Computational chemistry (CADD) capabilities at Paraza Pharma, Inc. support structure based drug design projects enabling medicinal chemists to expedite advancement of projects. Capabilities include virtual screening, de novo drug design, molecular modeling, docking, cheminformatics, data mining and management of analytics. Our team has over 15 years combined experience working in major pharmaceutical discovery organizations and can offer expertise to help reach your project milestones.

Infrastructure

HP Workstations z620, z640 (total cores 48)

Schrodinger Modeling suite (e.g., Maestro, Glide, Phase, Canvas)

LiveDesign (e.g., data management, ideas sharing, SAR)

Knime / Pipeline Pilot for workflow automation

Dotmatics’ Vortex and Browser (Project data mart & Analytics)

PARALLEL SYNTHESIS

The parallel synthesis group provides high quality focused libraries for lead optimization at competitive prices to match our customers’ needs. Our dedicated scientists can provide you with the necessary support required to help in your drug discovery program breakthrough.

Key Skills & Expertise

Experienced staff with backgrounds in biotech and multinational pharmaceutical companies

Parallel Synthesis (in solution) and Work-up

Multi experiment work stations (cooling, heating, inert atmosphere)

Parallel work up (biphasic and solid-phase extractions, solid support scavengers, ion-exchange resins)

The chemical sciences department also includes a dedicated peptide synthesis group ready to fulfill any of your project needs. From short linear peptides to complex macrocycles, our scientists will deliver quality products in short turnaround times at competitive prices.

Key Skills & Expertise

Solid phase and solution custom synthesis

Linear and macrocyclic peptides

Macrolactam, depsipeptide and disulfide bridge formation

On resin macrocyclisation

Custom amino acids synthesis and incorporation

Post resin cleavage peptide modification

Ready to suit customer’s specific needs like FITC, biotination

Accomplished synthesis from miligram to 100 gram

ANALYTICAL CHEMISTRY

Discovery teams are under great pressure to deliver quality lead compounds under tight deadlines and with limited budgets. Paraza Pharma’s Analytical Chemistry group provides high quality data in the shortest time frame at competitive prices. Our team has over 35 years combined experience working in major pharmaceutical discovery organizations. From running analytical to preparative chromatographic separation, our dedicated scientists can provide you with the necessary support required to achieve your project milestones.

We offer a wide variety of achiral and chiral separation by SFC and LC covering early discovery stage as well as more advanced compound characterization. State of the art equipment and columns allows us to meet your needs with efficacy.