This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation- dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Catalog #

F0024-02

Applications

Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications have not been tested.

Recommended Dilutions

Western Blot-1:2000-1:10,000,

Immunoprecipitation: 2-5ug/mg lysate

Optimal dilutions to be determined by the researcher.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Clone Type

Polyclonal

Isotype

IgG

Host

Rabbit

Source

Human

Concentration

~0.2mg/ml

Form

Supplied as a liquid in TBS, 0.1% BSA, 0.09% sodium azide.

Purity

Purified by immunoaffinity chromatography.

Immunogen

Synthetic peptide corresponding to a region between aa1 and 50 of human F-box only protein 11 using the numbering given in entry NP_079409.3 (GeneID 80204).

Specificity

Recognizes human FBXO11.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.