INTEGRATIVE MEDICINE FOR MOOD AND ANXIETY DISORDERS - PART 2

INTEGRATIVE MEDICINE FOR MOOD AND ANXIETY DISORDERS - PART 2

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JAMES GREENBLATT, MD

The monoamine hypotheses about psychiatry and associated treatments have revealed their limitations, and it is time to explore what the literature has been supporting for two decades: the inflammatory model of mental illness and the relevance of psychoneuroimmunology to a systems-based approach in the treatment of patients with syndromal depression. The role of cytokines and the immune system in depression is well-established as is the relationship between gut microbiota, intestinal integrity, and the brain. Exploring the gut-immune-brain connection, we must also consider the mediating role of the endocrine system. Lifestyle interventions around gut, immune, and anti-inflammatory influences will be explored, as will epigenetic modulators such as probiotics, methyl donors, and therapeutic foods.