Findings from a clinical trial comparing Victoza(R) (liraglutide 1.8 mg) and sitagliptin (100 mg), both in combination with metformin, demonstrated that switching from sitagliptin to Victoza(R) provided superior HbA1c reductions vs continuing with sitagliptin treatment in adults with type 2 diabetes. Results from the LIRA-SWITCH trial were presented at the Endocrine Society's 98th Annual Meeting and Expo (ENDO 2016) in Boston, MA, US.[1]

The 26-week LIRA-SWITCH trial assessed the efficacy and safety of Victoza(R) as an add-on to metformin in 407 adults with type 2 diabetes who switched from sitagliptin.[1] Of the 407 adults uncontrolled on sitagliptin (HbA1c 7.5-9.5%) at week 26, those who switched to Victoza(R) (n=203) achieved a superior reduction in HbA1c vs those who continued their sitagliptin treatment (n=204) (-1.14% vs -0.54%; estimated treatment difference [ETD] -0.61%, 95% confidence interval [CI]: -0.82 to -0.40, p