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A documentary film crew, led by a director named Terri Flores, hire a boat to take them down the Amazon River so they can research an allegedly lost Indian tribe called the Shirishamas. The don't find any Shirishamas, but what they do find is a giant-ass CGI anaconda snake that attacks the boat and proceeds to swallow its contents faster than a Jersey hooker.

The tagline for this film is, "When you can't breathe, you can't scream".

This is the film that started it all. Although it achieved only nominal popularity despite its all-star cast, Anaconda was the birth place of a cottage industry, which spawned a deluge of cheaply made direct-to-video films about giant man-eating reptiles. Many of these never-to-be classics were produced by The Asylum and aired on the Syfy Network as a "Syfy Original Picture".

"My Anaconda don't want none unless you got BUNS, hon!" That really doesn't have anything to do with the movie. I just felt like putting it here. That's a line from the Sir Mix-a-Lot song, "Baby Got Back". And yes, when he says "anaconda", he's actually referring to his pecker.