Arizona just made its largest meth bust ever, and it may be a signal from Mexico's most powerful cartels

US Customs and Border Protection agents at a border crossing in Nogales, Arizona, seized 387 pounds of methamphetamine on February 5, the largest meth seizure in the crossing's history.

A tractor-trailer hauling bell peppers and attempting to cross at the Mariposa Commercial Facility was stopped and CBP agents pulled 400 packages of meth worth $1.1 million out of the trailer's front wall and rear doors.

The driver, Juan Rodolfo Lugo-Urias, was turned over to Homeland Security Investigations agents.

But the location and size of the bust indicate that he may have been just one part of the operation.

Based on where Lugo was captured, it raises the possibility of two organizations: the Sinaloa cartel and the Beltran-Leyva Organization. And it may be a signal that neither of those organizations has faded from the scene, despite recent setbacks.

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Arizona just made its largest meth bust ever, and it may be a signal from Mexico's most powerful cartels

A Mexican soldier takes part in the burning of marijuana, heroin, cocaine and methamphetamine at a military base in Monterrey, Nuevo Leon state, on April 8, 2014. The Mexican Army burnt more than 17.5 tons of drug seized to groups of drug traffickers from the north of the country, reported a military authority. AFP PHOTO/Julio Cesar Aguilar (Photo credit should read Julio Cesar Aguilar/AFP/Getty Images)

A Mexican soldier takes part in the burning of marijuana, heroin, cocaine and methamphetamine at a military base in Monterrey, Nuevo Leon state, on April 8, 2014. The Mexican Army burnt more than 17.5 tons of drug seized to groups of drug traffickers from the north of the country, reported a military authority. AFP PHOTO/Julio Cesar Aguilar (Photo credit should read Julio Cesar Aguilar/AFP/Getty Images)

An iguana hangs from the uniform of a Mexican soldier during the burning of marijuana, heroin, cocaine and methamphetamine at a military base in Monterrey, Nuevo Leon state, on April 8, 2014. The Mexican Army burnt more than 17.5 tons of drug seized to groups of drug traffickers from the north of the country, reported a military authority. AFP PHOTO/Julio Cesar Aguilar (Photo credit should read Julio Cesar Aguilar/AFP/Getty Images)

A Mexican soldier takes part in the burning of marijuana, heroin, cocaine and methamphetamine at a military base in Monterrey, Nuevo Leon state, on April 8, 2014. The Mexican Army burnt more than 17.5 tons of drug seized to groups of drug traffickers from the north of the country, reported a military authority. AFP PHOTO/Julio Cesar Aguilar (Photo credit should read Julio Cesar Aguilar/AFP/Getty Images)

These DEA maps released last year show that the cartel controls the territory on both sides of the crossing at Nogales.

US Customs and Border Protection/KGUN9

"The Sinaloa Cartel maintains the most significant presence in the United States," the DEA noted in an intelligence report released last summer.

Guzmán's Sinaloa organization, a multibillion-dollar operation, is "the dominant [transnational criminal organization] along the West Coast, through the Midwest, and into the Northeast," the report added.

If Lugo was working for the Sinaloa cartel, then the product he was carrying would have slipped into the organization's extensive trafficking network within the US.

As the dominant cartel operating in the US, Sinaloa operatives supply much of the country. In 2013, the DEA believed that the cartel supplied "80% of the heroin, cocaine, marijuana and methamphetamine — with a street value of $3 billion — that floods the Chicago region each year."

Beltran-Leyva Organization

However, that Lugo was captured in Nogales suggests another possible backer.

The city was identified as an area of "significant or increasing presence" for the Beltran-Leyva Organization (BLO) by the DEA's 2015 National Drug Threat Assessment.

US Customs and Border Protection/KGUN9

The BLO, formed by the Beltran-Leyva brothers, was originally a close partner of the Sinaloa cartel, but broke with Guzmán's organization in the late 2000s.

Since 2010, however, the BLO has been significantly weakened, with much of its top leadership — guys like the Beltran-Leyva brothers and their top enforcer, "La Barbie" — killed or captured.

Despite those losses and the cartel's decline, it has maintained some alliances with Mexican cartels, and the DEA said that in 2014 that the BLO was both active in the US and working with Colombian traffickers to move cocaine into the US.

'... meth is the only way here to make some real money'

Though it's not clear who sent this specific shipment, agents on the US border have seen a surge in meth trafficking in recent years.

US Customs and Border Protection/KGUN9

"In fiscal year 2014, the United States Border Patrol seized a record 3,771 pounds of meth at the Mexican border," author Ioan Grillo wrote in January 2015.

That was "more than double the 1,838 pounds it seized in 2011."

Meth is incredibly cheap to produce, with often readily available chemicals, like those found in flu medicine, cobbled together in makeshift labs.

"These guys get ingredients worth $65 and turn them into drugs worth $18,000 or more," Mike Vigil, former head of international operations for the Drug Enforcement Administration, told Grillo.

With money like that to be made, the shipment seized in Nogales is unlikely to be the last.

"How the f--- else are we going to get by?" a meth cooker named Bernardo said to Grillo in Mexico. "I might get a job picking tomatoes now and again but meth is the only way here to make some real money."