…been achieved with inhibitors of programmed cell death 1 (PD-1), a protein expressed on the surface of T cells that negatively regulates T cell activity and that is overexpressed in many cancers. Anti-PD-1 therapies, such as nivolumab and pembrolizumab, have proven beneficial in patients with melanoma and certain other cancer…

work of Honjo

…colleagues discovered a protein called programmed cell death protein 1 (PD-1) on the surface of T cells. In later experiments, Honjo and colleagues deduced the function of PD-1 as a negative regulator of immune responses and found that PD-1 deficiency played a critical role in the development of lupus-like autoimmune…