Adrenal gland, Cortex - Hyperplasia in a female Sprague-Dawley rat from a chronic study. There is a circumscribed but noncompressive focus of hyperplasia (H) in the zona fasciculata.

Adrenal gland, Cortex - Hyperplasia in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 3). The cells in this hyperplastic lesion (H) are smaller and more closely packed than those in the adjacent normal cortex.

Adrenal gland, Cortex - Hyperplasia in a female F344/N rat from a chronic study. There is a hyperplastic lesion (H) in which cortical cells are increased in number but are smaller in size than adjacent normal cortical cells (NC).

Adrenal gland, Cortex - Hyperplasia in a female F344/N rat from a chronic study. The hyperplastic lesion (H) has an increased number of cells that are smaller than adjacent normal cortical cells (NC).

Adrenal gland, Medulla - Hyperplasia in a male B6C3F1/N mouse from a chronic study. There is a small, noncompressive focus of hyperplastic medullary cells at the corticomedullary junction (arrow). M = medulla.

Adrenal gland, Medulla - Hyperplasia in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). The hyperplastic cells (arrow) are increased in number but are smaller and more basophilic than adjacent normal medullary cells (M).

Adrenal gland, Medulla - Hyperplasia in a male F344/N rat from a chronic study. There is focal hyperplasia (arrow) deep in the medulla (M).

Adrenal gland, Medulla - Hyperplasia in a male F344/N rat from a chronic study (higher magnification of Figure 9). The hyperplastic cells (H) are smaller (so the nuclei appear more crowded) and more basophilic than the adjacent normal medullary cells (M).