The 53-year-old Cali, who had ties to the Inzerillo Mafia family in Palermo, Sicily, was taken to Staten Island University North Hospital in critical condition, sources said. He was shot several times.

No arrests have been made.

The FDNY responded at 9:18 p.m. to a home in the upscale Todt Hill section of Staten Island. The house is listed under the name of Rosaria Inzerillo.

Cali had been considered a unifying figure in the crime family, in the years after John Gotti was convicted and sent to prison by cooperating mob witnesses. Unlike the well-dressed Dapper Don of the late 80s and early 90s, Cali had kept a low profile.

Cali was the first New York crime family boss shot since 1985, when Paul Castellano, who owned a mansion on Todt Hill, was executed as he arrived at Sparks Steakhouse in Manhattan. John Gotti and his turncoat underboss, Sammy “Bull” Gravano watched the action from Third Avenue.