Levitra

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Levitra

OVERDOSE

The maximum dose of LEVITRA for which human data are
available is a single 120 mg dose administered to healthy male volunteers. The
majority of these subjects experienced reversible back pain/myalgia and/or
“abnormal vision.” Single doses up to 80 mg vardenafil and multiple doses up to
40 mg vardenafil administered once daily over 4 weeks were tolerated without
producing serious adverse side effects.

When 40 mg of vardenafil was administered twice daily,
cases of severe back pain were observed. No muscle or neurological toxicity was
identified.

In cases of overdose, standard supportive measures should
be taken as required. Renal dialysis is not expected to accelerate clearance as
vardenafil is highly bound to plasma proteins and not significantly eliminated
in the urine.

CONTRAINDICATIONS

Nitrates

Administration of LEVITRA with nitrates (either regularly
and/or intermittently) and nitric oxide donors is contraindicated [see CLINICAL
PHARMACOLOGY]. Consistent with the effects of PDE5 inhibition on the nitric
oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors, including LEVITRA,
may potentiate the hypotensive effects of nitrates. A suitable time interval
following dosing of LEVITRA for the safe administration of nitrates or nitric
oxide donors has not been determined.

Last reviewed on RxList: 5/20/2014
This monograph has been modified to include the generic and brand name in many instances.