As the name states, this theme is heard during the battle with the Queen Metroid in Area 8. It was also briefly heard in a pre-release tweet by Nintendo of America that showed the Queen Metroid in the remake for the first time.[3]

Boss Queen heavily consists of percussive beats, vocal chants, an organ, and other electronic instruments. These blend together to form a chaotic cacophony of sound, highlighting the terrifying and alien nature of the most powerful Metroid on SR388. It can be heard here: [1]

The Queen Metroid had a different theme for her original appearance in Metroid II: Return of Samus, which was composed by Ryoji Yoshitomi. However, Daisuke Matsuoka's version seems to be heavily inspired by the original theme and is very likely intended as an arrangement. In particular, the vocal chants heard halfway through the new song sound nearly identical to the original theme's opening; the section of the melody where an organ plays rapidly descending and ascending notes resembles part of the original theme's melody; and the dissonant organ chords are reminiscent of the very ending of the original theme's loop.