CEST-MRI
is increasingly evolving from brain to body applications. One of the known problems
in body imaging is the presence of strong lipid signals. Their influence on the
CEST signal is acknowledged but underexplored. The goal is to investigate the
effects of lipids on the Z-spectrum taking TE into account. We performed simulations
and verified the results in phantoms and in
vivo. We demonstrate
the mutual influence of fat fraction and TE on the Z-spectrum for gradient echo
based sequences. This study provides a systematic understanding of lipid
artifacts in CEST imaging and lays the foundations for their efficient removal.

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