Basic and Clinical Neuroscience Journalمجله علوم اعصاب پایه و بالینیBCNMedical Scienceshttp://bcn.iums.ac.ir137journal1372008-126X2228-744210.32598/bcnenjalali139011gregorian20114123online1fulltextenEffect of Mozart Music on Hippocampal Content of BDNF in Postnatal RatsOriginalOriginal<b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Introduction: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">It has shown that listening to Mozart music can potentiate spatial tasks in human and reduce seizure attacks in epileptic patients. A few studies have reported the effects of prenatal plus postpartum exposure of mice to the Mozart music on brain-drived neurotrophic factor (BDNF) in the hippocampus. Here we investigated the effect of postpartum exposure to The Mozart music on BDNF </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">concentration in the hippocampus of rat.</font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Methods: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Thirty male one day old newborn Wistar rats divided randomly in </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">two equal experimental and control groups. Experimental group exposed to slow rhythm Mozart music (Mozart Sonata for two pianos KV 448, 6 hour per day sound pressure levels, between 80 and 100 dB) for 60 successive days. The control group was kept in separate room with housing conditions like experimental group except music exposure. After 60 days the rats were euthanized and hippocampuses extracted then the content of BDNF protein was measured using ELISA sandwich </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">method. </font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Results: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Data analysis revealed that rats exposed to Mozart Sonata music had significantly increased BDNF content in the hippocampus as compared to control rats (P</font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">±</font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">0.01). The concentrations of BDNF were 86.30±2.26 and 94.60 ±6.22 ng/g wet weight in control and music exposure groups respectively.</font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Discussion: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Exposure to the Mozart music early in life can increase the BDNF </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">concentration in the hippocampus in rats. </font></font></font></b></b></b></b>Mozart Music,BDNF,Hippocampus,Rat2126http://bcn.iums.ac.ir/browse.php?a_code=A-10-8-3&slc_lang=en&sid=1MohsenMarzban137003194753284600945137003194753284600945Yes
AliShahbazi137003194753284600946137003194753284600946NoMahdiTondar137003194753284600947137003194753284600947NoMansoorehSoleimani137003194753284600948137003194753284600948NoMasoomehBakhshayesh137003194753284600949137003194753284600949NoArashMoshkforoush137003194753284600950137003194753284600950NoMehdiSadati137003194753284600951137003194753284600951NoSiamakAlizadeh Zendehrood137003194753284600952137003194753284600952NoMohammad TaghiJoghataei137003194753284600953137003194753284600953No