INTRODUCTION: Laparoscopic totally extraperitoneal (TEP) hernia repair has become increasingly widespread. Faster recovery than conventional open methods shortens the return to work. Polypropylene (PP) mesh is still in use in hernia surgery because it is an inexpensive and easily accessible patch.The post-operative chronic pain and foreign body sensation are the disadvantages of these PP patches. Poly-L-lactic acid and polypropylene (PLLA) was used in our study because of the good biocompatibility and low tissue inflammation response. We compared the early clinical outcomes of PP patch and PLLA patches.METHODS: Between January 2013 and April 2018,469 patients with inguinal hernia underwent TEP procedure. Patients were divided into two groups. PP mesh (n=211) in group 1, PLLA mesh (n= 258) in group 2. Patients were compared in terms of age, gender, hernia side, ASA scores, duration of operation, pain, time to return to work, sensation of foreign body, seroma and hematoma.RESULTS: A total of 469 patients were analyzed retrospectively (426 male,43 female). The mean age was 52.23±13.66 years. The operative times of the patients were 40.92 ± 8.9 minutes in group 1 and 38.82 ±8.5 minutes in group 2 (P<0.05).The time to return to work was 10.2 ± 1.47 days in Group 1 and 8.4 ± 1.0 days in Group 2(P<0.05).Visual Analog Scale (VAS) In group 2, it was lower than in group 2 (P <0.005). In group 2,the feeling of organic body decreased in early and late period (P<0.005). Seroma and hematoma were less in Group 2 than in Group 1 (P <0.005). The mean follow-up period of the patients was 18 (3-63) months, 2 patients in Group 1, 2 patients in Group 2 recurred. DISCUSSION AND CONCLUSION: The PLLA patch used in the TEP method is thought to be a herniated patch that can be safely used because of its ease of application and less postoperative complication rates and more rapid return to work.