The anterior cingulate cortex (ACC) has been implicated
in the pathophysiology of borderline personality disorder (BPD). Several
studies have reported anatomical and functional abnormalities in this region in
BPD patients. To date only one other study, however, has evaluated the ACC with
1H MRS in BPD patients. In this study we aimed to determine the
absolute concentrations of the metabolites in the ACC of 20 unmedicated female
patients with BPD and 22 healthy controls. We found a significant decrease of
N-acetylaspartate (NAA), total creatine (tCr) and glutamate (Glu) in the ACC of
patients with BPD compared to healthy control.