hypermutation

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

n. Frequent mutation

n. The organism or gene that results from such a mutation

Etymologies

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Examples

The same thing goes for the immune system (progressive improvement of binding), but somatic hypermutation is an informationally-driven process, with selection (and, in the case of SMH, it is an artificial selection) accounting for only a small part of the innovation.

When such patients were treated with Temodar and subsequently had a recurrence of the tumor, it was very likely to become resistant to treatment because of "hypermutation" -- an increased rate of gene changes that led to the tumor's ability to evade the drugs.

It is thus not inconceivable that some of the sequences in the proposed Universal Genome in the Origin of Metazoa might have no immediate effect on fitness, but still have a function by acting as a reservoir of genetic material on which variation inducing mechanisms such as sequence duplication, somatic hypermutation, gene conversion and homologous recombination can act upon during periods of selection.

It might tell us what its direct evolutionary history is, maybe allow us to distinguish genetic 'borrowings' [HGT] from duplication-hypermutation from top-down organization of trans-retrotrans pieces-parts.

The research findings still generate a lot of ink, but so far no researcher has empirically established via pre or post-selection genome sequencing of individual cells in the experimental population that triggered hypermutation occurs in ALL genes.

Mutagenesis research efforts, including novel techniques such as somatic hypermutation, are continuing in the search for yellow, orange, red, and deep red fluorescent protein variants that further reduce the tendency of these potentially efficacious biological probes to self-associate while simultaneously pushing emission maxima towards longer wavelengths.