CAB

Somehow I have been negligent and not let people know that I have written and posted a major update of my “Guide to Advanced Prostate Cancer.” As in the past, it is available as a free download from the Malecare web site. Helping me to update the book was prostate cancer survivor Craig Pynn and my own caretaker, Wendy Lebowitz. Anyone reading the first edition will be surprised when you see how many changes and updates this edition has included. It now has a very extensive conversation about living in the world as a cancer survivor as well as more [...]

It is known that Zoledronic acid (ZA) reduces the risk of developing skeletal-related events (SRE) which are caused by bone metastasis in prostate cancer (PCa). ZA also improves the quality of life (QOL). ZA has become a standard supportive therapy for men with prostate cancer who have bone metastasis. The big unknown is when should a man start ZA treatment. In a recent study researchers investigated whether the combination of ZA and combined androgen blockade (CAB) could delay a PSA relapse of prostate cancer as well as prevent the development of SREs. To look at this issue the researchers randomly [...]

There are different methods of performing ADT; these methods include continuous or intermittent as well as differences in the actual blockade itself. Understanding the superior schedule as well as the superior combination of drugs can both delay the onset to castrate resistance as well as provide for a longer overall survival (OS). In a research study Combined Androgen Therapy (CAB) with more then one drug having different modes of action was compared to Monotherapy where only one drug was used for the ADT. The researchers defined the time to the on set of Castrate Resistant Prostate Cancer (CRPC) as PSA [...]