Tri-6
Brand Names Mixture

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Chemical_Formula

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RX_link

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fda sheet

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msds (material safety sheet)

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Synthesis Reference

No information avaliable

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Molecular Weight

466.951 g/mol

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Melting Point

220-224 oC

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H2O Solubility

5 mg/mL

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State

Solid

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LogP

4.004

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Dosage Forms

Solution; Spray

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Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

Tri-6
Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

Tri-6
Absorption

Very limited systemic absorption, but good absorption at the point of delivery.