Alternative names for DSPP antibody

SwissProt ID

Gene ID

Ncbi ID

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P)

Background of DSPP antibody

DSPP may be an important factor in dentinogenesis. DSPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.The dentin sialophosphoprotein (DSPP) gene encodes two major noncollagenous dentin matrix proteins: dentin sialoprotein, known as DSP; and dentin phosphoprotein, known as phosphophoryn or DPP. The DSPP gene maps to human chromosome 4 and yields a 4.6 kb transcript containing 5 exons, with exons 1-4 encoding for DSP and exon 5 encoding for both the C-terminus of DSP and the full length DPP. DPP and DSP are acidic proteins that represent about 50% of the noncollagenous proteins in the dentin extracellular matrix of teeth. The DSPP gene is a likely candidate gene for the genetic diseases associated with abnormal dentin formation such as dentinogenesis imperfecta type II and dentin dysplasia type II. DPP may bind large amounts of calcium and may facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.

Formalin-fixed and paraffin embedded bone of mouse embryo labeled with Anti-DSPP Polyclonal Antibody, Unconjugated (bs-8557R) at 1:200 followed by conjugation to the secondary antibody and DAB staining