But beyond its young star, a number of famous actors also started their journey to fame and fortune with bit parts on the series. To celebrate this week's 25th anniversary of the Family Ties finale (the curtain call of which you can watch above), let's revisit some of the series' most significant cameos.

While Philip Seymour Hoffman's tragic death is the most recent to make headlines, heroin claimed the lives of many beloved artists, including Cory Monteith, Janis Joplin, River Phoenix and Chris Farley.

Other stars – from Angelina Jolie and Nicole Richie to Samuel L. Jackson – have admitted to dabbling if not struggling with the drug. And many have offered chilling personal accounts of their heroin use.

Here are six celebrities who have shared their experiences with the dangerous drug over the years:

If you have nothing nice to say … say it in print? It's probably not the best way to air your grievances, but it seems to be the motto among celebrities penning memoirs of late.

On Friday, word leaked of Tori Spelling's dis at Katie Holmes in her forthcoming book Spelling It Like It Is, in which she describes the former Mrs. Cruise as "plastic."

"As I sat waiting outside his music room, I heard his prior appointment working with him in the other room. It was some actress singing horribly off-key," Spelling writes of bumping into Holmes during a visit to her vocal coach. "I heard him say good-bye and then the actress walked out of the room. It was Katie Holmes."

Despite the history of former child stars having trouble transitioning into adulthood – as evidenced by Britney Spears's public meltdown in 2008, Lindsay Lohan's ongoing troubles, and, most recently, the upheavals taking place in the life of Amanda Bynes – former child star Mara Wilson said she "had a generally good experience" standing before the cameras in Mrs. Doubtfire (1993), Miracle on 34th Street (1994) and Matilda (1996).

She also clearly developed a pro's perspective on what can happen as a child star matures – because she's now shared her thoughts in a breezy yet thoughtful essay on the Cracked.com humor site, titled "7 Reasons Child Stars Go Crazy."

In it, the 25-year-old gets a handle on why "not many child stars make it out of Hollywood alive or sane." She also sheds light on why "at any given time there are at least three former ones having very public breakdowns."

Corey Feldman, who starred in the 1985 Warner Bros. box-office hit as Mouth, says that the original cast and crew, including executive producer and story writer Steven Spielberg, want to reunite on the big screen for part two.

"We [would] all like to see it happen," Feldman, 39, told the Hollywood Reporter, also admitting there are "stumbling blocks … no matter how much love there is."

As the '80s cult favorite The Goonies marks its quarter-century milestone, adoration for its misfit gang of treasure-hunting teens – including the not-yet-famous Josh Brolin and Sean Astin – is still alive and well.

This weekend, thousands of fans are due to converge upon the waterfront city of Astoria, Ore., where the 1985 film was set and shot, to celebrate all things Goonies. Among the "Come Join the Adventure" events are a tribute concert (performers include cast member Corey Feldman's band, Truth Movement) and a Truffle Shuffle 5k Run/Walk.

Can't make it to Astoria? Well, here are five fun facts about The Goonies – whose anniversary collector's edition is due on DVD and Blu-ray Nov. 2 – 25 years later.