DOE Joint Genome Institute

DOE JGI in Walnut Creek, California, provides state-of-the-science capabilities for genome sequencing and analysis. With more than 1100 worldwide collaborators on active projects, JGI is the preeminent facility for sequencing plants, microbes, and microbial communities that are foundational to energy and environmental research.

Mapping and Sequencing the Human Genome

Genetic Mapping

Physical Mapping

Complete a sequence tagged site (STS) map of the human genome at a resolution of 100 kb.*

DNA Sequencing

Develop efficient approaches to sequencing one- to several-megabase regions of DNA of high biological interest.

Develop technology for high-throughput sequencing, focusing on systems integration of all steps from template preparation to data analysis.

Build up a sequencing capacity to allow sequencing at a collective rate of 50 Mb per year by the end of the period. This rate should result in an aggregate of 80 Mb of DNA sequence completed by the end of FY 1998.

Gene Identification

Develop efficient methods for identifying genes and for placement of known genes on physical maps or sequenced DNA.

Technology Development

Substantially expand support of innovative technological developments as well as improvements in current technology for DNA sequencing and for meeting the needs of the Human Genome Project as a whole.

Model Organisms

Finish an STS map of the mouse genome at a 300-kb resolution.

Finish the sequence of the Escherichia coli and Saccharomyces cerevisiae genomes by 1998 or earlier.

Continue sequencing Caenorhabditis elegans and Drosophila melanogaster genomes with the aim of bringing C. elegans to near completion by 1998.

Sequence selected segments of mouse DNA side by side with corresponding human DNA in areas of high biological interest.

Informatics

Continue to create, develop, and operate databases and database tools for easy access to data, including effective tools and standards for data exchange and links among databases.

The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v5n4).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.

Citation and Credit

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