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Seeva, here's a bit of a progressive pipeline list for phase's 2 and 3 (the time line for approval of these ranges from rituxan which could be approved this year, to maybe 6-7 years for drugs just entering phase 2 trials):

The CUPID study of cannabinoids (currently on the list in phase 2) in the UK is:

- double-blind
- placebo-controlled
- multi-centre
- 3 years in duration
- and is aiming for enrollment of 500 people

I keep looking for some mention of what phase trial this is but can't find any. So, if it looks like a duck, walks like a duck and quacks like a duck, I'm going to call it a duck...in this case, a phase 3 trial.

I added Ocrelizumab (R1594) (Roche/Genentech/Biogen) to the list in phase 2. It's been discussed a bit in the last few months. It has the same CD20 target as rituxan and there has been some debate between the companies on how to proceed with trials, but I think they have been resolved now.

There are 40 substances in Phase II right now. Through the 90's, about 40% of drugs tested in Phase II moved on to Phase III trials. So using those stats that means about 16 of the current 40 substances being tested for MS would likely move on to Phase III trials.

There are 7 substances currently in Phase III trials and I assume Tysabri will either be pulled, or will be back on the market by early next year. The remaining 6 substances in Phase III will be there until AT LEAST the end of 2007.

So, it's quite possible that in 2008, there will be over 20 treatments for MS that will be in Phase III trials. So many that it may actually get hard to keep up with everything in Phase III. A change I look forward to.

Interesting that , now in 2008 there are 17 phase III's on your trial list.

I have been looking for signs of life from the Topiramate (aka Topamax) (with Avonex) phase 2 trial, but can't find any information from the last 2 years. I am taking it off the list. Please let me know if I'm wrong.

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