Datasheet Extract

Immunogen

Immunogen:

Peptide-KLH, C-terminal end of murine RIG-1

Application

Western Blot, This antibody is useful for Western Blot., Western Blot

Background

RIG-1/DDX58(Retinoic acid-inducible gene 1 protein/ DEAD-box protein 58) is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 and MDA5 (melanoma differentiation-associated gene 5) are key intracellular receptors that sense intracellular viral infection and trigger a signal for innate antiviral responses including the production of type I IFN. Clone SS1A has been shown to be useful for western blotting of the mouse RIG-1 protein.