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Tuesday, December 11, 2007

On the dominance of the Ivies..

“One thing we all must worry about — I certainly do — is the federal support for scientific research. And are we all going to be chasing increasingly scarce dollars?” says Drew Gilpin Faust, Harvard’s new president.

Not that Faust seems worried about Harvard or other top-tier research schools. “They’re going to be—we hope, we trust, we assume—the survivors in this race,” she says. As for the many lesser universities likely to lose market share, she adds, they would be wise “to really emphasize social science or humanities and have science endeavors that are not as ambitious” as those of Harvard and its peers.

Through a series of bold experiments begun in the 1980s, Capecchi demonstrated that he could alter any gene in a mouse cell by replacing it with a modified version. At the time, scientists were skeptical that such altered DNA could be targeted to a particular gene. But Capecchi was not to be deterred. Indeed, his studies demonstrated that it is possible to replace an intact, functional gene with a modified version that can zero in on the corresponding DNA in the chromosome.

Some 50 universities are located in the Boston area. Rather than collaboration, Capecchi felt that the thousands of researchers were working in isolation on projects that promised "immediate gratification." As he explained, "Everyone is so aware of what everyone else is doing. 'What's new?' was asked every day. That limits you to short-term returns, posing questions that you know can be answered in six months."

In contrast, the University of Utah in Salt Lake City offered "a relaxed atmosphere, where you could work on projects whose outcome may take 10 years. The relative isolation tends to make you more focused on the biological question you're working on.

"It was a good choice," said Capecchi of his decision to relocate to the U of U in 1973.