CAR Peptide Applications

A major limitation in the treatment of disease is the lack of therapeutic selectivity. Recent studies have shown that pathologically altered blood vessels express specific cell surface markers. These markers are detectable by specific homing peptides, which can be used for cell-targeted drug delivery. Tissue-penetrating homing peptides can activate a bulk transport pathway that translocates co-administered substances from the blood vessels into the target tissue. Our lead therapeutic candidate, CARSKNKDC (CAR) peptide, represents a new paradigm in targeted therapy. CAR preferentially homes to, and penetrates, diseased tissue while selectively augmenting the localized efficacy of therapies and accelerating wound healing. CAR can selectively enhance gene therapy, boost drug effectiveness, and reduce systemic side effects by enhancing the efficacy of co-administered therapeutics. This promises to usher in a new age of targeted therapies and disease-specific treatments that are not only more effective than current treatments, but can also reduce, and even eliminate the harmful side effects of current treatments.

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