Figure 3: Display of the rates of change (%/annum) and standardized response mean (SRM) in femorotibial cartilage compartments, plates and subregions. (a) View of the weight-bearing part of the medial (cMF) and lateral femoral condyle (cLF) from inferior. (b) View of the weight-bearing part of the cMF and cLF and of the medial (MT) and lateral tibia (LT) from posterior. (c) View of the MT and LT from superior. For an explanation of the subregion abbreviations, please see Table 1. The data represent mean values from 3 studies: (i) the KLG3 participants of the A 9001140 study (𝑛=28) [29], (ii) the high risk (BMI>30; KLG≥2) subcohort from a first release of OAI participants (𝑛=54) [30], (iii) knees with neutral alignment from the MAK study (𝑛=74) [31].