SoluMatrix™ Fine Particle Technology

The SoluMatrix technology is a scalable
and cost-effective manufacturing process that can produce submicron-sized drug
particles that are 10 to 200 times smaller than conventional drug particles.
The technology both grinds the drug particles into a superfine powder and
protects those submicron particles from subsequent agglomeration. The resulting
powder can be manufactured into tablets, capsules, and other dosage forms using
standard pharmaceutical unit operations.

The SoluMatrix technology has been applied
at commercial-scale and three products utilizing the technology have been
approved by FDA.

How
SoluMatrix Works

The
SoluMatrix technology improves the performance of lipophilic and poorly water
soluble pharmaceuticals by dramatically increasing the rate of drug dissolution
and improving oral absorption. By making submicron-sized particles of a drug,
it is possible to:

- Improve
the bioavailability and reduce the pharmacokinetic variability of a drug
- Reduce the
time to onset of therapeutic efficacy
- Reduce the
amount of drug required to achieve a desired plasma level
- Reduce or
eliminate food effects
- Change the
mode of administration of a drug

What
SoluMatrix Can Do For Your Product

Using the SoluMatrix technology,
iCeutica can transform development-stage or marketed pharmaceutical products in
a number of clinically relevant and commercially important ways. For poorly
soluble or highly variable products in development, we can ensure the product
successfully progresses through clinical development and that the patient
receives a consistent dose of the drug, with potentially less drug required and
fewer side effects experienced. For marketed products, we can unleash improved
performance and new intellectual property protection that extends the product
lifecycle and profitability of the product.