Patent Watch

February 21, 2011

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2011 ACS

Patent Number:

US 7858821

Title:

A process for preparing intermediate compounds useful for producing dolasetron

Abstract:
The invention relates to a process for the preparation of compds. I (wherein R1 is alkyl, R2 and R3 are independently alkyl, or both R2 and R3 attached resp. to the oxygen atoms belonging to the same carbon atom form a cycle), which are useful for producing dolasetron. For instance, the compound I (R1 = R2 = R3 = Me) was prepared by substitution of di-Me malonate with bromoacetaldehyde di-Me acetal followed by dealkoxycarbonylation in 75% yield, which was converted to dolasetron in about 5 steps.