Rare, life-threatening condition of progressive cutaneous necrosis due to small and medium sized vessel calcification

Also called calcifying panniculitis or vascular calcification-cutaneous necrosis syndrome

Etiology

Due to primary, secondary or tertiary hyperparathyroidism and associated elevated calcium and phosphate levels, which exceed their solubility and deposit in vessels, causing progressive vascular compromise in skin and subcutaneous fat, and less often muscle

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