Articles tagged with: Mannich

Fukuyama, Tokuyama, Han-ya. ACIEE, 2011, 50, 4884. DOI: 10.1002/anie.201100981
Not a full post, but it’s time to get some of these Chemistry World articles on here. This once is the most recent, in the June issue, and follows Tohru Fukuyama’s synthesis on Conophylline – a really neat piece of work, especially when you consider how sensitive some of the functionality here is. How many of you knew of the Polonovski-Potier reaction?

Ramharter, Mulzer, Weinstabl. JACS, 2010, 132, 14338-14339. DOI: 10.1021/ja107533m
I love the fact that one can just look at a molecule and then guess the author of the synthesis. And when I first glanced at Lycoflexine, the name Johann Mulzer was at the top of my mind. (However, on closer inspection, the starred author is one Juergen Ramharter, even though Mulzer is also named…) This makes me smile for two reasons – firstly, Mulzer always works on small, yet interesting targets. Secondly, I routinely learn something new in his work.
To say …

Shair, Liau, JACS, 2010, ASAP DOI: 10.1021/ja104575h.
After wading through the Heathcock paper last week, I’m glad that today’s topic of discussion is a little shorter and easier to read. (Seriously, part of me hates reading paper older that the 90’s as the style used in the schemes and figures is so difficult to follow. Some of those 1960’s JACS papers are a real slog to get through – but worth it, normally….)
The target of choice today is Fastigiatine, a member of the Lycopodium alkaloid family, a popular …

Overman, Martin, Rohde. JACS, 2010, ASAP. DOI: 10.1021/ja100178u.
I don’t think there is a single academic whose syntheses I look forward to more than Larry Overman. I’m not sure exactly why that it, but I think the main reason is the overall standard of his work, as well as his tendency to write fascinating and informing full-papers. He’s also one of those professors who ‘owns’ a particular type of natural product; ‘Overman molecules’ are of course, alkaloids.
This paper not only discusses a ‘first synthesis’ in a racemic form, but also a …

Fukuyama, Tokuyam, Ueda, Satoh, Matsumoto, Sugimoto. ACIEE, 2009, ASAP. DOI: 10.1002/anie.200902192.
And it’s done. It took almost as long to finish as it took Wiley to finally put it online (are they using dial-up modems?), but it’s finally here, after many (as yet) unsuccessful attempts [Corey, Padwa, Nicolaou]. Unfortunately, its difficult to know exactly what were the more challenging issues, as this is a very compact communication – we’re gonna have to wait even longer for the full paper. However, we can marvel at the more obvious …

Twitter

About Tot. Syn.

It's all about stirring pots and hoping for shiny white crystals. Read-on to see some of the best modern organic chemistry, and comments from the folks at the bench.