Neighbors inspect what’s left of a storm-razed home in the Roundaway community near Clarksdale, Miss., on Wednesday. A storm system killed multiple people as it swept across the country. Other people were missing.

HOLLY SPRINGS, MISS. — A storm system forecasters called “particularly dangerous” killed at least six people as it swept across the country Wednesday, and officials were searching for missing residents into the night.

Tornadoes touched down in Indiana and Mississippi, where three were killed. The springlike storms packing strong winds killed two more in Tennessee.

A tree blew over onto a house in Arkansas, killing an 18-year-old woman and trapping a 1-year-old child inside, authorities said. Rescuers pulled the toddler safely from the home.

In Benton County, Miss., where two deaths occurred and at least two people were missing, crews were searching each house and in wooded areas to make sure residents were accounted for. Police there said several homes were blown off their foundations.

A 7-year-old boy died in Holly Springs, Miss., when the storm picked up and tossed the car he was riding in, officials said. Marshall County Coroner James Anderson says the boy’s relatives in the car with him were taken to a nearby hospital for treatment.

A tornado damaged or destroyed at least 20 homes in the northwest part of the state. Clarksdale Mayor Bill Luckett said the only confirmed casualty was a dog killed by storm debris. Planes at a small airport overturned, injuring an unknown number of people.

“I’m looking at some horrific damage right now,” Luckett said. “Sheet metal is wrapped around trees; there are overturned airplanes; a building is just destroyed.”

Television images showed the tornado appeared to be on the ground for more than 10 minutes. Interstate 55 was closed in both directions as the tornado approached, the Mississippi Highway Patrol said.

After an EF-1 tornado struck the south Indianapolis suburb of Greenwood, TV stations showed pictures of damage, including a portion of a roof blown off a veterinary office.

The biggest threat for tornadoes was in a region of 3.7 million people in Mississippi, Tennessee and Arkansas and parts of Missouri, Illinois and Kentucky, according to the national Storm Prediction Center in Oklahoma.

The center issued a “particularly dangerous situation” alert for the first time since June 2014, when two massive EF4 twisters devastated a rural Nebraska town, killing two people.

The greatest risk for a few “intense, long-tracked tornadoes” will be through Wednesday night.

About 120 miles east of the tornado, Brandi Holland, a convenience store clerk in Tupelo, Miss., said people were reminded of a tornado that damaged or destroyed more than 2,000 homes and businesses in April 2014.

“They’re opening all our tornado shelters because they say there’s an 80 percent chance of a tornado today,” Holland said.

In parts of Georgia, including Atlanta, a flood watch was posted through Friday evening.

This winter's ongoing dry streak prompted both Douglas County and Castle Rock to put in place Stage 1 fire restrictions this week, which means residents will not be allowed to have open fires or shoot off fireworks.