In some circumstances, you may not be willing to submit a variant to Infevers
in order not to jeopardize further publication in a scientific journal.
However, it happened many times that we heard about a variant that was
eventually submitted to Infevers
by another contributor before being published by the initial discoverer.
Indeed, our policy is to favor dissemination of information.
To avoid these uncomfortable situations, we now offer the possibility
that your sequence variant remains confidential for a while.
If you ask for confidentiality, your data will not be visible, but you
will be credited with the date of submission when it becomes visible.
After submission you will be reminded every 6 months to allow or not
your variant to become publicly available.
After three reminders (18 months),
the variant will automatically become visible.
In the event that another contributor submits the same variant in the
meantime, you will be warned and this duplicated data submission will
automatically activate publication of your data.

• Statistics and graphs

Several novel applications are now available through
the "search entire database module".

Tabular list:
Provides a complete list of validated (and not confidential) sequence
variants currently recorded in Infevers.
A complete detailed tabular list can also be downloaded as an excel file.
All data can be cross-queried by selecting values in each item. For example
[location: "exon1"] + [alteration: "substitution"]
+ [technique: "sequencing"] extracts the list of sequence variants
matching these 3 parameters among the complete list.
Details on each variant are available as a specific "detailed variant
form" by simply clicking on "see details"
This detailed variant form contains all available information on the variant,
and shows the upstream and downstream 15bp surrounding the first base
mutated (in red).

Gene graph:
A schematic figure of the gene, with exons and introns roughly on scale
is provided. The distribution of the sequence variants along the gene
is represented, and the "detailed variant form" is available
by simply clicking on the variant name.

Statistics:
Histograms depicting the current number of sequence variants recorded
in Infevers are provided
per alteration type, location and ancestry . Data are shown as the total
number of sequence variants, or according to the phenotype associated
with the variant (red: number of variants with a defined associated phenotype,
orange: number of variants with unknown phenotype, green: number of variants
with no associated phenotype).

Sequences:
The cDNA sequence and the genomic sequence of the gene are shown.
You can download as a doc file the sequence of gene including 1000 bp
5' and 3' of the gene.
Exons are in upper case, introns are in lower case.
The ATG of the first translated Met codon, and the termination codon are
highlighted.

Note: Any table or illustration from this module is freely available, however you are kindly requested to quote Infevers.
The following citation format is appropriate: Infevers: an online database for autoinflammatory mutations. Copyright. Available
at http://fmf.igh.cnrs.fr/ISSAID/infevers/ Accessed (date of access) together with the following references:

Complex alleles (more than one change in one allele)
are now listed, and a new specific form is available for their submission.

List of complex alleles:
When one change participates in one or more complex allele(s), this
information is indicated in the "complex allele" column, available
at the right end of the tabular list of the "search entire database"
module. All recorded complex alleles including the specific change are
then detailed through the "see details" button.

Submission of complex alleles:
When you wish to contribute a novel sequence variant, you will now be
given the choice to submit either a simple variant, or a complex allele.
The sequence changes constituting the complex allele:

Must be already recorded in the database

Must appear sequentially from 5' to 3'
Example p.[S108R; M694V] and not p.[M694V; S108R]

Nomenclature :

Description of the nucleotidic change
Two variations in one allele, separated by at least
one nucleotide, are described as "[first change; second change]".
Consequently, the description c.76_77delinsTT is preferred over c.[76A>T;
77G>T].

c.[76A>C; 83G>C] denotes two changes in one allele; A to C
change at nucleotide 76 and a G to C change at nucleotide 83

Description of the protein change
Two variations in one allele

deriving from two independent changes
at DNA level are described as "[first change;second change]"

p.[Ala25Thr;Gly28Val] denotes two changes in one allele; amino acid Alanine-25
to Threonine and Glycine-28 to Valine

deriving from one change at DNA level that has more
than one effect on RNA/protein level are described as "[first change,
second change]"

p.[Ala5Thr, Ala5_Gly30delfsX] denotes two protein changes deriving
from a change in one allele at DNA level (c.13G>A, resulting in two
transcripts (r.[13g>a, 13_88del]); amino acid Alanine-5 to Threonine
and a deletion of amino acids Alanine-5 to Glycine-30 followed by
a frame shift