We present a concept, developed at the National Astronomy and Ionosphere Center (NAIC) at Arecibo, Puerto Rico, for suppression of Global Positioning System (GPS) signals in the 305 m dish radio receiver path prior to backend processing. The subsystem does not require an auxiliary antenna and is intended for easy integration with radio telescope systems with a goal of being a turnkey addition to virtually any facility. We have focused on detection and cancellation of the GPS L3 signal at 1381.05 MHz which, during periodic test modes and particularly during system-wide tests, interfere with observations of objects in a range of redshifts that includes the Coma supercluster, for example. The signal can dynamically change modulation modes and our scheme has demonstrated, through simulations using actual sampled telescope data, the ability to acquire and track these signals as well as detect the mode changes in order to apply cancellation or blanking, as appropriate. The subsystem can also be adapted to GPS L1 (1575.42 MHz), L2C (1227.6 MHz), and others. A follow-up is underway to develop a prototype to deploy and evaluate at NAIC.