Conus snail (Conus) venoms are a valuable source of pharmacologically active compounds; some of the peptide toxin families from the snail venoms are known to interact with potassium channels. We… (More)

The actions of alcohols and anesthetics on ion channels are poorly understood. Controversy continues about whether bilayer restructuring is relevant to the modulatory effects of these surface active… (More)

The Hodgkin and Huxley (1952) description of Na and K conductances underlying the action potential in squid giant axon is remarkable not only for its predic-tive accuracy in describing the shape and… (More)

Ion channels are membrane-spanning proteins that allow ions to permeate at high rates. The kinetic characteristics of the channels present in a cell determine the cell signaling profile and therefore… (More)