The four-momentum is useful in relativistic calculations because it is a Lorentz vector. This means that it is easy to keep track of how it transforms under Lorentz transformations.

The above definition applies under the coordinate convention that x0 = ct. Some authors use the convention x0 = t, which yields a modified definition with P0 = E/c2. It is also possible to define covariant four-momentum Pμ where the sign of the energy is reversed.

Note that the invariant mass of a system of particles may be more than the sum of the particles' rest masses, since kinetic energy in the system center-of-mass frame and potential energy from forces between the particles contribute to the invariant mass. As an example, two particles with four-momenta (5 GeV/c, 4 GeV/c, 0, 0) and (5 GeV/c, −4 GeV/c, 0, 0) each have (rest) mass 3 GeV/c2 separately, but their total mass (the system mass) is 10 GeV/c2. If these particles were to collide and stick, the mass of the composite object would be 10 GeV/c2.

One practical application from particle physics of the conservation of the invariant mass involves combining the four-momenta PA and PB of two daughter particles produced in the decay of a heavier particle with four-momentum PC to find the mass of the heavier particle. Conservation of four-momentum gives PCμ = PAμ + PBμ, while the mass M of the heavier particle is given by −||PC||2 = M2c2. By measuring the energies and three-momenta of the daughter particles, one can reconstruct the invariant mass of the two-particle system, which must be equal to M. This technique is used, e.g., in experimental searches for Z′ bosons at high-energy particle colliders, where the Z′ boson would show up as a bump in the invariant mass spectrum of electron–positron or muon–antimuon pairs.

If the mass of an object does not change, the Minkowski inner product of its four-momentum and corresponding four-accelerationAμ is simply zero. The four-acceleration is proportional to the proper time derivative of the four-momentum divided by the particle's mass, so

Canonical momentum in the presence of an electromagnetic potential[edit]

This, in turn, allows the potential energy from the charged particle in an electrostatic potential and the Lorentz force on the charged particle moving in a magnetic field to be incorporated in a compact way, in relativistic quantum mechanics.