1Biomedical Engineering, UNC-Chapel
Hill, Chapel Hill, NC, United States; 2Biostatistics and
Biomedical Research Imaging Center, University of North Carolina-Chapel Hill;
3Psychology and Biomedical Research Imaging Center, University of
North Carolina-Chapel Hill; 4Radiology and Biomedical Research
Imaging Center, University of North Carolina-Chapel Hill

The
brain is intrinsically organized by functional networks. However, most of the
brain functional imaging studies thus far have largely focused on the
interaction of different brain regions instead of among different brain
networks. In this study, a multivariate approach was developed to discern the
interaction of five predefined brain functional networks, including the
default (D), fronto-parietal control (FPC), motor-sensory (MS), visual (V),
and language (L) networks during resting, movie watching and finger tapping,
respectively. The ability to elucidate the interaction of different brain
networks and assess the dynamic perturbations of their interactions under
different cognitive statuses should complement our understanding of brain
functional interaction on a regional level and offer a more comprehensive
insight into how the brain works at a different scale.