Target

FunctionLigand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.

Involvement in diseaseDefects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA) [MIM:273395]. Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.

Thank you for your patience. Unfortunately, we do not currently have any information about the epitope for ab52568. I am sorry I could not be more helpful, please let me know if you have any other questions.

Abcam Scientific Support

Answered on Sep 26 2012

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