During the past few decades, improvements in cardiovascular risk factor control have exerted a significant impact on the incidence of stroke.1 Recently, the Framingham Stroke Risk Profile (FSRP) to establish a person’s 10-year risk of stroke was revised to take into account these changes in the distribution of the risk factors that were included in the original FSRP (ie, blood pressure, smoking, and diabetes mellitus).1 An important notion with regard to this revised FSRP is that it was developed in a mixed population of individuals qualifying for primary prevention of cardiovascular disease (CVD), patients with a history of noncerebrovascular CVD, and patients with a history of atrial fibrillation (AF). Contrary to the 1980s, during which the original FSRP was developed, nowadays, clear guidance is available for risk factor control in patients with a history of CVD, and particularly for patients with AF, the use of other validated stroke risk models are recommended.2 Hence, from a clinical point of view, it would be specifically interesting to determine the predictive ability of the revised FSRP in persons free of CVD and AF: particularly in these individuals, stroke risk estimation could actually affect risk factor management.