2 Apokryphes Zitat Dr. William H. Stewart (US Surgeon General ): It is time to close the book on infectious diseases, and declare the war against pestilence won. (The office of the Public Health Service Historian. Frequently asked questions. 7 December Available at: ABER He never made any such statement: Numerous other verfiable sources, however, confirm that other people in academia adopted this belief. (Spellberg B, Taylor-Blake B: On the exoneration of Dr. William H. Stewart: debunkering an urban legend. Infectious Diseases of poverty 2013, 2:3. Available at: )

7 The EU Innovative Medicines Initiative (Nature Medicine 2014; 20: 5; doi: /nm0114-5) The Innovative Medicines Initiative (IMI) launched in 2008 as part of a massive European push to foster public-private partnerships in biomedicine. Over its six years of existence, the 2 billion ($2.7 billion) joint venture between the EU and the European Federation of Pharmaceutical Industries and Associations has collaborated with 43 companies and worked with scientists from 31 participating countries. Nine IMI-backed medicinal products have gone into a total of 90 clinical trials. Close to 600 peer-reviewed research papers have come out of the effort. Now, the IMI is coming to the end of its first phase. Last month, the Brussels-based institution announced its eleventh and final call for proposals within the initial budget allocation. The next phase of the initiative what's known as IMI 2 is hoped to launch this spring and last another ten years. Here, Nature Medicine takes a look at where the IMI's money has been allocated to date and highlight the industry partners who have supplied funds in three areas.

8 Alternativen so oder so? Eat leeks in March and wild garlic in May, and all the year after the physicians may play. Traditional Welsh rhyme An apple a day keeps the doctor away. Traditional American rhyme (Martin KW, Ernst E, JAC 2003; 51: ; Cowan KW, CMR 1999; 12: )

21 Phase 3 Registration Trial In Mildly Infected Diabetic Foot Ulcers With Locilex registration trial mildly infected diabetic foot ulcers locilex Dipexium Pharmaceuticals, LLC today announced that it has has reached an agreement with the U.S. Food and Drug Administration on a Special Protocol Assessment for an upcoming Phase 3 registration trial in mild infections of diabetic foot ulcers with Locilex (pexiganan acetate cream 1%). Study DPX-305 will be a randomized, double-blind, multi-center, superiority, placebo-controlled Phase 3 Study of Pexiganan Cream 1% (Locilex(TM)) applied twice daily for 14 days to treat adult patients with mild infections of diabetic foot ulcers in the United States. Study DPX-305 will involve approximately 180 patients and the primary efficacy endpoint is resolution of infection in the medical judgment of each treating physician.

28 Eliava Institute of Bacteriophage, Microbiology and Virology Tbilisi, Georgia Dr. Elena Makashvili (links), Prof. Felix D Herelle (mitte), Prof. George Eliava (rechts) More than 15 effective bacteriophage preparations were elaborated and produced commercially at the Institute. For example, IBMV was used for prophylaxis and treatment throughout the former Soviet Union, in the Public Health network and in military forces. Throughout the 1970s to1980s, phage preparations such as Pyophage, Intestyphage, Pyoceaneus bacteriophages, Intravenous Staphylococcus bacteriophage, Dysenterial bacteriophage were recognized at national and international exhibitions and became brands know worldwide.

37 Leibniz-Institut DSMZ One of DSMZ s key aspects are medically relevant bacteria, also in the context of DZIF consortium (Deutsches Zentrum für Infektionsforschung, German Centre for Infection Research). The most obvious application of lytic phages is in the medical area: MRSA and ESBL producing bacteria In collaboration with the Eliava Institute IBMV, Tbilisi, Georgia, the DSMZ has finished a phage project to fight against MRSA. Another actual phage research focus at the DSMZ aims at bacteria of the order Burkholderiales that play a role in the biofilms of patients lungs suffering from COPD or CF

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