The game is a single-player side-scrolling game where the player controls a Ghostbuster through various stages based on the film, making their way to the museum before time runs out. One level involves riding around in the hero's famous car and another level requires the player to control the Statue of Liberty, shooting fireballs. The player's Ghostbuster character is armed with an unlimited supply of slime that can be shot out of a cannon and ghost traps. The game was noted for been exceptionally hard to complete. Aside from the time limit and sudden death rule for the character, the levels in the game often moved to the left, thus forcing the player to make quick decisions. The final level was especially difficult, not the least of which because the player had to repeat the level four times before the game's final ending would appear.