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Ages Eligible for Study:

28 Years to 75 Years (Adult, Older Adult)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Participants Age > 28 years and ≤ 75 years

Male or Female

Participants with Type 2 Diabetes who are treated for ≤ 10 years and are on stable oral diabetic medications for a minimum of 3 months

Participants with an HbA1c > 7.5 and ≤ 10.0%

Participants with a BMI > 24 and < 40

Participants willing to comply with study requirements and able to understand and comply with informed consent

Participants who have signed an informed consent form

Exclusion Criteria:

Participants diagnosed with Type I Diabetes or with a history of ketoacidosis

Participants that have known autoimmune disease as evidenced by a positive anti glutamic acid decarboxylase (GAD) blood test

Participants requiring prescription anticoagulation therapy and/or dual anti-platelet therapy including aspirin who cannot discontinue their medication for 14 days before and 14 days after the procedure

Participants with iron deficiency anemia - either currently or in their history

Participants with current symptomatic hypocalcemia or vitamin D deficiency (routine calcium and/or vitamin D supplementation would not be excluded)

Participants with or a history of abnormalities of the GI tract preventing endoscopic access to the duodenum,

Participants with symptomatic gallstones or kidney stones at the time of screening

Participants with a history of pancreatitis

Participants with an active systemic infection

Participants with or a history of coagulopathy, upper gastro-intestinal bleeding c conditions such as ulcers, gastric varices, strictures, congenital or acquired intestinal telangiectasia

Participants with celiac disease

Participants with active malignancy. Those who have had remedial treatment and/or are cancer free for 5 years can be enrolled

Participants with known active hepatitis or active liver disease

Participants emotionally unstable or who exhibit psychological characteristics which, in the opinion of the Investigator, make the participant a poor candidate for clinical trial participation

Participants with previous GI surgery that could affect the ability to treat the duodenum such as participants who have had a Bilroth 2, Roux-en-Y gastric bypass, or other similar procedures or conditions