WASHINGTON - Republican Scott Brown has won the open Senate seat in the heavily Democratic state of Massachusetts. The Republican upset is sure to impact President Barack Obama's push for healthcare reform.

Brown's Senate victory in Massachusetts is being called "one of the biggest political upsets in history."

"The voters of this Commonwealth defied the odds and the experts. Tonight the independent majority has delivered a great victory," Brown said in Tuesday evening's victory speech.

What do Tuesday night's election results mean for Democrats? Click play for analysis from Regent University School of Government Dean Charles Dunn and Nicole Kurokawa of Independent Women's Voice.

Gerson Moreno-Riano of Regent University's School of Government also gave his insight. Click here to watch.

He slammed Democrat Martha Coakley 52 to 47 percent - taking the seat held by the late Senator Edward M. Kennedy for nearly 50 years.

Brown will become the 41st Republican in the 100-member Senate -- and that will put an end to the Democrats filibuster-proof super-majority.

The loss will make it very hard for Democrats to push through health care reform legislation which has already cleared the Senate and House.

"One thing is very, very clear, as I traveled throughout the state, people do not want the trillion dollar healthcare plan that is being forced," Brown said.

Losing Independents is a troubling trend for this White House. They lost them in droves during governor's races in Virginia and New Jersey and now in liberal Massachusetts. The warning signs are apparent.

"Moderates and Independents even in a state as Democratic as Massachusetts just aren't buying our message," Sen. Evan Bayh, D-Ind., said.

Which means if Independents are turning on Democrats in a state like Massachusetts, it may spread elsewhere -- like in California where the GOP is looking at knocking off longtime liberal Democratic Senator Barbara Boxer.

Right Now, however, the immediate focus for the Democrats is what to do about healthcare reform now that the GOP has enough votes to block it.

Sen. Jim Webb, D-Va., released a statement after Brown's victory saying, "I believe it would only be fair and prudent that we suspend further votes on health care legislation until Senator-elect Brown is seated."

But House Speaker Nancy Pelosi, D-Calif., is remaining defiant.

"Whatever happens in Massachusetts, we will have quality, affordable health care for all Americans, and it will be soon," she said.

However, that may be wishful thinking. Democrats across the country were watching the Massachusetts race closely.

No doubt they will take seriously brown's statement last night when he said "what happened here can happen across America."

The newly elected senator will finish the late Sen. Kennedy's unexpired term. He will face re-election in 2012.

David Brody

CBN News Chief Political Correspondent

David Brody is an Emmy Award-winning veteran news journalist who has interviewed many prominent national figures during his career of nearly 25 years. Currently, David covers the White House and interviews national newsmakers across the country. Follow David on Twitter @TheBrodyFile and "like" him at Facebook.com/TheBrodyFile.