You're probably aware of this one: I dont use it myself but IIUC the screenshot can be automatically saved to clipboard -Post-capture options: Copy to Clipboard: [Image Bitmap]-there is the option to copy file there as well - I'm not sure what exactly the difference, possibly no file is saved when using image bitmap (?)

If nothing else, you could go into the Post-Capture Options and use the Post Capture Commandline Tools to Run section to invoke a command to delete the screenshot file ("del %file%" assuming that quotes are included if needed).

An alternative strategy can be used for those who don't want lots of images being stored.

An alternative is to modify your settings so SC always saves the LAST capture, but overwrites previous ones. That will give you only ever one single screenshot file.

You can do that by going to the File Naming Template options tab, changing the filename to something static, instead of something made with the date. For example: MyLastScreenshotAnd then UNCHECK the box under that that says to Auto Sequence New File Names.

Yes, SC expects that there will be a folder available for storing and viewing screenshots -- that's just how it works -- it's always monitoring a current screenshot folder and displaying a list of the images in that folder. While it does have options to tell it not to save images -- it really wasn't meant to work that way -- and i always encourage people to give in to letting SC at least save a single file (the last capture).