Mathematical modeling is a relatively new but fast developing area of substance use field providing researchers with additional dynamical dimension in epidemiological work and allowing scientists to simulate the consequences of various intervention and prevention scenarios. We illustrate these concepts by presenting two models. The first model describes Injecting Drug Users (IDU) networks, injecting behavior and HIV/HCV spread among the networks. The size, structure of the networks as well as frequency of injecting and HIV risks were obtained from published literature on urban IDU networks. This individual-based model was used to investigate the impact of introduction of Integral-cannula syringes (ICS) instead of commonly used Detachable Needle syringes (DNS).

This paper may be considered as a practical reference for those who wish to add (now sufficiently matured) Agent Based modeling to their analysis toolkit and may or may not have some System Dynamics or Discrete Event modeling background. We focus on systems that contain large numbers of active objects (people, business units, animals, vehicles, or even things like projects, stocks, products, etc. that have timing, event ordering or other kind of individual behavior associated with them). We compare the three major paradigms in simulation modeling: System Dynamics, Discrete Event and Agent Based Modeling with respect to how they approach such systems. We show in detail how an Agent Based model can be built from an existing System Dynamics or a Discrete Event model and then show how easily it can be further enhanced to capture much more complicated behavior, dependencies and interactions thus providing for deeper insight in the system being modeled.

The creation of IT simulation models for uses such as capacity planning and optimization is becoming more and more widespread. Traditionally, the creation of such models required deep modeling and/or programming expertise, thus severely limiting their extensive use. Moreover, many modern intelligent tools now require simulation models in order to carry out their function. For these tools to be widely deployable, the derivation of simulation models must be made possible without requiring excessive technical knowledge.

This paper explores the problem of fragmenting social networks enabled by spatial distancing between distinct socioeconomic classes. Such fragmentation is evidenced by the experience of urban sprawl without population growth. We develop a prototype model to examine the spatial dynamics of social network evolution in the face of neighborhood migration. This model draws upon the small world analogy by using an initial template of connections that are “rewired” over time. Spatially, connections are established for neighborhood proximity. Socially, connections are added based upon similarity of economic class.

This paper presents a hybrid simulation model for the management of an eye condition called age-related macular degeneration, which particularly affects the elderly. The model represents not only the detailed clinical progression of disease in an individual, but also the organization of the hospital clinic in which patients with this condition are treated and the wider environment in which these patients live (and their social care needs, if any, are met). The model permits a ‘whole system’ societal view which captures the interactions between the health and social care systems

The share of renewable energy sources in energy production is growing steadily. Domestic homes can be equipped with solar panels, micro combined heat and power systems, batteries, and they can become adaptive consumers. They can also deliver energy to the grid and react to the energy supply. This paper presents a hybrid simulation approach for the analysis of a grid of domestic homes equipped with different technological options with respect to efficiency and costs. For energy storage and energy flows the system dynamics modeling paradigm is used whereas control decisions are modeled as statecharts. The highly intermittent solar irradiation and also the electric power and heat demands are implemented as stochastic models. The component-based design allows for quick creation of new case studies. As examples, different homes with batteries, micro combined heat and power systems, or energy carrier carbazole as energy storage are analyzed

Product complexity in the aerospace industry has grown fast while design procedures and techniques did not keep pace. Product life cycle implications are largely neglected during the early design phase. Also, aerospace designers fail to optimize products for the intended operational environment. This study shows how a design, simulated within its anticipated operational environment, can inform about critical design parameters, thereby creating a more targeted design improving the chance of commercial success. An agent-based operational simulation for civil Unmanned Aerial Vehicles conducting maritime Search-andRescue missions is used to design and optimize aircrafts. Agent interactions with their environment over the product life-cycle are shown to lead to unexpected model outputs. Unique insights into the optimal design are gained by analysis of the operational performance of the aircraft within its simulated environment

Due to the ageing of the world population, the demand for technology innovations in healthcare is growing rapidly. All stakeholders (e.g., patients, healthcare providers and health industry) can take profit of innovative products, but the development degenerates often into a time consuming and cost-intensive process. Prospective Health Technology Assessment (ProHTA) is a new approach that combines the knowledge of an interdisciplinary team and uses simulation techniques to indicate the effects of new innovations early before the expensive and risky development phase begins. In this paper, we describe an approach with loosely coupled system dynamics and agent-based models within a hybrid simulation environment for ProHTA as well as a use-case scenario with an innovative stroke technology

Computer simulation is a way to imitate business processes based on reality. Due to the fact that the environment in hospitals is highly dynamic with local autonomy of stakeholders participating in the business processes, we found an agent–based modeling and simulation (ABMS) approach to be most suitable and it is therefore applied in this context. From an inception to a running simulation, followed by an analysis of the output, we need to keep in mind our user’s physical problem as well as their capability of digesting the results. An interface between a computer modeler/programmer’s deliverable and a user like a hospital manager who learns from the simulated behavior of physical reality, is a visualization tool. We call this tool a “Learning Cockpit” (LC). Although a manager has experience in managing their business and they use personal qualities to positively drive their organization in challenging business environments, a simulation provides them additional support in decision process. With the help of simulation, they should be able to clearly and concisely grasp the information about the current operations, the resources involved and the inherent costs to get an output. They should be able to measure the performance of the current setup, and if necessary, make some changes and bring more value to the organization