Posters

Identifying protein partners of a small bioactive molecule is of greatinterest in many aspects of life sciences and specifically in the drugdiscovery and development process cycle. It is a support to (i) decipherthe mechanism of action after for example a “High Content” screening,(ii) study “off-target” effects, (iii) adjust therapeutic indications andclinical regimens of a drug and (iv) consider drug repositioning.

This work represents a systematic exploration of a flavonoids collection for the inhibitory activity against Staphylococcus aureus biofilms and offers an improved methodological workflow for anti-biofilm screens of chemical libraries taking into account the connections between anti-biofilm and antibacterial properties.

EU-OPENSCREEN - The European Research Infrastructure of Open Screening Platforms for Chemical BiologyBahne Stechmann

EU-OPENSCREEN (www.eu-openscreen.eu) is the largest emerging academic chemical biology research infrastructure initiative in Europe with the aim to collaboratively develop novel research tool compounds with external scientists. As a joint effort of national networks in 16 European countries, EU-OPENSCREEN offers access to high-throughput screening platforms, chemistry services, an open-access database, a large compound collection and an open-access database.

3D-NET, “Drug Discovery & Development of Novel Eye Therapeutics”, is a new European research consortium of industry and academic partners focusing efforts to enhance the discovery and development of drugs targeting ocular pathologies that lead to blindness.

Idebenone significantly reduced cell proliferation and induced apoptosis in PC-3, CFPAC-1, HT-29, T-84 and Calu-3 cells having CaCCs activities. These data suggest that idebenone, an ANO1/CaCC inhibitor, has potential for use in cancer therapy.

Modern drug discovery and research labs are utilizing complex automation systems to assist inhigh throughput screening of novel drug candidates. A large portion of these laboratories areusing ANSI-SBS-standard 96- and 384-well plates to achieve the necessary throughput. The volumeof sample transferred into and out of these plates can be critical to the success of assays orvalidation of procedures.

Automated detection and control of controlled substancesJoe Bradley, Ian Johns

Scitegrity, in conjunction with the Pistoia Alliance and a number of pharmaceutical companies, have developed Controlled Substances Squared to scan large chemical libraries (millions of compounds) and determine whether a compound is considered as controlled in a selected country.