With the WTO hamstrung and the Doha Round dead in all but name, the future directions of international trade and investment liberalisation will be largely determined by the policy strategies and initiatives of the world’s economic superpowers. Looking at the trade and investment policy strategies of the EU, the U.S., and China, the authors of this policy brief assess how each of these economic giants is attempting to meet the challenges of a post-Doha world and thereby set the scene for a dynamic process of post-Doha international economic integration.