Abstract

Recent interest has focused on a class of decision problems in which subjects encounter options serially and must decide when to leave an option in search of a better one, rather than directly comparing simultaneously presented options. Although such problems have a rich history in animal foraging and economics, relatively little is known about their neural substrates. Suggestively, however, a separate literature has argued that the key decision variable in these tasks - the opportunity cost of time, given by the average reward rate - may also govern behavioral vigor and may be reported by tonic dopamine (DA). In this study, we test whether this putative dopaminergic opportunity cost signal plays an analogous role in serial decisions by examining the behavior of patients with Parkinson's disease (PD), on and off their DA replacement medication, in a patch-foraging task. In these tasks, subjects' decisions about when to leave a depleting resource implicitly reflect their beliefs about the opportunity cost of time spent harvesting that resource. Consistent with the opportunity cost hypothesis, unmedicated patients harvested longer than matched controls, and medication remediated this deficit. These effects were not explained by motor perseveration. Our results suggest a functional role for DA, and an associated cognitive deficit in PD, in a type of decision process that may be distinct from (but related to) the neuromodulator's well studied roles in behavioral invigoration and learning from rewards.

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