Junior Dos Santos demonstrated his high level stand up striking by knocking out Frank Mir in round two of their heavyweight championship main event in UFC 146. Dos Santos controlled the fight from the start with his stand up striking and footwork. Mir attempted to take him down early in the first round, but failed to do so. Dos Santos dominated the fight other than some leg kicks from Mir and he had him staggered bad by a right hand to the temple during the last 20 seconds of the opening round. By the following round, Dos Santos dropped Mir with another well timed right hand and delivered a hammer fist to him while dazed on the mat. Dos Santos also appeared to back off from a last grab submission attempt by Mir before dropping the hammer fist when he realized his opponent was too out of it to fight back.

In the featured undercard, Cain Velasquez beat down Antonio "Bigfoot" Silva to win by TKO in the first round. Cain quickly jumped on Silva and delivered a sharp elbow to him while on the mat leaving him a bloody mess. Cain kept grounding and pounding until the referee was forced to stop the bout.

The rest of the undercard bout also featured some good action and quick endings. "Big Country" Roy Nelson won by knock out over Dave Herman in round one via a well timed Suzy Q.