VOMITING and Diazepam

VOMITING Symptoms and Causes

Nausea is when you feel sick to your stomach, as if you are going to throw up. Vomiting is when you throw up.

What causes nausea and Vomiting?

Nausea and Vomiting can be symptoms of many different conditions, including

Morning sickness during pregnancy

Gastroenteritis (infection of your intestines) and other infections

Migraines

Motion sickness

Food poisoning

Medicines, including those for cancer chemotherapy

GERD (reflux) and ulcers

Intestinal obstruction

When should I see a health care provider for nausea and Vomiting?

Nausea and Vomiting are common. They are usually not serious. However, you should contact your health care provider immediately if you have

A reason to think that your Vomiting is from poisoning

Vomited for longer than 24 hours

Blood in the vomit

Severe abdominal pain

Severe headache and stiff neck

Signs of dehydration, such as dry mouth, infrequent urination or dark urine

How is the cause of nausea and Vomiting diagnosed?

Your health care provider will take your medical history, ask about your symptoms and do a physical exam. The provider will look for signs of dehydration. You may have some tests, including blood and urine tests. Women may also have a pregnancy test.

What are the treatments for nausea and Vomiting?

Treatments for nausea and Vomiting depend on the cause. You may get treatment for the underlying problem. There are some medicines that can treatment nausea and Vomiting. For severe cases of Vomiting, you may need extra fluids through an IV (intravenous).

There are things that you can do to feel better:

Get enough fluids, to avoid dehydration. If you are having trouble keeping liquids down, drink small amounts of clear liquids often.

Eat bland foods; stay away from spicy, fatty, or salty foods

Eat smaller meals more often

Avoid strong smells, since they can sometimes trigger nausea and Vomiting

If you are pregnant and have morning sickness, eat crackers before you get out of bed in the morning

VOMITING Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.

Success will be defined by the absence of VOMITING between 15 minutes and 4 hours after administration of study treatment.; Hospital admissions for acute gastroenteritis, intravenous infusion for rehydration, return emergency department visit, severity and duration of diarrhea and VOMITING. Treatment safety will also be assessed. These criteria will be assessed within 7 days

Complete Response rate (no VOMITING and no rescue anti-emetic therapy); Complete Response rate; Proportion of patients who did not vomit; No Significant Nausea: The proportion of patients who did not experience any nausea ≥ 3 on 0 - 10 scale; No Nausea: The proportion of patients who did not experience any nausea. Nausea = 0 on 0 - 10 scale; Complete Protection: The proportion of patients who did not vomit, require rescue therapy, or have nausea ≥ 3 on 0 - 10 scale; Total Protection: The proportion of patients who did not vomit, require rescue therapy, or have any nausea (Nausea = 0 on 0 - 10 scale).; VOMITING frequency: The frequency of VOMITING (# episodes per week) in patients who did vomit at least once.; Nausea frequency: The frequency of nausea (Nausea > 0 in a given week/ number of weeks during overall period of radiation treatment); Significant Nausea frequency: The frequency of significant nausea (Nausea ≥ 3 in a given week/ number of weeks during overall period of radiation treatment); Frequency of rescue medication use: The number of days in which rescue medication was taken / number of days of radiotherapy; Time to Failure: The time period in days from the start of radiation until the first VOMITING episode or use of rescue medication for all patients and for the subset of patients who do not have a Complete Response.; All adverse events that occur during radiation treatment with assessment of severity (CTC v.3) and relationship to study drug.

The Proportion of Participants with Overall No VOMITING for the Overall Stage; Number of Participants with a Complete Response - Overall, Acute, and Delayed; Time to First VOMITING Event Overall; Number of Participants with No VOMITING and No Significant Nausea; Number of Participants with No Impact on Daily Life - Overall; Number of Participants with No Use of a Rescue Therapy - Overall, Acute, and Delayed; Number of Participants with One or More Clinical Adverse Events; No VOMITING - Acute and Delayed

To evaluate the role of some predictive biomarkers for chemotherapy-induced nausea and VOMITING; To evaluate the clinical characteristics related to chemotherapy-induced nausea and VOMITING in Korean patients

Evaluating the effectiveness of intravenous lidocaine during anesthesia to decrease the numbers of events (VOMITING) during the immediate postoperative period up to 24 hours postoperatively, comparing to placebo; The prevention of the composite "nausea / or VOMITING"; Compare frequency of VOMITING by baseline risk; Time to first VOMITING; Time at which discharge criteria are met Postanesthesia care unit (PACU); Length of stay in PACU unit; PACU opioid consumption; Postoperative pain using Children and Infants Postoperative Pain Scale , face or Visual analoge Scale, as appropriate; Postoperative agitation using Pediatric Anesthesia Emergence Delirium Scale; Time to first emetic drug administered; Type and number of doses of antiemetic drug requiered during hospitalization; Total length of stay; Analysis of cost-effectiveness.

Proportion of patients with complete response, defined as no emesis and no use of rescue medication in acute phase (within first 24 hours of treatment); Proportion of patients with complete response, defined as no emesis and no use of rescue medication in delayed phase (within 2-4 days of treatment); Proportion of patients with complete response, defined as no nausea, defined as Visual Analog Scale (VAS) less than 5 mm on a 0-100mm horizontal scale in acute phase (within 24 hours of treatment); Proportion of patients with complete response, defined as no nausea, defined as VAS less than 5 mm on a 0-100mm horizontal scale in delayed phase (within 2-4 days of treatment); Proportion of patients with partial response, defined as 2 or fewer episodes of emesis (Common Terminology Criteria for Adverse Events [CTCAE] version 4.0 grade 1-2), regardless of the use of rescue antiemetic medications (in acute and delayed phase); Proportion of patients with treatment failures, defined as more than 2 episodes of emesis (CTCAE version 4.0 grade 2 or greater), regardless of the use of rescue antiemetic medications; Proportion of patients with partial response, defined as no significant nausea, defined as VAS less than 25 mm on a 0-100mm horizontal scale (in acute and delayed phase); Proportion of patients who developed nausea and VOMITING in the first course of treatment out of all enrolled patients; Proportion of patients who developed grade 1, 2, 3, or 4 nausea and VOMITING with all courses of treatment out of all patients who developed nausea and VOMITING; Proportion of patients who developed nausea and VOMITING on all courses; Proportion of patients who experience grade 1, 2, 3, or 4 adverse events out of all patients who have received study drugs; Proportion of patients who missed 0, 1, or more than 2 doses of scheduled antiemetic medication at home on days 2 to 3, out of all patients

the incidence and severity of any nausea, emetic episodes (retching or VOMITING), or both (i.e., postoperative nausea and VOMITING) during the first 24 postoperative hours.; The incidence and severity of throat pain; the incidence of oral mucosal injury; satisfactory scores of patients

Proportion of patients with no nausea, defined as a response of 0 in the nausea item of Nausea and VOMITING Daily Diary/Questionnaire; Nausea scores measured by the Nausea and VOMITING Daily Diary/Questionnaire; Complete response, defined as no emetic episodes and no use of rescue medication measured by the Nausea and VOMITING Daily Diary/Questionnaire; Incidence of potential toxicities related to olanzapine as measured by the Nausea and VOMITING Daily Diary/Questionnaire; Frequency of rescue medication repeatedly measured by the Nausea and VOMITING Daily Diary/Questionnaire

If you think you may have a medical emergency, call your doctor or 911 immediately.

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