GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

1_F

10_W

0.32861

2.794

11_L

85_F

0.27465

2.336

2_D

6_E

0.26721

2.272

7_I

89_A

0.23592

2.006

11_L

15_F

0.20934

1.780

15_F

20_I

0.20399

1.735

6_E

16_Y

0.19236

1.636

37_K

79_R

0.19088

1.623

2_D

97_K

0.18759

1.595

40_K

80_K

0.17734

1.508

42_Y

78_S

0.176

1.497

14_I

85_F

0.17061

1.451

14_I

18_Q

0.16493

1.402

21_G

37_K

0.16445

1.398

11_L

20_I

0.16246

1.381

8_K

24_I

0.15945

1.356

41_R

82_T

0.15303

1.301

14_I

105_N

0.15177

1.291

24_I

27_S

0.15163

1.289

29_K

105_N

0.1493

1.270

70_K

74_K

0.14587

1.240

15_F

19_G

0.14483

1.232

12_Q

73_K

0.14343

1.220

14_I

20_I

0.14324

1.218

23_V

80_K

0.14256

1.212

11_L

14_I

0.14244

1.211

38_N

94_K

0.14067

1.196

81_N

108_N

0.13853

1.178

28_D

88_R

0.13496

1.148

19_G

98_W

0.13426

1.142

25_E

35_K

0.13395

1.139

32_I

43_R

0.13193

1.122

30_K

33_V

0.131

1.114

38_N

81_N

0.12981

1.104

38_N

105_N

0.12696

1.080

16_Y

98_W

0.12599

1.071

8_K

34_F

0.12432

1.057

23_V

35_K

0.12402

1.055

39_G

80_K

0.12238

1.041

13_K

97_K

0.11907

1.013

24_I

42_Y

0.11901

1.012

4_K

32_I

0.11756

1.000

22_I

26_R

0.11749

0.999

3_D

6_E

0.11727

0.997

38_N

72_K

0.11628

0.989

41_R

80_K

0.11578

0.985

71_K

74_K

0.1157

0.984

72_K

75_R

0.11555

0.983

72_K

77_K

0.11547

0.982

42_Y

79_R

0.1147

0.975

93_K

102_V

0.11462

0.975

91_Y

110_P

0.11459

0.974

25_E

34_F

0.11444

0.973

73_K

76_T

0.1127

0.958

84_P

104_N

0.11192

0.952

11_L

89_A

0.11154

0.948

13_K

41_R

0.10847

0.922

40_K

76_T

0.10602

0.902

74_K

110_P

0.1059

0.901

12_Q

22_I

0.10461

0.890

28_D

33_V

0.1045

0.889

78_S

98_W

0.10443

0.888

10_W

40_K

0.104

0.884

73_K

77_K

0.10325

0.878

4_K

89_A

0.10311

0.877

93_K

106_E

0.10304

0.876

32_I

89_A

0.10193

0.867

87_I

100_L

0.10012

0.851

10_W

37_K

0.09995

0.850

8_K

81_N

0.09964

0.847

14_I

40_K

0.09897

0.842

12_Q

27_S

0.09889

0.841

5_D

108_N

0.0984

0.837

35_K

40_K

0.09791

0.833

43_R

100_L

0.09745

0.829

43_R

90_N

0.09688

0.824

7_I

19_G

0.0966

0.821

36_C

40_K

0.09607

0.817

1_F

11_L

0.09503

0.808

4_K

90_N

0.09491

0.807

13_K

104_N

0.09491

0.807

87_I

90_N

0.0944

0.803

5_D

41_R

0.09414

0.801

11_L

39_G

0.09413

0.800

27_S

32_I

0.09403

0.800

73_K

89_A

0.09384

0.798

23_V

85_F

0.09351

0.795

5_D

24_I

0.09326

0.793

39_G

108_N

0.09322

0.793

40_K

108_N

0.09263

0.788

35_K

42_Y

0.09262

0.788

25_E

80_K

0.09244

0.786

3_D

95_N

0.09239

0.786

6_E

91_Y

0.0922

0.784

93_K

104_N

0.09192

0.782

35_K

39_G

0.09185

0.781

40_K

81_N

0.09174

0.780

29_K

34_F

0.0917

0.780

17_P

45_K

0.09169

0.780

19_G

23_V

0.09146

0.778

29_K

39_G

0.09127

0.776

22_I

46_K

0.09106

0.774

2_D

82_T

0.09104

0.774

7_I

11_L

0.09062

0.771

2_D

24_I

0.09051

0.770

25_E

31_K

0.09041

0.769

30_K

72_K

0.08976

0.763

18_Q

99_T

0.08958

0.762

5_D

9_P

0.08957

0.762

5_D

47_K

0.08922

0.759

23_V

39_G

0.08914

0.758

9_P

74_K

0.08911

0.758

32_I

99_T

0.089

0.757

6_E

17_P

0.08873

0.755

78_S

81_N

0.08826

0.751

44_H

110_P

0.0881

0.749

89_A

102_V

0.08755

0.744

34_F

98_W

0.08747

0.744

73_K

110_P

0.08729

0.742

15_F

90_N

0.08726

0.742

15_F

21_G

0.08725

0.742

12_Q

15_F

0.08703

0.740

25_E

28_D

0.08666

0.737

12_Q

90_N

0.08658

0.736

44_H

71_K

0.08639

0.735

73_K

78_S

0.08585

0.730

3_D

106_E

0.08575

0.729

8_K

87_I

0.08574

0.729

11_L

23_V

0.08544

0.727

2_D

94_K

0.08486

0.722

4_K

24_I

0.0843

0.717

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)