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Nocturnal bruxism, the involuntary grinding and/or clenching of teeth during sleep, which has been classified as a parasomnia, reportedly causes many dental and oral problems. Moreover, it may be an untoward symptom that leads to a compromised ability to achieve or maintain therapeutic doses of selective serotonin reuptake inhibitors (SSRIs). To the best of our knowledge, this is the first report to document the successful monitoring of fluoxetine-induced nocturnal bruxism in a healthy adult without a change in the patient’s medication regimen.