Unique Properties

5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid tryptophan. Tryptophan is converted into 5-HTP, which in turn is converted into serotonin, an important neurotransmitter that is associated with the regulation of sleep, mood, appetite, aggression, temperature and sexual behavior.

Supplementation with 5-HTP is preferable to supplementing with L-tryptophan. 5-HTP is derived naturally from the seeds of the Griffonia plant, where L-tryptophan is produced synthetically or through bacterial fermentation. 5-HTP crosses into the brain more readily than L-tryptophan, as it is able to cross the blood-brain barrier without competing with other amino acids for uptake. Unlike L-tryptophan, 5-HTP cannot be shunted into niacin or protein production.

Supplementing with 5-HTP provides the advantage of bypassing the conversion of L-tryptophan into 5-HTP, eliminating possible obstacles in the synthesis of serotonin. This conversion process can be inhibited by many factors including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.

Oral 5-HTP is well-absorbed in the intestine without the need for a transporter and is not affected by the presence of other amino acids. As such, it may be taken with meals without reducing effectiveness.

Adequate levels of serotonin in the brain are related to a balanced emotional state. By regulating activity of certain excitatory hormones, including dopamine and noradrenaline, serotonin helps promote a sense of calmness and relaxation. In numerous studies, significant positive response was shown in individuals with negative mood status when supplementing with 50–300 mg 5-HTP daily.

Acting as a satiety signal in the brain, serotonin helps naturally regulate food intake. Studies support the role of 5-HTP in appetite and weight management. When used in higher doses (300 mg 3 times per day), 5-HTP has been shown to decrease food consumption and reduce weight.

As a precursor of melatonin, serotonin is involved in regulating sleep patterns and has a beneficial effect on sleep/wake cycles and sleep quality.

Research

Several small short-term studies have found that 5-HTP may be as effective as standard antidepressant drugs.(5,6) Since standard antidepressants are also used for insomnia and anxiety, 5-HTP has also been suggested as a treatment for those conditions.(7)

A randomized double-blind, placebo-controlled study was performed on 20 obese patients to investigate the effect 5-HTP would have on their eating habits. Significant weight loss was observed in those patients taking 5-HTP compared to placebo. A reduction in carbohydrate intake and a consistent presence of early satiety was also found.(1)

This product is free of ingredients derived from genetically modified organisms (GMOs).

Suggested Use

Take 1 -3 vegetarian capsules daily, in divided doses with or between meals, as a dietary supplement or as directed by a qualified health care professional.
To derive optimal benefits of 5-HTP, ensure adequate intake of Vitamin B6.

Warnings

5-HTP may intensify the effects of various antidepressant drugs. Do not use concurrently with SSRI medications, MAO inhibitors or other antidepressant medication unless under careful medical supervision. Not recommended for pregnant or nursing women. If you are taking any medications, consult your doctor before use. Discontinue use and consult doctor if any adverse reactions occur.