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Nmda receptor function the nmda receptor is involved in the long term potentiation of an action potential full activation of nmda receptors is both voltage gated and ligand gated the ion channels will only open if the post synaptic membrane has already been depolarized and the neurotransmitters glutamate and glycine are attached. Nmda receptors nmdars are glutamate gated cation channels with high calcium permeability that play important roles in many aspects of the biology of higher organisms they are critical for the development of the central nervous system cns generation of rhythms for breathing and locomotion and the processes underlying learning memory and neuroplasticity. Nmda receptors typically form tetrameric structures with nr1 dimerizing with either another nr1 subunit or with a combination of nr2 and nr3 subunits it is important to highlight several features of the nmda receptor in order to appreciate its physiological activation nmda receptors function as physiological coincidence detectors. Anti nmda receptor encephalitis is a type of brain inflammation due to antibodies early symptoms may include fever headache and feeling tired this is then typically followed by psychosis which presents with false beliefs delusions and seeing or hearing things that others do not see or hear hallucinations