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Abstract:

In Brief:

Although noninvasive prenatal testing for aneuploidy represents a tremendous advance in genetics, currently these tests have limitations that are important to consider when implementing them into prenatal screening and diagnosis programs.

Abstract:

In Brief:

The difference in pregnancy loss rates after chorionic villus sampling and amniocentesis decreased across time, with no clinically or statistically significant difference between the two in the period from 1998 to 2003.

Abstract:

In Brief:

Offering targeted ultrasound to women whose maternal serum alpha-fetoprotein is at least 2.0 multiples of the median is more cost-effective than offering amniocentesis when it is at least 2.5. multiples of the median.

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