The east end of the eastern segment of US 2 is near the Canada border just outside Houlton ME. I-95 runs east/west through Houlton and into New Brunswick. US 2 heads east out of Houlton, but the highway turns north just shy of the Canada border and ends at the last exit on I-95 (interchange 63):

Miller, Nov. 2001

Taylor, Oct. 2004

Straight ahead leads only to the onramp for southbound I-95 (the next photo was taken from that overpass). If one were to go right in the photo above (to north I-95), they would be on the on-ramp visible at far right in this photo:

Miller, Nov. 2001

That was looking east along the northbound barrel of I-95. The building in the median is the US customs station. The Canada line is right about where the road bends in the distance. Of course, before I-95 was built, it was US 2 that provided access to this border crossing, so its historic east end was in the distance (we'll see more of that below). But first, here is a shot from the last exit on northbound I-95:

Buchanan/Nitzman, June 2005

​That exit leads to the east beginning of US 2. The offramp has the following assembly:

Buchanan/Nitzman, June 2005

When a driver turns that direction, they are heading south, but US 2 traffic is directed to take another right:

Buchanan/Nitzman, June 2005

...and drivers are shortly reassured with the first westbound sign...

Buchanan/Nitzman, June 2005

...but if instead one were to turn left there (which is no longer an option), that would be where US 2 ran before I-95 was built, and before an extension of a runway at the Houlton airport. Not far in that direction, the old border inspection station still stands, mellowing with age:

Mortell, 1998

Mortell, 1998

The west end of the eastern segment of US 2 has always been in Rouses Point.