Fox Business Network host Lou Dobbs says House Speaker Paul Ryan, R-Wis. has accomplished "next to nothing" in his entire political career and should resign.

Dobbs' call for Ryan to quit comes amid a heated battle with the Republican Party over the plan to repeal and replace Obamacare and a day after Breitbart News released an audio recording of Ryan telling fellow GOP members of the House he had no intention of defending then-party nominee Donald Trump amid Trump's own audio tape scandal.

In early October, just as an old "Access Hollywood" audio emerged of Trump using lewd language about women, Ryan said during a conference call, "I am not going to defend Donald Trump — not now, not in the future. And I'm not going to be campaigning with him over the next 30 days. . . . Look, you guys know I have real concerns with the nominee. I hope you appreciate that I'm doing what I think is best for you, the members, not what's best for me."

Dobbs was dubious, saying on Tuesday's "Lou Dobbs Tonight" that Ryan was more interested in "what's best for his donors, corporate interests, banks, health insurers."

While Dobbs said he said in October, when news first broke of Ryan's comments, the speaker appeared "hell-bent" on destroying the Republican Party, he said Tuesday it looks now more like Ryan is interested in destroying Trump himself.

A Public Policy Polling survey shows Ryan less popular in his own district than Trump, Dobbs said, and more voters oppose his healthcare plan, which Dobbs dubbed "Ryancare," than favor it.

"He had achieved next to nothing in his entire career before becoming speaker, and he's worked against his party's presidential nominee and he has lost," Dobbs said. "He put forward a mantra instead of policies. He lost again."

Ryan even lost as the GOP's vice presidential running mate to Mitt Romney in 2012, he noted.

"It is time for his party, if not the speaker himself, to recognize his limitations, his decidedly poor judgment and poor prospects for in any way finding a better way," Dobbs said. "I believe it's time for Ryan to vacate the speaker's office in the interest of his party and, in fact, the nation."