This thesis describes the synthesis and application of four novel chiral ligand
classes. These were all hydroxyamide or oxazoline ligands with an L-pyroglutamic
acid derived terminus. These ligands ...

A great deal is known about the reactivity of catalysts derived from 2,2'-PyBOX and 2,2'-PheBOX ligands in asymmetric reactions. The initial aim of this research was to investigate a new type of bisoxazoline ligand, where ...

The aim of this work is the synthesis and investigation of artificial metallonucleases.
In the first part of this work a simple model system was used allowing for the
quantification of the artificial nucleases ability. ...

Iminosugars are naturally occurring polyhydroxylated alkaloids. These natural mimics of carbohydrates have found clinical use with their biological activity mainly attributed to their inhibition of glycoprocessing enzymes. ...

The first section of this thesis describes the synthesis of novel glycosphingolipids with an α-triazole at the anomeric carbon. Glycosphingolipids are amphiphilic molecules containing a carbohydrate head glycosidically ...

Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ...

Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ...

Chapter one and two of this thesis describe the synthesis of novel migrastatin derivatives. Migrastatin is a fourteen-membered macrocycle isolated by Japanese researchers from the Streptomyces platensis. It has been shown ...

This thesis details the synthesis and structural characterisation of thirty novel complexes via the utilisation of a variety of ligands (seven in total) including hydroxamic acids, Schiff base ligands and their hybrid ...

This thesis covers many areas within the field of molecular magnetism. With the exception of chapter 6, all novel complexes in this thesis have been synthesized using the bidentate ligand 2,2'-biphenol (LH2), usually in ...

Equipment Qualification is a formal quality assurance process in manufacturing which establishes confidence that specified equipment is ‘ready for its intended use’. This thesis, in drawing parallels between requirements ...

The objective of this thesis was to investigate the integration of enzymes and redox mediators capable of transferring electrons between enzymes and electrodes. This was done with a view to developing a semi- or fully ...

This doctoral thesis investigates the legal rights of photographers and photograph publishers in Ireland to take and/or publish still photographs. For comparative purposes, an analysis of the applicable law in the United ...

Despite the advances in Mergers and Acquisitions (M&A) research over the last 40 years, there has been little change in the failure rates and the human side of the deal is noted as one of the main causes of failure. ...

Osteoarthritis, the most common form of arthritis, is a progressive degenerative disease of cartilage and the synovial joint. Since cartilage is an avascular tissue with a limited capacity for self-repair, mesenchymal ...

The objectives of this thesis were to 1) explore the glycosylation of major bovine milk proteins, 2) investigate the effect of lactational stage on glycan structures and 3) examine how these documented changes may influence ...

This thesis sets out to explore the potential bioactivities of bovine milk fat globule membrane (MFGM) to enhance our understanding of the roles bovine milk glycoconjugates may play in humans and to contribute towards ...

The aim of this study is to achieve a better understanding of tax compliance decisions and to identify the factors that impact this decision-making. Adopting a quantitative research approach, this study investigates the ...

Coralline algae are important biological and ecological components in coastal environments around the world, and in this study a comprehensive molecular and ecological analysis of the group was performed. Questions related ...

Wet grassland habitats characterised by seasonal inundation and low-intensity agricultural practices support a rich mosaic of plant and animal communities. Whilst most of the conservation strategies aimed at protecting ...