Commonly utilized as an expression denoting moderate excitement, amusement, and/or mild indifference when cussy words are simply unacceptable, i.e. You're in a church/at a daycare/in a Carl's Junior drive-thru ordering a Hot Carl. When Holy AIDS has too much zazz and personality, and when Holy Shit just isn't feasible or polite, unzip your grab bag of phrases and reach for the stars. And, banality.

#1: "Did you see last night's episode of____? Holy Ryan Seacrest! It was so flamboyantly average, I could actually feel myself dying a little bit inside with every passing minute that I continued watching. Naturally, I recorded it so I could review it and subsequently spark uninspired discussions on my Facebook page, both for, and against, topics of my choosing surrounding said show."

#2: "I ordered a Big Mac and found myself having to take a--Holy Ryan Seacrest, did you just see that mime across the street get beat up by those ventriloquists?"

#4: "Your command of the English language has been classified as mildly-illiterate at best and you can barely secure the velcro on your dress shoes, yet you were voted in as Leader of the Free World for eight years? Holy Ryan Seacrest- I didn't think you had it in you, Georgie. Kudos."