Other frequent findings in sarcoidosis are concentric, lamellated fibrosis around granulomas (Figure 5, B), hyalinization of and within granulomas, granulomatous vasculitis,36,98 absence of granulomas within air spaces, absence of organizing pneumonia, and absence of interstitial inflammation away from the granulomas.

6] Last but not least, experimental studies have pointed out that the initial lesion appears to be crystal formation along the brush border of the proximal tubule, with eventual crystal deposition in collecting ducts and papillary interstitium, and eventual tubule obstruction, interstitial inflammation, and fibrosis.

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