Authors

Abstract

The anti-inflammatory activity of ethanolic and aqueous extract of the bark of Vitex leucoxylon Linn. was studied in albino wistar rats using the Carageenan induced rat paw edema model. The ethanolic and aqueous extract of Vitex leucoxylon (500 mg/kg p.o.) inhibited Carageenan induced rat paw edema. The extract was also studied for its preliminary phytochemical screening and acute toxicity studies. The result indicated that both the extract produced significant (P<0.001) anti-inflammatory activity when compared with the standard drug Indomethacin (10 mg/ kg p. o.) and untreated control. Phyto-chemical screening showed the presence of various constituent like phenolic compounds, phytosterol, protein, flavonoids, carbohydrate etc.