The prosecution's case against her "has been repeatedly revealed to be completely unfounded and unfair," she said in the statement, and an "objective investigation" and "capable prosecution" are needed if any questions remain about her innocence.

The Knox-Sollecito retrial 13 photos

The Knox-Sollecito retrial13 photos

Amanda Knox appears on NBC's "Today" show. Knox spent four years in jail because of murder charges in the death of her roommate Meredith Kercher while studying abroad in Perugia, Italy.

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The Knox-Sollecito retrial13 photos

Appeals Court Judge Alessandro Nencini, center, reads the verdict in the death of British student Meredith Kercher in Florence, Italy, on Thursday, January 30, 2014. The appeals court upheld the convictions of Knox and her ex-boyfriend Raffaele Sollecito for the 2007 murder of her British roommate. Knox was sentenced to 28½ years in prison, raising the specter of a long legal battle over her extradition. Sollecito's sentence was 25 years.

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The Knox-Sollecito retrial13 photos

Sollecito, left, and his father, Francesco, leave after attending the final hearing before the verdict on January 30. After nearly 12 hours of deliberation, the court reinstated the guilty verdict first handed down against Knox and Sollecito in 2009.

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The Knox-Sollecito retrial13 photos

Patrick Lumumba, the Congolese bartender Knox originally accused of Kercher's murder, talks to the press outside the courthouse during a break form the appeal trial of Knox and Sollecito on September 30.

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The Knox-Sollecito retrial13 photos

Knox and her former boyfriend Sollecito were convicted in 2009 to 25 years in prison (Sollecito got 26 years). The conviction was overturned in 2011 for "lack of evidence." But Italy's Supreme Court decided last year to retry the case, saying the jury that acquitted them didn't consider all the evidence and that discrepancies in testimony needed to be answered.

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The Knox-Sollecito retrial13 photos

Meredith Kercher, a 21-year-old British exchange student, was found dead with her throat slit in an apartment she shared with Knox on November 2, 2007.

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When Knox was detained for questioning in 2007, she implicated Lumumba, the owner of a bar where Knox worked. Lumumba was taken into custody and released after two weeks in prison when his alibi was corroborated. He later won a libel suit against Knox.

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The Knox-Sollecito retrial13 photos

Sollecito, Knox's boyfriend at the time of the murder, was convicted in December 2009 with Knox and released when their cases were overturned. Prosecutors testified that police scientists found Sollecito's genetic material on a bra clasp of Kercher's found in her room, while his defense claimed there wasn't enough DNA for a positive ID.

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The Knox-Sollecito retrial13 photos

Rudy Hermann Guede, an Ivory Coast native raised in Perugia, was convicted separately from Knox and Sollecito and is now serving 16 years. Guede admitted to being with Kercher on the night she died, but said he didn't kill her. Both Knox and Sollecito argued that he was the killer, and Guede suggested the couple took Kercher's life.

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The Knox-Sollecito retrial13 photos

Meredith Kercher's family lawyer Francesco Maresca, left, argued in court in 2011 that the multiple stab wounds implied more than one aggressor killed Kercher. Pictured from left are Maresca, Kercher's father John, sister Stephanie, brother Lyle and brother John at a press conference in 2008.

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Carlo Dalla Vedova, one lawyer on Knox's defense team, argued in court that "the only possible decision to take is that of absolving Amanda Knox" in his closing argument for her appeal hearing.

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Carlo Pacelli represented Patrick Lumumba in his civil suit case. He called Knox two-faced and a "she-devil."

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Giulia Bongiorno, the lead lawyer on Raffaele Sollecito's defense team, compared Knox to Jessica Rabbit on the movie "Who Framed Roger Rabbit?" Knox is not bad, just "drawn that way," Bongiorno said in her closing statements in the 2011 trial.

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"The prosecution responsible for the many discrepancies in their work must be made to answer for them, for Raffaele's sake, my sake, and most especially for the sake of Meredith's family. Our hearts go out to them," she said.

"No matter what happens, my family and I will face this continuing legal battle as we always have, confident in the truth and with our heads held high in the face of wrongful accusations and unreasonable adversity."

'Psychological impact'

Knox's attorney, Carlo Dalla Vedova, earlier told CNN that Knox was "upset and surprised because we thought that the case was over."

But, he added, "at the same time, as she's done in the last five years, she's ready to continue and we are ready to fight."

Dalla Vedova said he did not expect his client to leave Seattle for Italy "for many reasons," although she is free to travel.

Kercher's older sister, Stephanie, said Tuesday that the family welcomed the news of the retrial because they still hoped to discover the full story behind her death.

"We are never going to be happy about any outcome because we have still lost Meredith but we obviously support the decision and hope to get answers from it," she told CNN affiliate ITN from the family home in Coulsdon, south of London.

"There are still so many unanswered questions. All we have ever wanted to do is do what we can for Meredith and to find out the truth of what happened that night.

"Rudy Guede's conviction was on the basis that there was more than one person there so that is something that needs to be looked into."

The Kerchers' family lawyer, Francesco Maresca, earlier said they wanted a retrial because they believed the ruling that acquitted Knox and Sollecito was "superficial and unbalanced."

Judge Saverio Chieffi told the court he would publish the reasoning behind his decision within 90 days, after which the parties would have 45 days to present their case. The retrial is not expected until sometime early next year, to be heard in an appellate court in Florence.

After that, both parties would again be able to appeal at the Supreme Court.

Riccardo Montana, a law lecturer at City University London and an expert on the Italian legal system, said that the judges' decision to order a retrial is "not unusual when a case is very complex and there is a clear contrast between different accounts of the factual scenario."

While the Italian Supreme Court decides on points of law, the boundaries are not always clear, Montana said.

"In this specific trial, the use and interpretation of evidence was discussed," but the picture should become clearer when the full reasons for the court's ruling are issued in the coming weeks, he said.

Knox may be ordered to return to Italy for the retrial.

If she refuses, the Italian government could appeal to the U.S. government for her extradition.

But even if it does, Knox might still not end up before an Italian court.

Double jeopardy?

U.S. officials might reject such a request because it violates the U.S. legal principle that a criminal defendant can't be tried twice on the same allegation, said Joey Jackson, a contributor for HLN's "In Session."

Italy lacks the absolute prohibition present in U.S. law preventing authorities from retrying a criminal defendant who has been acquitted of a charge.

"We have principles that are well-founded within our Constitution, one of which is double jeopardy," Jackson said. "So as a result of that, I think it would be highly objectionable for the United States to surrender someone to another country for which justice has already been administered and meted out. So I don't think or anticipate that that would happen."

Another lawyer for Knox, Luciano Ghirga, said Monday that her client was confident in the Italian legal system and hoped one day to return to Italy as a free woman.

The Supreme Court did not order her retrial Tuesday on a charge of defamation.

Knox's conviction for defaming Patrick Lumumba, a club owner whom she accused of killing Kercher, was upheld in October 2011 by the same appeals court that cleared her of murder.

Knox has spent the last year and a half trying to resume a normal life, studying creative writing at the University of Washington in Seattle, her hometown, according to family spokesman Marriott.

She also has written a book on her ordeal, titled "Waiting to be Heard," which will be published next month.

According to Harper Collins, Knox "tells the full story of her harrowing ordeal in Italy -- a labyrinthine nightmare of crime and punishment, innocence and vindication -- and of the unwavering support of family and friends who tirelessly worked to help her win her freedom."

The publisher did not have any immediate response to the news that Knox now faces a retrial.

Francesco Sollecito, Raffaele's father, told CNN in a phone interview last year that the family was "not happy about the decision (to appeal). My son is trying to get back to normal life."

"We can do very little in this situation," he said, but as Italian citizens, they would have to accept the court's decision.

"We hope that the high court will finally put the words 'the end' to this story."