NHLBI’s Candidate-gene Association REsource (CARe) Study will support quite extensive genotyping in up to 50,000 participants from nine NHLBI-supported cohort studies (the CARe Cohorts). This project is expected to produce rapid scientific progress, rich opportunities for investigators, and great benefit to society.

Purpose of the CARe System

The purpose of the system is to enable the key objectives as stated in the Response to RFP HL-06-03/Genotyping in Large-scale Cohorts:

1. Receipt and management of DNA samples and associated phenotypic information from the large NHLBI cohorts

To summarize, the inputs to the system are DNA samples and associated clinical phenotypic information. The outputs will be a variety of analytic results from statistical and computational methods used to perform large-scale candidate gene association studies of phenotypes across multiple cohorts, whole-genome association studies, and tests for gene-gene and gene-environment interactions.