Niggas still want me dead like Osam'

Haters want 50 dead / gone like Osama bin Laden, the infamous mastermind behind the September 11, 2001 attacks on the World Trade Center in New York. This line implies that some people despise 50 as passionately as most Americans do the terrorist leader. Bin Laden was finally found and killed by Navy SEALs while hiding out in Pakistan in 2011.