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Improvements over the original Pixhawk :

Smaller, a third of the size.Rev 3 processor for long term software support.Improved sensors, both primary and secondary IMU MPU9250 and ICM20608 for more reliable flight.Included GPS module uBlox M8N GPS/GLONASS/BeiDou receiver for faster and stronger GPS lock.Micro JST rather than the hard-to-use DF13 connectors.Integrated piezo speaker and safety switch.Natively supports 4S batteries with the included PDB.