Increased implementation of oral and subcutaneous medication for breast cancer and other oncological or hematological diseases has led to new challenges for patients and oncologists. Optimal and continuous communication as well as lack of adherence and compliance are huge problems potentially impacting not just quality of life but also patient outcome. Where conventional systems, as evaluated in the PACT program [1], failed, modern eHealth and web-based platforms could be a possible solution for improving compliance and the doctor–patient relationship. Novel eHealth technology offers great potential for improved patient management but also needs to take substantial legal restrictions into account before implementation.