Gene therapy and genetically modified therapies are promising treatment option, which includes introduction of a normal or functional copy of a gene in the defective cell. Gene therapy has capability to cure or prevent the progression of diseases, which include inherited disorders, cancers, cardiovascular diseases, neurological disorder, and infectious pathogen. There are number of systems showing efficient transfer of therapeutics gene into the target cells, which includes viral or non-viral vector. The most popular viral vectors used in gene therapy include adeno-associated viral (AAV), adenovirus, lentivirus, and retrovirus. Similarly, non-viral vectors mainly rely on delivery of plasmid DNA.

The inherent complexity of viral-based vectors is highly challengeable to develop quality vectors in terms of its physical size, formulation, delivery function, and cost. To overcome this, manufacturers opt for various approaches for the development of vectors, which include current good manufacturing practices (cGMP), expression systems, development of cell line culture, and cell culture system that are ideal for early-stage development of vectors in terms of simplicity, speed, and limited investment. This may boost the growth of viral vectors and plasmid DNA manufacturing market.

Global Viral Vectors and Plasmid DNA Manufacturing Market Taxonomy

On the basis of product and application, global viral vectors and plasmid DNA manufacturing market is segmented as follows:

By Product

Viral Vectors

Non-Viral Vectors

Plasmid DNA

By Application

Cancers

Cardiovascular diseases

Inherited Disorder

Viral Infections

Others

Growing number of gene therapy candidates with rapid progression of diseases is increasing the demand for vectors, which may stimulate the growth of viral vectors and plasmid DNA manufacturing market

Celsion Corporation announced final clinical and translational data on OVATION study at American Association for Cancer Research (AACR) in 2017. Celsion developed standard neoadjuvant chemotherapy with IL-12 DNA plasmid vector as a non-viral delivery system, which is formulated in nanoparticle - GEN-1. It is designed to treat patients with advance stage (III/IV) of ovarian cancers. The DNA-based immunotherapy GEN-1 plus IL-12 showed positive results in clinical trial phase 1b by causing sustained local production and secretion of IL-12 protein at tumor site.

Researchers - R. Jude Samulski from University of North Carolina and Anamaria C. Sanchez from University of Chile, 2017, developed a gene therapy to treat alcoholism by using short hairpin RNA (shRNA), which is delivered in livers using viral vector – adeno-associated viral (AAV). This is expected to help in prevention of liver enzyme expression that is mainly involved in metabolizing process of conversion of ethanol into acetate.

However, the major factor that is inhibiting the growth of viral vectors and plasmid DNA manufacturing market is high cost of gene therapies and possible mutagenesis.

Increasing funding in gene therapies is expected to fuel the growth of viral vectors and plasmid DNA manufacturing market

The growth of viral vectors and plasmid DNA manufacturing market is attributed to increased fund for gene therapy research, which is a major market driver. For instance, Alliance for Cancer Gene Therapy (ACGT) is a public charity foundation in the U.S, which funds for advancement in cancer gene therapies from laboratory to clinical trials.

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

Primary Research (Trade Surveys and Experts Interviews)

Desk Research

Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Coherent Market Insights desk research is based on a principle set of research techniques:

National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.

Trade association, National and international media and trade press.

Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.

Scientific journals, and other technical magazines and whitepapers.

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization:

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

Micro-economic indicators

Macro-economic indicators

Environmental indicators

Socio-political indicators

Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

It provides first-hand information on the market dynamics, outlook, and growth parameters.

Industry experts validates the estimates which helps the company to cement the on-going research study.