FROM the opening on-screen affair to the final tortured scenes, Brad and Angelina’s romance was always pure Hollywood.

The sexual tension between the two on the set of the 2005 movie Mr and Mrs Smith blew the cover on their relationship — and shocked the world that Brad Pitt could cheat on perfect wife Jennifer Aniston.

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Brad and Angelina's sexual tension in Mr and Mrs Smith blew the lid on their affair

But Brad’s passion for the dangerously sexy Angelina Jolie was strong enough for him to risk the wrath of Friends fans.

Asked later why Mr and Mrs Smith had become his favourite film, Brad gushed: “Because I fell in love.”

It was the dagger in Jennifer’s heart. The same one which has been pulled out and used again on Angelina.

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Angelina said she 'couldn't wait to get to work' filming Mr and Mrs Smith as she so enjoyed spending time with Brad

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Brad was surprisingly open about the fact the romance had started while he was still married to Jen, sparking one of showbiz's most bitter feuds

The romance was revealed fully in April 2005, before the Pitt/Aniston divorce was even finalised, when Brad and Ange were pictured on holiday in Kenya with her adopted son Maddox.

With one photo, the world’s suspicions were confirmed – and Brangelina was born.

Jennifer was left heartbroken as the images were splashed across newspapers and websites across the world.

An ill-timed magazine photoshoot in July 2005, entitled Domestic Bliss, which depicted Brad and Angelina as a couple with children, did not help matters.

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The pair were depicted as a couple with children long before they became one

One of the biggest showbiz spats in history ensued, with Jennifer publicly lashing out at the couple for their insensitive behaviour.

She said: “The world was shocked, and I was shocked.

“I’d be a robot if I said I didn’t feel moments of anger, of hurt, of embarrassment.

“Am I lonely? Yes. Am I upset? Yes. Do I have my days when I’ve thrown a little pity party for myself? Absolutely.

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The on-set affair caused Brad to split from then-wife Jennifer Aniston, saying he had fallen in love filming Mr and Mrs Smith

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Jen was devastated at the news as the couple paraded their new romance in the press with no concern for her broken heart

Jen was confronted with streams of pics of the new couple together, leading the public to take sides - but she now says, 'What doesn't kill you makes you stronger'

That October Brad’s divorce was finalised, leaving him free to press ahead with Angelina – though they had yet to officially comment on it.

Angelina eventually acknowledged it in January 2006, along with some more news – she was pregnant with his child.

This was far more than just a fleeting celebrity affair – it was the start of a family.

Brad applied formally to adopt Angelina’s kids Maddox and Zahara before she gave birth to their first biological child, Shiloh, in Namibia in May 2006.

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Brad made their commitment official by adopting Angelina's children Maddox and Zahara

Gradually, more details of their relationship began to emerge.

In December that year Angelina spoke for the first time about their chemistry on Mr and Mrs Smith.

She recalled: “Because of the film, we ended up being brought together to do all these crazy things.

“And I think we found this strange friendship and partnership that kind of just suddenly happened.

“I think that a few months in I realised, ‘God, I can’t wait to get to work’.”

Her words sparked a furious reaction from Jennifer, who said: “That stuff about how she couldn’t wait to get to work every day? That was really uncool.”

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Angelina said the film Mr and Mrs Smith had brought them together and that the relationship's development was very sudden for both of them

The Brangelina brood then began to swell further.

The couple adopted another child, Pax, from a Vietnamese orphanage in 2007, before welcoming twins Knox Leon and Vivienne Marcheline the following year.

Angelina Jolie statement on filing for divorce from Brad Pitt

Meanwhile, Jennifer was fighting off claims that her marriage with Brad fell apart because she did not want children.

The actress, who is now married to actor Justin Theroux but is not yet a mum, said: “A man divorcing would never be accused of choosing career over children.

“I’ve never in my life said I didn’t want to have children. I did and I do and I will!”

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After the divorce Jen, who is now married to Justin Theroux, was plagued by rumours Brad had ditched her because she didn't want children

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Meanwhile Brangelina accumulated a huge brood of kids, both adopted and biological

The hammer blow then fell on Jennifer as the adultery rumours were all but confirmed.

Despite always denying infidelity, both Brad and Angelina admitted in 2008 their romance began while he was still married to Jennifer.

Asked why Mr and Mrs Smith was his favourite film, it was the moment Brad replied: “Because I fell in love.”

And Angelina, talking about her children seeing the film, added: “Not a lot of people get to see a movie where their parents fell in love.”

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Angelina has spoken very fondly of Mr and Mrs Smith, in which the couple even get married, as her children will be able to watch the film and see their parents fall in love

Of course, the Hollywood couple were no strangers to high-profile, showbiz relationships.

The Tomb Raider actress was married to British film star Jonny Lee Miller for three years before they divorced in 1999.

One year later she married actor Billy Bob Thornton in Las Vegas, having dated him for just two months.
They divorced in 2003.

Brad Pitt and Angelina Jolie in trailer for Mr. &amp; Mrs. Smith

Meanwhile, heart-throb Brad enjoyed a string of flings — often with his famous co-stars.

Exes included actresses Robin Given, Jill Schoelen and Juliette Lewis, as well as British pop star Sinitta. In 1994 he started dating Gwyneth Paltrow when they played husband and wife on the set of thriller Seven.

They were briefly engaged before calling things off in 1997.

But despite his womanising past, Brad certainly seemed set on ­Angelina — and the couple finally married in 2012 at their £40million estate in Chateau Miraval in the South of France.

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Brad had always been a womaniser enjoying flings with his famous co-stars - notably including Gwyneth Paltrow

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Angelina married actor Billy Bob Thornton in Las Vegas after dating him for just two months, but the pair divorced in 2003

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She was also married to Jonny Lee Miller during the 1990's, but Brad was her most significant relationship

However, their seemingly fairytale relationship was also blighted with trauma.

A year later Angelina announced she had a secret double mastectomy after discovering she was at high risk of breast and ovarian cancers.

Brad said at the time: “I’m quite emotional about it, of course. She could have stayed absolutely private about it.

“It was really important to her to share the story and that others would understand it doesn’t have to be a scary thing.

“In fact, it can be an empowering thing, and something that makes you stronger and us stronger.”

Last year Brad was by Angelina’s hospital bedside again as she had her ovaries removed over another cancer scare, ruling out the chance of more children.

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Multiple cancer scares have tested Brangelina's relationship, leading her to have a double mastectomy and a hysterectomy with Brad by her side

She admitted: “If we had married and were just starting a relationship it would have been a disaster.

“But because we’ve been together so long we wanted to see how far we could push our relationship and our love and see if we can work together under very intense circumstances and with very complex issues and see if it would make us better.

“It was our way of testing ourselves. I don’t think we want to go through it again though.”