Chelsea Handler has publicly slammed Angelina Jolie for allegedly breaking up Brad Pitt and Jennifer Aniston's marriage, it has been reported.

According to Us magazine, Handler took time out of her comedy gig at New Jersey's Prudential Center over the weekend to rebuke Jolie for hurting her friend Aniston.

"She's (Jolie) a homewrecker, she is," Handler said.

The Chelsea Lately host further suggested that she does not believe Jolie is sincere in her efforts as a children's advocate.

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The comedian added: "She can rescue as many babies from as many countries as she wants toâ€¦ I don't f**king believe you. She gives interviews, 'I don't have a lot of female friends'. Because you're a f**king c**t."

Last week, Handler revealed that she spent the Thanksgiving holiday with Aniston on vacation in Mexico.