These data demonstrate a cell-autonomous function of ApoER2 (显示 LRP8 ELISA试剂盒), and most likely VLDLR (显示 VLDLR ELISA试剂盒) and Dab1 (显示 DAB1 ELISA试剂盒), in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin (显示 RELN ELISA试剂盒).

The high affinity of apoE4 to the LDLR (显示 LDLR ELISA试剂盒) enhances VLDL sequestration on the hepatocyte surface but delays their internalization.

Data show that thrombospondin-1 (THBS-1 (显示 THBS1 ELISA试剂盒)) is a novel physiological ligand for ApoER2 (显示 LRP8 ELISA试剂盒) and VLDLR (显示 VLDLR ELISA试剂盒), and that lack of THBS-1 (显示 THBS1 ELISA试剂盒) results in anatomical abnormalities of the RMS and leads to a reduction of postnatal neuronal precursors entering the OB.

Human CD320 Molecule (CD320) interaction partners

Although not significant when corrected for multiple testing, eight single nucleotide polymorphisms (SNPs) in two genes, transcobalamin II (TCN2 (显示 TCN2 ELISA试剂盒)) and the transcobalamin II (显示 TCN2 ELISA试剂盒)-receptor (TCblR), were found to influence several clinical traits of cobalamin deficiency.

The soluble transcobalamin receptor is present in cerebrospinal fluid and correlates to dementia-related biomarkers tau proteins and amyloid-beta.

TCblr SNP were associated with omphalocele suggests that disruption of methylation reactions, in which folate, vitamin B12 (显示 NDUFB3 ELISA试剂盒), and homocysteine play critical parts, may be a risk factor for omphalocele.

Our data suggest that variation in TCblR plays a role in neural tube defect risk and that these variants may modulate cobalamin metabolism.

the cell cycle associated expression of TCblR appears to be tightly regulated in synchrony with the proliferative phase of the cell cycle.

Analysis of TCblR/CD320, the gene for the receptor for cellular uptake of transcobalamin-bound cobalamin, identified a homozygous single codon deletion, c.262_264GAG (p.E88del), resulting in the loss of a glutamic acid residue.

CD320 抗原简介

Antigen Summary

This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.