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QB Peyton Manning at Chiefs
33% (14)

WR A.J. Green vs. Raiders
33% (14)

WR Roddy White at Buccaneers
7% (3)

RB Frank Gore at Saints
12% (5)

WR Calvin Johnson vs. Texans
14% (6)

42 total votes.

START OF THE WEEK

After throwing for only one touchdown against Carolina in Week 10, Peyton Manning was able to pick apart San Diego's secondary for the second time this season to the tune of 270 yards and three touchdowns.

The 4-time M.V.P. has now thrown for three scores in six of his 10 games this season.

Next on his docket? Hapless Kansas City.

The Chiefs have allowed 20 passing touchdowns already and don't stand a chance against Manning.

The scary thing? He may throw the ball even more this week with Willis McGahee missing in action due to a MCL tear and leg fracture.

If you own Manning, be excited. Be very excited.

BALTIMORE AT SAN DIEGO

Obvious starters: RB Ray Rice (Ravens).

Who to start: While the Chargers defense has improved, pass defense is not their strong suit. Joe Flacco (Ravens) should be able to take advantage of a secondary that's allowed five passing touchdowns the past two weeks. With Rice's running keeping the Chargers honest, I can see Torrey Smith (Ravens) getting behind the secondary for a deep score. Baltimore's secondary is particularly susceptible to the deep ball, meaning Danario Alexander (Chargers) will come into play, assuming Philip Rivers (Chargers) can stay upright long enough. Alexander has 230 receiving yards and three touchdowns the past two weeks. Rivers has multiple touchdown passes in six of his last seven games.

Who to sit: Inconsistent usage and durability concerns have plagued Ryan Mathews (Chargers) this season. Even against a Ravens defense that has struggled stopping the run, I can't recommend Mathews. Something Baltimore does do, however, is keep tight ends out of the end zone. It's surrendered just one touchdown to the position this season. It's tough to sit Antonio Gates (Chargers), but he's no longer the must-start he once was.

Sleeper: With a season-high 12 targets in Week 11 at Pittsburgh, Anquan Boldin (Ravens) is still receiving enough opportunity to succeed in both standard and PPR formats. He caught eight balls for 79 yards against a much better Steelers secondary.

Who to start: Don't expect near record-setting performances again, but Matt Schaub (Texans) and Andre Johnson (Texans) will have success against a Detroit defense focused on containing Foster. Chad Henne had over 300 yards passing against Houston last week, so Matthew Stafford (Lions) should certainly find some passing lanes. Only three teams in the NFL have allowed more tight end touchdowns than the Texans. Brandon Pettigrew (Lions) should score for the second time in three weeks.

Who to sit: Going against one of fantasy's stingiest run defenses, Mikel Leshoure (Lions) will likely get stuffed on Thanksgiving (I'm allowed at least one holiday pun, aren't I?).

Who to sit: I applaud Pierre Garcon (Redskins) for giving it a go last week, but three receptions for five yards does not cut it. He was better off resting his foot. Miles Austin (Cowboys) has averaged 53.6 yards per game against Washington in his career, with just three touchdowns in seven games.

Sleeper: Cowboys running backs DeMarco Murray (foot) and Felix Jones (knee) were held out of practice Tuesday. If neither player suits up Thursday, then Lance Dunbar (Cowboys) would likely be the lead back against the Redskins.

NEW ENGLAND AT N.Y. JETS

Obvious starters: QB Tom Brady (Patriots).

Who to start: Wes Welker (Patriots) continues to get his 6-8 catches each week, and considering Rob Gronkowski is injured, there's a good chance his total number of targets double. Stevan Ridley (Patriots) has scored in five of his last seven games, including three straight. He faces a Jets defense that has allowed opposing backfields to top 100 yards in eight of 10 games this season, including 131 yards in Week 7 to the Patriots.

Who to sit: Aaron Hernandez (Patriots) will likely be limited in his return on Thursday. If you have better options at tight end, start them. Mark Sanchez (Jets) did have his best game this season against New England Week 7. Sadly, that game was 328 yards and a single score. Don't bet on him repeating that performance this week.

Sleeper: Julian Edelman (Patriots) was on the field for 52-of-61 snaps on offense in Sunday's win over Indianapolis. Brandon Lloyd's snap-count was cut to 34. Edelman certainly made a case for an expanded role, catching five passes for 58 yards and a touchdown, rushing once for 47 yards and returning a punt 68 yards for a score.

Who to start: Apparently, Percy Harvin's (Vikings) sprained ankle is still sore despite the bye week. He'll likely be questionable all week, but coach Leslie Frazier expects him to play. Harvin has averaged 89 total yards per game in six career meetings with Chicago. If Harvin can't go or is limited, tight end Kyle Rudolph (Vikings) will be the recipient of more targets. The Bears had serious issues stopping Vernon Davis on Monday night. If Jason Campbell returns at quarterback for Chicago, you have to downgrade your expectations somewhat of Brandon Marshall (Bears). Remember though, Marshall still scored last week.

Who to sit: I expect Chicago's vaunted secondary to make up for getting embarrassed in San Francisco by taking out its frustrations on Christian Ponder (Vikings). The Vikings will likely rely on Peterson anyways.

Sleeper: If Jay Cutler (Bears) is able to return from his concussion, expect him to perform well against Minnesota. He has a personal four-game win streak against them, with a 104.5 quarterback rating and 243 passing yards per game. He's also tossed 12 touchdowns against only four interceptions during the streak.

OAKLAND AT CINCINNATI

Obvious starters: WR A.J. Green (Bengals).

Who to start: With Oakland turning into one of the worst teams in the league, Carson Palmer (Raiders) is quickly becoming one of the best quarterbacks in fantasy. In the past three weeks, Palmer has thrown 146 passes (48.7 per game) for 1,094 yards (365 per game) and eight touchdowns. And now he faces his old team. I expect Denarius Moore (Raiders) to bounce back from his one reception for only nine yards last week. Before that, he had caught a touchdown in four of five games. Cincinnati is one of the defenses in fantasy at stopping tight ends, so that bodes well for Brandon Myers (Raiders), who has three touchdowns and 30 targets over the last three games. Andy Dalton (Bengals) has thrown for seven touchdowns and only one interception in three games since the Bengals' bye week. Jermaine Gresham (Bengals) has caught 15 of 20 passes in that time span. BenJarvus Green-Ellis (Bengals) faces a Raiders run defense -- I'm being kind calling it a defense -- giving up 170 rushing yards per game on a ridiculous 5.8 yards per carry in the past three games.

Who to sit: There's not a major player in this matchup I wouldn't consider starting.

Who to start: While Mike Wallace (Steelers) has less value with Ben Roethlisberger and Antonio Brown missing in action, you still have to start him. Wallace is always capable of turning a short pass into a long score. Rashard Mendenhall (Steelers) and Jonathan Dwyer (Steelers) are both good flex options. Cleveland has allowed three rushing touchdowns over the past two weeks. Trent Richardson (Browns) continues to be the only Cleveland player worth starting, and that's mostly due to the amount of touches he receives.

Who to sit: Neither starting quarterback should be in your lineup. Charlie Batch (Steelers) will be a game manager, while Brandon Weeden (Browns) is too inconsistent. Also, Pittsburgh has allowed more than 200 yards passing only once since its Week 5 bye.

Sleeper: Batch knows how to utilize his tight ends. It wouldn't surprise me if Heath Miller (Steelers) finds the end zone for the first time since Week 8.

BUFFALO AT INDIANAPOLIS

Obvious starters: WR Reggie Wayne (Colts) .

Who to start: Both C.J. Spiller (Bills) and Fred Jackson (Bills) are solid flex starts, if not RB2 options. Indianapolis owns the NFL's 22nd-ranked run defense. If the Colts can't handle the likes of Ryan Tannehill, Blaine Gabbert or Chad Henne at quarterback, they won't stop Ryan Fitzpatrick (Bills). Steve Johnson (Bills) will benefit greatly. He has five or more receptions in five of the past six games. Andrew Luck (Colts) has thrown eight touchdowns and two interceptions in Indy this year, as opposed to four touchdowns and 10 interceptions on the road. The Colts passing game is big enough for two receivers to thrive. T.Y. Hilton (Colts) has surpassed Donnie Avery as the No. 2 wideout behind Wayne.

Who to sit: Indianapolis couldn't stop Rob Gronkowski last week, but Scott Chandler (Bills) is no Rob Gronkowski.

Sleeper: Buffalo has allowed a NFL-worst 5.2 yards per carry, so Vick Ballard (Colts) is in line for a nice day.

Who to sit: When he is given 20-plus carries, Jamaal Charles (Chiefs) gets you 100 yards. He's done it all three times he's had the opportunity this season. Kansas City will likely be down early here, so I don't expect him to reach that level of production this week.

Sleeper: Brandon Stokely (Broncos) is Manning's go-to guy when a play breaks down. He has five touchdowns in the last eight games.

SEATTLE AT MIAMI

Obvious starters: RB Marshawn Lynch (Seahawks).

Who to start: Sidney Rice (Seahawks) has four touchdowns in the past three games. He'll make a decent WR3 against a secondary that has been generous to opposing wideouts.

Who to sit: Russell Wilson (Seahawks) has been very productive the past three weeks, but he's struggled all season long away from home. He has four touchdowns and eight interceptions in five road starts. Reggie Bush's (Dolphins) upside has been severely sapped over the past five games. Consider Bush as a flex option, at best, but I wouldn't bother against Seattle's tough defense.

Sleeper: Miami's secondary has surrendered four touchdowns to wide receivers the past three weeks, so touchdown-or-bust Golden Tate (Seahawks) could find his way to the end zone once again.

Who to start: Tampa Bay has allowed four touchdowns in the past five games to opposing tight ends, so get the G.O.A.T. Tony Gonzalez (Falcons) in your lineup. Josh Freeman (Buccaneers) has turned into top tier fantasy starter with 16 touchdown passes since Week 6. Vincent Jackson (Buccaneers) has caught five of those touchdowns, and has played a major role in Freeman's development.

Who to sit: Considering the Buccaneers have the top rush defense in football this season with the fewest yards allowed (818) and the lowest yards per carry (3.4), a banged up Michael Turner (Falcons) shouldn't be anywhere near your lineup.

Who to start: Chris Johnson (Titans) has been a beast since Week 6, with his lowest rushing output being 91 yards against Pittsburgh. Let's see, Jacksonville just gave up 527 yards and five touchdowns to Matt Schaub? Yeah, I'm starting Jake Locker (Titans) this week.

Who to sit: Let's not get too carried away with the Chad Henne (Jaguars)-Justin Blackmon (Jaguars) connection. Henne is still the same underachiever he's always been. However, it was good to see Blackmon break out. Let's see if he can do it again before we crown him.

Sleeper: I believe the return of Locker makes Jared Cook (Titans) relevant in fantasy once again.

ST. LOUIS AT ARIZONA

Obvious starters: None.

Who to start: Danny Amendola (Rams) is still dealing with injuries, but he has 18 receptions the past two weeks. There's no doubt he's a PPR stud. Even if I were starting at quarterback, you can't sit Larry Fitzgerald (Cardinals) unless you absolutely have a guaranteed better option.

Who to sit:LeRod Stephens-Howling (Cardinals) has led Arizona in rushing each of the past four games, but with Beanie Wells (toe) activated off injured reserve, the running back situation just got cloudy, with a chance of split carries.

Sleeper: Sam Bradford (Rams) only passed for 141 yards in Week 5 against Arizona, but he did toss two touchdowns.

Who to start: Whomever starts between Alex Smith (49ers) and Colin Kaepernick (49ers) this week is a solid start. With four scores in the past three games, Michael Crabtree (49ers) is finally living up to hype. I also like Vernon Davis' (49ers) chances against New Orleans, the worst defense in the NFL. Davis lit the Saints secondary up in the playoffs last season. Marques Coltson's (Saints) steady red zone targets (17) are good for second in the NFL behind New England's Rob Gronkowski.

Who to sit: They've ran the ball more effectively in recent weeks, but I wouldn't risk any of New Orleans' running backs against San Francisco's defense.

Sleeper: Limited by his complimentary role, Kendall Hunter (49ers) still has an inviting matchup with the Saints' porous rush defense. Hunter could be worthy of flex consideration in deeper leagues.

Who to start: Both Randall Cobb (Packers) and Jordy Nelson (Packers) are solid starts against the 25th-ranked pass defense of New York. Cobb has seven touchdowns in the past six games. Nelson has 218 receiving yards, including an 80-yard touchdown, in two career regular-season meetings with the Giants. Toss out the past three weeks for Eli Manning (Giants). Don't ever mention it again. That's how bad he has been. This is how good he's been the last two games against Green Bay: He's passed for 677 yards and six touchdowns. Hakeem Nicks (Giants) has also had success against the Packers. In three career meetings, he's caught 18 passes for 346 yards and five touchdowns.

Who to sit: Take away Jason Witten's explosion in Week 8, and the Giants have held all other tight ends to 52 yards per game and a total of one touchdown this season, so Jermichael Finley (Packers) is not advisable.

Sleeper: Martellus Bennett (Giants) has received 26 targets over the past four games. He's still a major part of this pass attack.

CAROLINA AT PHILADELPHIA

Obvious starters: None.

Who to start: I feel like RG3 broke Philadelphia's back last week. I expect Cam Newton (Panthers) to finish them off this week. The Eagles have only allowed three rushing touchdowns all year, so expect Newton, Steve Smith (Panthers) and Greg Olsen (Panthers) to provide the punctuation to scoring drives.

Who to sit: DeSean Jackson (Eagles) and Jeremy Maclin (Eagles) combined for two receptions and five yards last week. Even if Michael Vick returns, there's no guarantee he'll last the entire game.