The Cdk inhibitory protein p27 play a key role in regulating Cdk activity during G1 progression and in growth arrest.
Level of the inhibitory protein oscillate during the cell cycle and peak in G1 phase. Under most conditions investigated, p27 oscillations are the result of post-trascriptional mechanisms that include translational control and regulated protein stability.
Since p27 transcripts of various length have been described that differ in length of their 5'UTR between 152 and 575 nucleot......