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The Mojave Wasteland has multiple natural sources of pure, non-radioactive water, and as a result the player encounters clean water more often than in the Capital Wasteland, where most of the water is contaminated and radioactive.

Each bottle of purified water features the text "H²O" hand written on the label on the side of the bottle. This format is incorrect (at least according to IUPAC nomenclature), as in chemical formula numbers are written in subscript (Xy) and not in superscript (Xy). If read literally, the chemical formula H²O would mean there is one hydrogen and one oxygen isotope that contains two neutrons (instead of the standard eight). This would leave the oxygen extremely unstable and radioactive with a half life that would be so small that it would not be measurable.