Summary

This protocol compares use of single nucleotide polymorphism panels to common risk
assessment models. Women undergoing screening mammography or breast biopsy due to BIRADS
Category 4 lesion will be asked to provide buccal swabs and health information used to
complete each risk model. These risk models will be compared to see whether either improves
the positive predictive value of breast biopsy for BIRADS4 lesions. Subjects undergoing
biopsy will be followed to examine cancer outcomes.

Description

Calculating the risk that a woman will develop breast cancer in her lifetime can lead to
decreased mortality rates as a result of increased screening and prevention methods when a
person is known to be at high risk. Though there are several risk assessment models that
are commonly used, it is important to continue to improve the process of calculating risk.
Several genetic markers have been noted to potentially indicate risk of developing breast
cancer. New tests, called SNP panels, can detect some of these genetic markers. This study
aims to use both these SNP panels and the commonly used risk models to calculate risk and
examine outcomes in women coming in to do screening mammography. This study will enroll
women between the ages of 40-65 who are undergoing screening mammography (n=600), in
addition to women with BIRADS category 4 mammogram readings who are about to undergo biopsy
(n=600), all with no personal history of breast or ovarian cancer, ductal carcinoma in situ
(DCIS), mantle radiation, or known BRCA 1/2/mutation in self or family members. The
participants will only be expected rto provide consent, swabs of the inside of the cheek of
her mouth, and baseline questionnaire answers that will allow for a risk assessment to be
performed.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Mammography

Location

Abramson Cancer Center of the University of PennsylvaniaPhiladelphiaPennsylvaniaUnited States19104

Mammography as the most common secondary prevention method has known to be helpful in detecting breast cancer at the early stages. Low level of participation among women toward mammography uptake due ...

This experiment tested the effects of an individualized risk-based online mammography decision intervention. The intervention employs exemplification theory and the Elaboration Likelihood Model of per...

Screening with mammography can detect breast cancer early, before clinical symptoms appear. Some cancers, however, are not captured with mammography screening alone. Ultrasound has been suggested as a...

Breast cancer is a leading cause of cancer death among Hispanic women in the U.S., and mammography is the recommended screening for early diagnosing and preventing breast cancer. Several barriers exis...

Purpose To evaluate the early implementation of synthesized two-dimensional (s2D) mammography in a population screened entirely with s2D and digital breast tomosynthesis (DBT) (referred to as s2D/DBT)...

Medical and Biotech [MESH] Definitions

Mammography

Radiographic examination of the breast.

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