Hugh Laurie's inimitable role on House is doubtless a full-time job, and for the better part of the show's six-year run, it has kept him from doing anything major as far as the big screen is concerned.

But after doing voice work for Valiant, Stuart Little 3, and Monster and Aliens, Laurie may just make that precarious jump from small screen glory to headlining in a feature film, with a much buzzed-about May-December-themed dramatic comedy, reports the Los Angeles Times.

And not only that. Oranges - a dark, dramatic comedy about an older man who has an affair with the daughter of a family friend - may mark the reunion of Laurie, 50, reportedly in talks to play the lead role of the creepy older guy, with Gossip Girl villainess Leighton Meester, who is being considered to play either the female lead or some other role.

Meester has appeared on two episodes of House as Ali, an underage girl who had an obsessive crush on House, so it's not exactly unexplored territory for the two. She came to the clinic with her father who had a cold, and soon started calling the clinic obsessively to talk to him and show up in random places. She also sent him a Fresno calendar so he could count down the six months until she turns 18.

It was revealed later, however, that Ali had a spore in her brain from an earthquake while she was in California.

Mila Kunis, from That 70s Show and now doing voice for Family Guy, is also a top candidate for the other half of the May-December affair. The project, penned by Jay Reiss and Ian Helfer, is still in the works. It has, to its credit, bagged a spot on 2008's Black List of best unproduced works, a list that includes, among others, Inglorious Basterds and the upcoming comedy The Beaver.