4 males, 4 females; 21 to 34 years). The study was double-blind and placebo-controlled with a 4-way crossover design. The 4 treatments were placebo,
15 mg Delta-9-tetrahydrocannabinol (THC), 5 mg THC combined with 5 mg cannabidiol (CBD), and 15 mg THC combined with 15 mg CBD. These were formulated in 50:50 ethanol to
propylene glycol and administered using an oromucosal spray during a 30-minute period from 10 pm. The electroencephalogram was recorded during the sleep period (11 pm
to 7 am). Performance, sleep latency, and subjective assessments of sleepiness and mood were measured from 8:30 am (10 hours after drug administration). There were no
effects of 15 mg THC on nocturnal sleep. With the concomitant administration of the drugs (5 mg THC and 5 mg CBD to 15 mg THC and 15 mg CBD), there was a decrease in
stage 3 sleep, and with the higher dose combination, wakefulness was increased. The next day, with 15 mg THC, memory was impaired, sleep latency was reduced, and the
subjects reported increased sleepiness and changes in mood. With the lower dose combination, reaction time was faster on the digit recall task, and with the higher dose
combination, subjects reported increased sleepiness and changes in mood. Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting
properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC.

People use different essential oils to get the medicinal benefits that the oil provides. The good thing about these natural oils is that they come with zero
side effects and are completely safe to use. But when cannabidiol is mentioned, the public automatically start thinking of THC and its mind-altering effects. That has
long since put to rest when it was shown that CBD is unlike THC in that it provides a calming effect without the psychosis inherent in THC. Scientists have discovered
that CBD oil can help alleviate the debilitating symptoms of insomnia, and even improve the condition in some cases. In 2006, there was a clinical study that found some
surprising results about CBD and cannabis. Researchers have concluded that cannabidiol, which was the second constituent of cannabis, was by nature a non-psychoactive
factor. Conclusive tests with rats proved this to be true- the rats were observed to have heightened alertness in response to light, while having no particular negative
effect on how they slept without the presence of any light. This proved that CBD could be used as a therapeutic relief in cases of day time somnolence and it could
provide the same effect when an individual sleeps at night.

Cannabidiol’s mechanism is such that it works alongside our ECS, or endocannabinoid system, which controls all the homeostatic functions of our bodies. When our
ECS is functioning at a high level, then our bodies are more balanced and we enter a state of good homeostasis. The balance achieved through the use of CBD oil can help
with amnesia and other sleep imbalances that a person may experience. CBD is anti-anxiolytic, a component that helps patients fight off panic attacks, anxiety and general
depression. Anxiety is one of the major factors that keep people awake all throughout the night. By removing the state of anxiousness, the person feels more relaxed,
which brings about sleep conduciveness.

CBD OIL REMEDIX

Studies suggest that CBD may be therapeutic for substance use disorders. Study Finds Using CBD for Addiction Helps Prevent Relapses, one of the most overlooked benefits of CBD
is its ability to combat drug and alcohol addiction.

“How could you even use CBD for addiction?” you’re probably asking.

And you’re completely right. At a glance, it seems pretty bizarre. And to be frank, some would even interpret it as a load of BS from companies just trying to
sell more product. I mean, how could CBD be used to treat so many diverse conditions, of all things addiction? As bizarre as it may seem, there’s actually a ton of
medical research backing the effectiveness of using CBD for addiction, and when you think about how CBD interacts with our body’s endocannabinoid system (ECS), it all
makes sense. In a recent case study, researchers ran a series of tests to determine the “anti-relapse” potential of transdermal CBD. In the study, researchers
administered transdermal CBD to animal subjects who had a history of self-administering cocaine or alcohol and exhibited characteristics of a relapsing addict such as
dependency, anxiety, and impulsivity. After administering CBD once every 24 hours for just seven days, the researchers made a profound discovery. Based on their test
results, the researchers concluded that the brief 7-day period of CBD treatment not only prevented the development of previously displayed “addict-like” characteristics,
it deterred the subject’s from relapsing for 5months — even though the CBD cleared from the brain and body after 3 days.

So not only is CBD effective in preventing relapses in drug and alcohol addicts, the benefits it provides are long-lasting which is crucial when fighting
substance addiction. Now, sure, the results from a single study is not adequate evidence to validate the effectiveness of CBD in preventing relapses; however, this is not
the case of just a single study. There are many other studies from very credible research teams who have run similar tests and found the same results. Friedbert Weiss,
the lead researcher at Scripps Research Institute, stated that this study provides “proof of principle supporting the potential of CBD in relapse prevention”.

With substance addiction being such a huge problem in the world today, this a huge breakthrough that could change the lives of tens of thousands of people.
Generally, several studies have shown that CBD is highly beneficial among children and adults that are battling addiction. If you or a loved one is struggling with addiction,
you can also talk to your physician about CBD for addiction therapeutic aid.

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CBD OIL REMEDIX

What makes cigarettes feel and good and become addicting? Not only is there a plethora of chemicals that your brain has become used to consuming, Nicotine releases
Dopamine in your brain. Essentially making you feel happy and euphoric. Research has shown that Nicotine addiction has a direct correlation with out endocannabinoid
system.

Smoking cigarettes accounted for 500,000 deaths last year in the U.S. That’s 1300 deaths a day from tobacco use!

When nicotine becomes abused, our brains ability to create dopamine for regular circumstances becomes hindered due to the fact it’s been reprogrammed to be
triggered through smoking/nicotine. This leads to an effect called “Re consolidation”. Our brains have basically associated “good times” and being stress free with the
use of nicotine. Hence the desire to go for a smoke at certain times. Like when everyone is on a break, after a meal, during a coffee or with an alcoholic beverage.
These associations are what make dropping the smoking habit so tough. Our actions have led our brain to thinking a cigarette must be had to enjoy certain cues.

What makes CBD effective for thwarting the feeling and desire for a cigarette is its ability to disassociate good times with nicotine. This will help ease our
cravings when certain cues or activities that would normally lead us to lighting up.

The University of London studied the effects between CBD and smoking cessation. 24 participants who were attempting to quit smoking were given an inhaler. Half
were filled with a placebo and the other half with CBD. The findings were amazing, each user with a CBD inhaler had a drastic reduction in their tobacco consumption.
Patients with the CBD inhaler smoked 40% less cigarettes compared to the test group that was using a placebo.

Research found that the reduction in stress and anxiety from CBD reduced cravings and the need to smoke. As well as having an oral fixation that removed memory
cues from cigarettes was a great advantage. Dropping the habit of being a daily or casual smoker is extremely difficult. Millions of people around the world are addicted
to smoking, and up to recent were romanticized in movies and culture. If you are looking to engage in healthier activities and drop tobacco from your life, a CBD
vaporizer may be your secret weapon. This should come without saying but a strong desire and active effort to quit is needed. Will power is what will get your through
the deep valleys, but it’s all worth it!

CBD OIL REMEDIX

Almost everyone has experienced acne at one time or another: it’s the most common skin condition in the country. And, while it is frequent during the high school
days, it can happen at any age, from babies to Baby Boomers, and appear in a variety of areas on the body.

Interestingly, acne is an umbrella term not limited to just pimples: blackheads, whiteheads, cysts, nodules, and papules all fall under the definition as well.
It’s caused when a pore on your skin becomes clogged with dead skin cells. Bacteria sometimes plays a role too, inflaming the skin until it’s red and swollen.

The surest way to get acne is to schedule a photography session: senior photos, wedding shots, birthdays pics – pimples have a way of appearing out of nowhere an
hour before the camera clicks. But, the true causes of acne include hormones, certain medications, and diet (most often those high in dairy and carbs). Stress doesn’t
technically cause it, but it does increase cortisol, a hormone that releases oil and makes skin more inviting, all but asking pimples to pop on over. While some people
believe acne-suffers must simply let it run its course, medical professionals disagree. If untreated, it causes scarring and dark spots. It even influences self-esteem
and plays a role in depression.

While you probably shouldn’t replace your dermatologist with Dr. Mary Jane, cannabis possesses a natural talent for skincare. In particular, the cannabinoid CBD
has proven to be effective against acne, challenging Clearasil in the race of the face. CBD acts on receptors that help reduce inflammation as well as anxiety
(thus reducing the hormones conducive to outbreaks). A study conducted by the Journal of Clinical Investigation and the National Institute on Health found that CBD also
offered antiproliferative effects (making it able to stop the spread of cells) and skin regenerating properties.

The study based its theory on the use of CBD on sebaceous glands (these glands secrete oily sebum, which obstructs pores). The experiment found that CBD acted as
a sebostatic agent, giving it the ability to reduce sebum and, in the process, acne. CBD decreases lipid sysnthesis and proliferation of human sebaceus glands.

Research conducted by the Federation of American Societies for Experimental Biology uncovered similar findings: cannabinoids are responsible for lipid products
and, ultimately, helping the skin regulate itself against dryness and blemishes.

What’s more, both studies found that the benefits of CBD might not be limited to Z-I-T. It may also possess anti-aging effects and treat more serious conditions
like dermatitis and psoriasis. CBD has been shown to inhibit the production of sebum. This is because the endocannabinoid system regulates sebaceous gland function.
Research indicates that CBD oil works to prevent and treat acne, whether ingested or applied as a topical treatment. CBD provides a treatment that has no major side
effects, and will not lessen your quality of life. It is safe to use, and has many other benefits as well.

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CBD reduces the growth of skincells playing a potential role in the treament of psoriasis.

What is psoriasis? Psoriasis is a chronic autoimmune disorderthat causes the rapid build-up of skin cells. The new skin cells are produced so quickly that they reach the surface of the
skin before they’re mature. This immature buildup on the surface of the skin forms itchy, raised patches of silvery scales. Parts of your body may also become inflamed,
and you may have redness, swelling, and discomfort.

About 15 percent of people who have psoriasis will develop psoriatic arthritis. This condition causes painful swelling and stiffness of the joints. If left
untreated, it can also lead to permanent joint damage.

How psoriasis affects your mental health?Pain, fatigue, and sleeplessness often occur with psoriasis. Psoriasis can also take a profound toll on your mental health. The National Psoriasis Foundation notes
that people with psoriasis are at an increased risk for depression, anxiety, and suicide. A 2010 study published in the Archives of Dermatology found that people living
with psoriasis have a 39 percent higher risk of being diagnosed with depression than those without the disease. They also have a 31 percent higher risk of being diagnosed
with anxiety.

Is cannabis a solution?Psoriasis isn’t curable and can be difficult to control. Although there are a variety of medications and light therapies for treating the disease, some have serious
side effects and others lose their effectiveness when your body builds up a resistance to them. Given the physical and emotional burden of psoriasis, new treatment
options are needed. Cannabis is one of the treatment possibilities being explored. Research into the effectiveness of cannabis addresses different aspects of the disease.

Slowing cell growthSome studies suggest cannabis may be useful in slowing the rapid growth of keratinocytes. These are the immature skin cells found in people with psoriasis. One study
suggests that cannabinoids and their receptors may help control and limit the production of immature skin cells. Researchers add that cannabis may be useful in treating
several conditions involving keratinocytes, including psoriasis and wound healing.

Controlling painMany people use marijuana to control pain. Cannabis may be more effective than opioids in controlling acute and neuropathic pain. It may also be useful in reducing
chronic pain, according to an article in Current Rheumatology. An article published in the Journal of the American Medical Association also suggests that marijuana may
be effective in treating pain.

Regulating the immune systemAlthough more research is needed, some studies indicate that cannabis reduces the severity of inflammation associated with some conditions, including autoimmune
disorders like psoriasis. An article published in the journal Pharmacologyindicates that cannabis can suppress the immune system. Most research has focused on forms of
cannabis that are taken by mouth. Cannabis is also available as oil. Some people use this oil topically to treat psoriasis, claiming that it controls the speed of skin
cell production and reduces inflammation. More research is needed to support these claims.

Treatment of stressPsoriasis and stress go hand in hand, and THC has been shown to relieve stress. However, researchers note that while low doses of THC can produce stress-relieving
effects, higher doses may actually have a negative effect on mood.

Cannabinoids hold the key Cannabinoids are active chemicals found in marijuana plants. Your body makes cannabinoids, too. These chemical messengers are called “endocannabinoids.”
They play a role in some functions in your body. Cannabis holds promise for treating the symptoms of psoriasis. It’s well-established that cannabis can be useful in
controlling pain. More research is needed to determine if it’s safe and effective, though. The manner in which cannabis is used also needs more testing. Cannabis can be
used in a variety of forms, including: pills, inhalants, vaporizers, tinctures.

Cannabis hasn’t been better studied because it’s a Schedule I substance under the United States Controlled Substances Act. Schedule I substances are considered to
have a high potential for abuse, have no accepted medical use, and may not be safe for use under medical supervision. These restrictions have posed a significant obstacle
to cannabis research. Still, state laws allowing the use of medical marijuana have encouraged more research and efforts to deregulate the drug.

Speak with your doctorShould you consider cannabis to treat your psoriasis? This depends on where you live. Some parts of the United States allow the use of cannabis to treat psoriasis.
Others allow people to use it to relieve pain. Speak with your doctor to see if it’s advisable for you to use cannabis, given your overall health and state laws.

CautionWhen CBD is combined with THC, it causes a temporary lack of drive. There is an impairment of reward learning and motivation.

SafetyHemp nuts sold for dietary consumption are within acceptable standards for the quantity of CBD and THC.
CBD is well tolerated, and safe at high doses, and with chronic use in humans.

Side EffectsCBD decreased the activity of T and B cells, which may increase the risk of HIV infection and worsen disease progression, tumor growth, and metastases, and exacerbate
asthma.
The oil also may decrease the activity of liver enzymes called cytochrome P450, responsible for metabolizing more than 60% of prescribed drugs.
CBD may also cause mild low blood pressure, dry mouth, lightheadedness, and sedation.