New synthetic opioids emerge periodically circumventing existing administrative bans and fueling the opiate/opioid crisis with unknown substances In an effort to inform public health practitioners on new emerging substances in a timely manner, the eDarkTrends project aims to collect and analyze synthetic opioids-related data from Darknet cryptomarkets. Recently notified through the NDEWS network, new substances (U-48,800, ortho- Methylmethoxyacetylfentanyl, Despropionyl ortho-Methylfentanyl) were identified by the Organized Crime Drug Enforcement Task Force (0CDETF). Based on these recent developments, we would like to share some preliminary results from the eDarkTrends project.