18FVM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models

18FVM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models - Download this document for free, or read online. Document in PDF available to download.

Molecular Imaging and Biology

, Volume 17, Issue 5, pp 615–619

First Online: 24 February 2015

Abstract

PurposeFVM4-037 was recently developed as a positron emission tomography PET tracer for the detection of carbonic anhydrase IX CAIX, a tumor-specific protein upregulated under hypoxic conditions. In this study, the accumulation of FVM4-037 was determined in two CAIX-expressing preclinical human tumor models.

ProceduresU373 and HT29 tumor-bearing animals were injected with FVM4-037 and underwent microPET imaging up to 4 h post-injection p.i

Biodistribution throughout the different organs was assessed at 2 and 4 h p.i. using gamma counting.

ResultsMicroPET imaging showed high FVM4-037 uptake in the abdominal region, and biodistribution revealed high radioactivity in the kidney, ileum, colon, liver, stomach, and bladder. Although high CAIX expression was confirmed in both tumor models, tumor uptake assessed with microPET and biodistribution experiments was comparable to background tissues.

ConclusionsIn this study, FVM4-037 does not specifically accumulate in CAIX-expressing tumors, indicating that the tracer is not suitable for the detection of CAIX.

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