Hughes was a series regular from 1985 to 1992, winning a Daytime Emmy for the role in 1991. She returned for a few stints from 2006 to 2008 and again several times over the years to visit her friends and family in Port Charles, but this might be her most emotional reunion: Anna's back to help her daughter Robin (Kimberly McCullough) through what has been her toughest year yet.

Hughes' return only fuels rumors that Robin will be killed off this month for February sweeps, though "GH" reps have only said, "Everyone is very aware of Robin’s history of living with HIV and wants to do the right thing. I will leave it at that."