The former Karate Kid, 50, who finished fourth while on the dancing competition, will guest star on Wednesday's Happily Divorced finale, playing a New Yorker who vies for Fran Drescher's affection while he opens up a pizza parlor.

But with the announcement that DWTS is currently casting an all-star season, might Macchio be reaching for his dancing shoes once more?

Fran Drescher didn't have to look far for inspiration for her new TV Land show Happily Divorced, which premieres June 15. The sitcom, about a woman whose husband turns out to be gay, is actually based on her own experience.

After her marriage of 21 years ended, Drescher's husband, Peter Marc Jacobson, came out of the closet.

"He had already been living a gay life away from me after we divorced, and he said, 'I don't want you to be shocked. I'm dating men,' " the actress, 53, tells PEOPLE in its current issue, on stands now.

Everyone’s favorite nanny is looking to take her famous Queens accent to a new home – the U.S. Senate, that is.

Fran Drescher tells PEOPLE she's offering up her name as a replacement for Senator Hillary Clinton, who has been nominated as Secretary of State. New York Gov. David Paterson must find an interim to fill the remaining two years of Clinton's term.

"I'm a New Yorker. It's a part of the fabric of my being," says Drescher, 51. "It just seems natural to me to throw my hat in the ring."

Here's one way to prevent any filibusters: Fran Drescher's screechy voice.

The former star of The Nanny – and inveterate New Yorker – wants to fill the U.S. Senate seat being vacated by Hillary Rodham Clinton (who is leaving to become Barack Obama's Secretary of State).

New York Gov. David Paterson is said to be seriously considering former first daughter – and political activist – Caroline Kennedy, 51, for Clinton's position, but Drescher, also 51, is firm in her desire. New York magazine quotes the actress as saying she's qualified for the job, as well as "an authentic and honest person."