CRISPR/Cas9, Gene Editing Tool

What is CRISPR?

CRISPR/Cas9, is an RNA-guided targeted genome editing tool – allows researchers to do gene knockout, knockin
SNPs,
insertions and deletions in cell lines and animals. The CRISPR/Cas9 genome editing system requires two components,
Cas9,
the endonuclease, and a guide RNA (sgRNA); sgRNA guides Cas9 to the location in the genome sequence specifically.
With the protospacer-adjacent motif (PAM - the sequence NGG) present at the 3′ end, Cas9 will unwind the DNA
duplex and cleave both strands upon recognition of a target sequence by the guide RNA.

Products and Services

OriGene provides reagents to support a broad range of CRISPR/Cas9 gene editing applications. Click the following gene
editing
related product below and learn more about how we can help you.