Mutation details: This transgene consists of a 1.1-kb fragment of the mouse Msx2 gene containing 0.3 kb of the 3.5-kb intron and a PCR-mutagenized version of the second exon bearing the Pro7His mutation under the control of the Timp1 promoter. This single base pair mutation is seen in individuals affected with Boston-type craniosynostosis.
(J:26513)