Mouse studies suggest PYY
delivered as an oral spray could help suppress appetite and treat obesity.
Systemic delivery of PYY has been shown to suppress appetite but also causes
nausea and taste aversion. In mice given flavored water or food, i.p.
delivery of PYY caused taste aversion, whereas an oral spray did not. The
orally delivered PYY bound NPY2R in the oral cavity and stimulated a
dedicated neuronal pathway implicated in taste response. Next steps include
submitting an IND to the FDA to start a Phase I trial.
The authors are founding SalinomiRx LLC, a biotech
developing PYY and other GI peptides to modulate food intake, appetite,
satiation and body weight.

SciBX7(1);
doi:10.1038/scibx.2014.20
Published online Jan. 9, 2014

Patent application filed;
available for licensing from the University of
Florida
Contact: April Kilburn, University of
Florida Office of Technology Licensing, Gainesville, Fla.
e-mail:

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