Amino acid supplements are popular among bodybuilders because of unproven, yet attractive claims that pharmacologic dosages can elicit the release of growth hormone, an anabolic substance. Three female and nine male bodybuilders in training served as subjects. After an overnight fast, subjects were administered 40, 100 or 170 mg.kg-1 L-ornithine hydrochloride by mouth (oral route) in a random fashion over three successive Saturdays. Blood samples were drawn at baseline (T=0), 45 and 90 minutes post-administration. Regardless of dosage, mean 45 and 90 minute values for serum ornithine level were significantly (p less than 0.01) greater than baseline (T=0) values. Mean serum growth hormone levels tended to rise with ornithine ingestion, but only rose significantly (p less than 0.05) at 90 minutes post-administration at the 170 mg.kg-1 dosage. The findings indicate that oral ornithine is absorbed and systemic blood levels rise as a direct function of intake level. However, only at the highest dosage did ornithine elicit a predictable rise in serum growth hormone level

Amino acid supplements are popular among bodybuilders because of unproven, yet attractive claims that pharmacologic dosages can elicit the release of growth hormone, an anabolic substance. Three female and nine male bodybuilders in training served as subjects. After an overnight fast, subjects were administered 40, 100 or 170 mg.kg-1 L-ornithine hydrochloride by mouth (oral route) in a random fashion over three successive Saturdays. Blood samples were drawn at baseline (T=0), 45 and 90 minutes post-administration. Regardless of dosage, mean 45 and 90 minute values for serum ornithine level were significantly (p less than 0.01) greater than baseline (T=0) values. Mean serum growth hormone levels tended to rise with ornithine ingestion, but only rose significantly (p less than 0.05) at 90 minutes post-administration at the 170 mg.kg-1 dosage. The findings indicate that oral ornithine is absorbed and systemic blood levels rise as a direct function of intake level. However, only at the highest dosage did ornithine elicit a predictable rise in serum growth hormone level

Other subjects

ornithine

hormone hypophysaire

homme

hombres

aditivos alimentarios

additif alimentaire

suero sanguineo

hormonas pituitarias

femme

ornitina

mujeres

serum sanguin

From the journal

Nutrition research (USA)

ISSN
:
0271-5317

Other information

Language
:
English

Type
:
Journal Article

In AGRIS since
:
1990

Volume
:
10

Issue
:
3

Start Page
:
239

End Page
:
245

All titles
:

"
Ornithine ingestion and growth hormone release in bodybuilders
"

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