The indigenous peoples of the Americas are the pre-Columbian inhabitants of the Americas, their descendants, and many ethnic groups who identify with those peoples. They are often also referred to as Native Americans, First Nations and by Christopher Columbus' historical mistake Indians, modernly disambiguated as the American Indian race, American Indians, Amerindians, Amerinds or Red Indians. It's now considered racially insensitiveto call this race "Red Indians".

According to the still-debated New World migration model, a migration of humans from Eurasia to the Americas took place via Beringia, a land bridge which formerly connected the two continents across what is now the Bering Strait. These early Paleoamericans soon spread throughout the Americas, diversifying into many hundreds of culturally distinct nations and tribes. According to the oral histories of many of the indigenous peoples of the Americas, they have been living there since their genesis, described by a wide range of traditional creation accounts.

Application of the term "Indian" originated with Christopher Columbus, who thought that he hadreached India (his original destination). This served to imagine a kind of racial or cultural unity for the aboriginal peoples of the Americas. Once created, the unified "Indian" was codified in law, religion, and politics. The unitary idea of "Indians" was not originally shared by indigenous peoples, but many now embrace the identity.

While some indigenous peoples of the Americas were historically hunter-gatherers, many practiced aquaculture and agriculture. The impact of their agricultural endowment to the world is a testament to their time and work in reshaping, taming, and cultivating the flora indigenous to the Americas. Some societies depended heavily on agriculture while others practiced a mix of farming, hunting, and gathering. In some regions the indigenous peoples created monumental architecture, large-scale organized cities, chiefdoms, states, and massive empires.