In this Article

How does Gossypol work?

Gossypol interferes with sperm development and function.

Are there safety concerns?

Gossypol might be unsafe for use without close supervision by a healthcare professional. When men take gossypol by mouth, the effects on sperm are unpredictable and might cause sterility with long-term use. When women take gossypol by mouth, it might be toxic to cells lining the uterus and could prevent normal function of the ovaries. Gossypol can also cause loss of energy, changes in appetite, decreased sexual desire (libido), changes in body potassium levels, and digestive tract problems. High doses of gossypol (100 times the dose used for contraception) can cause changes in hair color, malnutrition, blood circulation problems, heart failure, and other problems.

There isn't enough information to know whether gossypol is safe to use directly on the skin. It can cause a burning sensation.