Our analysis revealed an extremely low number of variations in the ITGB1BP2 gene in nearly 1000 hypertensive/cardiopathic and healthy individuals, thus suggesting a high degree of conservation of the melusin gene within the populations analyzed

Findings implicate melusin as an enhancer of AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) pathways and as a novel player in cardioprotection from ischemia-reperfusion injury.

Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy.