TechPort requires a browser feature called JavaScript. All modern browsers support JavaScript. For more information please see How to enable JavaScript in your browser. If you use ad-blocking software, it may require you to allow JavaScript from this web application. Once you've enabled JavaScript you should reload this page.

SBIR/STTR

Microfluidic Cytometer for Complete Blood Count Analysis, Phase II

Project Introduction

We will fabricate and test microfluidic designs for a micro-electromechanical system based complete blood count (CBC) analysis in separate modules and integrate them into a working prototype. A first module constitutes a hydrodynamic focusing injector and cell impedance meter. A second module takes hydrodynamically focused cells and measures light scatter in the forward and orthogonal directions, as well as of fluorescence emission intensities from specific cell types using novel signal collection designs and micrometer scale, and Geiger-mode avalanche photodiodes that produce time-correlated photocount statistics from multiple optical sources. The third module will serve for blood sample dilution, routing, automated lysing and removal of human erythrocytes. This unit will also incorporate a sensor for measuring hemoglobin (Hgb) concentration. The proposed blood analyzer will utilize innovative optical and fluidic designs on a modular platform that enable compactness, high sensitivity, and robust service, while requiring no operator intervention.
More »