Results: In study 1, olanzapine (vs.
haloperidol) therapy, better clinical outcome, lower BBMI, and
nonwhite race significantly affected weight gain. Effects of
increased appetite and male gender on weight gain were
significant for olanzapine but not for haloperidol. In study 2,
better clinical outcome, lower BBMI, and younger age
significantly affected weight gain. Increased appetite was more
frequent during olanzapine treatment than during haloperidol, but
not significantly different from risperidone. Significant
differences in effect on weight change were found between
olanzapine and haloperidol but not between olanzapine and
risperidone. No evidence was found that lower antipsychotic drug
doses were associated with lower weight gain.