The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome-diabetes population

The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome-diabetes population - Download this document for free, or read online. Document in PDF available to download.

Lipids in Health and Disease

, 13:196

First Online: 16 December 2014Received: 29 August 2014Accepted: 11 December 2014

Abstract

BackgroundIngestion of polyunsaturated fatty acids PUFAs has been proposed to influence several chronic diseases including coronary heart disease CHD and type-2 diabetes T2D. There is strong evidence that omega-3 n-3 PUFAs provide protection against CHD and biomarkers of atherosclerosis. In contrast, there is more limited and inconsistent data for T2D. Few studies have examined the impact of n-3 PUFA-containing botanical oils on T2D.

MethodsFifty-nine subjects with early-stageT2D or metabolic syndrome participated in an 8-week, randomized, single-blind, parallel intervention study and were provided PUFA-containing oils. Individuals received either corn oil CO, a botanical oil BO combination borage Borago officinalis L.-echium oil Echium plantagineum L. or fish oil FO. The BO combination was enriched in alpha-linolenic, gamma-linolenic, and stearidonic acids and the FO in eicosapentaenoic and docosahexaenoic acids. Serum fatty acids and other serum lipidstriglycerides and total, HDL and LDL cholesterol, as well as markers of inflammation leptin, and C-reactive protein and glucose regulation glucose and hemoglobin A1c were assessed from fasting participants at baseline and after the intervention.

ResultsCompliance was verified by expected increases in specific PUFAs in each of the three oil arms. Participants in the CO group showed no differences in serum lipids, markers of inflammation or glucose regulation between pre- and post-treatment measures. Supplementation with BO significantly lowered total and LDL cholesterol levels and FO reduced serum triglycerides, hemoglobin A1c and increased HDL-cholesterol.

* Images in this website could be protected under copyright laws. They are picked automatically from bing.Please use the contact form to claim a copyright infriction and the item will be removed immediatelly.