A Morbidity and Mortality Weekly Report was presented which reviewed the mode and risk of tuberculosis transmission in health care settings. Recommendations were also provided for reducing the risk of transmission to persons in health care settings such as workers, visitors, patients, and volunteers. The report discussed general principles of tuberculosis control in the health care setting including means of preventing the generation of infectious droplet nuclei, decontamination methods, recommendations for early identification and preventive treatment of persons who have tuberculosis infection and are at high risk for active tuberculosis, ventilation systems, precautions for specific procedures, and precautions for specific settings such as hospitals and other inpatient facilities, ambulatory care facilities, emergency medical services, and home health services.