Yes, you can assign more than 1 effect to the same footswitch. If you assign 2 effects to the same footswitch and turn one effect on and the other off, then the footswitch becomes a toggle between the 2 effects. And if you want you could set it up so 2 effects turn on and a 3rd turns off at the same time, for example. Or any combination. Just assign them to the same footswitch.