Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.

@article{Pourdehnad2013MycAM,
title={Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.},
author={Michael Pourdehnad and Morgan L. Truitt and Imran N. Siddiqi and Gregory Stuart Ducker and Kevan M. Shokat and Davide Ruggero},
journal={Proceedings of the National Academy of Sciences of the United States of America},
year={2013},
volume={110 29},
pages={
11988-93
}
}

Myc is one of the most commonly deregulated oncogenes in human cancer, yet therapies directly targeting Myc hyperactivation are not presently available in the clinic. The evolutionarily conserved function of Myc in modulating protein synthesis control is critical to the Myc oncogenic program. Indeed, enhancing the protein synthesis capacity of cancer cells directly contributes to their survival, proliferation, and genome instability. Therefore, inhibiting enhanced protein synthesis may… CONTINUE READING