This new chapter in The Spider-Man legacy focuses on an untold story that reveals a different side of Peter Parker. He was abandoned by his parents as a boy and raised by his Uncle Ben and Aunt May. Now as a teenager, Peter discovers a mysterious briefcase that belonged to his father. It sends him on a quest regarding his parent's disappearance which leads directly to Oscorp and the lab of Dr. Curt Connors, his father's, partner. As Spider-man is set on a collision course with Connor's alter-ego, the Lizard, Peter will make life-altering decisions to use his powers and shape his destiny to become a hero.