Current Research and Scholarly Interests
Dr. Zack is involved with ongoing research related to the treatment of adolescent and adult trauma (Trauma Focused Cognitive Behavioral Therapy - TF-CBT; Prolonged Exposure - PE), and the effective provision of Dialectical Behavior Therapy (DBT) to adolescent girls and women with disorder of emotion regulation. She additionally studies Acceptance and Commitment Therapy (ACT) for adolescent girls with anxiety. More broadly she is interested in the impact of Evidenced Based Treatments on improving quality of life, and helping individuals find the right match for clinical care. Research is conducted through the Early Life Stress and Pediatric Anxiety Disorders Program at Stanford Children's Hospital and the Stanford Dialectical Behavior Therapy Program.

Current Research and Scholarly Interests
Imaging of cerebral hemodynamics with MRI and CTNoninvasive oxygenation measurement with MRIClinical imaging of cerebrovascular diseaseImaging of cervical artery dissectionMR/PET in NeuroradiologyResting-state fMRI for perfusion imaging and stroke

Current Research and Scholarly Interests
The most common problem with people's heartbeat is when it becomes irregular, whichis called atrial fibrillation (AF). AF is a problem as it can lead to strokes and heartattacks. It is difficult to cure, with many tablets required that aren't thateffective. A new way of picking where to ablate has focussed on rotors - areas where the electricity spins around like a hurricane. At Stanford, I am working with the developer of this technique to improve understanding of how and why they occur.

Current Research and Scholarly Interests
My academic and scientific training has been focused on design and development of novel fiber-optic based biomedical instrumentation to improve the detection and, intervention, and treatment of various diseases. Currently, I am on a Western State Affiliate Winter 2013 Postdoctoral Fellowship from the American Heart Association (AHA) at the Stanford University School of Medicine in the laboratory of Professors Lei Xing and Michael V. McConnell, where I developed a novel fiber-optic catheter based optical imaging system to detect vulnerable atherosclerotic plaque in carotid arteries. In this work, I developed a novel scintillating balloon which can detect the vulnerable atherosclerotic plaque from stable plaque with high sensitivity after 18F-FDG uptake by the macrophages within the thin cap fibro atheroma (TCFA). The TCFA causes 60-70% of acute coronary syndrome that leads to sudden cardiac death and myocardial infarction.

Current Research and Scholarly Interests
My current research focuses on novel methods to Erk1/2 MAP kinase (MAPK) cascade in cancer. Up-regulation occurs in >30% of human cancers, making this a key therapeutic target. MAPK scaffolds, such as IQGAP1, assemble pathway kinases together to effect signal transmission. Disrupting scaffold function offers a potentially orthogonal approach to MAPK cascade inhibition. We have IQGAP1 to be necessary for Ras-driven tumorigenesis and are utilizing this discovery to dissect the ERK1/2 pathway.

Current Research and Scholarly Interests
Our laboratory focuses on translational research in 2 main areas - genomic approaches to diagnosis and minimal residual disease testing for patients with cancer, and molecular basis of disorders of thrombosis and hemostasis. My clinical focus is in diagnosis and treatment of disorders of hemostasis and thrombosis and general hematology.

Current Research and Scholarly Interests
(1) Mechanisms of Arrhythmia, including Ventricular Tachycardia, Atrial Fibrillation and other arrhythmias. (2) New technologies and devices for catheter ablation.

Current Research and Scholarly Interests
Dr. Zeitzer's research examines non-image forming light perception. Basically, everything that the eye does with light except what is thought of as "vision". He examines the manner in which humans respond to light and ways to manipulate this responsiveness. His work has direct application in jet lag, shift work, and altered sleep timing in teens and older individuals.

Current Research and Scholarly Interests
My lab is focused on developing novel therapeutic methods against stroke using rodent models. We study protective effect of postconditioning, preconditioning and mild hypothermia. The rationale for studying three means of neuroprotection is that we may discover mechanisms that these treatments have in common. Conversely, if they have differing mechanisms, we will be able to offer more than one treatment for stroke and increase a patients chance for recovery.