Results: :
EGFP–positive cells integrated into the hostretina of Transducin knockout mice and extended neurites. Manyintegrated cells of host retina migrated to the outer nuclearlayer (ONL) and exhibited typical morphology of photoreceptorcells–with cell body localized in the ONL and extendedouter segment–like structure into the outer segment layer.Most of these cells were also expressed with photoreceptor markers,Recoverin and Nr2e3.

Conclusions: :
Our results revealed that transplanted retinal cellscould integrate and differentiate into photoreceptors in thephotoreceptor dysfunctional host with gliotoxin treatment. Treatmentof gliotoxin to the host may be a prerequisite for the successof retinal transplantation therapy.