While DisplayFusion works well and is fully tested on Windows 10, there are a few issues due to the big changes between Windows 7/8 and 10.
This is the current list of known issues, which we'll be keeping up to date as we find more issues, and also as we find workarounds and resolutions for them.

Taskbar buttons for Universal apps remain on the Windows taskbar when the app is moved to another monitor.

TitleBar Buttons overlap tabs on Edge browser.

Windows not coming to front when clicked (this is a Windows 10 bug triggered by any program that uses TOPMOST on its windows). Workaround: Enable the "SetWindowPos: Disallow TopMost Calls" option in Settings > Advanced Settings.

Start menu opens briefly on the Primary monitor before moving to the DisplayFusion taskbar when monitors have differing scaling settings or if monitor splitting is enabled. [Not fixable, due to not being able to hook the Windows 10 Start menu]