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Implications for practice and research

Increased rates of Clostridium difficile in healthcare facilities and in the community mandates comprehensive infection prevention and control (IPAC) strategies including deprescribing proton pump inhibitors and antibiotic stewardship.

Research to examine frailty as a predictive marker of recurrent C. difficile infections (rCDI) among older adults who take acid-reducing agents, antibiotics, and corticosteroids may provide greater clarity on the influence of the living environment.

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