Forum for Science, Industry and Business

University of Alberta Researchers Find New Cause of Blindness

05.09.2007

The scientific community is just starting to appreciate the importance of pH regulation in normal vision.

Drs Joe Casey and Yves Sauvé found evidence for blindness associated with a gene involved in retinal pH regulation. Their characterization of a mouse model with a targeted disruption of the Slc4a3 gene has revealed a new cause of blindness.

Identification of Slc4a3 as underlying a previously unrecognized cause of blindness has direct clinical implications: it opens the door to a new diagnostic possibility for many yet unknown causes of blindness, including hereditary vitreoretinal degenerations (HVDs). No link has been established between Slc4a3 and HVDs.

The similarities between the disease of Slc4a3 deficient mice and individuals with HVDs, however, suggest that Slc4a3 null mice represent the first model of these blinding conditions, for which there is no cure.

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