blood vessel formation

The images shown are examples from a cellular assay in which human endothelial cells, cells that comprise blood vessels, can be induced to extend sprouts that form a vascular-like network. The image on the left demonstrates control cells extending elongated branches that interconnect with one another while the image on the right shows that in the absence of the transcription factor CASZ1, the cells are unable to sprout properly. UNC/Conlon Lab