Welcome to week four on the NFL Talkboard. Also known as The First Week With The Real Refs Back. At last. No doubt there will now be various sagas relating to the returning officials' rustiness or long-standing capacity for making mistakes of their own, but it cannot be worse than some of what we have seen over the last few weeks. It will be nice just to concentrate on the football again.

Anyway, many of you know the drill with this blog by now, but for those who don't, the Pick Six competition works as follows: every week I will select six games – usually the ones I think will be toughest to call – and post my predictions. You are invited you to submit your own picks below the line. We will keep track of everyone's scores over the course of the season, so as to determine an overall winner.

Loud whooping this week, please, for itsmilks and shadow76, each of whom picked all six games correctly. As always, I shall post the overall standings below the line as soon as I can.

This week's live blog, hosted by my colleague David Lengel, is New York Giants @ Philadelphia Eagles. Kick-off is at 8.20pm ET on Sunday, or 1.20am BST on Monday, so be sure to join David for that. Now, without further ado, here are this week's games:

San Francisco 49ers @ New York Jets (Sunday 1pm ET/6pm BST)

Much has been made over the Jets' loss of Darrelle Revis – arguably the best cornerback in the NFL – but it is questionable whether he would have been a huge factor in this game. Even with Randy Moss added to the line-up this season, the 49ers are still a run-first team. Then again, Revis's absence cannot hurt an offense whose main focus will be on eliminating the turnovers that cost them so dearly last week in Minnesota. They are the better team but this is a long cross-country trip and New York's defense, even without Revis, will make life difficult. Nevertheless …49ers to win

San Diego Chargers @ Kansas City Chiefs (Sunday 1pm ET/6pm BST)

Momentum is a mysterious thing. Late in the third quarter of their game against the Saints last weekend, Kansas City were 24-6 down and headed for an 0-3 record. They had been outscored 99-47 over the course of the season. Then, out of nowhere, Jamaal Charles goes 91 yards for a score and the Chiefs come back for an overtime win. San Diego, by contrast, had their early season momentum halted emphatically in a 27-6 home loss to Atlanta. Are these teams headed in opposite directions or was that just a blip? I'm not at all convinced by the Chargers. But I'm even less sure of the Chiefs.

Chargers to win

Seattle Seahawks @ St Louis Rams (Sunday 1pm ET/6pm BST)

Green Bay weren't the only ones frustrated by the replacement officials' blown call at the end of Monday Night Football. The Rams, like the rest of the NFC West, were also left stewing after seeing a rival given a leg-up in what has become an extremely competitive division. St Louis may be the weakest team within it, but the margins are not so great as some have imagined, and a defence which has recorded five interceptions already will give Russell Wilson a difficult afternoon. With Steven Jackson closer to full fitness and Seattle on a short week, they can spring the upset at home.

The league's worst offense goes up against its 30th-ranked defense. Tampa Bay have generated just 243.7 yards per game so far, but Washington are giving up an average of 429.3. Unless the Buccaneers can find a way to slow down Robert Griffin III – and they would be the first – they will need to take this opportunity to get their own offense kick-started. Washington's games so far have all wound up being shoot-outs, and I just don't like the Buccaneers' odds in that sort of match-up.

This should be fun. Two of the more explosive offenses in the NFC go head-to-head, with each team's quarterback aware that he will be up against a ferocious pass-rushing defensive line. Oh, and these teams also happen to hate one another. Eagles running back LeSean McCoy set the tone nicely when he reignited a long-running feud by calling the Giants defensive end Osi Umenyiora a "ballerina". But with Michael Vick struggling and the Giants moving on up after their slow start, McCoy may not be laughing on Sunday.Giants to win

Chicago Bears @ Dallas Cowboys (Monday 8.30pm ET/Tuesday 1.30am BST)

Monday Night Football brings another big NFC match-up between teams with high aspirations but also clear flaws. The Bears, as ever, are having trouble keeping Jay Cutler upright, and offensive tackle J'Marcus Webb could be in for another earful unless he is given sufficient help dealing with DeMarcus Ware. Chicago's defense, however, is second in the league with nine takeaways and could have some fun with Tony Romo. Dallas have been underwhelming since their week-one win over the Giants, but I still like them to take this one at home.Cowboys to win

And the rest

Here are the rest of this week's games. These are not included in the Pick Six, just for informational purposes. Feel free to post your picks for these as well, but if you do so then please keep them separate from your Pick Six predictions, as it will make life a lot easier when tallying up your scores.