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Publications21

..Natural killer cells also contributed to tumor protection. These results show that dendritic cells can be loaded with antigen and activated, in situ, and provide the basis for dendritic cell- targeted clinical strategies...

Langerhans cells arise from monocytes in vivo

Florent GinhouxDepartment of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USANat Immunol 7:265-73. 2006

..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...

Langerhans cells renew in the skin throughout life under steady-state conditions

..Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation...

..The use of defined DC subtypes to stimulate both innate and adaptive immunity, either in combination or in a prime-boost vaccine sequence, may prove most useful clinically by harnessing both effector cell compartments...

..Here, we review studies on DC homeostasis and trafficking after transplantation, and examine the role of the host and graft DC in post-transplant immune responses. We also discuss the therapeutic implications of these studies...

Langerhans cells at the interface of medicine, science, and industry

Miriam MeradDepartment of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USAJ Invest Dermatol 128:251-5. 2008