Rhinosinusitis is one of the three most common disorders presenting to primary care physicians, generating high socioeconomic costs (Moss and Parsons 1986; Poole 1999). Understanding the pathomechanisms of inflammation, ...

Inflammation is a physiological process initiated in response to an injury or infection. Proper execution of the inflammatory response requires activation of several pro- inflammatory transcription factors. Nuclear Factor ...

Marignol, Laure(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)

Gene therapy targeted to hypoxic tumour cells may allow selective killing of malignant cells. The induction of gene expression under hypoxic conditions is governed by the activation of hypoxia-inducible factor 1 and its ...

Summary: Some historical notes of the knowledge and beliefs regarding congenital malformations were reviewed. Based on a survey carried out at the Lagos Island Maternity Hospital, Nigeria, amongst 16,720 consecutive ...

Food-based dietary guidelines (FBDG) are guidelines derived from nutrient targets which are translated into food-based guidelines so they can be adopted by the general population. In order for FBDG to be successful, they ...

Postprandial hypertriglyceridaemia predicts cardiovascular disease and is a characteristic of both obesity and poorly controlled diabetes. To address the relative impact of improved glycaemic control and weight loss on ...

Regan, Julie(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)

The aim of this research was to adapt the Functional Lumen Imaging Probe (FLIP), a novel non-radiological measurement tool, to measure upper oesophageal sphincter (DOS) distensibility and opening patterns during swallowing. ...

BROWN, AISLING(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)

Staphylococcus aureus bloodstream infection is a common and life-threatening condition. Treatment outcomes are poor, suboptimal clinical management is common, antimicrobial resistance continues to emerge, and there are few ...

Phipps, Sinead(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)

Oesophageal adenocarcinoma (OAC) is the sixth leading cause of cancer-related deaths
worldwide, and has proven most challenging for surgeons as less than a third of patients are suitable for surgical resection due to ...

The North/South Ireland Food Consumption Survey (NSIFCS) was conducted between
1997 and 1999, on a representative sample of 1379 adults from the Republic of Ireland
and Northern Ireland, aged 18 to 64 years. Food intakes ...

Walshe, Peter(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)

The anatomy of the mammalian ear is similar between the different subspecies. This applies to the structure of the utricle in humans and in guinea pigs. Hence the choice of the guinea pig utricle allows any findings ...

Becker, Christine(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)

This thesis concerns an analysis of caspase-1 and ASC, key components of the inflammasome. At the outset Rab39a had been found in a complex with caspase-1. Rab39a is a member of the Rab GTPase family, a group of proteins ...

Browne, Joseph(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)

Osteoporosis is defined as a skeletal disorder characterised by compromised bone strength resulting in an increased risk for fracture. Hip fractures are the most common osteoporotic fracture in older adults and occur due ...

Fanning, Áine(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)

This thesis investigates the role of CD44 in signalling active migration in T lymphocytes. A number of murine studies have demonstrated that loss of CD44 expression by T lymphocytes resulted in a delayed migration to sites ...

RYAN, LAURA(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)

High-level resistance to and treatment failures with ceftriaxone and azithromycin, the first line agents for treatment of gonorrhoea are reported and antimicrobial-resistant N. gonorrhoeae is now an urgent public health ...

Risk assessment of food chemical intake is at the core of food safety policy within the EU and the assessment of food chemical exposure is an integral part of the risk assessment process. There is an increasing demand to ...

In section A, two studies were conducted to systematically investigate and compare the cross sectional and longitudinal physiological determinants of the age-related loss of lower extremity muscle power in healthy and ...

Kiiski, Hanni(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)

Cognitive impairment (CI) affects up to 65% of multiple sclerosis (MS) patients and can occur in the absence of physical disability (Hoffmann, Tittgemeyer, & von Cramon, 2007). MS is the most common chronic inflammatory ...

HANNON, GARY(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)

5-year survival for pancreatic cancer is about 10% worldwide. A subset of this cancer, pancreatic ductal adenocarcinoma (PDAC), is estimated to become the second leading cause of cancer-related deaths in the US by 2030. ...