The protein encoded by RAMP1 is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). Additionally we are shipping RAMP1 Antibodies (58) and RAMP1 Proteins (8) and many more products for this protein.

These findings suggest that RAMP1 may be a new therapeutic target to regulate CGRP (show CALCA ELISA Kits)-mediated effects during disease including pathophysiological states in which Ang II (show AGT ELISA Kits) plays a major role.

Co-expression of RAMP1 and CRLR (show CALCRL ELISA Kits) reconstituted a CGRP (show CALCA ELISA Kits) receptor that was able to activate the pheromone-signaling pathway with pharmacological properties similar to those observed previously in mammalian cells.

The mouse cDNA for RAMP1 was cloned and we examined the signal transduction mechanism through the CGRP (show CALCA ELISA Kits) receptor. mRAMP1 is a 148-amino acid single membrane-spanning protein with a short cytoplasmic portion.

The present finding demonstrated that RAMP1 immunoreactivity was localized in many neurons and phenopalatine ganglion.

The T-A-C haplotype is a genetic marker for cerebral infarction, and RAMP1 is associated with increased susceptibility to cerebral infarction.

RAMP1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.