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I love the 22-250 for antelope. We mostly meat hunt and with a 50 grain ballistic tip in the lungs there won't be an once of meat lost. I am yet to see one walk further than 50 feet or stay standing more than 30 seconds.

Did they just make the 22-250 legal last year? I thought about taking mine 2 years ago but I looked and 22 cal wasnt legal. Last year I took my old 30-30 and made what I believe was the most well placed shot of my life. Right behind the shoulders through the ribs on both sides, didnt waste any meat at all and that antelope took about 3 steps, stood there for a few seconds and fell over!!!

Your 30-06 using the 180 gr. bullet you are shooting and it is sighted in with will work just fine. It's not a bad excuse to pine for a new rifle though. The 6mm Remington, 257 Roberts, and 25-06 are all excellent antelope rifles if you really want a new rifle.

Jeremy, I'd use the '06 and use the money you'd spend on an unneeded rifle for the antelope tag & gas for your trip. Not that buying another gun is ever a bad idea, but the truth is that the rifle that you're familiar with is the best choice. Just my take on it.

Did they just make the 22-250 legal last year? I thought about taking mine 2 years ago but I looked and 22 cal wasnt legal. Last year I took my old 30-30 and made what I believe was the most well placed shot of my life. Right behind the shoulders through the ribs on both sides, didnt waste any meat at all and that antelope took about 3 steps, stood there for a few seconds and fell over!!!

The Wy regs say: "Any center fire firearm of atleast 22 cal and having a bullet weight of atleast 60 grains, or a cartridge that generally delivers atleast 500 foot pounds of impact at 100 yards, and using a lead or expanding point bullet"

Does that mean it has to be 22 cal, 60 grains, and 500 energy? It could be taken to mean anything that has atleast 500 of energy at 100 yards would be legal. A 204 ruger with a 24 gr hornady NTX makes 717 of energy at 100 yards. I have no desire to shoot an antelope with that light of a bullet, just saying

Any center fire firearm of at least 22 cal and
a) having a bullet weight of atleast 60 grains, or
b) a cartridge that generally delivers atleast 500 foot pounds of impact at 100 yards,and using a lead or expanding point bullet