I think you will love to use SAAM II as a tool for your teachingstudents who are interested PK-PD modeling since this software isvery friendly and you could start with simple concept of PK-PDmodeling all the way to the sophisticate compartmental and numericalmodule which covers the whole pharmacokinetic analysis.For furtherinformation of SAAM II , their updated teaching program please searchthe web site http://courses.washington.edu/rfka/. Also, I recommendthe book "Mathematical Modeling in Experimental Nutrition"(ISBN0-306-46020-3) in which you may find more useful information aboutSAAM II and other related and rich resource of reference of the areayou may be interested.

Regarding you inquiry about suitable pharmacokinetics software for teachingand demonstration purposes, allow me to invite you to take a look at "PKSolutions". This is an Excel-based program designed for easy, interactiveand comprehensive pharmacokinetics analysis. The program is in use ineducational institutes and research labs in over 27 countries. Severalpharmacy and medical schools use it as part of their curriculum content.

More information about PK Solutions, a price list, a demo, and a free listof the 75 pharmacokinetic equations are available at:

http://www.SummitPK.com/

For special academic pricing follow the link to the "Learn-and-Keep" planwhich offers an 80% discount to students and a 50% discount for adepartment license.

Dear Dr. Duncan, you can find two useful freeware at thefollowing URLs:http://aut.ethz.ch/~keller/pharmasim.htmlhttp://aut.ethz.ch/~keller/pharmacalc.html

At PCCAL web site (http://www.coacs.com/PCCAL/) there are twointeractive pharmacokinetic simulations software and other simulationsoftwares (with demo and prices).Yuors sincerely-----Federico Pea, MDInstitute of Clinical Pharmacology & ToxicologyUniversity of UdineItaly

I would suggest that you check out SAAM IIhttp://courses.washington.edu/rfka/; a a compartmental and numericalmodeling program (two separate programs actually) which can be used in theanalysis of pharmacokinetic, pharmacodynamic and enzyme kinetic studies withan excellent (simplistic) user interface. It contains no "canned" models -but the compartment tool has several tools for setting up different modes ofadministration and will ofcourse also handle repeated dosing (constant orvariable). It can handle compicated linear models ans simple non linearmodels. It can also be used both for fitting models to a dataset as well asfor simulating models.

My view is that when teaching, even at the under-graduate level, one shouldstay away from programs with a multitude of "canned" (pre-defined) models. Ihave seen far too many examples of how the erroneous use of such systems canlead to completely absurd results. After all, we need to teach studentsexactly what they are doing and why- and the construction of the modellitself (and its components) is maybe the most important part of thatprocess.I have some experience in using the program in a "classroom setting" and youare welcome to mail me onn.o.hoem.-a-.farmasi.uio.no to exchange experiences.

Dear Duncan I can suggest you good PK/PD software available for free download isBOOMER. It is good software for teaching PK/PD and simulations. In fact youcan download manual for the software too. Dr.David.W.A.Bourne has been usingthe software to teach pharmacokinetics to the students in our college. Andmoreover it is easy to use and a compiled program. It is available on"http://www.boomer.org/ Dr.Bourne has written a book "Mathematical Modeling of PharmacokineticData". The publisher is Technomic Publishing House.I hope this book reallyhelps you a lot on from scratch to final output. Its a well written book.

I apologise if this appears to be an advert but the software we have may beapt for you needs. We have recently released a new modelling softwarepackage called ModelMaker 4. The software is ideal for teaching modeling tostudents leaving the students time to concentrate on the models, not thesoftware. Requiring no programming, ModelMaker provides a very simplecompartmental type interface to design models from scratch whilst stillhaving in-depth features such as sensitivity analysis, Monte Carlo analysis,optimisation and simulation.

Hi Everyone,Of all the suggestions for teaching software i would like to put up a case forthe software which we use here at Rutgers-STELLA. for Systems ThinkingExperimental Learning Laboratory with Animation. One can simulate simpleprocesses as constant rates, multiple doses, IV dose, distribution, eliminationusing this very user friendly software available from High Performance Systems.Although, STELLA is not a strictly PK software and can be used forlots of otherapplications it works good for teaching basic PK concepts. It can especiallyenhance your lectures rather than working as a full fledged lab.There is a bookpublished by the Ellis Horwood series in pharmacological sciences on usingSTELLA for PK modelling.Hope this helps.Pankaj