As of October 1, 2010, the city has an estimated population of 86,631 and a population density of 184.53 persons per km². The total area is 469.48 km².

In 1595, what is now Uwajima was known as Itajima Village. Takatora Tohdo became lord of the Uwa region, and ordered the restoration of Marugushi Castle. The city was founded by the mergers of the city of Uwajima and parts of former Kitauwa District.

After Date Hidemune, the eldest son of Date Masamune, a prominent lord in northern Japan, took over Uwa in 1614, the clan strongly promoted Uwajima Castle as a center of industry, education, and culture.

In 1871 Uwa became Uwajima Prefecture. The following year it was renamed Kamiyama Prefecture. In 1873, Kamiyama Prefecture was combined with Ishizuchi Prefecture. After Ehime Prefecture was established, the capital was moved to Matsuyama to the north.

Uwajima has a Date Family Museum[3] which features many historically important objects tied to the history of the region and the Daimyō family Date which ruled this area.

Uwajima Castle is well known as one of the 12 Japanese castles to have an original donjon built in the Edo Period.

Uwajima is home to an unusual fertility shrine called Taga Shrine, which features a large, realistic phallus carved from a log approximately 9 feet in length, 1 foot in diameter. Next to the shrine is a graphic sex museum, filled with artifacts and paintings from around the world.

A mask of the Cow Demon (牛鬼,ushioni), one of the many used at the bullfighting festival.

Every July a festival is held in Uwajima known as the Uwajima Ushi-oni Festival, "Gaiya Festival," or the "Warei Shrine Festival." Among the festivities are ushioni teams parading down the street, a dance contest to the town song known as the "Gaiya" dance, traditional dancing, and a bullfight. The word "Gaiya" is in a local dialect, approximately translating to "awesome" in English.

The city is known for bullfighting, which differs from the more widely known Spanish bullfights in that there is no matador. Two bulls fight in a ring until one bull's knees touch the ground or flees, marking it the loser. Bullfights are generally held in January, April, July, and August.

Tsushima occupies an area of approximately 200 km² and has a significant proportion of Uwajima's current land area, despite not being highly populated (fewer than 15,000 people). It's made up of small villages that shared a municipal government as Tsushima until they were amalgamated into Uwajima.

Tsushima is known for the Iwamatsu River and its annual festival where people eat tiny, live fish, as well as pearl and fish farming. It is part of the prefecture's mikan industry.