During the 2005-2006 television season, Hamilton had a recurring role on the hit ABC drama Desperate Housewives as Sister Mary Bernard, a nun trying to pursue married man Carlos Solis. Teri Hatcher, Mark Moses, Brenda Strong, and Alfre Woodard were all regulars on this series at the time, and Paul Dooley had a recurring role. Hamilton was seen in an episode of the short-lived NBC series Raines, starring former Enterprise actress Linda Park. She also had a recurring role as Anna Draper on the AMC series Mad Men.