Conclusion: These results suggest that ob/ob mice require glucocorticoid excess and related changes in hypothalamic neuropeptides (NPY, POMC and AgRP) to maintain their body weight and appetite. Because hypothalamic AgRP expressions are quite parallel to circulating glucocorticoid levels in the present study, hypothalamic AgRP is considered as a key molecule in glucocorticoid-induced hyperphagia.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.