A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the journal “EMBO”, by Prof Sinclair, North BJ, and others.

Tomatidine has been shown to shown to function as anti-hyperglycemic agent.However, the exact mechanism of action is far from clear.

From research findings to therapeutic Opportunity:

D-Tagotose, a stereoisomer of fructose, is found in fruits, cacao and milk products (fig.1).It is 92% as sweet as sucrose, but only with 38% of calories of sucrose.

This study suggests, for the first time, thatD-Tagotose, by increasing the expression of its target gene, it may: (a) increase the expression of BuBR1; (b)decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (Fig. 1).

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Figure 1. Natural sweetener D-Tagotose may extend mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase

Figure 2. D-Tagotose as a longevity-promoting agent.

Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus,pharmacological formulations encompassing“D-Tagotose or its analogues, either alone or in combination with other drugs,“may be used to extend the lifespan of an individual (fig. 1).

Details on the research findings:

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $500#

Undisclosed mechanistic information: How D-Tagotoseincreases the expression of BubR1 and extends mammalian life-span