HHMI researchers have determined the three-dimensional structure of a protein-RNA complex that shepherds the production of infectious copies of HIV. The structure is a promising target for new antiviral drugs. Article published in the January 16, 1998 issue of Science.

Researchers suspect that a combination of genes and environment determine one's susceptibility to allergic conditions. Hughes researchers and colleagues at Washington University have identified a mutant protein that may cause hypersensitivity to common allergens.

Benjamin Doranz, an HHMI predoctoral fellow, is helping to devise a gene therapy technique that could destroy the hidden, latent reservoir of HIV-infected cells that escape drug therapy. Article published in the November 21 issue of Science.