Medicines for Erection Problems: Reactions With Nitrate

Topic Overview

Phosphodiesterase-5 inhibitors, such as sildenafil
(for example, Viagra), have made a big difference in the
treatment of
erection problems (erectile dysfunction). But they can
cause life-threatening side effects for anyone who also takes nitroglycerin or
another medicine containing an organic nitrate. This combination can make your
blood pressure fall too low. This can possibly cause a
stroke, a
heart attack, or death. Do not take nitrate medicines up to 24 hours after you take sildenafil (for example, Viagra) or vardenafil
(for example, Levitra). Do not take nitrate medicines up to 48 hours after you take tadalafil (for example, Cialis).

Medicines that contain organic nitrates include:

Nitroglycerin (such as Nitro-Dur,
Nitrolingual, Nitrostat).

Isosorbide (such as
Dilatrate,
Isordil).

Nitroprusside (such as Nitropress).

Amyl nitrite
or amyl nitrate. These are sometimes called "poppers." They are sometimes
abused.

Nitrates found in foods are not a danger when taking
phosphodiesterase-5 inhibitors.

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