Careful voltage clamp studies have been undertaken to quantify the maximal conductance, reversal potential, and dynamics governing the gating of many of the channels typically present in neuronal cell membranes. (jneurosci.org)

This can be achieved by prolonging the action potential duration (APD), primarily by inhibiting potassium channels, or by blocking sodium channels, which increases cardiac excitation threshold, slows conduction, and creates a period of refractoriness after the action potential has repolarized without significant prolongation of APD, making this method less proarrhythmic. (ahajournals.org)

Our study also suggests a therapeutic strategy to improve ischemic vascular occlusion by lowering 15-HETE level and preventing Kv channel down-regulation which makes 15-LOX as a new target for the treatment of cerebral hypoxia. (welbourneprimary.com)

Keywords: 15-lipoxygenase (15-LOX) 15 acid (15-HETE) hypoxia Kv1.5 Kv2.1 Introduction Cerebral vascular disease is MP470 one of diseases with high morbidity and mortality 75 of which is caused by ischemic cerebrovascular. (welbourneprimary.com)

Our study was also aimed at extending our current knowledge on the in situ vascular pharmacology of DPO-1 and XE991 regarding K V 1.5 and BK Ca channels, in helping to identify the nature of K + channels that could contribute to PVAT-mediated relaxation. (frontiersin.org)

TCR ligation is followed by a transient release of calcium from intracellular stores, which precedes a sustained calcium influx through Ca 2+ release-activated Ca 2+ channels that is required for complete activation. (jimmunol.org)