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This graduate/undergraduate course by Marc Madou taught at the Technical University of Ulsan introduces engineering and...
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This graduate/undergraduate course by Marc Madou taught at the Technical University of Ulsan introduces engineering and science students to BIOMEMS. After a study of the fundamentals of sensing techniques, various types of biosensors are introduced and the biological principles involved are explained. The course also dedicates several classes to nanomachining and biomimetics.UC Irvine’s OCW is a Web-based publication of the courses and course materials that support higher education. Educators are encouraged to use the materials for curriculum development, while students can augment their current learning by making use of the materials offered, and self-learners are encouraged to draw upon the material for self-study or supplementary use. Course materials offered on the UC Irvine Web site typically may be used, copied, distributed, translated and modified, but only for non-commercial educational purposes that are made freely available to other users. Each course shows its own license provisions, so please check carefully. In the openly licensed format, UCI contributes to global education at no marginal cost to itself beyond the already completed filming. Our own students also benefit by being able to review presentations and because it is available on YouTube, we don’t have to worry about maintaining it on course pages behind password protection. By making it open, another institution or professor can use some or all of the video presentations without even having to contact us for permission. So we are fulfilling the mission of a land-grant, public university effectively and efficiently.

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bioRxiv (pronounced bio-archive) is a free online archive and distribution for unpublished preprints in the life sciences. It...
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bioRxiv (pronounced bio-archive) is a free online archive and distribution for unpublished preprints in the life sciences. It is operated by Cold Springs Laboratory, a not-for-profit research and educational institution. By posting preprints on bioRxiv, authors are able to make their findings immediately available to the scientific community and receive feedback on draft manuscripts before they are submitted. bioRxiv subjects include: Animal Behavior and Cognition; Bioinformatics; Biophysics; Cancer Biology; Pharmacology; Scientific Communication; Clinical Trials; Synthetic Biology; and more.

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In this work, a 2.5-million-neuron model of the brain (called “Spaun”) is presented that bridges this gap by exhibiting many...
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In this work, a 2.5-million-neuron model of the brain (called “Spaun”) is presented that bridges this gap by exhibiting many different behaviors. The model is presented only with visual image sequences, and it draws all of its responses with a physically modeled arm. Although simplified, the model captures many aspects of neuroanatomy, neurophysiology, and psychological behavior, which is demonstrated via eight diverse tasks.

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This video was recorded at PRO(MO)GRAM - predstavitveni filmi raziskovalnih programov / promotional videos of research...
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This video was recorded at PRO(MO)GRAM - predstavitveni filmi raziskovalnih programov / promotional videos of research programs. Life sciences experience the transition from molecular to the systemic level, fostering the development of a new quality in our understanding of complex biological systems such as immune and metabolic system. Program connects basic research with application in the areas of research, which have primarily relevance to the health. The emphasis of the program is on the understanding of the response of the human organism to bacterial infections and conformational diseases at the molecular level and understanding of the microbial metabolism directed towards the improvement of the various pharmaceutically interesting products. Within the research of the LPS receptors we will investigate the extracellular (MD-2, TLR4, CD14) as well as intracellular receptors. Understanding of interactions at the molecular level can lead to new compounds, which might be used to neutralize the excessive immune response. The aim of this research is to elucidate the biochemical specificity of the so called "PAMP receptors״, i.e. receptors that recognize the molecular patterns of pathogenic microorganisms. Based on the structure-activity relationship (SAR) we plan to develop new (lipo)peptides and establish the differences in the selectivity between bacterial and eukaryotic membranes. In the area of health we are also investigating diseases, particularly transmissible spongiform encephalopathies (TSE) connected to conformational changes of proteins. Monoclonal antibodies have been established as diagnostic tool as well as for the therapy. By the combination of immunochemistry with methods of protein and structural biochemistry we made the first step analyzing the specificity of antibodies that recognize the pathogenic form of prion protein (PrPSc), linked to Creutzfeld-Jakob disease. This and other tools will allow us to improve the detection and early diagnostics of disease and in parallel to contribute to the understanding of the infectivity of TSE. Program also involves the research of primary metabolism of industrial microorganisms, particularly 6-phosphofructo-kinase (pfkA), whose properties significantly change during the posttranslational modification. We intend to transfer the shortened gene encoding more active enzyme into other commercially important microorganisms. We will develop the new fluorescent intracellular biosensors to monitor the events particularly in eukaryotic cells. We will put the emphasis on the analysis of Ca, cAMP and pH inside of living cells.

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Select this link to open drop down to add material Molecular biotechnology: from dynamics of biological systems to applications to your Bookmark Collection or Course ePortfolio

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This video was recorded at PRO(MO)GRAM - predstavitveni filmi raziskovalnih programov / promotional videos of research...
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This video was recorded at PRO(MO)GRAM - predstavitveni filmi raziskovalnih programov / promotional videos of research programs. Research of the program Biotechnology and plant systems biology helps to understand and solve the problems regarding food safety, detection and regulation of genetically modified organisms (GMOs), and new diseases, such as fire blight and the disease caused by Flavescence dorée phytoplasma. In addition, some important discoveries have been made during the research of devastating pathogens such as Clostridium spp. Developed sensitive diagnostic methods allow us to track individual molecules in plant samples, seeds, food and drinking water, and different pathogenic microorganisms in the environment. Our expert knowledge is integrated into the widespread international activities and serves to the Ministry of Agriculture, forestry and food, environment and spatial planning, defense and health for addressing genetically modified organisms, existing and emerging plant diseases. Our studies have revealed new defense mechanisms in plants under attack by viruses, bacteria, and Colorado potato beetle. A holistic view of plant disease development is accessed by the methods of systems biology. Thousands of genes and hundreds of proteins are monitored at the transcriptome and proteome level, followed by data analysis and accurate interpretation. In order to better understand the complex network of cell, bacteria or whole plant molecular processes, we are applying bioinformatics tools, biostatistics analysis, data mining, visualization soft wares and mathematical modeling. The synthetic biology approaches for constructing new plants, viruses or viral proteins allow us to confirm new findings. By the electron microscopy we are opening the door into the exciting "nano world" of living beings. The results of the research team are published in the most prestigious journals, such as Nature Biotechnology and Nature structural & molecular biology. We are participating in the education process by teaching and publishing textbooks, some of them being translated in other languages. Members of the research team write popular articles and broadcast to bring science closer to the people. Our international cooperation is reflected in participation in four ongoing European projects. We also closely cooperate with research institutions and companies, responsible for development in Slovenia. Our research results are used for the improvement of drug production in cooperation with companies Lek Sandoz, Krka and in a newly established Competence research centre lead by company Acies Bio. Our methods have also been involved in the stem cell and cancer treatment research. Biosensor research and research on viruses as therapeutics is carried out in the Centre of Excellency COBIK together with successful high-tech companies such as Bia Separations and Instrumentation technologies. In the previous year we have started our first spin-out company BioSistemika which develops and trades in our research results. Our most successful scientists have been awarded in 2010 by the American Society for Microbiology, Slovenian Microbiological Society, National Institute of Biology and Prešeren award for students.

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