Smoking is one of the leading preventable causes of death worldwide. It not only plays a key role in the initiation of cardiovascular disease but also significantly contributes to the progression of the disease and the high morbidity and mortality outcomes associated with it. These poor outcomes are not only seen in active smokers but also in second hand smokers. The benefits of smoking cessation are immediate and substantial. However, due to aggressive marketing and the highlyaddictive nature of nicotine, this goal can be challenging for many individuals. Thus, every opportunity and agent should be grasped to assist patients to quit smoking as smoking cessation is and will remain the most effective method of preventing smoking-related cardiovascular disease and its sequel. A recent randomised study demonstrated the safety and efficacy of varenicline for smoking cessation in patients following an acute coronary syndrome.