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dyskinesia

The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.

FUNDED GRANTS (
172)

Study Rationale:As wearable technology -- smartphones and wearable devices with built-in sensors -- became increasingly more common, affordable and effective, its use in the evaluation and treatment of Parkinson's disease (PD) has advanced rapidly. Such technology can collect data on mobility, symptom intensity and medication effects. While useful, these devices have limitations: They must be wor...

Study Rationale:The two main types of the enzyme 5α-reductase (5αR) play a key role in the production of steroids in the brain and other organs. In pre-clinical testing, we found that inhibitors of both major types of this enzyme prevent damage to brain cells that occur in Parkinson's disease and reduce the severity of dyskinesias. Dyskinesias are one of the major complications of standard treatm...

Study Rationale:Levodopa-induced dyskinesia is abnormal involuntary movements that can affect people with Parkinson's disease after years of treatment. Available therapies for dyskinesia are only partly effective to alleviate the abnormal movements, and dyskinesia remains a hindrance to quality of life. Several experimental treatments for dyskinesia have focussed on a chemical substance of the bra...

Promising Outcomes of Original Grant:In our original proposal, we identified two chemical scaffolds (protein support structures) as dopamine receptor 4 (D4R) antagonists (compounds that block the activity of dopamine) and optimized their strength and ability to pass into the brain. We then tested the lead molecule in a pre-clinical model of L-DOPA-induced dyskinesias (LIDs), disabling involuntary ...