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Ages Eligible for Study:

18 Years to 69 Years (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Age ≥18 to <70 years, with screening sUA > 8.0 mg/dL.

Diagnosis of gout according to the criteria of the American Rheumatism Association (1977).

Be willing and able to take colchicine 0.6 mg per day or naproxen 250 mg twice daily (with proton pump inhibitor if needed) as prophylaxis for gout flares.

Be willing to abstain from blood donations from Day -14 to Day 29/Early Termination.

Female participants must be sexually abstinent, sterile, post-menopausal, or on stable contraception.

Post-menopausal - females greater ≥ 45 years of age whose last menstrual period, including spotting, was > 1 year ago.