In approximately 2241, Amanda's son defended her when other Vulcan children insulted her. After this became a physical fight and was then ended, Sarek told Spock that marrying Amanda was a decision based on logic instead of love. At a later point, Spock consulted with his mother on whether to pursure kolinahr. She reassured him of her pride in him, no matter the choice that he selected. (TOSmovie: Star Trek)

Amanda was with Sarek and Vulcan elders in the katric ark during Nero's 2258 attack on Vulcan. While Spock managed to rescue the elders and Sarek, Pavel Chekov could not transport her to the USS Enterprise in time. Amanda died on Vulcan moments before the planet was destroyed. Soon after, James T. Kirk used Spock's mother's death to prove he was emotionally compromised thus leaving Kirk in charge of the Enterprise. Eventually, Sarek revealed the true reason he married Amanda Grayson: love. (TOSmovie: Star Trek)

Months after his mother's death, Spock still dreamed about the destruction of Vulcan. In his dreams, she was successfully transported to the Enterprise only to have Spock sucked into space via a hull breach while the ship exploded, and Amanda blaming Spock for killing everyone. (TOScomic: "Countdown to Darkness, Number One")