Summary: The ability of Ukrain, a semi-synthetic
alkaloid thiophosphoric acid derivative (NSC-631579), to influence thyroid hormone
levels in plasma and nuclear thyroid hormone receptors in female rat liver,
as well as to modify the effects of short-term whole body gamma-irradiation
on nuclear thyroid-hormone receptors in the liver was evaluated after intraperitoneal
administration of the drug at 0.4 mg/kg body weight. Ukrain had no effect on
the concentration of thyroid hormones in rat blood and increased the concentration
of thyroid hormone receptors in the liver of intact rats during the first 2
months after administration. Ukrain normalized the level of nuclear thyroid
hormone receptors influenced by short-term whole body gamma-irradiation of rats
with 1 Gy, beginning from the first day after administration of the drug. Thus,
Ukrain can minimize the consequences of irradiation in the endocrine system
of experimental animals.