This new trial involved 516 paramedics who, between October 2015 and May 2018, recruited 1149 participants (n=568 in the GTN group, n=581 in the sham group) to the study. There was no difference in primary (modified Rankin Scale) or secondary (death, serious adverse events) outcomes in participants with a final diagnosis of stroke or transient ischaemic attack comparing the GTN group versus the sham group.

The investigators found that early administration of GTN in the ambulance within 4 hours of stroke onset did not change outcomes in people with suspected stroke. The study was a major advance in stroke trials showing that it was feasible for UK paramedics to recruit, consent, randomise and treat patients with stroke in the prehospital setting.