- Explore the mechanisms by which TGC or SGC impact distress and quality of life.

OUTLINE: This is a randomized, multicenter study. Participants are stratified according to
participating site. Participants are randomized to 1 of 2 groups.

- Group 1 (standard genetic counseling): Participants undergo an in-person genetic
counseling session. Participants are then given the option of providing blood for
genetic testing at the study site. Participants who choose to undergo genetic testing
receive their results in-person from their genetic counselor.

- Group 2 (telephone-based genetic counseling): Participants undergo a telephone-based
genetic counseling session. Participants who choose to undergo genetic testing receive
a pre-labeled blood kit in the mail. Participants receive their results over the phone
from their genetic counselor.

After completion of genetic counseling, all participants are followed periodically for 1
year.

PROJECTED ACCRUAL: A total of 600 participants will be accrued for this study.

Inclusion Criteria

DISEASE CHARACTERISTICS:

- Must have at least 10% chance of carrying the BRCA1/BRCA2 gene, as defined by ≥ 1 of
the following:

- First-degree relative of affected family member with a 50% chance of inheriting
a BRCA1/BRCA2 mutation

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