Abstract : Internet of Things, connected devices, and other wireless sensors networks offer a number of new opportunities to manage transportation flows. This is particularly interesting for critical Supply Chains like Blood Supply Chains. In this research work, we investigate how such new technologies can enhance transportation system by better managing hazards and changes. By developing an event-driven decision support system, we demonstrate how a hyperconnected solution could change the way to design and control transportation routes. This decision support system will both inform users in real-time with relevant information and propose appropriate behaviors. This system will also allow improving the whole collaboration that exists between the shippers, the carriers and the customers. A dawning application to the Blood Logistics in France is developed to highlight potential benefits of such an approach.