Kinase Fusions

Kinase fusion cell signaling pathways promote genetranscription, cell growth, proliferation, differentiation, and survival. These pathways also play a role in cellular metabolic regulation. Kinase fusions are abnormal genome alterations in tumor cells that result from the aberrant rearrangement of translocation of two genes, one of which encodes a proteinkinase.

Figure 1.Kinase fusions activate downstream cell signaling pathways such as MAP kinase signaling, JAK/STAT signaling, and PI3K/AKT1/MTOR signaling. Ultimately, the activation of downstream cell signaling pathways promotes genetranscription, cell growth, proliferation, differentiation, and survival. Click here to open a larger version of this image in a new window.

Genes Involved in the Pathway

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