Synephrine is an adrenergic agonist that has gained popularity as being an alternative to ephedrine. It is found in many species of plants, however the main source today for synephrine is citrus aurantium, also known as “bitter orange”. Once the ephedra ban took place, many supplement retailers switched ingredients to synephrine or methyl-synephrine for their fat loss products.

Methyl-synephrine differs from standard synephrine in that it contains a superior chemical structure. Data suggests that this not only inhibits MAO activity, but also increases the compounds affinity for the beta-adrenergic receptors. It is often compared to octopamine and suggested to primarily activate beta-3 receptors.

Synephrine is an adrenergic agonist that has gained popularity as being an alternative to ephedrine. It is found in many species of plants, however the main source today for synephrine is citrus aurantium, also known as “bitter orange”. Once the ephedra ban took place, many supplement retailers switched ingredients to synephrine or methyl-synephrine for their fat loss products.

Methyl-synephrine differs from standard synephrine in that it contains a superior chemical structure. Data suggests that this not only inhibits MAO activity, but also increases the compounds affinity for the beta-adrenergic receptors. It is often compared to octopamine and suggested to primarily activate beta-3 receptors.

mmm, methyl synephrine!

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I'm in love <3 this makes for a kick ass stack with caffeine and AT2 , throw in EP for lean dryness!!! PES always comes up with the supplements I need to keep it natty and never have to consider PHs <3!!!

Yeah. Currently running an Alpha t2 log for you guys. Probably wont stack my log bottle with ms, but for future knowledge

Full-dosed MS with caffeine will actually be much more effective than Alpha-T2. I will be picking up a few bottles as this is pretty much the best supplemental fat-burning ingredient we have at our disposal currently (not counting ephedrine).

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The above is my own opinion and does not reflect the opinion of PES

I did for about the last half of the bottle as I was logging AT-2. Take it that might have been a mistake from your tone

FWIW I may have needed a big stim break when I took it.

Your results/experiences with MS?

I havent taken it standalone as its easy for me to use ec, but Im open for trying it out in the future. I should get a couple of bottles before (in case) they are gone.

I did have good experience with the very original Alpha T-2 but that has other things in it as well and the MS. I dont recall how much MS was in Alpha T-2, but I think it had 30mg and with added caffeine should be a decent enough dose to have effect, although 60mg should be much better I heard.

Originally Posted by uvawahoowa

I just got a bottle...is this supposed to be dosed with caffeine for maximum effectiveness?

I think 60mg with 200mg caffeine is an effective dose. There isnt research with stacking MS with caffeine the same way there is with EC, but 60MS/200C should be something I personally would do.

Originally Posted by neuron

Caffeine is definitely a must with methylsynephrine. Even ephedrine itself has demonstrated weak lipolytic inducing potential in the absence of caffeine. This makes sense as caffeine potentiates the transduction (Gs) mechanism involved in fat loss (inc. cAMP).

Originally Posted by neuron

One of the things which I wanted to elaborate upon was the transduction mechanisms inherent to different adrenergic receptors.

For example, alpha1-receptors activate the IP3-DAG transduction cascade which ultimately results in calcium release and contraction/vasoconstriction (in smooth muscle). This mechanism is potentiated by caffeine co-consumption since caffeine enhances calcium release. Conversely, beta-receptors (all three of them) work through elevation of intracellular cAMP. Since caffeine also functions as a PDEi, cAMP levels will be prolonged. This explains why ephedrine alone (a beta-3 agonist) is only a weak lipolytic-inducing agent, but extremely potent in concert with caffeine.

Synephrines downsides
Increasing peripheral vascular resistance is a negative characteristic of a lot of stimulants and is especially exacerbated in compounds which primarily activate alpha-receptors like synephrine. Not only is the incidence of stroke and hemorrhage higher with these agents, but the work-load put on the heart can trigger ventricular fibrillations or other arrhythmias [6, 7, 8]. Using caffeine in conjunction with synephrine will potentiate the peripheral vasoconstriction by synergizing with the transduction mechanism induced by alpha-adrenergic agonism [9, 10]. Adrenergic agonists with high affinity to alpha-receptors also have the unfortunate capacity to induce platelet aggregation by agonizing alpha-2 receptors on platelets which can lead to intravascular clotting [11, 12].

I havent taken it standalone as its easy for me to use ec, but Im open for trying it out in the future. I should get a couple of bottles before (in case) they are gone.

I did have good experience with the very original Alpha T-2 but that has other things in it as well and the MS. I dont recall how much MS was in Alpha T-2, but I think it had 30mg and with added caffeine should be a decent enough dose to have effect, although 60mg should be much better I heard.

I think 60mg with 200mg caffeine is an effective dose. There isnt research with stacking MS with caffeine the same way there is with EC, but 60MS/200C should be something I personally would do.

Very interesting... good thing I saw this thread. For recomp or cutting, is this better pre meal or pre cardio?

Very interesting... good thing I saw this thread. For recomp or cutting, is this better pre meal or pre cardio?

Id dose 3 times a day. You can take it pre-workout which makes sense since if you like taking stims pre-workout it just makes for good timing (and eliminate the 4th dose in that day of taking a stim). You want to make sure your in a good state of health and dont run into blood pressure issues when taking pre-training.

If you want the best effect I would take it fasted on an empty stomach. Some people such as myself cant take caffeine in such a way due to a nauseating effect from the caffeine so I take my ephedrine with coffee for example, the half and half makes a dramatic difference for me.

Id dose 3 times a day. You can take it pre-workout which makes sense since if you like taking stims pre-workout it just makes for good timing (and eliminate the 4th dose in that day of taking a stim). You want to make sure your in a good state of health and dont run into blood pressure issues when taking pre-training.

If you want the best effect I would take it fasted on an empty stomach. Some people such as myself cant take caffeine in such a way due to a nauseating effect from the caffeine so I take my ephedrine with coffee for example, the half and half makes a dramatic difference for me.