Iranian Biomedical Journal مجله بیومدیکال ایرانIBJBasic Scienceshttp://ibj.pasteur.ac.ir1admin1028-852X2008-823X-10.22034/ibj-8888-enjalali139681gregorian2017111216online1fulltextenA review of Brucellosis in Iran: Epidemiology, Risk Factors, Diagnosis, Control, and Prevention Related FieldsRelated Fieldsمقاله مروریReview ArticleBrucellosis caused by species of <em>Brucella</em> is among the most prevalent zoonoses with the annual incidence of half a million cases globally. Most parts of Iran are endemic for brucellosis, and the annual incidence of the human and animal brucellosis is still high. At present, there is no safe and protective human vaccine against brucellosis, and the only preventive strategy is animal vaccination, which harbors significant disadvantages. Considering the identification of many immunogenic proteins in <em>Brucella</em>, several studies have recently been performed to evaluate the vaccine potency of such antigens as a new subunit vaccine candidate. This review represents an overview of brucellosis in Iran, including epidemiology, transmission routs, diagnosis, and treatment. Moreover, it mainly highlights the history of brucellosis control and prevention in Iran, including eradication programs, vast livestock vaccination programs, and subunit vaccine studies. It also discusses major problems that the country encounters with disease control. In recent years, Persian scientists have focused on evaluating the efficacy of best <em>Brucella</em> immunogens <em>in vivo </em>to introduce a new subunit vaccine. The results of some studies could demonstrate the vaccine potential of some immunogensBrucellosis, Iran, Epidemiology, Transmission, Subunit vaccine349359http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-684&slc_lang=en&sid=enMaryamGolshani100319475328460030684100319475328460030684Yes
Department of Molecular Biology, Pasteur Institute of Iran, Tehran, IranSaeidBuozari100319475328460030685100319475328460030685NoDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran