IJRDPLijrdpl.comeditor@ijrdpl.comFormulation and evaluation of an Anti-pyretic (Paracetamol) syrup for PaediatricPawan Singh*, Prevesh Kumar and Neelkant PrasadAntipyretic syrup, Stability, Assay of paracetamol syrup2924-2930Vol 7, Issue 1 (2018)January - FebruaryBackground: Studies suggested that fever may have a beneficial for safe drug delivery. The use of paracetamol in therapeutic doses generally is safe, although hepatotoxicity has occurred with recommended dosages in children. Martial and Method: home storage conditions at a temperature ranging from (2-8 °C) representing refrigerator and accelerated condition. Prepare a solvent mixture consisting of 0.4 volumes of formic acid, 15 volumes of methanol and 85 volumes of water. Result:Evaluated prepared 4 formulations the physical description (Color, odor, and taste) were found colorless, none and sweet. The pH of F1, F2, F3, and F4 was found 5.39,5.16,5.09 and 5.04. In these four formulations, we were selected F1 on the behalf of best pH. The F1 formulation weight per ml was found 1.0312 gm/ml. the assay of paracetamol syrup F1 formulation was found 99.88%. The stability of four formulations was found 5.36,5.16,5.08 and 5.03 Conclusion:It was concluded that F1 formulation was good and stabilized formulation. Like syrup formulations made by use of a combination of physiologically compatible mixed solubilizes. The proposed mixed solubilizes are known to be safe; hence, toxicities/safety related issues may not raise concern, suggesting the adaptability for large-scale manufacturing i.e. industrial feasibility.