We have reviewed studies of disturbed primordial structure of the lunar regolith, which is caused by both artificial and natural factors. To identify such disturbances, we used orbital high resolution photometry data in conjunction with the method of phase ratios, which makes it possible to evaluate the surface roughness of the light scattering element on the scale of less than imaging resolution. In particular, this method allows the identification of soil talus; it is also an efficient way to find new craters and places of falling meteoroid streams. The reliability of the new method is proved by the photometric detection of the anomalies associated with changes in the structure of the surface layer of regolith in landing sites of manned spacecraft, i.e., where the impact of human activity on the lunar regolith is well known. The results can be used in a planning and implementation of space missions to the Moon and other atmosphereless bodies of the solar system by the space agencies