It'll all depend on what the most common "lanes" end up being. Will there be a solo bot? A duo bot? A rush for the enemy team's nearest point to "backdoor"? It's hard to say. Speed boost/blink champs look very powerful, though, much like on TT.

From what I saw today it's not really about laning... why Singed wont be able to farm 20m then proceed to trololool.

i feel like there is going to be a split in champs. defenders like heim, burst attackers like annie, some kind of ad (maybe keep the ranged carry, maybe melee gets a revival, or maybe even casters), and map controll/movement. maybe yi will be viable =)

Any tanky DPS with auto sustain would be an awesome pick, Nasus and Renekton Ults will be invaluable to defend a position with self heal and AOE damage, Nasus may be slightly weaker than Renek do to not be able to properly farm his Q while Renek Q will give him some extra sustain while defending.