Selasa, 31 Maret 2015

Mesothelioma And Bidimensionally Measureable Lesions

Another interesting study is known as, Modified RECIST criteria for assessment of response in malignant pleural Mesothelioma cancer by M. J. Byrne along with a. K. Nowak - Ann Oncol (2004) 15 (2): 257-260. Here's an excerpt: Abstract - Background: The development pattern of malignant pleural mesothelioma cancer makes using RECIST (response evaluation criteria in solid tumours) response criteria difficult. We've developed and validated Modified RECIST criteria modified towards the growth pattern of malignant pleural mesothelioma cancer. Patients and techniques: We examined 73 patients from two clinical tests of cisplatin/gemcitabine chemotherapy in malignant pleural mesothelioma cancer. Tumor thickness verticle with respect towards the chest wall or mediastinum was measured in 2 positions at three separate levels on thoracic CT scans. The sum six dimensions defined a pleural unidimensional measure. Bidimensionally measureable lesions were measured unidimensionally for RECIST. All dimensions were added to get the total tumor measurement. A discount with a minimum of 30% on two occasions 4 days apart defined an incomplete response a rise of 20% within the nadir measurement, progressive disease. The validity from the modified criteria was measured by evaluating survival and lung function. Results: Response based on these criteria predicted for superior survival (15.1 versus 8.9 several weeks P = .03) and compelled vital capacity (FVC) increase throughout treatment (P