Warning: Use only as directed. Consult a health care practitioner if you have a serious medical condition or use prescription medications. This product should not be taken by women. For adult use only. Keep out of the reach of children. Keep product at room temperature and humidity (59-86F, 40% RH).

Testofen® and Fenuside™ are trademarks of Gencor Nutrients, Inc.

Health Notes

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This scientific independent research is provided by Aisle7 and is for informational use only. GNC provides this information as a service but does not endorse it. Likewise, Aisle7 does not recommend or endorse any specific products.

For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Dose: Follow label directionsThiamine (vitamin B1), pantothenic acid (vitamin B5), and other B vitamins have all been shown to play a role in wound healing. For this reason, some healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.(more)

Acne Rosacea

Dose: Refer to label instructionsThe relationship between B vitamins and rosacea is unclear, one study found it caused rocacea-like symptoms, other preliminary reports have found benefits.(more)

Vitiligo

Dose: Refer to label instructionsPABA, a compound commonly found in B-complex vitamins, has been shown to repigment skin affected by vitiligo.(more)

Dose: Follow label directionsThiamine (vitamin B1), pantothenic acid (vitamin B5), and other B vitamins have all been shown to play a role in wound healing. For this reason, some healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.(more)

Dose: Refer to label instructionsB-complex vitamins are needed to produce energy from carbohydrates. Exercisers may have slightly increased requirements for some of the B vitamins, including vitamins B2, B6, and B5, athletic performance can suffer if these slightly increased needs are not met.(more)

Dose: Refer to label instructionsPeople with achlorhydria (no stomach acid) or hypochlorhydria may not metabolize B vitamins properly, putting them at risk of developing various nutritional deficiencies, which could presumably contribute to the development of a wide range of health problems.(more)

Dose: Refer to label instructionsIn one trial postmenopausal women who combined hormone replacement therapy with B vitamins and other nutrients and dietary changes increased their bone density by a remarkable 11%.(more)

Thiamine (vitamin B1),1pantothenic acid (vitamin B5),2 and other B vitamins3 have all been shown to play a role in wound healing in animal studies. For this reason, although human research is lacking, some alternative healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.

Preliminary reports in the 1940s claimed that rosacea improved with oral supplements or injections of B vitamins1, 2, 3 On the other hand, one report exists of rosacea-like symptoms in a patient taking 100 mg per day of vitamin B6 and 100 mcg per day of vitamin B12; these symptoms subsided when the supplements were discontinued.4 More research is needed to evaluate the potential benefits or hazards of B vitamins for rosacea.

An early report described the use of PABA (para-aminobenzoic acid)-a compound commonly found in B-complex vitamins-for vitiligo. Consistent use of 100 mg of PABA three or four times per day, along with an injectable form of PABA and a variety of hormones tailored to individual needs, resulted, in many cases, in repigmentation of areas affected by vitiligo.1

Thiamine (vitamin B1),1pantothenic acid (vitamin B5),2 and other B vitamins3 have all been shown to play a role in wound healing in animal studies. For this reason, although human research is lacking, some alternative healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.

Several preliminary studies,1, 2, 3, 4 though not all,5 have found a surprisingly high incidence of iron and B vitamin deficiency among people with recurrent canker sores. Treating these deficiencies has been reported in preliminary6, 7 and controlled8 studies to reduce or eliminate recurrences in most cases. Supplementing daily with B vitamins-300 mg vitamin B1, 20 mg vitamin B2, and 150 mg vitamin B6-has been reported to provide some people with relief.9 Thiamine (B1) deficiency specifically has been linked to an increased risk of canker sores.10 The right supplemental level of iron requires diagnosis of an iron deficiency by a healthcare professional using lab tests.

The B-complex vitamins are important for athletes, because they are needed to produce energy from carbohydrates. Exercisers may have slightly increased requirements for some of the B vitamins, including vitamin B2, vitamin B6, and vitamin B5 (pantothenic acid);1 athletic performance can suffer if these slightly increased needs are not met.2 However, most athletes obtain enough B vitamins from their diet without supplementation,3 and supplementation studies have found no positive effect on performance measures for vitamin B2,4, 5 vitamin B3 (niacin),6 or vitamin B6.7 On the contrary, large amounts of niacin have been shown to impair endurance performance.8

Dose: Refer to label instructionsMany minerals and vitamins appear to require adequate concentrations of stomach acid to be absorbed optimally-examples are iron,1 zinc,2 and B-complex vitamins,3 including folic acid.4 People with achlorhydria (no stomach acid) or hypochlorhydria may therefore be at risk of developing various nutritional deficiencies, which could presumably contribute to the development of a wide range of health problems.

Dose: Refer to label instructionsVitamin B12 supplementation may be beneficial for a subset of people suffering from indigestion: those with delayed emptying of the stomach contents in association with Helicobacter pylori infection and low blood levels of vitamin B12. In a double-blind study of people who satisfied those criteria, treatment with vitamin B12 significantly reduced symptoms of dyspepsia and improved stomach-emptying times.1

B vitamins, particularly vitamin B6, have also been used for ADHD. Deficient levels of vitamin B6 have been detected in some ADHD patients.1 In a study of six children with low blood levels of the neurotransmitter (chemical messenger) serotonin, vitamin B6 supplementation (15-30 mg per 2.2 pounds of body weight per day) was found to be more effective than methylphenidate (Ritalin(R)). However, lower amounts of vitamin B6 were not beneficial.2 The effective amount of vitamin B6 in this study was extremely large and could potentially cause nerve damage, although none occurred in this study. A practitioner knowledgeable in nutrition must be consulted when using high amounts of vitamin B6. High amounts of other B vitamins have shown mixed results in relieving ADHD symptoms.3, 4

According to preliminary studies from many years ago, lack of hydrochloric acid (HCl) secretion by the stomach was associated with chronic hives, presumably as a result of increasing the likelihood of developing food allergies. In one such study, 31% were diagnosed as having achlorhydria (no gastric acid output), and 53% were shown to be hypochlorhydric (having low gastric acid output).1 In a related study, treatment with an HCl supplement and a vitamin B-complex supplement helped to treat people with hives.2Betaine HCl is the most common hydrochloric acid-containing supplement; it comes in tablets or capsules measured in grains or milligrams. One or more tablets or capsules, each containing 5-10 grains (325-650 mg) are typically taken with a meal that contains protein. Diagnosis of a deficiency of HCl and supplementation with HCl should be supervised by a doctor.

"Vitamin B" was once thought to be a single nutrient . Researchers later discovered these extracts contained several vitamins, which were given distinguishing numbers, leading many people to the erroneous conclusion that these vitamins have a special relationship to each other. Further adding to confusion has been the "unofficial" designation of other, non-essential vitamins, as members of the B-complex, such as choline, inositol, and para-aminobenzoic acid (PABA).

Each member of the B-complex has a unique structure and performs unique functions in the human body. Vitamins B1, B2, B3, and biotin participate in different aspects of energy production, vitamin B6 is essential for amino acid metabolism, and vitamin B12 and folic acid facilitate steps required for cell division.

Each of these vitamins has many additional functions, though none that require all B-complex vitamins simultaneously. Human requirements for each B vitamin vary considerably-from 3 mcg per day for vitamin B12 to 18 mg per day for vitamin B3 in adult males, for example. So, taking equal amounts of each one-as provided in many B-complex supplements-makes little sense. Megadoses of B-complex vitamins sometimes taken to combat everyday stress, boost energy, or control food cravings, do not appear to offer benefit unless a person is deficient in one or more of them.

Most multivitamin-mineral products contain the B-complex along with the rest of the essential vitamins and minerals. Since they are more complete than B-complex vitamins alone, multiple vitamin-mineral supplements are recommended to improve overall micronutrient intake and prevent deficiencies.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2016.

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I see other reviews that thay think it does not work - maybe it does not work for everyone - what does? This will not make you feel like you are 20 years old again, nothing does - but it does make me feel better, more energy, more sex drive than I did before (not bad for 58 years old) - It took a while to feel a difference - the effect came on slowly. I also take Royal Jelly - they work good together for me: more energy and sex drive.

Not sure why some men did not get results but when I miss a day of not taking Nugenix I feel sluggish. You must take as directed meaning on an empty stomach. The product could be a bit more affordable.

I started using Nugenix in July of 2013 and made time in my schedule to workout 3-4 times per week, 1 hr. per session. The energy level increase that I experienced was incredible...I came home, after what used to be an exhausting day and HAD to workout! I had energy I just had to burn! In the first 30 days I lost 26 lbs. After increasing my cardio & reps, I've maintained the weight. I have most likely lost more but, have replaced a lot of the fat with leaner muscle, which weighs more. Lately, I've noticed a decrease in energy. I had been a firm believer in this product & will not give up until further investigation. I am currently not taking Nugenix. My scheduled physical is coming up & I will have my T levels checked. If low, I will return 2 Nugenix & see if the same results with added energy, reoccur.

This is a completely ineffective product. I will go so far as to say it is an outright fraud. It delivered none of the stated benefits. It has a horrible odor and taste and upsets my stomach. I have canceled my monthly delivery program. I would not recommend this product to anyone.