valuable advice and guidance through this study. I would also like to include my gratitude to Dr. Stefan Bassarab, Dr. Patrick Garidel, Dr. Silke Mühlau, Heidrun Schott and Torsten Schultz-Fademrecht at Boehringer Ingelheim Pharma GmbH & Co. KG for their fundamental support of this work. Boehringer Ingelheim Pharma GmbH & Co. KG is acknowledged ...

valuable advice and guidance through this study. I would also like to include my gratitude to Dr. Stefan Bassarab, Dr. Patrick Garidel, Dr. Silke Mühlau, Heidrun Schott and Torsten Schultz-Fademrecht at Boehringer Ingelheim Pharma GmbH & Co. KG for their fundamental support of this work. Boehringer Ingelheim Pharma GmbH & Co. KG is acknowledged for the supplying of materials and for the financial support. I am deeply indebted to Andrea Eiperle, Matthias Heggy and Inge Miller at Boehringer Ingelheim Pharma GmbH & Co. KG and Dr. Armin Giese and Tobias Högen at the Center for Neuropathology and Prion Research of the Ludwig-Maximilians-University for helping with the experimental studies. I am extremely grateful to all members of our research group for the friendly atmosphere and the numerous French breakfasts, especially to: Cornelius Pompe Minimize