Water contamination due to antibiotics is a serious environmental problem. Flushing of unused medications and discharge through body waste increase this problem, especially since most of sewage treatment plants and septic systems were not designed to deal with such contaminants. In several studies, scientists have reported presence of major pollutants like persistent organic pollutants (POPs), pesticides, pharmaceuticals and personal care products (PPCPs). PPCPs represent pollutants of emerging concern, these contaminants are in surface water and drinking water. This research is intended to remove two antibiotics by Leucaena Leucocephala plant as an alternative to remediate water contaminated with antibiotics. The antibiotics studied in this research belong to the group of fluoroquinolones and are widely used for infections. Ciprofloxacin and Levofloxacin determinantion in L. Lecucocephala extract was made by reversed-phase high-performance liquid chromatography and cyclic voltammetry. Results show that contaminants are entering in the L. Leucocephala plant. It was found that was accumulated a 15.8% for Ciprofloxacin and 26.6% for Levofloxacin in the plant.