The relationship between GPR40 and lipotoxicity of the pancreatic β-cells as well as the effect of pioglitazone.

@article{Wu2010TheRB,
title={The relationship between GPR40 and lipotoxicity of the pancreatic β-cells as well as the effect of pioglitazone.},
author={Peiwen Wu and Liyong Yang and Ximei Shen},
journal={Biochemical and biophysical research communications},
year={2010},
volume={403 1},
pages={36-9}
}

Free fatty acids (FFAs) acutely stimulate insulin secretion from pancreatic β-cells, whereas impair β-cell function following long term exposure. GPR40, a FFAs receptor, has been demonstrated to be activated by both medium and long chain FFAs and played an important role in insulin release. This study was performed to determine the contribution of GPR40 to short- and/or long-term effects of FFAs on glucose-stimulated insulin secretion (GSIS) and the expression of PDX-1 and GLUT2 in pancreatic… CONTINUE READING