Not if he is super saiyan...telling you DBZ is really not understood on this forum.

Even as a Super Saiyan, he has no defense against Reality Warping, Matter Manipulation, Probability Manipulation, Time Manipulation, or Energy Manipulation(all of which are represented in the collective powers of the Amalgam team).

He also can't do anything to prevent being devolved(something that at least 2 of the characters on the Amalgam team are capable of).

He also has no defense against magic(especially magic on the power level presented on the Amalgam team).

With Matter Manipulation, Vegito can be dissolved on a sub-atomic level.

With Reality Warping, Vegito can be made to never have existed.

With Probability Manipulation, Vegito can be made to suddenly have a heart attack, a brain aneurysm, and severe organ failure in multiple organs, all at the same time.

With Time Manipulation, time can be made to speed up, which causes Vegito to die of old age, in less than a second.

With Energy Manipulation, any Ki attack that Vegito uses, is turned around on himself.

This is just a few of the ways that the Amalgam team can, not only defeat, but kill Vegito, in a matter of seconds.