Rheumatoid arthritis (RA) is a heterogeneous autoimmune condition with a complex aetiology. Despite the identification of over 100 risk loci associated with susceptibility to RA, the mechanisms through which these variants contribute to pathogenesis remain poorly characterised. CD4+ T cells are strongly implicated in RA disease processes, and the aim of this study is to identify how genetic and epigenetic variation can impact expression of genes in this relevant cell type. To this end, we use techniques including array-based profiling of genome-wide DNA methylation, together with the integration of genotype and transcriptome data, to understand CD4+ T cell immune dysregulation during early arthritis.

Sarah Thompson

(Prof S. Ali, Prof J. Kirby, Prof N. Sheerin)

Post-translational modification of Chemokines during heart transplantation: Implications for their biological function

Post-translational modifications of chemokines occur as a result of ischaemia-reperfusion injury during transplantation, and nitration in particular has been shown to affect chemokine activity (through alterations in receptor-binding and GAG-binding), as well as detectability. The functionality of nitrated chemokines must be better understood in order to maximise their potential as potential therapeutics or biomarkers.

Ally Leitch

(Prof M. Wright)

An Ionic Liquid activates estrogen receptorsAn ionic liquid has been discovered to be present in an active landfill site and found to have toxic effects. We have shown that this chemical also acts as a xenoestrogen and activates the estrogen receptors.