The protein encoded by ABCC3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC3 Kits (14) and ABCC3 Proteins (8) and many more products for this protein.

More Antibodies against ABCC3 Interaction Partners

Data suggest that hepatic expression of MRP3 is up-regulated and canalicular localization of MRP2 (show ABCC2 Antibodies) is altered in pediatric patients with advanced nonalcoholic steatohepatitis; these alterations may be involved in changes observed in drug metabolism.

ABCC3 expression may serve as a marker for MDR and predictor for poor clinical outcome of NSCLC.

A functional Nrf2 (show GABPA Antibodies) response element within the eighth intron of the ABCC3 gene.

Renal function of MRP3 is related to renal cell proliferation and cyst formation and that restoring MRP3 may be an effective therapeutic approach for polycystic kidney disease.

These results suggest that carboplatin and paclitaxel may induce drug resistance mediated by MDR1 (show TBC1D9 Antibodies) and MRP3, which may be enhanced by the simultaneous use of both drugs.

ABCC3 promoter methylation does not seem to exhibit any impact on maximum platelet aggregation and clopidogrel response at all

data show that this transporter activity is involved in ABCC3-induced senescence, demonstrating that this protein has a complex role in cancer, since its loss of function may promote escape from OIS and tumor formation

role of the bile acid membrane transporter Mrp3 (Abcc3), which is expressed in the liver and gut (show GUSB Antibodies), in the hepatic growth response elicited by bile acids and in liver regeneration after partial hepatectomy

These results suggest that Mrp3 plays major roles in the efflux transport of various glucuronide conjugates from the enterocytes to the portal blood in the small intestine together with unknown transporter(s)

induction of Mrp3 plays a significant role in hepatocyte protection during obstructive cholestasis

VDR (show CYP27B1 Antibodies) has a role in the protection of colon cells from bile acid toxicity through regulation of the Mrp3 expression

Mrp3 does not have a major role in bile salt physiology, but is involved in the transport of glucuronidated compounds, which could include glucuronidated bile salts in humans

ABCC3 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.