Marine dinoflagellates of the Amphidinium genus are a remarkably prolific source of bioactive secondary metabolites. More than thirty macrolides have been isolated from different strains, which are… (More)

The development of an effective protocol for the palladium-catalyzed cross-coupling of (E)- and (Z)-alkenylsilanols with aryl triflates is described. A critical component in the optimization of this… (More)

A total synthesis of (+)-papulacandin D has been achieved in 31 steps, in a 9.2% overall yield from commercially available materials. The synthetic strategy divided the molecule into two nearly equal… (More)

Kinetic, spectroscopic, crystallographic, and computational studies probing a Pd-catalyzed C-H arylation reaction reveal that mono-oxidation of the bis-phosphine ligand is critical for the formation… (More)

The marine natural products amphidinolide C (1) and F (4) differ in their side chains but share a common macrolide core with a signature 1,4-diketone substructure. This particular motif inspired a… (More)