This paper reports further evidence from an archaeological occupation surface in southern India that was buried by tephra from the Toba volcanic super-eruption ca. 74,000 years ago. The open-air site, designated Jwalapuram Locality 22 and located in the Kurnool District of Andhra Pradesh, preserves more than 1600 stone artefacts assigned to the Indian Middle Palaeolithic. Sedimentological, isotopic and lithic data along with optically stimulated luminescence ages confirm the site as occupied closely prior to the eruption. The hominin taxon responsible for creating the site is not known, but the stone tool evidence is most consistent with contemporaneous Homo sapiens technologies in Africa and to the east of South Asia. The findings have relevance for understanding Indian Middle Palaeolithic technology, and for identifying the behavioural and environmental adaptations of the hominin group(s) that occupied India when Toba erupted.