Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Recombinant Human Interleukin-1 receptor-like 2 is produced by our Mammalian expression system and the target gene encoding Asp20-Tyr337 is expressed with a 6His tag at the C-terminus.

Region:

Asp20-Tyr337

AA Sequence:

DGCKDIFMKN

EILSASQPFA

FNCTFPPITS

GEVSVTWYKN

SSKIPVSKII

QSRIHQDETW

ILFLPMEWGD

SGVYQCVIKG

RDSCHRIHVN

LTVFEKHWCD

TSIGGLPNLS

DEYKQILHLG

KDDSLTCHLH

FPKSCVLGPI

KWYKDCNEIK

GERFTVLETR

LLVSNVSAED

RGNYACQAIL

THSGKQYEVL

NGITVSITER

AGYGGSVPKI

IYPKNHSIEV

QLGTTLIVDC

NVTDTKDNTN

LRCWRVNNTL

VDDYYDESKR

IREGVETHVS

FREHNLYTVN

ITFLEVKMED

YGLPFMCHAG

VSTAYIILQL

PAPDFRAYHH

HHHH

Expression System:

Human Cells

Source Species:

Human

Tag:

6His,C-terminus

Purification:

Greater than 95% by SDS-PAGE

Bio-Activity:

Not Tested

Endotoxin:

Less than 1.0 EU/µg protein (determined by LAL method).

Presentation:

Lyophilized from 0.2 µm filtered PBS, pH 7.4.

Storage:

Lyophilized protein should be stored at less than -20°C. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at less than -20°C for 3 months.

Description: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system.