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LONDON — Milos Raonic’s preparations for Wimbledon received a setback when he lost to No. 698-ranked Thanasi Kokkinakis 7-6 (5), 7-6 (8) Tuesday in the first round of the Queen’s grass-court tournament.

The third-seeded Raonic, from Thornhill, Ont., was the runner-up at both Queen’s and Wimbledon in 2016, losing in the final to Andy Murray both times.

Kokkinakis trailed 6-3 in the second-set tiebreaker but won on his third match point with a backhand winner into the corner.

It was the first win over a top-10 opponent for the 21-year-old Australian, who has been ravaged by injury problems for the past 22 months. He only played one match in 2016 because of a shoulder problem, and has also missed most of this year because of injury.

“It’s everything. It’s huge for me,” Kokkinakis said. “I’ve been out for so long.”

Wimbledon starts on July 3.

Earlier, Andy Murray was handed a new opponent for his first-round match after Aljaz Bedene withdrew because of a wrist injury.

Murray will now play Jordan Thompson, an Australian player ranked No. 90. Thompson lost to Jeremy Chardy in qualifying on Sunday.

French player Julien Benneteau advanced to the last 16 by beating James Ward 6-2, 6-2.