Journal: Journal of Pharmacy Research

Article Id:JPRS-PCS-0000373Title:Design, development and In vitro characterization of Felodipine Mucoadhesive buccal tabletsCategory:Pharmaceutics

Abstract

Audio Abstract

Authors

Pdf File

Citation

My Reference

Methodology

Abstract

In recent years, there has been a growing interest in the use of delivery of therapeutic agent through various transmucosal routes to provide a therapeutic amount of drug to the proper site in body. The objective of this investigation was to develop and evaluate felodipine mucoadhesive buccal tablets using mucoadhesive polymers like HPMC K4M, SCMC and Carbopol 934P. The buccal tablets prepared by direct compression method. Pre and post compression parameters were found to be within specified limits. The tablets were evaluated for weight variation, drug content, hardness, friability, permeation studies and In vitro residence time. FTIR studies indicate that there is no interaction between drug and polymers. The result of permeation of drug indicates that the formulation- F5 showed maximum drug permeation up to 12 h and maximum in vitro residence time. The result indicates that felodipine mucoadhesive buccal tablets may be good choice to bypass hepatic first pass metabolism with an improvement in the bioavailability through buccal mucosa.