The Effects of Ibandronate or Teriparatide Therapy on Bone Histology and Biochemical Indices in Patients on Hemodialysis With Low Bone Mineral Density

This study has been terminated.

(due to financial problems)

Sponsor:

Papageorgiou General Hospital

ClinicalTrials.gov Identifier:

NCT00446589

First Posted: March 13, 2007

Last Update Posted: October 29, 2014

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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HD pts suffering from osteoporosis and adynamic bone disease who received teriparatide

Drug: teriparatide

sc injection using a pen like device during every hemodialysis session (thrice a week)

Experimental: I

Hemodialysis pts suffering from osteoporosis who received iv ibandronate

Drug: ibandronate

iv 1mg ibandronate monthly for one year

Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:

18 Years and older (Adult, Senior)

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Bone mineral density (T-score<-2.5)

Adynamic bone disease for the teriparatide group

Increased osteoclast number on bone biopsy (high turnover) for the ibandronate group

Calcium greater than 8.1 mg/dl

Exclusion Criteria:

Suspected carcinoma

Unstable clinical setting

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00446589