The former Secretary of Defense and director of the CIA Leon Panetta has had many roles in Washington, including Bill Clinton's chief of staff during the last government shutdown in 1995 and 1996 - and before that, chairman of the House Budget Committee. He talks to Wolf Blitzer about what the shutdown means for America.

(CNN) - On Wednesday, Wolf Blitzer will sit down for a rare joint interview with Secretary of State Hillary Clinton and Defense Secretary Leon Panetta at NATO headquarters in Brussels, Belgium. In the exclusive interview they will discuss Afghanistan, Iran, Syria, North Korea and the presidential election.

Panetta and Clinton are traveling to Brussels for a meeting with NATO ministers to discuss withdrawal strategy from Afghanistan.

Wolf will anchor from Brussels Tuesday and Wednesday. The interview will air 4-6 pm Wednesday in The Situation Room with Wolf Blitzer on CNN.