190 Technologies found

Researchers at the University of California, Riverside have developed a transparent, highly stretchable, self-healing, ionic conductor. The conductor is comprised of a polar polymer and an ionic salt solution. The material is held together via charge interactions between these two components, which prevents leakage of the ionic solution out of the material. This material can tolerate strains above 5000% and maintains an optical transmittance of 92%. Additionally, the material is spontaneously reversible (goes back to its original shape) for strains under 50%. When a sample of this material is cut into two pieces and connected together, the sample spontaneously self-healed under ambient conditions within 24 hours. Fig. 1 Photos of a healed material sample in the non-deformed state and stretched to five times its original length. Fig. 2 Optical microscope images of a cut material sample after different healing times at room temperature. The damaged sample fully healed after 24 hours. Scale bar is shown at 500 μm. Fig. 3 Healing efficiency (recovered fracture toughness) at different ambient temperatures

Researchers at the University of California, Davis, have discovered a composition of 5-phenoxyalkoxypsoralens that inhibits potassium channels to treat autoimmune diseases and disorders that involve abnormal homeostasis, body weight and peripheral insulin sensitivity.

UCLA researchers in the departments of Molecular, Cell & Developmental Biology and Biological Chemistry have elucidated a novel mechanism by which pyruvate oxidation can be inhibited in order to promote hair growth.

The invention is a surgical device designed to remove miniature fragments of uroliths that are less than 2 mm in size. Through the invention’s novel design, such small fragments are captured in the device which will then be easily removed by the surgeon. Removing small stone fragments will reduce the need for future medical procedures.

Though deep sedation is a routine part of many medical procedures, patients under anesthesia are susceptible to airway obstruction as their throat and tongue muscles relax. Most common methods to prevent obstruction are complicated and carry additional risks. Researchers at UCI have developed a safe and comfortable medical collar that maintains patients’ airways and is entirely adjustable.

UCLA researchers in the Departments of Molecular, Cell, and Development Biology & Surgery have identified Angiopoietin 2 (Ang-2) as a marker and potentially a strong contributing factor to the clinical presentation of pulmonary arteriovenous malformations.

UCLA researchers in the Department of Bioengineering have developed a new class of cell-compatible copolypeptide hydrogels that possess chain conformation directed polyion complex (PIC) supramolecular architectures.

State of the art antimicrobial therapeutics, while effective and promising, remain only short-term solutions to the overall challenge of drug-resistant microbes. UCI researchers have developed a chitosan-based nanoantibiotic that is non-toxic and carries potential for broad spectrum use.

Researchers at the University of California, Irvine (UC Irvine) have discovered specific biomarkers that will enable innovations in diagnosis, prognosis, monitoring, and therapy of PWS and other related syndromes.

UCLA researchers in the Department of Electrical Engineering have invented a novel full-fledged implant power management unit, which is highly programmable and can process multiple input power deliveries on-chip.

Researchers at the University of California, Davis, have identified a target for therapeutic intervention and agents that disrupt HIV latency in patients under suppressive HIV therapy. It amplifies the effects of other latency reversal agents and primes the cells harboring the virus for immune clearance and death.

Gene therapy applications necessitate cell transfection techniques for delivering biomaterial into multiple or a single cell(s). The global market for transfection technologies can be worth more than half a billion by 2017. Current viral and chemical transfection techniques have limited ease of fabrication, transfection efficiency, dosage control, and cell viability. The invention discloses a simple yet efficient technique for nanoinjection of material into a single cell with high transfection efficiency, controlled dosage delivery, and full cell viability.