Network Analysis - Upload Data

The InnateDB curation team has annotated 25,000 molecular interactions of relevance to innate immunity - constructing the
first innate immunity interactome (see our paper published in BMC Systems Biology).
Although InnateDB curation focuses on innate immunity-relevant interactions, InnateDB also incorporates detailed annotation
on the entire human, mouse and bovine interactomes by integrating data (352,782+ interactions) from other major interaction databases.
InnateDB network analysis allows users to build, visualize and analyze the molecular interaction networks that a gene list of
interest and their encoded products are components of. Users can potentially uncover as yet unknown signaling cascades or pathways,
functionally relevant sub-networks and the central molecules, or hubs, of these networks.

To do a Network Analysis, first upload a tab-delimited text file or Excel spreadsheet (.xls files only) of gene/protein
identifiers (human, mouse or cow only) and any associated quantitative data (e.g. gene expression data fold-changes and p-values)
from up to 10 conditions/time-points. Please see our help page
if you are unsure how to do this and to see what IDs are accepted. On the options page you can then specify criteria to filter the returned interaction list

Once you have a list of interactions associated with your gene/protein list - click on the "Cerebral" button at the top of the page
to visualise and analyse the network.

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada),
the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia)
and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health
through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database.
Contact: innatedb-mail@sfu.ca