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Genome sequencing: missing a stage, John Sulston

Interviewee: John Sulston.
John Sulston, a key figure in the public genome project, speaks about the difficulties posed by missing a step in the sequencing process.
(DNAi Location: Genome >The project > Players > Private project > Genome shotgun: missing a stage)

Transcript:

The Celera approach was to miss out this intermediate stage, they did a single shotgun going straight from the genome down to small pieces. So when they started to reassemble, of course you can do a lot, it goes quite well for large parts of the genome, but when you come to places where there's severe confusion between a sequence here and a sequence over here, then you've got something to deal with.