Break-up rumors once again plague George Clooney and Stacy Keibler's relationship

George Clooney and Stacy Keibler are heading towards a break-up, insiders say, as they are started to feel the effects of their age difference.

Clooney, 51, and Keibler, 33, have reportedly been disconnected the last few months and a split seems likely.

“They have little in common,” a source told Us Weekly. "She likes to go out and have fun. She's been feeling the age difference."

Another reason for the disconnect is that Clooney’s friends don’t get along with Keibler’s.

An insider says "The end is near. It's a matter of time."

In October of last year, the couple had to deny similar rumors of a break-up, with a source telling the New York Post at the time “They’re barely talking. She is worried that he may break up with her any day now.”

They showed up to the premiere of Argo, holding hands and looking in love.

“A story published by a London tabloid, The Sun, concerning George Clooney and Stacy Keibler is not true,” his rep said at the time, adding the story is “total fabrication designed to sell newspapers.”