Custom antibody development

We offer world-leading antibody development platforms based on a proprietary RabMAb® rabbit monoclonal platform, a phase display platform (AxioMx), and a next-generation sequencing platform (NGS-RabMAb®)

Description

Associated products

Specifications

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Purity

70 - 90% by HPLC.

Form

Liquid

Additional notes

- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.- If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer. - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised. - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

Preparation and Storage

General Info

Alternative names

Cathepsin K

Cathepsin O

Cathepsin O1

Cathepsin O2

Cathepsin X

CATK_HUMAN

CTS02

Ctsk

CTSO

CTSO1

CTSO2

MGC23107

PKND

PYCD

see all

Function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Tissue specificity

Predominantly expressed in osteclasts (bones).

Involvement in disease

Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.