Background: There are several specific inflammatory and oxidative correlates among patients with hypothyroidism, but most studies are cross-sectional and do not evaluate the change in parameters during the treatment. The aim of this study was to investigate the effect of levothyroxine replacement therapy on biomarkers of oxidative stress (OS) and systemic inflammation in patients with hypothyroidism.

Conclusion

In conclusion, this study observed a significant reduction of pro-inflammatory cytokines and an increase of one anti-inflammatory cytokine in hypothyroid patients using levothyroxine. In these patients, the reduction of low-grade chronic inflammation may have clinical relevance because of the known connection between chronic inflammation, atherosclerosis and cardiovascular events.

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Musicmonkey, Untreated subclinical and overt hypothyroidism increases inflammation and oxidasive stress which cause narrowing of the arteries and leads to heart disease/attacks. The study finds treatment with Levothyroxine reduces the inflammation and oxidasive stress markers which reduces the likelihood of developing of heart disease.

Thanks Clutter. The question is does it actually look at the level of treatment required to achieve this? Do so hope so.....perhaps finally a dig at the protocol of treatment via the TSH. Then again there is adequate and optimal.....lol!!!