fat necrosis necrosis in which fat is broken down into fatty acids and glycerol, usually occurring in subcutaneous tissue as a result of trauma.

liquefactive necrosis necrosis in which the necrotic material becomes softened and liquefied.

massive hepatic necrosis massive, usually fatal, necrosis of the liver, a rare complication of viral hepatitis (fulminant hepatitis) that may also result from exposure to hepatotoxins or from drug hypersensitivity.

subcutaneous fat necrosis of newborn a benign, self-limited disease affecting term newborns and young infants, characterized by circumscribed, indurated, nodular areas of fat necrosis. It is thought to be related to trauma on bony prominences during delivery, hypothermia, asphyxia, or maternal diabetes; it usually resolves spontaneously by 2 to 4 weeks with no scarring. Called also adiponecrosis neonatorum or subcutanea.

ne·cro·sis

(nĕ-krō'sis),

Pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changes are mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterations are nuclear: pyknosis, shrunken and abnormally dark basophilic staining; karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture, and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, and affected cells may merge, sometimes forming a focus of coarsely granular, amorphous, or hyaline material.

[G. nekrōsis, death, fr. nekroō, to make dead]

necrosis

/ne·cro·sis/ (nĕ-kro´sis) pl. necro´ses [Gr.] the morphological changes indicative of cell death caused by progressive enzymatic degradation; it may affect groups of cells or part of a structure or an organ.

aseptic necrosis necrosis without infection, usually in the head of the femur after traumatic hip dislocation.

central necrosis that affecting the central portion of an affected bone, cell, or lobule of the liver.

cheesy necrosis that in which the tissue is soft, dry, and cottage cheese–like; most often seen in tuberculosis and syphilis.

coagulation necrosis necrosis of a portion of some organ or tissue, with formation of fibrous infarcts, the protoplasm of the cells becoming fixed and opaque by coagulation of the protein elements, the cellular outline persisting for a long time.

colliquative necrosis that in which the necrotic material becomes softened and liquefied.

contraction band necrosis a cardiac lesion characterized by hypercontracted myofibrils and contraction bands and mitochondrial damage, caused by calcium influx into dying cells resulting in arrest of the cells in the contracted state.

fat necrosis that in which the neutral fats in adipose tissue are split into fatty acids and glycerol, usually affecting the pancreas and peripancreatic fat in acute hemorrhagic pancreatitis.

phosphorus necrosis necrosis of the jaw bone due to exposure to phosphorus.

postpartum pituitary necrosis necrosis of the pituitary during the postpartum period, often associated with shock and excessive uterine bleeding during delivery, and leading to variable patterns of hypopituitarism.

subcutaneous fat necrosis induration of the subcutaneous fat in newborn and young infants.

necrosis

Death of cells through injury or disease, especially in a localized area of a tissue or organ.

ne·crot′ic(-krŏt′ĭk) adj.

necrosis

[nekrō′sis]

Etymology: Gk, nekros + osis, condition

localized tissue death that occurs in groups of cells in response to disease or injury. In coagulation necrosis, blood clots block the flow of blood, causing tissue ischemia distal to the clot. In gangrenous necrosis, ischemia combined with bacterial action causes putrefaction to set in. See also gangrene.

Tissue necrosis

necrosis

Cell or tissue death due to disease, trauma, hypoxia, radiation, acute infection, etc.; the constellation of changes that accompany and follow irreversible cell injury in living organisms.

ne·cro·sis

, pl. necroses (nĕ-krō'sis, -sēz)

Pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage; earliest irreversible changes are mitochondrial, consisting of swelling and granular calcium deposits seen by electron microscopy; most frequent visible alterations are nuclear pyknosis and abnormally dark basophilic staining; karyolysis, swelling and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. After such changes, the outlines of individual cells are indistinct, and affected cells may become merged, sometimes forming a focus of coarsely granular, amorphous, or hyaline material.

[G. nekrōsis, death, fr. nekroō, to make dead]

necrosis

(ne-kro'sis) ('sez?) plural.necroses [Gr. nekrosis, (state of) death]

NECROSIS: Necrotic wound of the foot

The death of cells, tissues, or organs. Necrosis may be caused by insufficient blood supply, pathogenic microorganisms, physical agents such as trauma or radiant energy (electricity, infrared, ultraviolet, roentgen, and radium rays), and chemical agents acting locally, acting internally after absorption, or placed into the wrong tissue. Some medicines cause necrosis if injected into the tissues rather than the vein, and some, such as iron dextran, cause necrosis if injected into areas other than deep muscle or vein. See: illustration; gangrene; mortificationnecrotizing (nek'ro-tiz?ing), adjective

thrombotic necrosis

total necrosis

Zenker necrosis

necrosis

The structural changes, such as those of GANGRENE, that follow death of a body tissue. The most obvious changes are in the cell nuclei which become shrunken and condensed (pyknosis) and no longer take a basic stain. Cell CYTOPLASM becomes more homogeneous and spaces (vacuoles) develop.

necrosis

the localized death of plant and animal tissue, such as the response of a leaf to invasion by a pathogen. An affected area is described as being ‘necrotic’. see DIPHTHERIA.

Necrosis

The death of cells, a portion of tissue, or a portion of an organ due to permanent damage of some sort, such as a lack of oxygen supply to the tissues.

necrosis

necrosis (n·krōˑ·sis),

n tissue death due to disease or localized injury.

necrosis

Death of some or all cells in an organ or tissue. The process involves swelling of the nucleus (pyknosis), fragmentation of the nucleus (karyorrhexis) and complete dissolution of the nuclear chromatin (karyolysis). Necrosis is caused by disease, trauma or interference with blood supply. There are many sequelae to ocular necrosis (e.g. inflammation, reduction in aqueous humour production following ciliary epithelium necrosis, corneal opacity following necrosis of corneal epithelial cells, and visual loss and floaters following retinal necrosis). Seeapoptosis; retinal necrosis.

ne·cro·sis

, pl. necroses (nĕ-krō'sis, -sēz)

Pathologic death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage.

[G. nekrōsis, death, fr. nekroō, to make dead]

necrosis (nekrō´sis),

n1. the death of a cell or group of cells in contact with living tissue. n2. the local death of cells resulting from, e.g., loss of blood supply, bacterial toxins, or physical or chemical agents.

necrosis, avascular

n the consequence of temporary or permanent cessation of blood flow to the bones. The absence of blood causes the bone tissue to die, resulting in fracture or collapse of the entire bone.

necrosis, caseous

n a change commonly associated with tuberculosis and characterized by dry, soft, and cheesy tissue.

necrosis, exanthematous

n an acute necrotizing process involving the gingivae, jawbones, and contiguous soft tissues. It is of unknown cause, primarily affects children, and resembles noma. It differs from noma, however, in that it has a slight odor, tendency for self-limitation, low mortality rate, and normal leukocyte count. See also noma.

necrosis, gingival,

n death and degeneration of the cells and other structural elements of the gingivae (e.g., necrotizing ulcerative gingivitis).

necrosis, interdental,

n a progressive disease that destroys the tissue of the papillae and creates interdental craters. Advanced interdental necrosis leads to a loss of periodontal attachment.

necrosis, ischemic,

n death and disintegration of a tissue resulting from interference with its blood supply, thus depriving the tissues of access to substances necessary for metabolic sustenance. It may occur in the periodontal ligament as a result of occlusal trauma.

necrosis of epithelial attachment,

n the death of cells composing the epithelial attachment. In a specific periodontitis produced by organisms similar to Actinomyces, necrosis of the epithelial attachment may exist, permitting a rapid apical shift of the base of the pocket.

necrosis, periodontal ligament,

n necrosis of a portion of the periodontal ligament, usually resulting from traumatic injury (e.g., in occlusal traumatism). Much of this necrotic change is the result of ischemia.

necrosis

necrosis in which the tissue is soft, dry and cheesy, occurring typically in tuberculosis.

central necrosis

necrosis affecting the central portion of an affected bone, cell or lobule of the liver.

cheesy necrosis

that in which the tissue resembles cottage cheese; most often seen in tuberculosis.

coagulation necrosis

death of cells, the protoplasm of the cells becoming fixed and opaque by coagulation of the protein elements, the cellular outline persisting for a long time.

colliquative necrosis

see liquefactive necrosis (below).

liquefactive necrosis

necrosis in which the necrotic material becomes softened and liquefied.

moist necrosis

necrosis in which the dead tissue is wet and soft.

Zenker's necrosis

hyaline degeneration and necrosis of striated muscle; called also Zenker's degeneration.

Patient discussion about necrosis

Q. can necrosis in a brain tumor kill you? If so, how? husband has glioblastoma.Tumor seems under control at this point as much as they can tell but sounds like there is a lot of necrosis. He has lots of tumor progression symptoms but since he has had the tumor for so long == 6 years = I guess the necrosis is there moreso than the actual tumor == how dangerous can this be?

A. Tumors and not only in the brain tend to develop necrosis the longer they exist because the tumor cells divide so rapidly so the blood supply can't keep up with its' own cells demands, so some cells within the tumor die (therefore are seen as necrotic). This does not usually predict prognosis, but only means that the tumor is longstanding.

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