Additional files

Additional data file 1:

The relative accessibility prediction assigns a value between 0 (fully buried) and
9 (fully exposed) to each residue. For phosphoserines, phosphothreonines and phosphotyrosines,
accessibility is significantly higher than for their non-phosphorylated counterparts
in the same proteins. The overall accessibility of phosphoproteins is also significantly
higher than for a random set of around 1,000 human proteins in Swissprot.

(a) Conservation of phosphoserine surrounding sequences (green) in comparison to the average
conservation of phosphoproteins (red). (b) Conservation of phosphothreonine surrounding sequences (claret-red). (c) Conservation of phosphotyrosine surrounding sequences (yellow). Regions around phosphosites
are significantly less likely to be conserved than phosphoproteins on average.