The Undergraduate Program in Biology offers courses at all levels of biological organization: molecular, cellular, organismal and population, and concentration programs with varying degrees of multidisciplinary or specialty foci.

There is a vast range of collaborative opportunities for independent study and research under the mentorship of the faculty. Faculty maintain research programs at the cutting edge of their fields including biochemistry, biophysics, cell biology, developmental biology, ecology, evolution, genetics, immunology, molecular biology, neurobiology, physiology, anatomy, artificial organs, microbiology, virology, experimental pathology, and pharmacology. The close administrative relationship with the Alpert Medical School offers additional opportunities for blending fundamental biology and clinical sciences in research projects at the Brown-affiliated hospitals.

The Office of Biology Undergraduate Education is a full service academic resource center, serving a key role for students of the life sciences here. The Office provides individualized advising for students at all levels; oversees student- faculty research collaborations, holds special events and maintains a variety of programs that support and enrich student life.

Introduces the basic principles of human nutrition, and the application of these principles to the specific needs of humans, and the role of nutrition in chronic diseases. Provides an overview of the nutrients and their use by the human body. Also examines the role of nutrients in specific functions and disease states of the body. Not for biology concentration credit. Enrollment limited to 100. LILE

Fall

BIOL0030

S01

14793

MW

8:30-9:50(01)

(M. Flynn)

BIOL 0040. Nutrition for Fitness and Physical Activity.

Reviews the role of nutrition in physical activity and health. It is designed to provide the student with the information and skills needed to translate nutrition and physical activity recommendations into guidelines for both the athlete for maximal performance and the non-athlete to improve both health and body weight. Students will learn the use of the energy yielding nutrition in physical activity and how food choices can influence both athletic performance and long-term health through the effect on risk factors for chronic diseases. Prerequisite: BIOL 0030. Enrollment limited to 20. Instructor permission required.

BIOL 0060. Introduction to Human Physiology.

An introduction to human physiology aimed primarily at undergraduates who have minimal to no Biology background or who are not concentrating in biology. Acquire a basic understanding of the physiological mechanisms that allow for the running of each major organ systems. Topics include basic cardiovascular, respiratory, urinary, digestive, endocrine, and neuromuscular function, as well as aspects of reproduction and exercise physiology. Not for biology concentration credit. Lab.

BIOL 0080. Biotechnology Management.

An examination of the pharmaceutical, biotechnology, and medical product industries: what they are, how they function, whence they originate, and various perspectives on why some succeed and others fail. Pathways from lab-bench to marketplace are described as are the pervasive influences of the FDA, patent office, and courts. Extensive reading; emphasis on oral presentation. Primarily intended for students planning a career in biomedical industry. Not for biology concentration credit. Students MUST register for the lecture section and the conference. Enrollment limited to 20.

Participants will understand how to read scientific research papers to interpret their findings and communicate these to a broader lay audience; analyze and understand best practices in science writing and the challenges of covering science for mass media; interviewing; fair and balanced coverage in reporting; give and receive peer feedback. Not for concentration credit in Biological Sciences programs. Enrollment limited to 10. Instructor permission required. S/NC WRIT

Spr

BIOL0140A

S01

23920

W

5:00-6:30(14)

(S. Turner)

BIOL 0140B. Communicating Science: Biological Illustration.

This Sophomore Seminar is an immersion practicum that conjoins art and science. Employing a series of techniques, students will learn the protocols of scientific rendering in an intensive hands-on approach. Field trips will include the RISD Nature Lab, the Brown Greenhouse, and John Hay collection of biomedical and botanical folios. Media will include graphite/ carbon dust; pen and ink (stipple, line); coquille board; scratch-board, colored pencil, watercolor and polymer clay. Course will be driven by project presentations focused on communicating science through illustration. Not for concentration credit in Biological Sciences programs. Instructor permission required; enrollment 10 students. 1/2 credit. SOPH

BIOL 0140C. Communicating Science: Animating Science.

Taught by RISD/Brown professors with the Science Ctr and Creative Mind Initiative, this course explores the pedagogy of using visual media to convey scientific concepts. The goal is to assess the quality of existing material and design new material that fill an educational need and makes science engaging and accessible. Lectures, labs, discussions, critiques and speakers. Teams collaborate on a series of short exercises leading to the creation of videos/animations explaining scientific concepts. Projects evaluated on accuracy, clarity of explanation, educational value, viewer engagement and creativity. Not for concentration credit in Biological Sciences programs. Enrollment limited to 12; instructor permission.

Fall

BIOL0140C

S01

14794

W

1:00-6:00(06)

(J. Stein)

BIOL 0140K. Conservation Medicine.

How have fruit bats contributed to the emergence of Nipah virus in Malaysia? Is an infectious cancer going to drive the Tasmanian Devil to extinction? Will a warmer world be a sicker world? We will consider these and additional topics at the intersection of global change biology and infectious disease emergence in this course. The course should be of interest to pre-med, general biology and environmental studies concentrators seeking interdisciplinary learning classroom experience. This will satisfy "Area 3" organismal biology concentration requirement for Biology/Health-Human Biology. Expected background: BIOL 0200 or equivalent placement. Enrollment limited to 12 sophomores. Instructor permission required. SOPH

BIOL 0150A. Techniques and Analyses using DNA-Based Biotechnology.

Students will study and practice a range of methods used in molecular biology while examining the ways in which those tools are used in research and in the development of medical treatments. This experience, combined with the reading and discussion of selected papers from the primary literature, fosters development of a skill set critically important for the modern day biology student. Expected background: high school Biology course. Enrollment limited to 10 first year students. Instructor permission required. Half-credit course. S/NC. FYS

Fall

BIOL0150A

S01

14796

T

5:00-8:00PM(09)

(J. Hall)

Fall

BIOL0150A

L01

14998

Arranged

(J. Hall)

BIOL 0150B. Statistical Computing for Biology.

Modern biological research is a data rich endeavor, necessitating strong quantitative and computational skills to interpret the results of experimental and observational studies. In this course we will explore the application of statistics and modeling in biological research and environmental science. Topics covered will include basic probability, experimental design, sampling, hypothesis testing and mathematical models for prediction. No prior statistics knowledge is assumed. Enrollment limited to 10 first year and sophomore students. Instructor permission, based on a portfolio review. This is a half-credit course. S/NC

Plant secondary metabolites are currently the subject of much research interest when investigating new target compounds for potential medicine from natural products. New leads for drugs and phytomedicines from plants and plant parts have been increasing at a rapid rate especially by the pharmaceutical industry. Many plants have been selected and collected for their specific secondary compounds and healing powers by ethnobotanists in the field. The final step is the extraction, analyzing and identification of these plant specimens. Enrollment limited to 10 first year students. Instructor permission required. Half-credit course. S/NC. FYS

Regenerative Medicine, also known as Tissue Engineering, is the process of creating living, functional tissues to repair or replace native tissue or organ functions that have been lost due to disease or congenital defects. As such, it is a prominent scientific discipline that can either "stand alone" or complement material-based research efforts in the areas of device design, drug delivery, diagnostics and pharmaceuticals. Students will develop proficiencies in basic cell culture techniques, early stage tissue regeneration strategies and histochemical characterization of mammalian cell constructs. Enrollment limited to 10 first year students. Instructor permission required. Half-credit course. S/NC. FYS

Fall

BIOL0150D

S01

14797

F

1:30-3:30(10)

(B. Zielinski-Habershaw)

Fall

BIOL0150D

S01

14797

T

12:00-2:00(10)

(B. Zielinski-Habershaw)

BIOL 0160. Plants, Food, and People.

Examines the selection, breeding, cultivation and uses of food plants. Discusses the effects on agriculture of pathogens, climate change, and loss of biodiversity. Considers whether enough food can be produced for a world population of potentially 10 billion, while sustaining biodiversity and environmental quality. Course will include two papers and assistance from Writing Fellows; feedback from first paper will be available when writing second paper. Enrollment limited to 50. LILE

Spr

BIOL0160

S01

23923

TTh

10:30-11:50(09)

(P. Heywood)

BIOL 0170. Biotechnology in Medicine.

Introduces undergraduates to the main technological advances currently dominating the practice of medicine. Provides an overview of the objectives, techniques, and problems related to the application of biomedical technology to the diagnosis and treatment of disease and the contemporary health care industry. Topics include: pharmaceutical development and formulation; organ replacement by prosthesis and transplantation; medical imaging; tissue engineering, therapeutic cloning, regenerative medicine; stem cells; societal, economic, and ethical issues. This course does carry Biology concentration credit.

Fall

BIOL0170

S01

14798

MWF

12:00-12:50(12)

(B. Zielinski-Habershaw)

BIOL 0180. The Biology of AIDS.

AIDS represents an example of the vulnerability of humans to new infectious agents. We will review some human infectious diseases including small pox yellow fever and influenza, and then explore AIDS/HIV. First characterized in 1981, AIDS became the leading cause of death in U.S. males aged 25-44 within a decade. We will examine what factors make HIV such a potent pathogen. The course is intended for students beginning in biology. Expected: BIOL 0200, or equivalent placement. This course does carry Biology concentration credit.

BIOL 0190E. Botanical Roots of Modern Medicine.

This course will explore a variety of medicinal plants found throughout the world, the diverse cultures that use them in their daily lives and the scientific underpinnings of their medicinal uses. In conjunction with readings, students will gain a hands-on approach in lab, observing, identifying and growing these plants. Enrollment limited to: 20. Students MUST register for the lecture section and the lab. FYS

Fall

BIOL0190E

S01

14799

MW

3:00-4:20(17)

(F. Jackson)

Fall

BIOL0190E

L01

14997

W

4:30-5:50

(F. Jackson)

BIOL 0190F. Darwinian Medicine.

Explores evolutionary explanations of why we get sick, and how this can shape, or misshape, our interpretations of medicine. Draws on evolutionary genetics, population biology, molecular biology and physiology. This course will build on evolutionary biology and then focus on disease processes such as infection, aging, cancer, allergy, diabetes, and obesity. Enrollment limited to 20 first year students. FYS

Fall

BIOL0190F

S01

14800

TTh

1:00-2:20(10)

(M. Tatar)

BIOL 0190P. Pride and Prejudice in the Development of Scientific Theories.

We will examine how the pace and shape of scientific progress is affected by the social/cultural context and the "personality" of the individual. We will look into how the interplay between society and the individual affects how scientific theories arise, are presented, are debated and are accepted. The course will initially focus on Charles Darwin and his theory of Natural Selection using the biography of Adrian Desmond and James Moore, "Darwin: The Life of a Tormented Evolutionist." Enrollment limited to 20 first year students. FYS DPLL

Fall

BIOL0190P

S01

14801

TTh

2:30-3:50(03)

(S. Helfand)

BIOL 0190Q. Climate Change and Species Extinction.

In this course students will go beyond the headlines and delve into the science to explore the impact of climate change on species extinction. Students will explore the integration of science and technology through traditional textbooks, primary literature, open source databases, simulations, and discussions. Students will investigate the impact of climate change on species distribution, ecology, and behavior through interactive, inquiry-based, collaborative classroom investigations. Students will learn to integrate information from a variety of sources and disciplines and share their ideas through classroom discussion, written assignments, and oral presentations. Enrollment limited to 20 first year students. FYS WRIT

BIOL 0190R. Phage Hunters, Part I.

A research-based lab class for freshmen; both semesters are required in the sequence. Students will isolate and characterize a bacteriophage viruses found in the soil. Lab work includes isolation and purification of your own phage, DNA isolation and restriction mapping, and EM characterization of your phage. Several phages will be selected for genome sequencing over winter break, and are annotated in the spring. One hour lecture, discussion, and 3 hours lab per week. Expected: AP Biology or equivalent, and HS chemistry. Instructor permission required. Admittance based on review of applications in the first class. Limited to 20 freshmen. FYS

Fall

BIOL0190R

S01

14802

M

3:00-5:30(15)

(Y. Zhou)

Fall

BIOL0190R

L01

14996

Arranged

(S. Taylor)

BIOL 0190S. Phage Hunters, Part II.

A research-based laboratory/class for freshmen; both semesters are required. Students will isolate and characterize a bacteriophage viruses found in the soil. Lab work includes isolation and purification of your own phage, DNA isolation and restriction mapping, and EM characterization of your phage. Several phages will be selected for genome sequencing over Winter Recess, and annotated in the spring. One hour of lecture/discussion, and 3 hours lab per week. Expected: AP Biology or equivalent, HS chemistry, and permission of the instructor. Students are expected to take fall and spring courses in the sequence. Enrollment limited to 20 first-year students. Instructor permission. FYS

Spr

BIOL0190S

S01

23925

M

3:00-5:30(13)

(S. Taylor)

Spr

BIOL0190S

S01

23925

W

3:00-5:30(13)

(S. Taylor)

Spr

BIOL0190S

L01

23926

Arranged

(S. Taylor)

BIOL 0190T. Bioinformatics: A Practical Introduction.

The amount of biological sequence data has grown at an exponential pace and spurred the development of computational tools that allow biologists to use this information. Students will become familiar with useful bioinformatics tools used by researchers. The course will introduce concepts of information transfer in biological molecules, storage in public databases, and how to use tools to access this information and organize it meaningfully. We will explore tools for studying whole genomes, including high-throughput sequencing data to assemble genomes and mapping subsets. Students will gain hands-on experience using these tools. Expected: AP credit or equivalent placement for BIOL 0200. FYS

BIOL 0190U. Plant Development, Structure and Function.

This course presents an integrated account of development, structure and function in plants, especially seed plants. Enrollment limited to 20 first year students. FYS WRIT

Fall

BIOL0190U

S01

14803

W

3:00-5:30(17)

(P. Heywood)

Fall

BIOL0190U

S01

14803

M

3:00-5:30(17)

(P. Heywood)

BIOL 0200. The Foundation of Living Systems.

A broad overview of biological systems, emphasizing patterns and processes that form the basis of life. Explores essentials of biochemistry, molecular, and cellular biology and their relationship to the larger issues of ecology, evolution, and development. Examines current research trends in biology and their influence on culture. Appropriate for all students interested in biology. Serves as a gateway course to much of the intermediate and advanced curriculum. Placement tests are offered (contact Jody_Hall@brown.edu); AP scores of 4 or 5 are equivalent to BIOL 0200, and place a student out of this course. Students will be assigned to a lab section during the second week of class. LILE

Spr

BIOL0200

S01

23928

MWF

11:00-11:50(04)

(K. Miller)

Spr

BIOL0200

L01

23929

Arranged

(J. Hall)

Spr

BIOL0200

L02

23930

Arranged

(J. Hall)

Spr

BIOL0200

L03

23931

Arranged

(J. Hall)

Spr

BIOL0200

L04

23932

Arranged

(J. Hall)

Spr

BIOL0200

L05

23933

Arranged

(J. Hall)

BIOL 0210. Diversity of Life.

This course will explore biological diversity – the number of taxa, and the functions, and processes that support life – from the perspectives of ecology and evolutionary biology. It will draw on examples and case studies from the geological record, functional morphology, the evolution of organ systems in vertebrates, genomics, behavior and sexual selection in birds and invertebrates. Overarching themes will emphasize that taxonomic diversity is an emergent property of complex life on Earth, and the importance of diversity of biological functions and processes in generating and maintaining taxonomic diversity. Class Restriction: Freshmen and sophomores; others by instructor permission.

Fall

BIOL0210

S01

14804

MWF

11:00-11:50(02)

(J. Kellner)

BIOL 0280. Introductory Biochemistry.

Lectures and recitation sections explore the mechanisms involved in the principles of macromolecular structure and function, the organization and regulation of pathways for intermediary metabolism, and the transfer of information from genes to proteins. It is expected that students have taken CHEM 0350 or are taking it concurrently.

Spr

BIOL0280

S01

23934

TTh

1:00-2:20(10)

(G. Jogl)

Spr

BIOL0280

C01

23935

Arranged

(L. Lapierre)

Spr

BIOL0280

C02

23936

Arranged

(L. Lapierre)

Spr

BIOL0280

C03

23937

Arranged

(L. Lapierre)

Spr

BIOL0280

C04

23938

Arranged

(L. Lapierre)

Spr

BIOL0280

C05

23939

Arranged

(L. Lapierre)

Spr

BIOL0280

C06

23940

Arranged

(L. Lapierre)

Spr

BIOL0280

C07

23941

Arranged

(L. Lapierre)

Spr

BIOL0280

C08

23942

Arranged

(L. Lapierre)

Spr

BIOL0280

L01

23943

Arranged

(L. Lapierre)

Spr

BIOL0280

L02

23944

Arranged

(L. Lapierre)

BIOL 0285. Introductory Biochemistry Laboratory.

Working in small groups, students will examine enzymatic reactions in bacterial metabolic pathways. They will gather information from online databases, define a working model and test this model by purifying a target enzyme and characterizing its biochemical function. They will then propose a hypothesis for the enzymatic reaction mechanism and test this hypothesis by designing mutations in the enzyme active site and characterizing these mutant enzymes experimentally. Priority given to sophomore and junior students planning to enter research careers. Expected:Students have previously taken or are concurrently enrolled in BIOL 0280; preference given to students concurrently enrolled. Instructor permission required. Course credit 0.5; final grade determined for BIOL 0285.

Spr

BIOL0285

S01

23953

M

1:00-5:00(06)

(S. Taylor)

Spr

BIOL0285

S02

24941

Th

2:30-6:30(11)

(S. Taylor)

BIOL 0300. Endocrinology.

A basic examination of endocrinology with emphasis on hormone biosynthesis, mechanism of action, physiological roles, and endocrine pathology. Topics include: mechanism of action of steroid, amine, and peptide hormones; neuroendocrinology; reproductive endocrinology; and endocrinology of metabolism and calcium homeostasis. It is expected that students have taken BIOL 0200 (or equivalent) and CHEM 0350.

BIOL 0320. Vertebrate Embryology.

Introduction to the developmental anatomy of vertebrate embryos, including humans, in an evolutionary context, through lecture, discussion and microscope slide study. Gametogenesis through germ layers and their organ system derivatives. Expected: BIOL 0200, or equivalent placement, or AP Biology score of 4 or 5. Limited to 18 freshmen and 18 sophomores. Students MUST register for the lecture section and the lab.

BIOL 0350. The Fossil Record: Life through Time on Earth.

Course is designed for students with prior background in geology or evolutionary biology and who want to learn more about the fossil record, the origins of modern biodiversity and ecosystem structure, and interaction between organisms, and the geological and chemical cycles on the Earth. Lectures will cover major time periods during which animals and plants lived, as well as focusing on major transitions in the evolution of life on Earth. This course will fulfill requirements in both the geology/biology and evolutionary biology concentrations. Expected: BIOL 0210, GEOL 0240 or equivalent. Instructor permission, enrollment limited to 20 sophomores/juniors; register for course/lab.

Spr

BIOL0350

S01

25369

MWF

10:00-10:50(03)

(A. Leslie)

Spr

BIOL0350

L01

25370

Arranged

(A. Leslie)

BIOL 0380. The Ecology and Evolution of Infectious Disease.

We will survey the diverse biology of microbes responsible for human infectious disease, develop and apply ecological and evolutionary theory to infectious microbes, and provide practical experience interpreting and synthesizing the peer-reviewed scientific literature. The discovery of infectious microbes, the role of genetic novelty, population structure and transmission mode, and the influence of clinical therapies and host immune response will be considered. Evaluation will be based on preparation, participation, weekly student presentations, brief weekly written assignments, a midterm and a final. Expected: BIOL 0200 or equivalent. Enrollment limited to 25 first year students and sophomores. LILE

Fall

BIOL0380

S01

14805

MWF

10:00-10:50(14)

(D. Weinreich)

BIOL 0390. Vertebrate Evolution and Diversity.

An overview of vertebrate evolution that not only covers historical events, but also introduces various scientific concepts and modes of thought. Topics include past and present biodiversity, convergent evolution, biogeography, competition, continental drift, climatic change over time, the notion of evolution as progress, and a whole-animal approach to understanding evolutionary events. Enrollment limited to 50. WRIT

BIOL 0400. Biological Design: Structural Architecture of Organisms.

Many questions about the workings of living creatures can be answered by joining math, physics, and biology. We will identify basic physical science concepts that help biologists understand the structure and function of animals, plants, and microorganisms, and use these to study how the physical world constrains and facilitates the evolution of the extraordinary design and diversity of organisms. For first and second year students; others by permission. Recommended background: BIOL 0200, or equivalent. Enrollment limited to 40. Instructor permission required. WRIT

Fall

BIOL0400

S01

14806

MWF

2:00-2:50(07)

(J. Allen)

BIOL 0410. Invertebrate Zoology.

A survey of invertebrate animals emphasizing evolutionary patterns and ecological relationships. Functional morphology, physiology, reproduction, development, and behavior of invertebrates will be examined. Laboratory exercises and two separate day-long field trips provide firsthand experience with the animals. Expected: BIOL 0200 or equivalent. Enrollment limited to 44. Students MUST register for the lecture section and a lab.

Fall

BIOL0410

S01

14807

MW

11:00-11:50(02)

(C. Dunn)

Fall

BIOL0410

S01

14807

F

11:00-11:50(02)

(C. Dunn)

Fall

BIOL0410

L01

14995

W

1:00-3:50

(C. Dunn)

BIOL 0415. Microbes in the Environment.

Examines the diversity of microbial life in the environment. Surveys key services that microbes perform on land and sea, including biodegradation of contaminants in the environment and ecosystem processes related to climate change. Examines biological interactions of symbioses, quorum sensing, and antibiotic production in a ecological context. Explores the genomic mechanisms explaining phylogeny and life history strategies in microbes. Demonstrate knowledge of the diversity of microbes in the environment and benefits in an ecological/evolutionary context. Lecture based, two fieldtrips to expand appreciation for microbial ecology. BIOL 0200 or equivalent placement; CHEM 0330. Enrollment limited to 20 sophomores, juniors and seniors. WRIT

BIOL 0420. Principles of Ecology.

The principles, concepts, and controversies involved in the study of the distribution and abundance of plant and animal populations and their integration into natural communities. Emphasizes interactions among organisms and the hierarchical nature of ecological processes affecting individuals, populations, and communities. Expected: BIOL 0200 (or equivalent) and MATH 0090. Lectures and weekly discussion.

Spr

BIOL0420

S01

23956

TTh

9:00-10:20(08)

'To Be Arranged'

Spr

BIOL0420

C01

23957

Arranged

'To Be Arranged'

BIOL 0430. The Evolution of Plant Diversity.

Examines the evolutionary history of plants from a phylogenetic perspective. Introduces the science of phylogenetics - how to infer phylogenies and how to use them to understand organismal evolution. Highlights major trends in plant evolution over the past 400 million years. Lectures survey major plant lineages, with special focus on flowering plants. Weekly labs, field trips, and assignments stress basic plant anatomy and morphology, identification, and learning the local flora. Expected: BIOL 0200 (or equivalent placement). WRIT

This course focuses on what plants do and how they do it. Introduces the biology of plants, their growth and development, structural features, and their cellular and organismal responses to key stimuli. Examines physiological, reproductive and developmental strategies throughout the plant life cycle and in relation to environmental challenges. Discusses the significance of various plant model systems for genetic research and understanding of mechanisms controlling plant growth and development. Prerequisites: BIOL 0200 (or equivalent placement). Students MUST register for the lecture section and a lab. Enrollment limited to 24 students.

BIOL 0455. Coastal Ecology and Conservation.

Will enable to students to master fundamental ecological concepts and understand how this knowledge can be used to inform coastal conservation and management. Case studies from New England and elsewhere, field trips to rocky shores, salt marshes and coastal ecosystems enable students to develop scientific skills and experience the challenges of coastal conservation science. The course is aimed at freshmen and sophomores. Expected background: BIOL 0200 or equivalent placement. Enrollment limited to 10 students, and written permission required. Email (Mark_Bertness@brown.edu) to receive course application (due May 1). Admitted students register for the course in September.

Fall

BIOL0455

S01

16467

TTh

1:00-2:20(10)

(M. Bertness)

BIOL 0460. Insect Biology.

Focuses on characteristics that make insects unique and why more insect species have been described than all other organisms combined; the opportunity to investigate diversity and adaptation; their abundance, small size, and short lifespans; their importance as agents of biocontrol pollination, agricultural pests, and disease vectors. Expected: BIOL 0200 or equivalent. Enrollment limited to 20. Students MUST register for lecture AND lab. Primarily for freshmen and sophomores.

BIOL 0470. Genetics.

Genetic phenomena at the molecular, cellular, organismal, and population levels. Topics include transmission of genes and chromosomes, mutation, structure and regulation of the expression of the genetic material, elements of genetic engineering, and evolutionary genetics. One laboratory session and one discussion session per week. (Students should not plan to take BIOL 0470 after 1540.) Expected: BIOL 0200 (or equivalent placement). Students will be assigned to Lab sections the first week of class.

A first course in probability distributions and the use of statistical methods for biological data. Topics covered will include describing data, statistical inference (hypothesis tests and confidence intervals), analyzing associations, and methods for categorical data (contingency tables and odds ratios). Methods will be applied to data drawn from areas of biological inquiry. For statistics or related science credit in Biology programs. Expected background: BIOL 0200 or equivalent, math equivalent to MATH 0100. This course is for related science credit only in Biological Sciences concentration programs. Enrollment limited: 40 undergraduates-20 juniors and 20 sophomores. Registration for seniors requires permission from the instructor.

Spr

BIOL0495

S01

23960

TTh

10:30-11:50(09)

(S. Ramachandran)

Spr

BIOL0495

C01

23961

Arranged

(S. Ramachandran)

BIOL 0500. Cell and Molecular Biology.

This course examines the structure and function of the basic unit of an organism, the cell. An experimental approach is used to examine cellular functions, ranging from gene transcription, cell division and protein secretion, to cell motility, and signal transduction. Relevance to health and disease will be considered. Expected: BIOL 0200 (or equivalent placement).

Spr

BIOL0500

S01

23962

MW

8:30-9:50(02)

(P. Heywood)

BIOL 0510. Introductory Microbiology.

Introduces role of microbes in our understanding of biology at the cellular and molecular level. Focuses on microbial significance for infectious disease, public health, genetics, biotechnology, and biogeochemical cycles. Laboratory involves basic microbiological techniques and selection and manipulation of microbes. Expected: BIOL 0200 (or equivalent placement). Students MUST register for the lecture section, conference, and the lab. Enrollment limited to 108.

Introduction to the function and integration of organ systems with an emphasis on human physiology. Includes basic concepts in cell and organ system physiology as well as fundamentals of modern trends in physiological science. Emphasizes the application of physical and chemical principles to organ function at both the cellular and systemic levels. Expected: BIOL 0200 or equivalent.

Fall

BIOL0800

S01

14812

TTh

10:30-11:50(13)

(J. Stein)

Fall

BIOL0800

L01

14980

Arranged

(A. Sobieraj)

Fall

BIOL0800

L02

14981

Arranged

(A. Sobieraj)

Fall

BIOL0800

L03

14982

Arranged

(A. Sobieraj)

Spr

BIOL0800

S01

23968

MWF

10:00-10:50(03)

(C. Hai)

Spr

BIOL0800

L01

23969

Arranged

(A. Sobieraj)

Spr

BIOL0800

L02

23970

Arranged

(A. Sobieraj)

Spr

BIOL0800

L03

23971

Arranged

(A. Sobieraj)

Spr

BIOL0800

L04

23972

Arranged

(A. Sobieraj)

Spr

BIOL0800

L05

23973

Arranged

(A. Sobieraj)

BIOL 0860. Diet and Chronic Disease.

This course addresses the relationship of food to the development and treatment of chronic diseases. Chronic diseases discussed are obesity, dyslipidemia/heart disease, diabetes mellitus, cancers and osteoporosis. Dietary recommendations for these diseases are critically assessed. Geared toward students interested in nutrition, medicine, and public health. Prerequisites: BIOL 0030 and 0800, plus permission of the instructor. Enrollment limited to 20.

Spr

BIOL0860

S01

24547

T

4:00-6:30(16)

(M. Flynn)

BIOL 0920A. Controversies in Medicine.

Why and how do controversies in medicine emerge at specific moments in time? Why do scientists come to different conclusions based on the same data? Does it matter how we interpret controversies? This sophomore-level seminar critically analyzes contemporary controversies in medicine and public health. Using a case study approach, we will examine the social and political assumptions that inform important controversies. Questions related to the relationship between science, media, activism, and health inequality will be woven into the case studies. Enrollment limited to 20 sophomores. (For theme, not biology, credit in Health and Human Health and Biology only.) SOPH

BIOL 0940A. Viral Epidemics.

This sophomore seminar will examine epidemics (outbreaks) of viral infections from a historical perspective. We will also cover current literature and up to the minute news accounts of infectious disease related outbreaks occurring around the globe. The major focus will be on virus related diseases but any microbial outbreak in the news will be explored. The seminar will cover basic aspects of microbial pathogenesis so students can gain an appreciation of microbial host interactions. Essential writing skills will also be developed. Enrollment limited to 20 sophomore students. WRIT SOPH

Fall

BIOL0940A

S01

14814

Th

4:00-6:30(04)

(W. Atwood)

BIOL 0940B. Sophomore Seminars in Biology: Life in a Shell.

This Sophomore seminar is an examination of broad themes in whole animal physiology with an emphasis on environmental adaptations. The foundation of the course will be the instructor’s recent book “Life in a Shell: A Physiologist’s View of Turtle.” A consideration of this iconic animal’s novel biological traits will lead into comparisons with our own biology and that of other animals. Topics: respiration, circulation, metabolic rate, buoyancy control, overwintering, migration, reproduction, and bone structure and function. Relevant original research papers will be used. Mandatory S/NC; enrollment of 20 students; override required. Expected: BIOL 0200 or equivalent placement credit. SOPH

Fall

BIOL0940B

S01

14815

T

4:00-6:30(09)

(D. Jackson)

BIOL 0940C. Sophomore Seminar: Insect Biology.

Focuses on characteristics that make insects unique and why more insect species have been described than all other organisms combined; the opportunity to investigate diversity and adaptation; their abundance, small size, and short lifespans; their importance as agents of biocontrol pollination, agricultural pests, and disease vectors. Expected: BIOL 0200 or equivalent. Enrollment limited to 12 sophomores only. Students MUST register for lecture AND lab. SOPH

This Sophomore Seminar focuses on species level identification of plants in Rhode Island and will cover the dominant plant species in each of the state’s main habitats including coastal wetlands and uplands, freshwater wetlands, peatlands, upland forests, and disturbed areas. Students will learn to identify plants using online interactive keys as well as more technical dichotomous keys and will also cover basic ecological processes in each habitat including the interaction of soils, geology, and hydrology. Materials related to plant morphology, plant taxonomy, plant evolution, understanding phylogenetic trees, and botanical illustration. Pre-requisites: BIOL 0200. Instructor permission required. SOPH

Fall

BIOL0940D

S01

16470

F

1:00-5:00(06)

(T. Whitfeld)

BIOL 0960. Independent Study in Science Writing.

Incorporates a nontechnical science journalism component into the BioMed curriculum. A series of four to six specific assignments are recommended, based on topics derived from another biology course taken previously by the student, whose instructor has agreed to serve as a BIOL 0960 sponsor. Assignments may include, for example, investigative or analytical reviews, or feature articles on ethical or social impacts of new discoveries. The student and instructor schedule meetings to discuss topics and due dates, review rough drafts, and evaluate completed work.

Not for concentration credit in the biological sciences programs. Permission must be obtained from the instructor prior to registering. Section numbers vary by instructor. Half credit.

BIOL 1040. Ultrastructure/Bioimaging.

This course examines microscopy and image analysis in the life sciences. Theoretical and practical aspects of microscopy will be discussed. Students will obtain hands-on experience with electron microscopy, light microscopy, fluorescence microscopy, and confocal microscopy. Students will learn to display images in 3D. Advanced undergraduates. Instructor permission required.

Spr

BIOL1040

S01

24902

M

2:00-5:00(07)

(G. Williams)

BIOL 1050. Biology of the Eukaryotic Cell.

Examines organelles and macromolecular complexes of eukaryotic cells with respect to structural and functional roles in major cellular activities. Emphasizes experimental basis for knowledge in modern cell biology using original literature, and discusses validity of current concepts. For advanced undergraduates and beginning graduate students. Complementary to BIOL 1270 and 1540. Prerequisites: BIOL 0280 or 0470 or 0500, or instructor permission. Graduate students register for BIOL 2050.

Fall

BIOL1050

S01

14820

TTh

1:00-2:20(10)

(K. Miller)

Fall

BIOL1050

C01

14977

Th

12:00-12:50

(K. Miller)

BIOL 1070. Biotechnology and Global Health.

This course examines contemporary biotechnologies used to combat the predominant, worldwide problems in human health. Global health will be addressed from the scientific and engineering perspectives while integrating public health policy, health systems and economics, medical and research ethics, and technology regulation and management. This course is intended for graduate and advanced undergraduate students in biology, engineering, or related fields who have an interest in global health initiatives. Expected background: BIOL 0200 and BIOL 0800, or equivalents. Preference will be granted to graduate students in the Biotechnology and Biomedical Engineering programs. Only for related course credit in Biology, and for theme course credit in Health and Human Biology programs. Enrollment limited to 20. Instructor permission required.

Current topics in cell physiology, with an emphasis on membrane-mediated interactions between cells and their environment. Topics may include: ion channel structure, function and regulation; intracellular regulatory molecules; mechanisms of sensory transduction; membrane receptors and second messenger systems; vesicle secretion; and cytoskeletal regulation of cell function. Lectures, discussion, and student presentations of the current literature. Expected: BIOL 0800 or NEUR 0010. Instructor permission required. Registration overrides will not be given out until after the first one or two classes. Enrollment limited to 30, and admission is based on seniority -- graduate students, seniors, then juniors. (Not for first and second-year undergraduates.)

Spr

BIOL1100

S01

23974

M

3:00-5:30(13)

(D. Horrigan)

BIOL 1110. Topics in Signal Transduction.

Signal transduction is one of the most rapidly developing fields in biomedical sciences. Defects in signaling pathways can be responsible for diseases such as cancer, diabetes, cardiovascular disorders and psychoses. This course offers students an overview of the molecular pathways that allow cells to receive and process signals from their external environment, with an emphasis on the emerging state-of-the-art techniques used in their study. Expected background: BIOL 0200, 0280, 0470, or 0500. Enrollment limited to 20 juniors and seniors. Instructor permission required.

BIOL 1120. Biomaterials.

A biomaterial is defined as a material suitable for use in medical implants that come in direct contact with patients' tissues. These include polymers, metals, and ceramics, and materials obtained from biological sources or through recombinant biotechnology. Goal: to provide comprehensive coverage of biomaterial science and technology. Emphasizes the transition from replacement to repair strategies. For advanced undergraduates and graduate students. Prerequisite: BIOL 0800 or instructor permission.

Spr

BIOL1120

S01

24812

Th

4:00-6:30(17)

(B. Zielinski-Habershaw)

BIOL 1140. Tissue Engineering.

Tissue engineering is an interdisciplinary field that incorporates progress in cellular and molecular biology, materials science, and engineering, to advance the goal of replacing or regenerating compromised tissue function. Using an integrative approach, we will examine tissue design and development, manipulation of the tissue microenvironment, and current strategies for functional reconstruction of injured tissues. Expected: CHEM 0330, plus BIOL 0500 or 0800. Enrollment limited to 20. Instructor permission required.

Fall

BIOL1140

S01

14825

Th

3:00-5:50(04)

(D. Hoffman-Kim)

BIOL 1150. Stem Cell Engineering.

Stem cell engineering focuses on using adult, embryonic, and induced stem cells to repair damaged or diseased tissues. This course will examine the role of stem cells in development, tissue homeostasis, and wound healing, as well as how they are being applied in regenerative medicine. A lecture and discussion format for major topic areas. Students will receive hands-on training in how to isolate, culture, and differentiate adult stem cells in a laboratory setting. Expected: CHEM 0330 and BIOL 0500 or an equivalent course in cell biology or physiology. Cell culture experience highly recommended. Enrollment limited to 20. Instructor permission required.

Spr

BIOL1150

S01

23975

Th

3:00-5:20(17)

(E. Darling)

Spr

BIOL1150

L01

23976

F

9:00-12:50

(E. Darling)

BIOL 1160. Principles of Exercise Physiology.

Application of the basic principles of physiology to the study of the response mechanisms of the human body during exercise. Topics include muscle and neural control, energy metabolism, cardiovascular and respiratory effects, endocrinology, principles of training, and special topics (e.g., diving, high altitude, and microgravity). Student presentations based on scientific articles are included. Expected: BIOL 0800 or written permission of the instructor.

Fall

BIOL1160

S01

14826

MWF

1:00-1:50(06)

(C. Hai)

BIOL 1180. Comparative Animal Physiology.

Comparative approach to the function and regulation of animal systems with an emphasis on vertebrates. Topics include circulation, gas exchange, neuromuscular function, excretion, acid-base and ion regulation, and temperature regulation. Considers the unity and diversity of physiological processes in animals differing both in phylogeny and environmental adaptation. Original papers are discussed. Expected: BIOL 0800 or equivalent.

BIOL 1190. Synaptic Transmission and Plasticity.

Synapses are the means by which the nervous system communicates. In this seminar-style course, we will explore the molecular and physiological underpinnings of synaptic transmission. We will then examine ways in which synapses can modulate their strength during development, learning, and other adaptive processes. Expected: BIOL 0800 or NEUR 1020. Enrollment limited to 20. Instructor's permission required.

Spr

BIOL1190

S01

23977

TTh

1:00-2:20(10)

(J. Kauer)

BIOL 1200. Protein Biophysics and Structure.

Structural Biology is the science to determine 3-dimensional structures of biomacromolecules (i.e. proteins, RNA, and DNA). These structures enable biologists to understand and explore their function. Since proteins, RNA, and DNA are the primary molecules of life, structural biology enables us to understand and influence these molecular machineries which form the basis of all biological processes. Throughout the class, the students will see examples of biologically important proteins and protein complexes that will allow them to correlate structure and biological function. Prerequisite: BIOL 0280.

Spr

BIOL1200

S01

23978

Th

4:00-6:30(17)

'To Be Arranged'

BIOL 1210. Synthetic Biological Systems.

A multidisciplinary course that combines science and engineering providing a solid foundation in a cutting edge field of biological engineering. Synthetic biology is a mixture of biology, chemistry, engineering, genetic engineering and biophysics. It builds on recent work in systems biology which involves the modeling of biological systems, but goes further in that it involves the construction and standardization of biological parts, that fit together to form more complex systems. Expected: at least four courses beyond BIOL 0200, CHEM 0330, PHYS 0300, ENGN 0300, MATH 0900, or CSCI 0040.

BIOL 1220. Synthetic Biological Systems in Theory and Practice.

A multidisciplinary laboratory, lecture, and discussion based course that combines several areas of science and engineering providing a foundation in the cutting edge field of synthetic biological engineering. The field of synthetic biology is centered around trying to make biology easier to engineer. It builds on recent work in systems biology which involves the modeling of biological systems, but goes further in that it involves the construction and standardization of biological parts that fit together making complex systems. This course will combine classes, guest lectures and discussion lab visits to give students the best possible tools for understanding and applying research in synthetic biology. Expected: at least two courses in any of the key disciplines (biology, chemistry, physics, math, engineering, computer science) beyond the introductory level, and permission of the instructor.

BIOL 1222A. Current Topics in Functional Genomics.

A technological revolution in genomics has exponentially increased our ability to gather biological data. A host of new methods and types of analysis has arisen to accommodate this dramatic shift in data collection. The broad scope of inquiry has ushered in an era of “system-wide” approaches and brute-force strategies where rare signals can be detected and studied. In this seminar we will cover papers that embody this new approach. Students typically have taken an advanced undergraduate-level course in biology.

Fall

BIOL1222A

S01

16089

M

10:30-1:30

(N. Neretti)

BIOL 1250. Host-microbiome Interactions in Health and Disease.

Will focus on our current understanding of how various microbiomes communicate and interact with the host and the factors that influence these interactions. We will discuss how the new technologies such as metagenomics and metabolomics have enhanced our understanding of host-microbiome interactions in health and disease. Students will have the opportunity to participate in discussions on how to apply recent discoveries to disease processes, health restoration and maintenance. The course will help students develop skills in critical thinking and in reading and evaluating original scientific literature. Expected: students with a background in basic microbiology (BIOL 0530 or its equivalent). 20 enrollment.

Spr

BIOL1250

S01

24943

Arranged

(S. Vaishnava)

BIOL 1260. Physiological Pharmacology.

Covers the physiology of human disease (e.g., Heart failure and arrhythmia; cancer signaling pathways with a focus on breast cancer; neurological disorders such as schizophrenia and Parkinson's disease) and discusses the pharmacology of the drugs used to treat disease. A group of the most commonly prescribed drugs is discussed in terms of their fundamental modes of action and clinical importance. Expected: BIOL 0800.

Interactions between the molecules of life-proteins, RNA, DNA, membrane components-underlie all functions necessary for life. This course focuses on how nature controls these interactions, how these interactions can go awry in disease, and how we can learn the rules of these interactions to design drugs to treat disease. Students will review the physical basis of molecular interactions, learn classic and state-of-the-art high-resolution and high-throughput tools used to measure interaction, and survey the experimental and computational strategies to harness these interactions using a case study in rational drug design. Prerequisite: Introductory Biochemistry (BIOL 0280). Enrollment limited to 20; instructor permission. WRIT

Fall

BIOL1300

S01

14951

M

3:00-5:30(15)

(N. Fawzi)

BIOL 1310. Developmental Biology.

Covers the molecular and cellular events of development from fertilized egg to adult. Genetic basis of body form, cell fate specification and differentiation, processes controlling morphogenesis, growth, stem cells and regeneration will be examined. Differential gene regulation, intercellular signaling and their evolutionary conservation will be central to discussion of mechanisms governing developmental processes. Additional topics: developmental plasticity, impact of epigenetic and environmental factors, and basis of disease gleaned from developmental biology research. Live embryos will complement and reinforce concepts covered in class. Enrollment limited to 36. Expected: BIOL 0200 (or equivalent), and one course in genetics, cell biology or embryology.

Fall

BIOL1310

S01

14952

TTh

9:00-10:20(08)

(K. Wharton)

Fall

BIOL1310

L01

14953

W

1:00-4:50

(K. Wharton)

BIOL 1330. Biology of Reproduction.

This course is an advanced, seminar-based course. Primary literature is emphasized to complement the format of extensive student seminar presentations. It is essential that students have a strong background in biology in order to gain the most from this course. The emphasis of the course is student seminar presentation and extensive discussion on the material. This is often the first opportunity for students to present/discuss science in a seminar format. Expected background: a course in Cell Biology (e.g. BIOL 0500 or 1050), and two additional Biology courses above the introductory (BIOL 0200) level. Enrollment limited to 20.

Spr

BIOL1330

S01

23979

M

3:00-5:30(13)

(G. Wessel)

BIOL 1410. Evolutionary Genetics.

This course will focus on selected topics in molecular population genetics, molecular evolution, and comparative genomics. Classic and current primary literature at the interface of evolution and genetics will be discussed in a seminar format. The laboratory involves wet-lab exercises (allozymes, PCR- RFLP, sequencing), plus computer labs using DNA analysis packages. Students will prepare a final grant proposal on specific research interests. Expected: BIOL 0470 or 0480. Students MUST register for the lecture section and the lab. Enrollment limited to 20.

BIOL 1420. Experimental Design in Ecology.

An overview and discussion of the basic principles used to design lab and field experiments in ecology and environmental science. Topics include: replication and statistical power, appropriate use of factorial designs, nonparametric methods, post hoc texts, natural versus manipulative experiments, experimental artifacts and impact study design. Discussions based on primary literature and a new text. Expected: BIOL 0420.

BIOL 1425. Phylogenetic Biology.

This course is the study of the evolutionary relationships between organisms, and the use of evolutionary relationships to understand other aspects of organism biology. This course will provide a detailed picture of the statistical, mathematical, and computational tools for building phylogenies and using them to study evolution. Enrollment is by instructor permission. Students will present scientific papers in class and complete a final project consisting of their own phylogenetic analysis. Expected Background: Evolutionary Biology and quantitative methods (such as statistics, computation, or math). Open to juniors, seniors, and graduate students. Enrollment limited to 16.

BIOL 1430. Computational Theory of Molecular Evolution and Population Genetics.

Population genetics is the study of how biological processes such as mutation, natural selection, population size, and subdivision drive evolution over the timescale of generations. The past 20 years have seen a flowering in our understanding of this process from both theoretical and experimental perspectives. This course will present a rigorous introduction to modern population genetics, with particular emphasis on the complementary interplay between theory and experiment. Students will also gain extensive experience with the primary literature of the field. Prerequisites: MATH 0100 and one of BIOL 0470 or 0480, or permission. LILE

BIOL 1440. Marine Biology.

An examination of current topics in the ecology of marine organisms and communities. Current literature and ideas are analyzed in a seminar format (5hr/week). A class research project provides hands-on experience with designing and interpreting experimental field work. Prerequisites: BIOL 0410 and 0420. Instructor's permission required.

Spr

BIOL1440

S01

24542

Arranged

(M. Bertness)

BIOL 1450. Community Ecology.

This course will explore foundational concepts in community ecology, and will draw on examples and case studies from marine and terrestrial ecosystems, including species-rich tropical rain forests and coral reefs, the marine intertidal and benthic environments, and species-poor forests and grasslands of the temperate zone. Overarching themes will emphasize theoretical frameworks to understand the evolutionary origins and maintenance of this biological diversity. This will be accomplished using traditional lectures, weekly student-led discussions, readings of the primary literature, and class activities. Expected background: BIOL 200 or equivalent placement; and BIOL 0420; OR instructor permission.

BIOL 1465. Human Population Genomics.

An introduction to human genomics and the evolutionary forces that shape observed genetic variation across humans today. Topics will include the relationship among humans and other primates, human population genetics and genomics, and examples of the concomitant evolution of both cultural traits and domesticated organisms. Assignments include a class presentation and reviewing papers on a selected topic. Expected background: BIOL 0470 or 0480, and BIOL 0495, PHP 2500, or equivalent. Enrollment limited to 25. Instructor permission required. WRIT

BIOL 1470. Conservation Biology.

Conservation Biology is the scientific study of the phenomena that affect the maintenance, loss, and restoration of biological diversity. Topics covered include: 1) the impacts of global warming, species invasions, and habitat destruction on biodiversity, 2) strategies developed to combat these threats, and 3) a consideration of key economic and ethical tradeoffs. Special attention will be paid to current debate and controversy within this rapidly emerging field of study. Readings will include the primary literature. A term-paper will be required. Prerequisite: BIOL 0420 or instructor permission. Enrollment limited to 30.

Fall

BIOL1470

S01

14958

TTh

9:00-10:20(08)

(D. Sax)

BIOL 1475. Biogeography.

Will provide an overview of the field of biogeography--the study of geography of living organisms. Class meetings will be split between lectures and discussions. Each discussion will expose students to foundational papers, which set the context for the field's development, and more recent papers, which show where the field is headed. Each student will conduct a short (but time consuming) original research project on some topic in biogeography. Prerequisites: BIOL 0420 and 0480. Expected: one taxonomy-based course (e.g., BIOL 0410, 0430, or 0460). Enrollment limited to 15 juniors, seniors, and graduate students. Instructor permission required.

BIOL 1480. Terrestrial Biogeochemistry and the Functioning of Ecosystems.

Three fundamental multidisciplinary questions will be addressed: How do ecosystems work? What limits the growth of life on Earth? How are humans altering the framework in which all life exists? Earth is basically a closed chemical system, and the reactions that support life are fueled by sunlight. But added to this chemistry and physics is the tremendous influence of life. Life created an oxygen atmosphere; the evolution of biological nitrogen fixation exponentially increased how many organisms could exist, and the soils that support human food production developed only by biologically-mediated processes. Throughout Earth's 4.5 billion-year history changes in Earth's basic biogeochemical processes have been fairly slow. Under our inattentive stewardship, we have almost instantaneously altered all of the major element cycles. We will focus heavily on what these changes mean for life on Earth. Instructor permission required.

Fall

BIOL1480

S01

15660

MWF

10:00-10:50(14)

(S. Porder)

BIOL 1485. Climate Change Health and Ecology.

Explore the linkages between climate change and health. Students will come to appreciate the topic through the foundations of the primary disciplines relevant to the field including global health, environmental change, disease ecology, and others. Climate-health linkages will be learned through weekly case studies addressed collectively through student-centered lectures, discussion of the primary literature, groups activities and guest lectures from campus faculty on topics ranging from climate migration to infectious disease range shifts. Expected background: BIOL 0475, or BIOL 1470, or PHP 1070, or PHP 1920, or equivalent experience with instructor's permission. Enrollment limited to 12 juniors and seniors.

BIOL 1500. Plant Physiological Ecology.

An in-depth look at plant ecological strategy, focusing on the anatomical and physiological adaptations of plants to particular environments. Additional topics include plant-animal interactions, historical biogeography, and community assembly processes. A comparative, phylogenetic approach is emphasized. Lectures present a broad overview of topics, and discussions focus on current outstanding problems. Lab exercises provide hands-on experience in designing experiments, measuring plant performance, and scientific writing. Required laboratory hours to be arranged by the instructor. Expected: BIOL 0430 or BIOL 0440. Enrollment limited to 15.

BIOL 1520. Innate Immunity.

Innate immunity is the initial response to microbes that prevents infection of the host. It acts within minutes to hours, allowing the development of the adaptive response in vertebrates. It is the sole mechanism of defense in invertebrates such as insects. The components and mechanisms dictating this response are explored. Prerequisite: BIOL 0530. Enrollment limited to 30. Graduate students must obtain instructor permission.

Fall

BIOL1520

S01

14960

MW

8:30-9:50(01)

(L. Brossay)

BIOL 1540. Molecular Genetics.

Covers advanced genetic and molecular methods and their use in analysis of complex biological phenomena such as development, signaling, behavior, and disease. Discusses how these techniques are applied in various organisms, with emphasis on the major Eukaryotic genetic model systems (Drosophila, nematodes, mouse, yeast, Arabidopsis) and on human genetics. Uses primary literature to analyze the design of forward– and reverse–genetic approaches to discover novel gene function. For advanced undergraduates and beginning graduate students. Prerequisite for undergraduates: BIOL 0470 or instructor permission. Expected background: any of BIOL 0280, 0500, 1050, or 1310. Graduate students should register for BIOL 2540.

Spr

BIOL1540

S01

23987

TTh

2:30-3:50(11)

(E. Larschan)

BIOL 1550. Biology of Emerging Microbial Diseases.

Emerging diseases influence the health of human populations in less developed countries and are expected to have similar effects worldwide. Rising incidence of "new" diseases underscores the need for knowledge of infection mechanisms and their outcomes. Focuses on biochemical, genetic, cellular and immunological events of emerging pathogens and host responses. Expected: BIOL 0470 or BIOL 0530.

BIOL 1555. Methods in Biomedical Informatics.

Will provide a methodological survey of approaches used in biomedical informatics. Particular emphasis given to formalisms and algorithms used within the context of biomedical research and health care, including those used in biomolecular sequence analysis, electronic health records, clinical decision support, and public health surveillance. Practical programming skills will also be taught within these contexts. The final project of the course is to demonstrate an understanding of biomedical informatics approaches through development of a solution within biomedical research or healthcare context. Prerequisite: introductory statistics course. Enrollment: 20 students. For biological science concentrators, graduate students, others with permission.

Spr

BIOL1555

S01

24944

W

3:00-5:30(14)

(N. Sarkar)

BIOL 1560. Virology.

Emphasizes the understanding of molecular mechanisms of viral pathogenesis. Begins with a general introduction to the field of virology and then focuses on the molecular biology of specific viruses that are associated with human disease. Lectures based on current literature. Prerequisite: BIOL 0280, 0470, or 0530, or instructor permission.

Spr

BIOL1560

S01

23991

MWF

9:00-9:50(02)

(A. Jamieson)

BIOL 1600. Development of Vaccines to Infectious Diseases.

Provides background steps involved in vaccine development, from conceptualization to production to deployment. Considers infectious diseases and associated vaccines in context of community health. Appropriate for students wanting to gain an understanding of vaccine science. Provides a foundation for advanced courses in immunology and infectious disease, biomedical research, or medical/graduate studies. Activities include a weekly section meeting for discussion of relevant primary literature, and a final project of the student’s choice in the form of an in–class presentation, a research paper or an approved alternative format. Expected: BIOL 0200 or equivalent placement; BIOL 0530, and at least one additional biology course.

Spr

BIOL1600

S01

23993

MW

3:00-4:20(17)

(R. Bungiro)

BIOL 1800. Animal Locomotion.

How and why do animals run, jump, swim and fly? Physiology, anatomy, ecology, and evolutionary history all influence, and are influenced by, the way animals move around. We will integrate analyses from many levels of biological organization - from molecular motors, through bone-muscle systems, to biogeography - with methods and approaches from mechanics, fluid dynamics, and robotics. Expected: BIOL 0800 and PHYS 0030. Instructor permission required. WRIT

Spr

BIOL1800

S02

25995

TTh

10:30-11:50

(A. Chew)

BIOL 1820. Environmental Health and Disease.

Fundamental concepts relating to the adverse effects of chemical agents on human health. Topics include dose-response relationships, absorption, distribution, metabolism, excretion, mechanisms of toxicity, and the effects of selected environmental toxicants on organ systems. Many of these concepts will be reinforced through the use of a case-study approach where a pertinent environmental issue is incorporated into the ongoing lectures. Expected: BIOL 0500 and BIOL 0800, plus either ENVS 0490 or BIOL 0420.
Advanced students have priority.

Spr

BIOL1820

S01

24927

MW

8:30-9:50(02)

(T. Johnston)

BIOL 1850. Environmental and Genetic Toxicology.

Human disease is produced by complex interactions between inherited genetic predisposition and environmental exposures. These interactions will be explored at the molecular, cellular, and systemic levels. Prototype diseases will include hereditary disorders of hemoglobin, hypercholesterolemia, birth defects, and cancer. Expected: Cell Biology.

The biology, structure, and evolutionary history of the vertebrates considered phylogenetically, emphasizing evolution of the major body systems. Stresses an evolutionary approach to the correlation of structure and function with environment and mode of life. Labs include dissection of several different vertebrates and comparative osteological material. Emphasis of course is on critical thinking rather than memorization of material. Recommended: BIOL 0320 or 0800. First year students must obtain instructor permission to register. Enrollment limited to 32. Students MUST register for the lecture section and the lab.

Spr

BIOL1880

S01

23996

MWF

11:00-11:50(04)

(A. Chew)

Spr

BIOL1880

L01

23997

W

1:00-4:50

(A. Chew)

BIOL 1890. Human Histology.

This course will provide an in-depth treatment of the “stuff we are made of” and the wonderful logic of its organization. This course focuses fi rst on the biology of the four basic tissues (epithelium, connective tissue, muscle and nerve) and second, how they contribute to the functional anatomy of all organs and systems. For Pfizer students only.

BIOL 1920B. Health Inequality in Historical Perspective.

Seminar takes a historical perspective to explore causes of health inequality in the US. Draws on studies from the 19th century-present. Examines socio–political and economic context of health/disease, focusing on how race, class, and gender shape the experience of health, disease causality, and public health responses. Includes health consequences of immigration, incarceration, race-based medicine, the Chicago heatwave, and Katrina. BIOL 0200 and work in Africana Studies and/or science-technology courses SUGGESTED. Not for biology concentration credit. Suitable as related science or theme course for HHB. Enrollment restricted to 20, third- AND FOURTH-year students.

Spr

BIOL1920B

S01

24045

Th

4:00-6:30(17)

(L. Braun)

BIOL 1920C. Social Contexts of Disease.

What shapes our understandings of disease, and what makes a disease real? How might we explain the demise of formerly prevalent diseases and the arrival of others? How do politics, technologies, and institutions affect conceptions of disease and structure their treatment? Will examine the impact of social context on patients' experiences of disease, including clinical, scientific, and public health approaches. Will consider disease in relation to social relationships, power of the state to regulate disease, and cultural care of the body. Enrollment limited to 20 students; instructor permission required; serves as Capstone in Health and Human Biology. Not for concentration credit. WRIT

This advanced seminar places the current debate over race, health, and genetics in historical context. An overarching goal is to understand how the social world informs the scientific questions we ask, design of research studies, and interpretation of findings. How have the theories and practices of biomedical science and technology produced knowledge of “race” and racial difference historically? How does race relate to gender and class? What are the implications of this debate for understanding health inequality? Previous coursework in Africana Studies, biomedical science, history of science, and/or science and technology studies preferred. Enrollment limited to 20; instructor permission. WRIT

BIOL 1941A. Plants in a Changing Planet.

Plants are the foundation of Earth's ecosystems and essential to human survival and civilization. This seminar will examine the physiological, ecological, and evolutionary responses of plants to rapid environmental change, and the consequences for agriculture and the structure and function of natural systems. Expected background: at least one of the following courses - BIOL 0420, 0430, 0440, 0480, or ENVS 0490.

BIOL 1950. Directed Research/Independent Study.

Directed research/independent study in biological sciences: basic science, social studies of biomedical science, and clinically-oriented projects, mentored by individual faculty members in the Division of Biology and Medicine. Sites include campus and hospital based facilities. Projects can serve as the basis for Honors theses, or to fulfill research requirements in a Bio-Med concentration program. Students planning to use 1950/1960 to fulfill a concentration requirement must receive approval from the concentration advisor. No more than two (2) semesters of BIOL 1950/1960 may be used toward a concentration program in the biological sciences. Faculty from outside the Division may supervise projects for bio-med program concentrators, but should do so using their Department's own Independent Study course number.

BIOL 1960. Directed Research/Independent Study.

Directed research/independent study in biological sciences: basic science, social studies of biomedical science, and clinically-oriented projects, mentored by individual faculty members in the Division of Biology and Medicine. Sites include campus and hospital based facilities. Projects can serve as the basis for Honors theses, or to fulfill research requirements in a Bio-Med concentration program. Students planning to use 1950/1960 to fulfill a concentration requirement must receive approval from the concentration advisor. No more than two (2) semesters of BIOL 1950/1960 may be used toward a concentration program in the biological sciences. Faculty from outside the Division may supervise projects for bio-med program concentrators, but should do so using their Department's own Independent Study course number.

BIOL 1970A. Stem Cell Biology.

Senior seminar course will provide an interactive forum by which up to twenty seniors (and qualified juniors with permission) will explore the biology of stem cells from their humble beginnings in the embryo to their potential use in regenerative medicine. The potency and regulation of embryonic and adult stem cell populations derived from diverse organisms will be contrasted with laboratory-derived human stem-like cells for biomedical applications. Critical reading of classical and modern literature in the field of stem cell biology will form the basis of student-led presentations, papers and ethical forums. Expected: biochemistry, genetics and/or cell biology. Instructor permission; 20 students.

Fall

BIOL1970A

S01

16048

M

2:00-4:30(07)

(R. Freiman)

BIOL XLIST. Courses of Interest to Biology Concentrators.

Fall 2016

The following courses may be taken for concentration credit. Please see the sponsoring department for the time and location of each course.

Environmental StudiesENVS 0490 Environmental Science in a Changing World

Biology

The Biology concentration invites students to study, in depth and in breadth, the science of life and living matter. Whether pursuing the A.B. or Sc.B. in biology, students can expect to learn broadly in the discipline through a selection of courses in three areas: cell and molecular biology, structure and function, and organismal biology. In addition, students pursuing the Sc.B. complete a thematic track through which they gain an in-depth understanding of a particular subfield (such as, Immunopathology; Ecology and Evolutionary Biology; Physiology/Biotechnology; Cell and Molecular Biology; Physical Sciences; Marine Biology (through 2016). The concentration also emphasizes practical skills and experimental design. Concentrators are required to take at least 3 courses with a laboratory or fieldwork component. Within all of these requirements, students have a high degree of flexibility and choice. Broad research opportunities are also available across several departments within the basic sciences as well.

Standard program for the A.B. Biology

The concentration program for the A.B. in Biology consists of four prerequisite courses in math, chemistry, and a statistics course as well as ten courses in biological sciences, including at least one course in each of the following three areas: Area 1: Cell/Molecular Biology, Area 2: Structure/Function, and Area 3: Organismal Biology.

Six additional courses chosen from BIOL and/or NEUR offerings for concentrators. At least two at the advanced (1000-2000) level. The Core may include up to two related sciences, with advisor approval.

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Total Credits

10

1

AP scores of 4 or above may substitute Math courses.

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At least two biology and/or neuroscience courses must be at the advanced level (between 1000-2999). EXCLUSIONS: BIOL 0920 series courses, BIOL 1070, & BIOL 1920 series courses. *Courses numbered below BIOL 0100 do not carry concentration credit. At least three of the Biology and/or Neuroscience courses must include laboratory or fieldwork. BIOL 1950/BIOL 1960, (Directed Research) may be included, but is not required. If a lab project, this can count for ONE of the three lab course requirements, and one advanced course.

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No substitutions per above Area list. If a course is listed in more than one area, it may be used to fulfill one of those, the other must be fulfilled by a different course.

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Biology courses for concentration credit include those numbered greater than 0100 with some exceptions noted within the course descriptions. Courses numbered over 3000 do not count towards Undergraduate requirements either quantity or for concentration.

Standard Program for the Sc.B. Biology

The concentration program for the Sc.B. in Biology consists of seven prerequisite courses in math, chemistry, and physics as well as thirteen to fourteen courses in biological sciences, including courses in each of the following three areas: Area 1: Cell/Molecular Biology, Area 2: Structure/Function, and Area 3: Organismal Biology, and the three-course Track. The biological sciences requirement also requires research (BIOL 1950/BIOL 1960), which should reflect the advanced cluster.

As of the 2014-15 academic year, students pursuing a ScB in Biology have the option to substitute a course for CHEM 0360 (Organic Chemistry) in their background core. For students pursuing the Marine Biology track, an upper level course in Geological Sciences may replace CHEM 0360. For students pursuing all other tracks, BIOL 0280 (Introductory Biochemistry) may serve as the replacement course. Please note that approval from the concentration advisor is required for these background course substitutions. If the student has already declared, then a revised concentration plan must be submitted and approved via the ASK system. If BIOL 0280 is used as a substitute for CHEM 0360, it cannot be counted as a core course, as a laboratory course, or as an Area 1 course. Students planning to apply to medical or graduate school should seek additional advising (such as from the Health Careers Office) in crafting their course plan.

Five additional courses chosen from BIOL and/or NEUR offerings for concentrators. Alternatively, students may may include up to two related (non-BIOL/NEUR) sciences suitable for science concentrators. 4

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RESEARCH: 5

Typically, two courses in Track is advanced level research (BIOL 1950,1960).

At least two biology and/or neuroscience courses numbered at the 1000 or 2000 level. EXCLUSIONS: BIOL 0920 series courses, BIOL 1070, or BIOL 1920 series courses. *Courses numbered below BIOL 0100 do not carry concentration credit. At least three of the biology and/or neuroscience courses must include laboratory or fieldwork. No substitutions per above Area lists. If a course is listed in more than one area, it may be used to fulfill one of those; the other must be fulfilled by a different course

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Biology courses for concentration credit include those numbered greater than 0100 with some exceptions noted within the course descriptions. Courses numbered over 3000 do not count towards Undergraduate requirements either quantity or for concentration.

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See listing at http://biology.brown.edu/bug/ for options. Related sciences must be above prerequisite level, and suitable for science concentrators.

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If substantial research is carried out away from Brown, it must be approved by an appropriate Brown BioMed faculty member but does not carry course credit toward the Core program.

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At least two, and preferably all three, must be above 1000-level. Courses used for the cluster, must be approved by an advisor and/or Associate Dean of Biology, Katherine Smith.

For double concentrations, no more than two courses may overlap (i.e., be used to meet requirements of both) programs, prerequisites excepted.

No more than two semesters of directed research may be used as concentration credits. Each does count as an individual core towards the program, but only carry one lab credit towards the three required.

A limited number of transfer or study abroad courses may be used within the program, subject to approval of advisor, and Associate Dean of Biology, Katherine Smith.

Health & Human Biology

Health and Human Biology is an interdisciplinary concentration that provides a rigorous foundation in the biological sciences with substantive course work in humanities and social sciences within a subfield of Human Health and Disease. The program includes: background courses, biology core courses, a set of theme courses, and a Senior Capstone activity. Background courses provide the essential foundations in chemistry, mathematics, methods, and basic biology. These support the Biology core, which is comprised of a flexible menu of intermediate and advanced courses. A required portion of the Biology core is Genetics, a cornerstone of human biology and its interface with other fields. The Biology core underscores the related coursework within the Health and Disease Theme. The Theme courses are social science and humanities courses that form a cohesive, thoughtful grouping. Theme groupings must be approved by the advisor. A required senior capstone course or activity builds on the program's focus.

In addition to the stated background in Chemistry, Math, Biology and Statistics, five (5) Biology plus four (4) coherently-grouped Theme courses, plus a Senior-Year Capstone course or project. (See description of Capstone at link below this table).

Applied Mathematics-Biology

The Applied Math - Biology concentration recognizes that mathematics is essential to address many modern biological problems in the post genomic era. Specifically, high throughput technologies have rendered vast new biological data sets that require novel analytical skills for the most basic analyses. These technologies are spawning a new "data-driven" paradigm in the biological sciences and the fields of bioinformatics and systems biology. The foundations of these new fields are inherently mathematical, with a focus on probability, statistical inference, and systems dynamics. These mathematical methods apply very broadly in many biological fields including some like population growth, spread of disease, that predate the genomics revolution. Nevertheless, the application of these methods in areas of biology from molecular genetics to evolutionary biology has grown very rapidly in with the availability of vast amounts of genomic sequence data. Required coursework in this program aims at ensuring expertise in mathematical and statistical sciences, and their application in biology. The students will focus in particular areas of biology. The program culminates in a senior capstone experience that pairs student and faculty in creative research collaborations.

Standard program for the Sc.B. degree

Required coursework in this program aims at ensuring expertise in mathematical and statistical sciences, and their application in biology. The students will focus in particular areas of biology. The program culminates in a senior capstone experience that pairs student and faculty in creative research collaborations. Applied Math – Biology concentrators are prepared for careers in medicine, public health, industry and academic research.

In addition to required courses listed above, students must take the following:

Two additional courses in Applied Math or Biology. At least one of these must be a directed research course, e.g. a senior seminar or independent study in Applied Math or a directed research/independent study in Biology. For example:1

Four classes in the biological sciences agreed upon by the student and advisor. These four courses should form a cohesive grouping ina specific area of emphasis, at least two of which should be at the 1000-level. Some example groupings are below:

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Areas of Emphasis and Suggested Courses:

Some areas of possible emphasis for focusing of elective courses are listed below. Given the large number of course offerings in the biosciences and neuroscience, students are free to explore classes in these areas that are not listed below. However, all classes must be approved by the concentration advisor.

Students whose independent study is expected to be in an experimental field are strongly encouraged to take APMA 1660, which covers experimental design and the analysis of variance (ANOVA), a method commonly used in the analysis of experimental data.

Honors

Requirements and Process: Honors in the Applied Math-Biology concentration is based primarily upon an in-depth, original research project carried out under the guidance of a Brown (and usually Applied Math or BioMed) affiliated faculty advisor. Projects must be conducted for no less than two full semesters, and student smust register for credit for the project via APMA 1970 or BIOL 1950/BIOL 1960 or similar independent study courses. The project culminates in the writing of a thesis which is reviewed by the thesis advisor and a second reader. It is essential that the student have one advisor from the biological sciences and one in Applied Mathematics. The thesis work must be presented in the form of an oral presentation (arranged with the primary thesis advisor) or posted at the annual Undergraduate Research Day in either Applied Mathematics or Biology. For information on registering for BIOL 1950/BIOL 1960, please see https://www.brown.edu/academics/biology/undergraduate-education/undergraduate-research

Excellence in grades within the concentration as well as a satisfactory evaluation by the advsors are also required for Honors. The student's grades must place them within the upper 20% of their cohort, in accordance with the university policy on honors. Honors recipients typically maintain a Grade Point Average of 3.4 or higher in the concentration. However, in the case of outstanding independent research as demonstrated in the thesis and supported by the Thesis Committee, candidates with a GPA between 3.0 an 3.4 will be considered and are encouraged to apply.

The deadline for applying to graduate with honors in the concentration are the same as those of the biology concentrations. However, students in the joint concentration must inform the undergraduate chair in Applied Mathematics of their intention to apply for honors by these dates.

Biochemistry & Molecular Biology

How does life work at the molecular level? This question is at the core of the concentration program Biochemistry and Molecular Biology. In earlier years of this discipline, the focus was on structure and function of proteins, nucleic acids, lipids, carbohydrates and small molecules such as vitamins. Today the logical approach and tools of biochemical science are being expanded to new areas in neuroscience, developmental biology, immunology, pharmacology and synthetic biology (the design of analogs of biological systems). Training in biochemistry begins with a foundation in mathematics, physics, chemistry and biology. Some courses offered in other departments, including engineering, geology and computer science, are also useful. A key component of this program is the year of hands-on research carried out in collaboration with a faculty member here at Brown. Faculty sponsors are drawn from both the Chemistry Department and the Division of Biology and Medicine, and include basic science and clinical faculty.

Standard program for the Sc.B. degree

Students must take twenty courses in biology, chemistry, mathematics, and physics, including the following core requirements, some of these may be fulfilled with AP credits. Students are expected to take courses that will count toward the concentration ABC/NC. Students should discuss the S/NC option with their concentration advisor if circumstances warrant consideration. Students should not register S/NC for a concentration course without advisor pre-approval.

Students are required to take six (6) elective courses: four (4) taken from the chart below and two (2) from any science or mathematics course relevant to biochemistry, cell and molecular biology from the suggested courses below:

Select two electives from any quantitative science or mathematics course relevant to biochemistry (including courses on the preceding list) and approved by a concentration advisor.

Total Credits

20

1

Note that the mathematics and physics requirements may be satisfied by Advanced Placement credit.

2

or any NEUR course in Cell, Genetics, Molecular Biology, or Development.

Honors Requirements for Biochemistry

All ScB Biochemistry concentrators are candidates for Honors; no separate application is necessary.

The requirements for Honors in Biochemistry are:

* A strong grade record in concentration courses. This means a grade point average for the concentration that is higher than 3.25.

* Two semesters of Independent Study (CHEM 0970, CHEM 0980 or equivalent. Guidelines and requirements associated with Independent Study are in the Undergraduate Concentration Handbook which can be found at the department website.

* A Thesis in a form approved by the research advisor, and recommended by the research advisor. Additional information about thesis guidelines will be provided by the Concentration Advisor in the first half of the fall semester.

Biomedical Engineering

The Sc.B. program in Biomedical Engineering is accredited by the Engineering Accreditation Commission of ABET, http://www.abet.org/. It is jointly offered by the School of Engineering and the Division of Biology and Medicine as an interdisciplinary concentration designed for students interested in applying the methods and tools of engineering to the subject matter of biology and the life sciences. The education objectives of the Biomedical Engineering program are to prepare graduates: (1) to be employed in careers of useful service to society, including scientific and technical areas within medicine, industry, and health care delivery; (2) to demonstrate the ability to apply the basic principles of engineering and science, as well as problem solving skills and critical thinking, to a broad spectrum of biomedical engineering problems; (3) to demonstrate their ability to work in teams, and to effectively communicate and understand the broad social, ethical, economic and environmental consequences of their lifelong education. The student outcomes of this program are the (a) - (k) Student Outcomes as defined by the "ABET Criteria for Accrediting Engineering Programs (available online at http://www.abet.org/accreditation-criteria-policies-documents/)." The Biomedical Engineering concentration shares much of the core with the other engineering programs, but is structured to include more courses in biology and chemistry, and a somewhat different emphasis in mathematics.

The requirements regarding Mathematics, Advanced Placement, Transfer Credit, Substitutions for Required Courses, and Humanities and Social Science Courses are identical to those of the Sc.B. degree programs in Engineering. Please refer to the Engineering section of the University Bulletin for explicit guidelines.

The Biomedical Engineering concentration shares much of the core with the other engineering programs, but is structured to include more courses in biology and chemistry, and a somewhat different emphasis in mathematics.

Or other advanced bioengineering courses, subject to concentration advisor approval.

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Biomedical engineering students are also encouraged to pursue independent research with faculty members in the School of Engineering or the Division of Biology & Medicine.

Biophysics

Biophysics is that it is a quantitative science that requires a significant level of competence in physics, chemistry, mathematics, and biology. These areas therefore form the required background coursework for this program, and serve as a springboard to an advanced focus, developed in consultation with a concentration advisor. Advanced foci may include structure-function relations of macromolecules, biomechanics of cell cytoskeleton, biotechnology for drug and gene delivery, molecular mechanisms of membrane transport, sensory signal transduction, for examples. The program also requires a capstone research project that reflects this focus and may be drawn from collaborative research opportunities offered by faculty in biology, chemistry, or physics departments.

Computational Biology

Computational biology involves the analysis and discovery of biological phenomena using computational tools, and the algorithmic design and analysis of such tools. The field is widely defined and includes foundations in computer science, applied mathematics, statistics, biochemistry, molecular biology, genetics, ecology, evolution, anatomy, neuroscience, and visualization.

Students may pursue a Bachelor of Arts or a Bachelor of Science. Students pursuing the ScB have the option of electing a concentration in Computational Biology with one of three focus areas: Computer Sciences, Biological Sciences, or Applied Mathematics & Statistics. Both programs require a senior capstone experience that pairs students and faculty in creative research collaborations.

As part of Brown’s writing requirement, all students must demonstrate that they have worked on their writing both in their general studies and their concentration. There are a number of ways for Computational Biology concentrators to fulfill these requirements:

Enrolling in an independent study: CSCI 1970, BIOL 1950, APMA 1970

Writing an Honors Thesis

Taking a “WRIT” course in the final two years

Capstone Experience

Students enrolled in the computational biology concentration will complete a research project in their senior year under faculty supervision. The themes of such projects evolve with the field and the technology, but should represent a synthesis of the various specialties of the program. The requirements are either one semester of reading and research with a CCMB Faculty member or approved advisor, or a 2000-level Computational Biology course.

Honors:

In order to be considered a candidate for honors, students will be expected to maintain an outstanding record, with no "C's" in concentration courses and with a minimum of an "A-" average in concentration courses. In addition, students should take at least one semester, and are strongly encouraged to take 2 semesters, of reading and research with a CCMB faculty member or approved advisor. Students must submit to a public defense of their theses to be open to the CCMB community.

Students seeking honors are advised to choose a Thesis Advisor prior to the end of their Junior year

Students must complete the Registration form for Comp Bio and submit it to CCMB@BROWN.EDU

Any deviation from these rules must be approved by the director of undergraduate studies, in consultation with the student's advisor.

Marine Biology

Note: This concentration program is being phased out for Class of 2017 students and greater in favor of a track program within the Sc.B. in Biology.