• at P12, Leydig cell number was already reduced by 37%, although nonsignificantly relative to wild-type controls

• Leydig cell number was markedly reduced at all later ages, reaching only 22% of wild-type numbers at P140

• unlike in wild-type controls, where the LC cytoplasmic volume was relatively constant up to P20, more than doubled between P20 and P50 and remained constant up to P140, the LC cytoplasmic volume of hemizygous mutant males remained virtually unchanged from P12 to P140, reaching only 60% of that in controls at P140

• at P12, Leydig cell number was already reduced by 37%, although nonsignificantly relative to wild-type controls

• Leydig cell number was markedly reduced at all later ages, reaching only 22% of wild-type numbers at P140

• unlike in wild-type controls, where the LC cytoplasmic volume was relatively constant up to P20, more than doubled between P20 and P50 and remained constant up to P140, the LC cytoplasmic volume of hemizygous mutant males remained virtually unchanged from P12 to P140, reaching only 60% of that in controls at P140