Table 2: Visceral abnormalities in fetuses obtained from pregnant female rats after repeated oral administration of 500, 1000, and 2000 mg norfloxacin per kgbwt once daily from 6th to 15th day of pregnancy once daily ().

Parameters

Control group

500 mg/kg·b·wt (A)

1000 mg/kg·b·wt (B)

2000 mg/kg·b·wt (C)

Number of examined fetuses

15

15

15

15

Brain diverticulum

—

8 (53.33%)

9 (60%)

12 (80%)

Thymus hypoplasia

—

6 (40%)

8 (53.33%)

9 (60%)

Lung hypoplasia

—

9 (60%)

9 (60%)

11 (73.33%)

Heart enlargement

—

8 (53.33%)

9 (60%)

12 (80%)

Liver enlargement

—

10 (66.67%)

12 (80%)

14 (93.33%)

Suprarenal gland enlargement

—

7 (46.67%)

8 (53.33%)

11 (73.33%)

%: percent of total abnormalities in relation to the number of examined fetuses.