O’Neal was known for his work as a stand-up comedian and as a radio personality on ‘The Opie & Anthony Show.’ He also made appearances in films such as ‘25th Hour,’ ‘Scary Movie 4’ and ‘Furry Vengeance.’ On television, he showed up on ‘Tough Crowd With Colin Quinn,’ ‘Chappelle’s Show’ and ‘The Office.’

O’Neals most recent glory was being one of the many comedians who got a few jabs in on Charlie Sheen during his roast on Comedy Central in September.

Patrice O’Neal, a larger-than-life personality with “the greatest laugh EVER” will definitely be missed by friends and fans alike.