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What are dendrimers ??????• Dendrimer is a nanoparticle and has many advantagesover micro particles or others due to its small size, easyuptake by cells. (through endocytosis)• Dendrimers are branched macromolecules have a centralcore unit having a high degree of molecular uniformity,narrow molecular weight, distribution, specific size and shapecharacteristics, and a highly- functionalized, terminal surface.The manufacturing process is a series of repetitive stepsgenerating shells starting with a central initiator core.

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Dendrimers can be define three different regions: core, branchesand surface. They are an ideal scaffold to assemble a greatnumber of functional units in a volume of nanometric dimensionwith a precise control on the nature, position, and distance of thevarious groups. Moreover, thanks to their three-dimensional structure,they possess dynamic cavities in which small ions or molecules can behosted.

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Biocompatibility of DendrimersAccumulation of low MW dendrimers is not usually aproblem due to excretion in the urine or in feces after metabolism.Injected polymers of high MW are not easily execrated if they can notto be degrade or filtered via the kidney.To be useful in the biological system, Denderimer must beNon toxicNon immunogenicAble to stay in circulation for the time needed to have a clinical effectAble to cross bio barrier (i.e. intestine, blood tissue barrier, cell membrane)Able to target specific structures.