Replicating Vaccines

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Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.Gu J, Korteweg C (2007) Pathology and pathogenesis of severe acute respiratory
syndrome. ... between the occurrence of undifferentiated bovine respiratory
disease and titer changes to bovine coronavirus and bovine viral diarrhea virus
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Title

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Replicating Vaccines

Author

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Philip Dormitzer, Christian W. Mandl, Rino Rappuoli

Publisher

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Springer Science & Business Media - 2010-11-02

ISBN-13

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