This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

别名

AURA2

c COT

Cancer Osaka thyroid oncogene

CCOT

COT

COT proto oncogene serine/threonine protein kinase

EST

ESTF

Ewing sarcoma transformant

FLJ10486

M3K8_HUMAN

MAP3K 8

MAP3K8

MEKK8

Mitogen activated protein kinase kinase kinase 8

Mitogen-activated protein kinase kinase kinase 8

Proto oncogene cCot

Proto-oncogene c-Cot

Serine/threonine protein kinase cot

Serine/threonine-protein kinase cot

TPL 2

TPL-2

TPL2

Tumor progression locus 2

see all

功能

Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.

组织特异性

Expressed in several normal tissues and human tumor-derived cell lines.