How to cite this article: de Vendômois JS, Roullier F, Cellier D, Séralini GE. A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health. Int J Biol Sci 2009; 5:706-726. Available from http://www.biolsci.org/v05p0706.htm

Abstract

We present for the first time a comparative analysis of blood and organ system data from trials with rats fed three main commercialized genetically modified (GM) maize (NK 603, MON 810, MON 863), which are present in food and feed in the world. NK 603 has been modified to be tolerant to the broad spectrum herbicide Roundup and thus contains residues of this formulation. MON 810 and MON 863 are engineered to synthesize two different Bt toxins used as insecticides. Approximately 60 different biochemical parameters were classified per organ and measured in serum and urine after 5 and 14 weeks of feeding. GM maize-fed rats were compared first to their respective isogenic or parental non-GM equivalent control groups. This was followed by comparison to six reference groups, which had consumed various other non-GM maize varieties. We applied nonparametric methods, including multiple pairwise comparisons with a False Discovery Rate approach. Principal Component Analysis allowed the investigation of scattering of different factors (sex, weeks of feeding, diet, dose and group). Our analysis clearly reveals for the 3 GMOs new side effects linked with GM maize consumption, which were sex- and often dose-dependent. Effects were mostly associated with the kidney and liver, the dietary detoxifying organs, although different between the 3 GMOs. Other effects were also noticed in the heart, adrenal glands, spleen and haematopoietic system. We conclude that these data highlight signs of hepatorenal toxicity, possibly due to the new pesticides specific to each GM corn. In addition, unintended direct or indirect metabolic consequences of the genetic modification cannot be excluded.

Thursday, December 10, 2009

Let's do a lot of sitting around together

Date: 2009-09-21, 10:56PM CDT

I'm not active. I don't like to hike, bike, rollerblade or run. Nor walk around the lakes. I'm inactive and I work very hard at it. There is a lot to see in TV land. There are good movies coming out every week. There are some books worth spending time with. Then there is eating. You can't eat and do anything else. You have to just sit and eat. I have a desk job that keeps me mostly immobile and when I get home I like to unwind by sitting even more. Sometimes I like to take my show on the road and sit around outside, especially if there is a beach or a lake or a campfire.

Sure, there is some adipose tissue that goes with all this. But this is a lifestyle after all and I am committed.

Want to sit around with me? Fuck it I say. Throw in the towel. Stop sucking in your gut and let it go. Admit defeat. Let's have queso dip and watch M*A*S*H reruns, the way god intended. Let's sit around together. We can play cribbage or something. Order take out. Take a nap. Microwave some leftovers.

Come on. You know you want to.

Put "fajitas" in your subject when you reply so I know you're not retarded.

Thursday, December 03, 2009

The DNS protocol is an important part of the web's infrastructure, serving as the Internet's "phone book". Every time you visit a website, your computer performs a DNS lookup. Complex pages often require multiple DNS lookups before they complete loading. As a result, the average Internet user performs hundreds of DNS lookups each day, that collectively can slow down his or her browsing experience.

We believe that a faster DNS infrastructure could significantly improve the browsing experience for all web users. To enhance DNS speed but to also improve security and validity of results, Google Public DNS is trying a few different approaches that we are sharing with the broader web community through ourdocumentation:

Speed: Resolver-side cache misses are one of the primary contributors to sluggish DNS responses. Clever caching techniques can help increase the speed of these responses. Google Public DNS implements prefetching: before the TTL on a record expires, we refresh the record continuously, asychronously and independently of user requests for a large number of popular domains. This allows Google Public DNS to serve many DNS requests in the round trip time it takes a packet to travel to our servers and back.

Security: DNS is vulnerable to spoofing attacks that can poison the cache of a nameserver and can route all its users to a malicious website. Until new protocols like DNSSEC get widely adopted, resolvers need to take additional measures to keep their caches secure. Google Public DNS makes it more difficult for attackers to spoof valid responses by randomizing the case of query names and including additional data in its DNS messages.

Validity: Google Public DNS complies with the DNS standards and gives the user the exact response his or her computer expects without performing any blocking, filtering, or redirection that may hamper a user's browsing experience.

We hope that you will help us test these improvements by using the Google Public DNS service today, from wherever you are in the world. We plan to share what we learn from this experimental rollout of Google Public DNS with the broader web community and other DNS providers, to improve the browsing experience for Internet users globally.