The Tyrant deserves many accolades for inspiring so many subsequent bosses in the franchise. Without the original Tyrant, there could be no Mr. X, no Nemesis, or really any humanoid terror beyond the simple zombie.

The prototype Tyrant T-001 was first encountered by Rebecca Chambers and Billy Coen. His thick hide and super-strength made him a beast to contend with, but his exposed spinal column offered a lone point of weakness. The more well-known Tyrant T-002 in Umbrella's Arklay facility was improved, but gamers could take it down - thanks to a similarly-unfortunate weak point in its chest.

Eventually Umbrella wised up, and we've been seeing newer and more deadly varieties of Tyrant in subsequent games. Each is more durable and more intelligent than the last. Rarely is something as simple as an exposed heart present to even the odds. Many people have nightmares of being stalked by a relentless and unseen predator. Thanks to Resident Evil, we can know put a face on that predator.