EC 3.4.23.20

Accepted name: penicillopepsin

Reaction: Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20Glu in the B chain of insulin. Clots milk, and activates trypsinogen

Comments: From the imperfect fungus Penicillium janthinellum. In peptidase family A1 (pepsin A family). Closely related enzymes have been isolated from P. roqueforti [2] and P. duponti [3]. Formerly EC 3.4.23.7, and included in EC 3.4.23.6