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Resveratrol is a natural occurring polyphenol with diverse biological activities in vitro and poor pharmacokinetic profile because of its rapid metabolism in vivo. In this project, polymer conjugate approach was evaluated for masking resveratrol against the metabolism. Various polymer conjugates were prepared and evaluated both in vitro and in vivo. Among those tested, resveratrol-PLA-PEG and resveratrol-PEG ether conjugates were found capable of providing better pharmacokinetics than native resveratrol.

Quantification of pegylated drugs in biological matrices is often complex and challenging. This paper describes a sensitive HPLC method with fluorescence detection for the analysis of pegylated resveratrol, resveratrol ...

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Curtin University would like to pay our respect to the indigenous members of our community by acknowledging the traditional owners of the land on which the Bentley Campus is located, the Wadjuk people of the Nyungar Nation; and on our Kalgoorlie Campus, the Wongutha people of the North-Eastern Goldfields.Watch our traditional Aboriginal welcome