Objective To explore the therapeutic effect of combined therapy treating chronic schizophrenia and its influential factors.Methods 106 patients with chronic schizophrenia who met the criteria of Chinese Classification and Diagnostic Criteria of Mental Disorders 3 (CCMD-3) were randomly divided into study group (n=53,on the basis of assisted drug treatment,combined therapy given) and control group (n=53,on the basis of assisted drug treatment,occupation recreational therapy given). At prior treatment and post-treatment 3 month,Brief Psychiatric Rating Scale (BPRS),Nurses Observation Scale for Inpatient Evaluation (NOSIE),Scale of Social Function in Psychosis Inpatients (SSPI),Insight and Treatment Attitudes Questionnaires (ITAQ) and Scale to Assess Unawareness of Mental Disorder (SAUMD) were applied to comprehensively evaluating the therapeutic effect.Results There were significant differences in BPRS,NORS,SSPI,ITAQ and SAUMD grading score as well as score subtraction rates between before and after treatment. Multielement stepwise regression analysis showed that the score after treatment was negatively correltive to treatment frequency,while positively correlative to locomotor activity and treatment compliance.Conclusion Combined therapy is effective to amelioration of patients' symptoms,improvement of self-care ability and social adaptability,as well as insight recovery.