Summariesfor CYP1A1 gene

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins

are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,

steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by

some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous

substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has

been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from

CYP1A1 on chromosome 15. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP1A1 Gene:

CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP1A1 include oral cancer, and cardia cancer. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP1A2.