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The two that comes to my mind immediately which fits the criteria above are:

- Aishiteruze Baby
- Kure-nai

I enjoyed Kure-nai a whole lot. In fact, I hold it as one of my most favorite anime series in my long list of anime I've watched.

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Kudara nai na!Sig by TheEroKing.Calling on all Naruto fans, One Piece fans, and Shounen-fans in general... I got two words for you: One-Punch Man!Executive member of the ASS. Ready to flee at the first sign of trouble.

Chi's Sweet Home and Chi's New Address concern a kitty who gets lost from its mother and ends up being adopted by a young Japanese family. The son is about three so the parents have to manage both him and the kitty.

Higepiyo has a more edgy script. It's about a bearded chick (the small yellow kind) that has samurai aspirations. He's purchased at a summer fair by another young family. Higepiyo can talk; Chi has no extraordinary powers except cuteness, smarts, and a friendly personality.

Another show that you might like is Tokyo Magnitude 8.0. A pre-teen brother and sister are stranded when an earthquake hits Tokyo harbor. (This was made before the Tōhoku quake.) They are befriended by a woman in her late twenties who takes on the task of seeing them home.

In Seirei no Moribito, a similar familial bond develops between 30-yo spear-wielding bodyguard Balsa and her charge, a young prince who has been targeted for assassination. There are some powerful scenes between them throughout, but especially around episodes 18-19 and beyond.

Like monir, I'm a fan of Kurenai. However the "parent" in this case is a 16-year-old boy who becomes responsible for a seven-year-old kidnapped heiress. Their relationship is wonderfully developed, but I'm not sure Shinkarou entirely qualifies as a parent. I still recommend the show regardless.

Finally I'll recommend the first installment of Otona Joshi no Anime Time, though the story is mostly about the mother and less about her relationship with her son.