Granulocyte colony-stimulating factor (G-CSF), 2.5 mg/kg/day for five days, was administered to 10 patients with CAD. Ischemia was assessed by treadmill exercise testing. The effects of G-CSF on blood were measured by auto hematology analyzer and semi-auto chemistry analyzer.

The findings show that granulocyte colony-stimulating factor mobilizes stem cells from bone marrow in patients with coronary artery disease and improve treadmill exercise testing. The therapeutic strategy was safe and tolerable in patients with CAD.