The president said that Mills was the lead voice for promoting the administration’s stance on entrepreneurship, and played a key role in the passage of the 2010 Small Business Jobs Act.

“Over the last four years, Karen has made it easier for small businesses to interact with the federal government by reducing paperwork and cutting through red tape,” he said in a statement released on Monday.

Politico reported on Monday that Heather Higginbottom, the deputy director of the Office of Management and Budget, was leaving the agency to join the State Department as the counselor to Secretary of State John Kerry. Current acting OMB Director Jeff Zients also is expected to leave the agency and is currently the frontrunner for the U.S Trade Representative job, meaning that Obama will need to fill two positions at the top of his budget office.

And on Friday, U.S Customs and Border Protection leader David Aguilar announced his resignation after 30 years of service with the agency. He had served as the agency’s deputy commissioner since 2010, and was the interim commissioner after the retirement of Alan Bersin in December 2011. The Associated Press said that Homeland Security Secretary Janet Napolitano had not announced a replacement to lead the 60,000-person bureau as of Friday.