I think there is indeed a clear trend if you think about it.Each new revolution in physics brings something like an order of magnitude increase in complexity of math (calculations), not just a new theory.So I would guess doing calculations to solve physics problems using TOE will be practically impossible using pen and paper only.I think it will require a (quantum) computer.(Realize that all physics problems (where answer is possible) can be solved today using non-quantum (super) computers/calculators/pen&paper.)

I think if Universe (or Reality) turns out to be a Cellular Automata design running on an ND matrix qubit (register) quantum computer (with Planck scale cells)then it would fit into above guess about future of physics (TOE) perfectly.