Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website. See our User Agreement and Privacy Policy.

Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website. See our Privacy Policy and User Agreement for details.

Neuroscience pls

1.
The proton bomb: acid-base chemistry as an
effective treatment paradigm for cancer and
neurodegenerative diseases
Historical concepts of the importance of physiological pH at the cellular
level have recently gained attention as potential hallmarks of cancer
progression and neurodegeneration. Healthy people normally exhibit a
physiological pH value of ~7.4, which represents an overall balance
between acidic and basic (alkaline) environments within and outside
organs and cells. At the cellular level, passage of ions (hydrogen, calcium,
etc.) through the cell membrane enables regulation of this balance. This
review by Harguindey et al. highlights research that shows cancer and
various neurodegenerative diseases to alter the pH of cells in ways which
eventually determine their malignancy. Cellular homeostasis is maintained
by protein complexes that allow the passage of charged molecules
between the cellular compartment and its surrounding environment.
Studies show that cells associated with multiple types of cancer and some
neurodegenerative diseases, such as Alzheimer’s disease, alter this
“proton flux” to change intracellular pH, thereby reprogramming cellular
processes, including altering levels of proteins responsible for maintaining
homeostasis, to promote their disease-specific survival (cancer) or
destruction (neurodegeneration). The authors highlight known drugs and
hormones that target the “gatekeepers” responsible for these fluctuations
and offer promising avenues for potential therapeutic strategies to
combat these persistent diseases.