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The Weinstein Co. is laying off about 11 percent of its workforce as the sickly economic environment further invades Tinseltown, The Post has learned.

Two sources close to the situation said that the company’s human-resources officials called their employees into a meeting shortly after 2 p.m. yesterday to break the news.

Roughly two dozen people are being let go across the independent studio’s operations, according to the sources.

How much the company will save as a result of the cuts could not be determined, but estimates put it well into the millions.

The move reduces the studio’s total workforce to 200 from 224 across offices in New York, Los Angeles, the UK and Hong Kong.

The laid-off employees will be given severance packages based on their length of time at the studio.

A spokesman for The Weinstein Co. declined to comment.

Questions about The Weinstein Co.’s financial health have circulated almost since the day it opened its doors in 2005.

Last year, amid speculation that the studio was running out of money, the Weinstein brothers declared in an exclusive interview with The Post that they would not need to raise equity in 2008. So far, they have stayed true to that declaration.

But the layoff move is bound to stir a new round of rumors that the studio is on the brink of collapse.

Sources said the job cuts were due to the economy rather than issues unique to The Weinstein Co.’s financial position.

“If this was a real financial emergency for the studio, I imagine the layoffs would be greater than 24 people,” said one source, who added that the layoffs are expected to be a one-time event.

The Weinstein Co. certainly isn’t alone among Hollywood studios in feeling the pain from the financial crunch.

In the last year, Warner Bros. closed its New Line and Picturehouse specialty units, and Paramount shut down its Paramount Vantage label. Lionsgate earlier this month said it would eliminate 41 jobs, or 8 percent of its workforce, to deal with the current economic climate.

Earlier this year, Bob Weinstein said the economy and tightening credit markets would generate a “shakeout” among independent studios.

The Weinsteins’ biggest hit so far has been “1408,” which has grossed $72 million domestically and $131 million worldwide. Its most recent release, Kevin Smith’s “Zach and Miri Make a Porno,” has grossed $27 million domestically so far.