Human Genome Project

About the Project

The Human Genome Project (HGP) is an international effort to sequence and annotate the entire estimated 3.3 billion bases of the human genome. The project was conceived in the mid-80s, and it began in 1990.

The first HGP effort at the BCM-HGSC was completed in 2006, with chromosomes 3, 12 and 30 Mb of X (~10% of the genome). We performed manual annotation and analysis according to Human Annotation Workshop (HAWK) standards, adding hundreds of gene models to those produced by Ensembl analysis. These annotations are available through Vega (see below). Following further analysis the results were published. We used chromosome 12 for our work in the HapMap Project, in expression studies via NimbleGen oligo arrays, and in development of novel genetic analysis tools with Dr. John Belmont. The sequence data and annotations can be viewed with Genboree.