'The Amazing Spider-Man 2' is being released internationally this weekend, so Avi Arad and Matt Tolmach talked to IGN and Arad had this to say about possible team-ups:

I think I’m probably a little bit of the militant here. I think it will take a moment in which we’ve run out of ideas. There’s so much to tell about Spider-Man. There’s so much to tell about the Sinister Six. Peter Parker is unique; he’s really different. He’s not an Avenger. He’s not an X-Man. He’s unique and we revere that.

While Tolmach offered that:

When you think about the Sinister Six and you think about Venom and you think about Carnage and you think Spider-Man in whatever way you want in association with those movies, they feel like they’re built for Spider-Man. Like that’s where his story needs to go and wants to go and it has to be about more than a stunt.

Stunts can be cool but it’s also a business, and so the other side of the answer is they’re owned by different companies. And there’s a ton left in Sony’s world; there’s a lot of business left because there’s a lot of story left. So for them to want to take this character and put it with Marvel and Disney is a huge undertaking and probably, as Avi’s saying, isn’t necessary until you feel like, ‘Wow, we’re sort of out of ideas. What should we do?’ And we’re far from out of ideas.

Ultimately Sony has put a lot of eggs in their Spider-Man basket with two additional sequels and spin-offs 'The Sinister Six' and 'Venom' plotted between now and 2018. It's their go-to franchise, which puts a lot of weight on the success or failure of 'The Amazing Spider-Man 2,' which opens in theaters May 2.