Fusion

STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:query proteins and first shell of interactors

white nodes:second shell of interactors

Node Content

empty nodes:proteins of unknown 3D structure

filled nodes:some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

XP_449873.1

Hypothetical protein (144 aa)

Predicted Functional Partners:

XP_449289.1

Hypothetical protein (242 aa)

0.963

XP_446717.1

Hypothetical protein (260 aa)

0.963

XP_449874.1

Hypothetical protein (114 aa)

0.792

XP_449664.1

Hypothetical protein (149 aa)

0.779

XP_447553.1

Hypothetical protein (84 aa)

0.742

DRE2

Hypothetical protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death (338 aa)

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1

node2

node1 accession

node2 accession

node1 annotation

node2 annotation

score

DRE2

XP_446717.1

XP_446446.1

XP_446717.1

Hypothetical protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death

Hypothetical protein

0.943

DRE2

XP_449289.1

XP_446446.1

XP_449289.1

Hypothetical protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death

Hypothetical protein

0.943

DRE2

XP_449664.1

XP_446446.1

XP_449664.1

Hypothetical protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death

Hypothetical protein

0.904

DRE2

XP_449873.1

XP_446446.1

XP_449873.1

Hypothetical protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death

Hypothetical protein

0.568

XP_445845.1

XP_446717.1

XP_445845.1

XP_446717.1

Hypothetical protein

Hypothetical protein

0.637

XP_445845.1

XP_449289.1

XP_445845.1

XP_449289.1

Hypothetical protein

Hypothetical protein

0.637

XP_445845.1

XP_449664.1

XP_445845.1

XP_449664.1

Hypothetical protein

Hypothetical protein

0.617

XP_445845.1

XP_449873.1

XP_445845.1

XP_449873.1

Hypothetical protein

Hypothetical protein

0.508

XP_446532.1

XP_446717.1

XP_446532.1

XP_446717.1

Hypothetical protein

Hypothetical protein

0.637

XP_446532.1

XP_449289.1

XP_446532.1

XP_449289.1

Hypothetical protein

Hypothetical protein

0.637

XP_446532.1

XP_449664.1

XP_446532.1

XP_449664.1

Hypothetical protein

Hypothetical protein

0.617

XP_446532.1

XP_449873.1

XP_446532.1

XP_449873.1

Hypothetical protein

Hypothetical protein

0.508

XP_446717.1

DRE2

XP_446717.1

XP_446446.1

Hypothetical protein

Hypothetical protein; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death

0.943

XP_446717.1

XP_445845.1

XP_446717.1

XP_445845.1

Hypothetical protein

Hypothetical protein

0.637

XP_446717.1

XP_446532.1

XP_446717.1

XP_446532.1

Hypothetical protein

Hypothetical protein

0.637

XP_446717.1

XP_447553.1

XP_446717.1

XP_447553.1

Hypothetical protein

Hypothetical protein

0.963

XP_446717.1

XP_448421.1

XP_446717.1

XP_448421.1

Hypothetical protein

Hypothetical protein

0.742

XP_446717.1

XP_449873.1

XP_446717.1

XP_449873.1

Hypothetical protein

Hypothetical protein

0.963

XP_446717.1

XP_449874.1

XP_446717.1

XP_449874.1

Hypothetical protein

Hypothetical protein

0.963

XP_447048.1

XP_449873.1

XP_447048.1

XP_449873.1

Hypothetical protein

Hypothetical protein

0.494

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)

Enrichment analysis is still ongoing, please wait ...

Statistical background

For the above enrichment analysis, the following statistical background is assumed: