To the Editor: Dr Steinhubl and colleagues1 found that following PCI with clopidogrel therapy,
in addition to traditional aspirin therapy, significantly reduced the likelihood
of adverse events at 1 year. They also found that a loading dose of clopidogrel
at least 3 hours prior to the procedure did not reduce events at 28 days,
but that a loading dose of clopidogrel at least 6 hours prior to PCI may offer
some benefit.