RPS6KA5

RPS6KA5

A gene on chromosome 14q31-q32.1 that encodes a p90 ribosomal S6 serine/threonine-protein kinase required for the mitogen or stress-induced phosphorylation of transcription factors CREB1 and ATF1, as well as for regulating transcription factors RELA, STAT3 and ETV1/ER81. RPS6KA5 contributes to gene activation by histone phosphorylation and helps regulate inflammatory genes; it plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.

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