Would it be effective to give a Type 1 diabetic PTx a Sulfonylurea drug? So would a Sulfonylurea drug be effective in the majority of diabetic dogs?

No, bc Ptx cannot produce Insulin (the drug's MOA is to stim Insulin release from β-cells which have been destroyed)No, bc the majority of dogs have Type 1 (βs are gonna be pretty stimulated if you put SULFur in their water!)

In the long term are Sulfonylurea drugs a good choice to treat diabetic cats?

No, even thought cats usually have Type 2 Diabetes, the long term success rate is 15% (bcm Glucose resistant)(it's just working the system harder, not smarter)

What was the source of the Biguanide drugs?

Galega officinalis

Give an example of a Biguanide

Metformin (Met was Bi, FORMally OR I formally Met a Big guy)

Metfromin a human drug used to treat Diabetes Mellitus is unlikely to cz HypOglycemia bc of its MOA. How does Metformin work? What doesn’t it stimulate?

What type of drug is Acarbose? How does it work? Why is it unpopular as a human drug?

Acarbose is a α-glucosidase inhibitor. It works by competitively inhibiting small intestine enzymes used to break down carbohydrates, ↓ absorption of carbohydrates from intestinal tract. It is unpopular in human med bc of its GI side effects: flatulence, bloating, diarrhea(CARBS BLOAT up your SIDES(α-glucoSIDase) & people think you're nasty (fart, diarrhea), so take some A-CARB (A = w/o) so you don't break it down & absorb it)

Where are incretins secreted from? What stimulates their secretion

Secreted by GIT, Stimulated by ingestion of food (INcretins IN skIN from INgesting)

DPP4 degrades GLP-1 (The D Degrades)(GLP-1 is a incretin, which is a GIT hormone which ↑ Insulin secretion)

What are the 3 actions of Pramlintidine in humans?

Slows gastric emptyingPrevents rise in Glucagon after mealSatiety(I would go to the PRAM, but my stomach is too full (slows the emptying) & I'm not hungry & I don't have any Glucagon, so I'm missing out on the dinner part!)

(1) Protamine ZINC Insulin (PZI vet)(2) Insulin Glargine (Lantus) (GLARGINE the great w/ his protein-&-zinc sword will last long in the battle)

PZI is what percentage beef Insulin & pork Insulin?

90% beef, 10% pork(although it starts w/ P, it's only 10% P, so, WHERE THE BEEF? in the PZI!)

Why does Glargine Insulin not have pronounced peak effect when given SC?

Acidic solution is neutralized → forms microprecipitates → small amounts are slowly released, resulting in relatively constant/time profile over 24 hrs (GLARGINE the great gets under your skin for a long time, leaking into your mind 1 precipitate at a time)