There are thousands of recognized single gene (monogenic) disorders. Their cumulative incidence is roughly 1%.

Also, the penetrance is usually very high with single gene disorders. So must be the clinical validity or predictive value of the DNA tests.

The new-generation methods of DNA sequencing or, for that matter, chip genotyping could probably be capable of detecting all single-gene disease mutations listed in the Genetests reviews over single run. Conceivably, in the clinical diagnostics setting the computer-annotated sequence data should be examined and verified by a qualified physician.

Thus, the rapid comprehensive analysis of the genes implicated in single-gene genetic disorders appears to be feasible.