Pseudacanthicus is a member of the Acanthicus clade. Species of the Acanthicus clade are distinguished from other Loricariidae species by the presence of (1) longitudinal rows of keels (pointed odontodes) along the body sides; (2) eight or more dorsal-fin rays (vs. six or seven in most other loricariids except Pterygoplichthys, Chaetostoma, Pogonopoma and Pseudancistrus pectegenitor); (3) seven to eight infraorbitals (vs. usually five or six); (4) five anal-fin branched rays (vs. usually four); and (5) presence of hypertrophied odontodes along the snout margin (vs. hypertrophied odontodes absent in other loricariids except Isbrueckerichthys and Pareiorhaphis, in Neoplecostominae; Panaque and Pseudancistrus and Neblinichthys, in Ancistrini; and most dimorphic males of Loricariinae). Within the Acanthicus group, Pseudacanthicus is distinguished by the presence of two small plates in the posterior area of the compound pterotic (vs. one median plate or plate absent), and by the presence of narrow premaxillae with a small number of elongate and curved teeth (except from Leporacanthicus).

Similar to both Pseudacanthicus leopardus and L273, it is not clear what this fish is or what it will look like when it gets a bit larger.

Proportionally sized pieces of bogwood (the fish does not appear to particularly like rockwork) are a good idea as are equally dimensioned pipes. Plants are just a nuisance to this fish and while not orally molested, they tend to be battered by the fishes movement.

The temptation with large tough Loricariids is to keep them with other large tough fish such as Oscars or other brutish characters. This actually works quite well with most omnivorous or mainly vegetarian plecos. Pseudacanthicus despite their defensive protection can be bullied by faster moving fish of similar size. They are carnivores and only eat vegetables when their preferred food is unavailable. The amount of waste produced depends on their diet but is considerably less than a Panaque or Pterygoplichthys of similar size.