Mebeverine is a muscolotropic spasmolytic with a strong and selective action on the smooth muscle spasm of the gastrointestinal tract, particularly of the colon. It does not have the acetylecholine side effect commonly seen in an anticholinergic antispasmodic.

Peppermint oil has been traditionally used as an antispasmodic, and a review of studies on the topic found that it "could be efficacious for symptom relief in IBS"[3] (as an antispasmodic) although more carefully controlled studies are needed. A later study showed it is an effective antispasmodic when test-applied topically to the intestine during endoscopy.[4]

Bamboo shoots have been used for gastrointestinal and antispasmodic symptoms.
Anisotropine, Atropine, Cindinium Cap are also the most commonly used modern antispasmodics.

Spasm may also be seen in movement disorders featuring spasticity in neurologic conditions such as cerebral palsy, multiple sclerosis, and spinal cord disease. Medications are commonly used for spastic movement disorders, but research has not shown functional benefit for some drugs.[6][7] Some studies have shown that medications have been effective in decreasing spasticity, but that this has not been accompanied by functional benefits.[6] Medications such as baclofen, tizanidine, and dantrolene have been used.[5]