She told Politico her experience in the shipping industry and as a business development head at Clemson University makes her uniquely qualified to represent the coastal-based 1st Congressional District.

“This is a privilege to be able to do this," Colbert Busch said. "My gut says you're never going to get this opportunity again. And you don't want to turn around as an old woman and say I didn't try.”

Colbert said he won’t be mentioning his older sister whom the family calls Lulu, on ‘The Colbert Report.’

“Lulu has a job to do, and that's run for Congress. I have a job to do and that's to make jokes," he said. "I would never use my show to get my sister elected.”

"But the fact my sister is running, or that Mark Sanford is running or Teddy Turner is running or Chip Limehouse, who I knew when I was younger, is running ..."

"Those are all opportunities for my character to make jokes. But I want people to know this is her own thing. It's not me doing anything," he added.

On September 11, 1974, when Colbert Busch was 19 and Stephen aged 10, their father James William Colbert and two of their brothers Peter and Paul died in a plane crash.