This pair of bed bug bite photos below show the immediate (left) and next day (right) reaction after feeding a colony of bedbugs from a container in the lab. (That's why they are contained in a small circular area). The hive-like immediate symptoms are replace by dark red rash type reaction the following day with inflammation and less severe redness radiating out to a larger area.
Bedbugs can live in any area of the home and use tiny cracks in furniture as well as on textiles and upholstered furniture as hiding places. They tend to be most common in areas where people sleep and generally concentrate in beds, including mattresses or mattress covers, box springs, and bed frames. They do not infest the sleeping surfaces of beds as commonly as cracks and crevices associated with the bed frame and mattress. Other sites where bedbugs often reside include curtains, edges of carpet, corners inside dressers and other furniture, cracks in wallpaper (particularly near the bed), and inside the spaces of wicker furniture.

Bed bugs are an increasing cause for litigation.[69] Courts have, in some cases, exacted large punitive damage judgments on some hotels.[70][71][72] Many of New York City's Upper East Side home owners have been afflicted, but they tend to be silent publicly in order not to ruin their property values and be seen as suffering a blight typically associated with the lower classes.[73]

I have various skin lesions which might or might not be bed-bug bites–small, raised, sometimes red, sometimes itchy. The problem is I live right next door to a large park and get all kinds of insects in summer, may small enough to get through my window-screen. Also, I have Parkinson’s disease, and the meds I take for it can produce hives and itching as a side-effect. And, my bedding and mattress are all dark colored, so I likely would not see fecal stains or shed bed-bug skins.
My husband returned from a Military Deployment…and brought bed bugs home with him. The day after we realized we had them, an exterminator that specializes in Bed Bugs came to our house and sprayed. They scheduled themselves to come back in 14 days to spray again (to kill the new bugs that hatch after the initial spray). We were old the spray would kill all the adults and babies…and the second spray would get the new hatchlings. 3 days after the initial spray, we started seeing adult bugs again!
A variety of low-odor sprays, dusts, and aerosol insecticides help with bed bug control. People must apply these pesticides to all areas where the bugs are observed as well as hiding places or spaces where they may crawl. The pest control company can help you determine if an infested mattress can be disinfected or must be discarded. Since beds cannot readily be treated with insecticides, it's often necessary to discard infested mattresses and beds.

Doctors often misdiagnose those afflicted because it is nearly impossible to tell, if you are experiencing an allergic reaction, what bit you. Often healthcare providers and individuals that have been bitten by a member of the Hemiptera order mistake bites for those of a mosquito. The only way to discern, with complete surety, what your bites are from, is to get a sample of what has bitten you.

As if you needed something else to worry about, bedbugs, those pests from the old bedtime rhyme are making a comeback. More of a nuisance than a health hazard, they’re showing up to suck blood from people in hotels, college dorms, and hospitals. Take an informative look at bedbugs: what they are, where they lurk, and how to spot them before they get you.