Stuart Johnston Knechtle

Mary and Deryl Hart Professor of Surgery, in the School of Medicine

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects. These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses. During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients. This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways. The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance. My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Knechtle, SJ, and Fairchild, RL. "Regulating T Cell Behavior."American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
16, no. 7 (July 2016): 1949-1950.
Full Text

Advising & Mentoring

Over the past 24 years, I have helped train over 6 graduate students, 18 post-doctoral fellows, 15 surgical research fellows, and 10 medical students in my research lab, and helped train over 50 transplant fellows in surgical transplantation.

Scholarly, Clinical, & Service Activities

Service to the Profession

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