How Liposomal Doxorubicin Works and What to Discuss With Your Doctor

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How Does Liposomal Doxorubicin Work?

Liposomal doxorubicin is part of a group of medications called anthracyclines. Anthracyclines kill cells (including cancer cells and normal cells) by working in several ways. Liposomal doxorubicin binds to DNA in cells, changing the shape of the DNA and causing other problems with the DNA. The medication can damage the membranes (outer coating) of cells and may damage other parts of cells as well.

While liposomal doxorubicin can kill both healthy and cancerous cells, it has a greater effect on cells that are multiplying rapidly. In general, cancer cells multiply more rapidly than healthy cells, and are therefore more affected by liposomal doxorubicin.

Liposomal doxorubicin is a pegylated liposomal formulation of doxorubicin. This means that the drug molecules are trapped within liposomes (tiny fatty bubbles). This changes how the medication is distributed throughout the body and also increases the time the drug lasts in the body. It is thought that liposomal doxorubicin is less toxic to heart tissues but more toxic to skin tissues, compared to nonliposomal doxorubicin.

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