Osweiler, who signed to a $72 million contract from Denver in the offseason, was helped by an offense filled with playmakers.

''There was nothing about the game that was perfect but we just kept playing ... and we made the big plays when we needed to,'' Osweiler said.

He completed passes to eight different receivers, led by rookie first-round pick Will Fuller, who became the first player in franchise history to have 100 yards receiving in a debut with 107 and a touchdown. DeAndre Hopkins added 54 yards and a score and running back Lamar Miller had 106 yards rushing in his first game with the Texans.

Osweiler's day started with a hiccup when he threw an interception on the first drive, but soon got going and looked comfortable after that.

Houston trailed by 1 point entering the fourth quarter before Osweiler found Fuller on a short pass and he scampered 18 yards for a touchdown to make it 20-14.

The Texans added a 38-yard field goal later in the quarter to make it 23-14.

Chicago's Jay Cutler threw for 216 yards with a touchdown and an interception, but was also sacked five times and hurried several others on a day when linebackers Whitney Mercilus and 2014 top overall pick Jadeveon Clowney led the pass rush.

''Those struggles occurred a little bit more in the second half when we had to play backyard football where we had to throw it to catch up,'' Chicago coach John Fox said. ''They're a talented front and when you get too one-dimensional like that, it becomes problematic for everyone.''

J.J. Watt didn't seem to be limited in his return after sitting out all of the preseason after back surgery. But last year's Defensive Player of the Year wasn't as effective as he normally is, and seemed to have a tough time dealing with three-time Pro Bowl left guard Josh Sitton.

WHAT'S NEXT

Chicago: The Bears have a Monday night matchup with the Eagles on Sept. 19.

Texans: Houston hosts Kansas City next Sunday, looking for a win to erase the memory of last season's 30-0 Wild-Card loss to the Chiefs.

CUSHING INJURED

Houston middle linebacker Brian Cushing, who had 110 tackles last season, injured his knee in the first quarter and did not return. Cushing started every game last season and 14 in 2014 after playing just 12 games combined in the previous two seasons because of two significant injuries to his left knee. Coach Bill O'Brien didn't specify exactly what the injury was after the game, but said he would miss some time and they'd have more details on Monday.

THEY SAID IT

''I love everything about him,'' Osweiler said of Fuller.

WHITE MAKES DEBUT

Bears receiver Kevin White, the seventh overall pick in the 2015 draft, made his debut on Sunday after missing all of last season with a stress fracture in his left shin. He showed of flashes of the game-breaking ability that made him a top-10 pick and finished with 34 yards receiving. But his inexperience cost the Bears when he appeared to run a wrong route that led to an interception early in the third quarter.

''I'll talk to Kevin about it and that was his first game out there,'' Cutler said. ''But it left my hands and it's my responsibility.''

Alshon Jeffery led Chicago's receivers with 105 yards.

IS IT THE SHOES?

Hopkins became the first to wear low-top Kanye West-designed Yeezy Boost 350 cleats on Sunday.

He and two other Adidas players received the 350's on Friday, a day after Von Miller wore the high-top Yeezy Boost 750's in Denver's game against Carolina.

''They were great,'' Hopkins said of the shoes in the popular turtle dove colorway. ''It was just Adidas cleats with the Yeezy design on them. It wasn't anything different than what I've already been wearing. Just the design.''

The star receiver, who was second in the NFL with a career-high 1,521 yards receiving last season, compared his ones to those that Miller wore, which look more like a boot.