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JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY December 2017 • Volume 10 • Number 12
O R I G I N A L R E S E A R C H
increase skin moisturization, and decrease
transepidermal water loss. The test products
(skIN3; Alphaeon Corp., Irvine, California)
were a day facial cream, a night facial cream,
a eye cream, a day lip cream, and a night lip
cream, each using the DermaTriPlex technology
platform.
METHODS
Two studies were performed: a 56-day
controlled clinical trial for each individual
test product and an experience trial involving
more than 200 patients using a strategic
combination of products.
The 56-day study. In the first study,
female subjects (n=5) were enrolled in each
of the five studies. Subjects were recruited by
advertisements in local periodicals, community
bulletin boards, phone solicitation, and
electronic media. Demographic data are shown
in Table 1. Inclusion criteria were healthy
women aged 35 to 60 years for the facial and
eye creams, and Caucasian women aged 35
to 55 years for the lip creams. Subjects were
asked to abstain from the use of any anti-aging
and moisturizing products, including lotions,
creams, gels, and nutritional supplements for
at least eight weeks prior to the study. Each of
the subjects exhibited fine lines and wrinkles
at the test site and abstained from using any
anti-aging products or moisturizing products
on the lips or surrounding area (e.g., lotions,
creams, lipsticks, chapsticks, gels, nutritional
supplements) for at least 72 hours prior to the
start of the study (for the lip creams).
Subjects were excluded if they were under a
physician's care or were taking any medication
that might mask or interfere with the test
results. Those who had a history of skin cancer,
melanoma, lupus, psoriasis, connective tissue
disease, diabetes, or any disease that would
increase risk associated with study participation
were excluded. Women who were pregnant,
lactating, intending to become pregnant during
the study period, or had given birth during the
previous six months were excluded. Subjects
were excluded if they had chronic skin allergies
or a history of hypersensitivity to cosmetics
in general. Further exclusion criteria included
neurologic, dermatologic, or systemic disorders
that would interfere with the results. Smokers,
patients who had dermal filler injected into
the lips or had fat grafting, silicone injections,
or implants in the lips during the previous
year were also excluded. Subjects who had
botulinumtoxin type A around the lips during
the previous six months, had laser resurfacing,
chemical peels, or dermabrasion done to
the lips were excluded. Finally, patients with
lip disease, previous lip surgery, or systemic
disease (e.g., diabetes, scurvy, or chelitis) were
excluded.
All subjects provided signed, informed
consent to participate in the study.
Test product. Each of the five test
products contained the anti-aging ingredients
of the technology platform (Table 2) at
concentrations known to be efficacious. To be
clear, not all of the ingredients used in the
platform were present in each product, but
some combinations of each were used. Table 2
represents the common tradenames; any single
TABLE 1. Demographics of test product populations
TEST PRODUCT
CREAM
AGE RANGE CAUCASIAN HISPANIC
Day facial 42–51 years 4 1
Night facial 34–56 years 5 none
Eye 38–51 years 5 none
Day lip 46–54 years 5 none
Night lip 46–55 years 5 none
TABLE 2. Ingredients of test products
Cromoist™ CM glucan
Vitamin E (tocopheryl acetate)
Vitamin E (tocopheryl acetate)
White tea extract
Liquorice extract
Niacinamide
Zinc citrate
Hexapeptide-3 (argireline)
Dermaxyl
Dermaxyl
Haloxyl
Sepilift
Eyeliss
Rigin
Maxilip
Ederline L
Silymarin (milk thistle, 80%)
Caffeine
Dexpanthenol (vitamin B5)
Cucumber extract
Ivy extract
Shitake extract
Allantoin
Avocado oil/sterol
Avocado butter
White petrolatum
Illilpe butter
Shea butter
Shora seed butter
Ceraphyl 847
C12-15 alkyl benzoate
Pentaerythrityl tetraisostearate
Diisopropyl adipate
Evening primrose
FIGURE 1. Outer view of a Novasome—Inside are 2 to 7
bilayer membranes surrounding a large "cargo hold" that
can carry multiple active ingredients.
FIGURE 2. Most liposomes consist of concentric membranes
with a solid core (right). The left cutaway illustration of a
Novasome shows the membranes that surround the inner
chamber, or "cargo hold."