Precautions

Monitor

Periodically assess response to therapy.

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy in patients younger than 18 y have not been established.

Eye exposure

Eye disorders, including severe eye pain, eyelid edema, eyelid ptosis, and periorbital edema, can occur after exposure. If accidental exposure occurs, the area should be flushed with water and the patient should seek medical care as soon as possible.

Local skin reactions

Severe skin reactions in the treated area can occur. Administration is not recommended until the skin is healed from any previous drug or surgical treatment.

Overdosage

Symptoms

Local skin reactions.

Patient Information

Advise patient that ingenol is for external use only and to avoid contact with the eyes.

Inform patient that treatment with ingenol may lead to local skin reactions.

Advise patient to avoid inadvertent transfer of ingenol to other areas or to another person.

Instruct patient to allow the treated area to dry for 15 min after application. Instruct patient to avoid washing and touching the treated area or participating in activities that cause excessive sweating for 6 h after treatment. Following this time, advise patient that the area may be washed with a mild soap.