More than 10 years after 9/11, when thousands of rescue and recovery workers descended on the area surrounding the World Trade Center in the wake of the terrorist attacks, a research team led by Benjamin J. Luft, M.D., the Edmund D. Pellegrino Professor of Medicine, and Medical Director of Stony Brook's World Trade Center Health Program, and Evelyn Bromet, Ph.D., Distinguished Professor, Departments of Psychiatry and Behavioral Science, and Preventive Medicine, Stony Brook University School of Medicine, has published results of a study examining the relationship
between the two signature health problems among WTC first responders -- respiratory illness and post-traumatic stress disorder (mg{PTSD}). The findings are published in the "FirstView" section online in Psychological Medicine.

First responders to the WTC site were simultaneously exposed to an extraordinary environmental disaster and extreme mental trauma. Together, the unprecedented physical hazards, such as exposure to the combustion of jet fuel and the smoldering debris fire, combined with the emotional trauma of witnessing events related to
massive death and destruction, has led to two persistent health problems among the workers: respiratory ailments and
PTSD.

"This study illustrates the integral relationship between mental health and physical diseases that WTC
responders suffer," says Dr. Luft. "The analysis not only shows that relationship but also connects PTSD as a
possible co-factor in responders' diseases, which reinforces our view at Stony Brook's WTC Health Program that the
illnesses suffered by 9/11 responders are a compilation of problems that often present as an entire syndrome of diseases and
conditions."

In "Exposure, Probable PTSD and Lower Respiratory Illness Among World Trade Center Rescue,
Recovery and Clean-Up Workers," Dr. Luft and colleagues at Stony Brook and other WTC clinics reported data from 8,508
traditional responders, primarily police officers, and 12,333 non-traditional responders, including maintenance and
transportation workers. They were examined between July 16, 2002, and September 11, 2008, at WTC Health Program clinics -- a
network in the New York Metro area established by the National Institute for Occupational Safety and Health (NIOSH). The
research team found a striking correlation between PTSD and respiratory symptoms, with evidence that PTSD might play a
mediating role in the exposure-symptom relationship.

The study explored patterns of associations among
WTC exposures, health risk factors such as obesity and smoking, WTC-related PTSD, physician-assessed respiratory symptoms
that arose after 9/11 and were present at examination, and abnormal pulmonary functioning defined by low forced
vital capacity.

The researchers found lower rates of probable PTSD among police (5.9%) than non-traditional
responders (23%). Somewhat fewer police (22.5%) suffered from respiratory symptoms than non-traditional responders
(28.4%). Yet pulmonary function test results were similar in both groups. Statistical analyses showed that PTSD and
respiratory symptoms were moderately correlated, and PTSD was potentially mediating the relationship between WTC exposure and
respiratory symptoms in both groups.

"The results are indicative that PTSD appears to have a major and
complex role in relation to respiratory illnesses in this patient population," says Dr. Bromet, a world renowned
expert in psychiatric epidemiology and disaster research. "Our findings mirror research results found in several veterans'
populations and in patients in primary care settings around the world. Mental and physical health are integrally
linked. It is not always obvious which one is the driver, but in the end, what matters is that both mental and
physical health are recognized and treated with equal care and respect."

Drs. Bromet and Luft say the findings
underscore the idea that mental health screening of WTC responders is just as essential as screening for respiratory
symptoms. More broadly, they believe that preventative interventions should be in place for non-traditional responders who
volunteer to participate in disaster-related activities, as the study revealed that non-traditional WTC responders reported
significantly higher rates of probable PTSD than police. Furthermore, the study's findings emphasize the need to recognize
the role of PTSD and its consequent risk for long-term disability in WTC responders.

Dr. Luft cautions
that additional investigation and long-term data are needed to better define the link between PTSD and respiratory symptoms
in WTC responders and to measure the impact of this interaction on the extent of disability in WTC
responders.

"The results are a first step in nailing down the exact relationship between PTSD and respiratory
illness," says Dr. Luft. "We need to continue to study the relationship and its implications to help us to better treat
responders who suffer from multiple mental and physical conditions."

Additional study co-
authors include: J. Broihier and K. Guerrera of Stony Brook's WTC Health Program; R. Kotov, Department of Psychiatry and
Behavioral Science, Stony Brook University School of Medicine; C. Schechter, Department of Family Medicine, Albert Einstein
College of Medicine; D. Reissman, NIOSH; I. Udasin, Environmental and Occupational Health Sciences Institute, University of
Medicine and Dentistry of New Jersey; J. Moline, Department of Population Health, Hofstra North Shore-Long Island Jewish
School of Medicine; D. Harrison and G. Friedman-Jimenez of the Departments of Medicine and Environmental Medicine, New York
University School of Medicine and Bellevue Hospital Center; and R.H. Pietzrak and S.M. Southwick of the Department of
Psychiatry at Yale University School of Medicine and Mount Sinai School of Medicine in New York.
The study was supported
by NIOSH and the Centers for Disease Control and Prevention.