Objectives: In this study, we aimed to investigate the
agents which were isolated from cerebrospinal fluid (CSF)
samples in our hospital for three years, retrospectively.
Materials and methods: The CSF samples, which were
sent our laboratory, of the patients those had presumptive
diagnosis of meningitis between September 2008 and
September 2011 were included into the study. Isolated
bacteria were identified with conventional methods, biochemical
tests and/or Phonix (BD, US) kits. Antimicrobial
susceptibility of the strains were investigated according
to Clinical Laboratory Standards Institute (CLSI) recommendations.
Results: 11 Streptococcus pneumoniae, 8 Klebsiella
pneumoniae, 7 Pseudomonas aeruginosa, 7 Acinetobacter
baumannii, 5 Escherichia coli, 4 Enterococcus
spp., 2 Enterobacter spp., 25 Coagulase-negative staphylococcus,
1 Morganella morganii, 2 Neisseria meningitidis,
1 Brucella spp., and 1 Candida albicans were isolated
(overall n:74; 5.2%) from total 1408 CSF samples. In susceptibility
test, 2 S.pneumonia was found as penicillin-resistant,
and one E.coli and two K.pneumoniae were found
as extended spectrum of beta-lactamase producers. Additionally,
carbapenem resistance was detected in three
A.baumannii and one P.aeruginosa strains.
Conclusion: Determination of agent profile and antimicrobial
resistance pattern from different localizations and
patients’ groups will help to improve protective and therapeutic
health policies.