The drug "Sinaflan" (ointment). Instructions for use

"Sinaflan" - hormonal ointment with antipruritic, anti-inflammatory, anti-allergic effect. The product is produced in tubes weighing 10 g. One gram contains 0.25 mg of the active ingredient - fluocinolone acetonide. The preparation “Sinaflan” (ointment) is described as a yellow or light yellow paste with a specific odor. Auxiliary substances in the composition of the drug are anhydrous lanolin, propylene glycol, soft white paraffin.

pharmachologic effect

"Sinaflan" - ointment (instruction includes this information) from the group of topical glucocorticosteroids. Its active ingredient is of synthetic origin, it has a glucocorticoid-like pharmacological activity. The agent molecule contains two additional fluorine atoms, which contribute to the enhancement of the anti-inflammatory effect and decrease in absorption. Fluocinolone acetonide produces almost no mineralocorticoid effect.Among other things, the drug "Sinaflan" (ointment) instructions for use determines as a means of promoting local vasodilation. The mechanism of action of the drug is to inhibit the activity of phospholipase A2, which leads to the prevention of transformation of arachidonic acid into an active pharmacological form, and a decrease in the number of prostaglandins and leukotrienes, which are the main mediators of inflammation. By reducing the release of histamine from mast cells, the drug does not allow hypersensitivity reactions to develop. And since fluocinolone acetonide helps to narrow the lumen of the bronchi, the likelihood of exudative reactions decreases. It also has a good effect on protein metabolism.«Sinaflan (ointment). The instructions show that when applied topically, the agent is perfectly absorbed through the epidermis (stratum corneum) and cumulates in the dermis. In this case, the medicament is not biotransformed in the skin.

Means is used 1-3 times a day. Apply the ointment on the affected area should be a thin layer, rubbing a little. The therapeutic course is usually 5-10 days, but sometimes it can be prolonged for up to 25 days. The drug is not recommended to apply to large areas of the skin or areas with hypersensitivity of the skin. So, the instruction does not advise applying the medicine on the skin folds and face.

Side effects

If therapy is prolonged for a long time with Sinaflan ointment, skin atrophy and even necrosis can develop. In addition, there may be systemic negative effects that are directly characteristic of drugs from the group of glucocorticoids, for example, adrenal hypofunction.