Children with GH excess underwent medical treatment with lanreotide and a minimum clinical/biochemical follow up of 2 years is reported. The present study demonstrates that GH excess should be considered as a relative frequent endocrine manifestation in NF1 (zeige NF1 Proteine) patients, similarly to central precocious puberty

Thus, GHRH (zeige GHRH Proteine) analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of GHRH (zeige GHRH Proteine) receptors levels.

The intrinsic amyloidogenicity of growth hormone, in the presence of contaminating prion protein (zeige PRNP Proteine) (and perhaps prolactin (zeige PRL Proteine) as well) and amyloid-beta contained in some cadavers' pituitaries, may have led to the observed co-occurring of Creutzfeldt-Jakob disease and Alzheimer's disease.

To our knowledge, c.-223C>T is the first homozygous point mutation in the GH1 promoter that leads to short stature due to idiopathic growth hormone deficiency.

Data show that the recombinant protein produced by the plasmid-free E coli strain was purified and characterized to be human growth hormone (hGH).

Mouse (Murine) Growth Hormone 1 (GH1) Interaktionspartner

These results indicate that up-regulation of GH in the lungs of DJ-1 (zeige PARK7 Proteine) KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.

Confirmation of the impairment of GH-IGF-1 (zeige IGF1 Proteine) release in hyperphagic MC4R (zeige MC4R Proteine) KO mice suggests a role for insulin (zeige INS Proteine) in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 (zeige IGF1 Proteine) levels

Thiol-disulfide exchange reactions in hGH and related model peptides were influenced by higher order structure, by the size of the thiol reactant and by an Arg residue adjacent to Cys (zeige DNAJC5 Proteine) in the thiol reactant.

Acylated ghrelin (zeige GHRL Proteine) is not required for the surge in pituitary growth hormone observed in pregnant mice.

STAT5 (zeige STAT5A Proteine) signaling is increased in the liver in GH-transgenic mice during the growth period, with a balance between positive and negative effectors resulting in accelerated but controlled growth.

The total frequencies for the combined genotypes for the bGH and RORC (zeige RORC Proteine) genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle

one GH1 SNP, GH33, was significantly associated with milk protein (zeige CSN2 Proteine) yield in the second lactation. Several GH1 SNPs were significantly associated with fertility.

GH and IGF-I (zeige IGF1 Proteine) genotypes had no substantial effect on productive parameters, though IGF-I (zeige IGF1 Proteine) genotype affected calving-first service interval in primiparous cows. However, the genotypes do alter the endocrine/metabolic profiles of the transition dairy cow.

Pig (Porcine) Growth Hormone 1 (GH1) Interaktionspartner

Data indicate that the dual effects of cortistatin (zeige CORT Proteine) on growth hormone release parallel those of somatostatin (zeige SST Proteine) and are probably mediated by the same receptor(s) and signaling pathway(s) for both peptides.

Guinea Pig Growth Hormone 1 (GH1) Interaktionspartner

Expression of PRL (zeige PRL Proteine) and GH in the guinea pig is prominent in the anterior pituitary, similar to known expression patterns of PRL (zeige PRL Proteine) and GH for other species.

Zebrafish Growth Hormone 1 (GH1) Interaktionspartner

Reproductive tests showed that double transgenic males did not differ from non-transgenics. It is possible that GHR (zeige GHR Proteine) excess in the muscle tissues of double transgenics may have contributed to lower circulating GH levels and thus reduced the negative effects of this hormone with respect to reproduction.

Growth Hormone 1 (GH1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.