Tag: BDNF

Tag Archives: BDNF

With all of the hype around fasting, you may believe it to be just another modern dietary fad, but the truth is that fasting is as old as our species. Until very recently, humans have always had periods of going without food. Fasting is baked into our evolution and our physiology, and it can yield benefits to our brains and bodies, un a biochemical level, that we’re only just beginning to understand.

Many of us are blessed to live in a world with abundant food, but that wasn’t always the case. Throughout our evolutionary history, sometimes days, weeks, and months would pass during which food resources were scarce. These periods without food provided small hormetic stresses on our genome — meaning stresses that turn out to be beneficial to our bodies. In the absence of calories, life-sustaining, protective genes responsible for cellular repair and protection are activated, inflammation is reduced, and anti-oxidative defenses are increased.

This means that simply going without food for a while may have anti-aging, anti-inflammatory, and anti-tumor benefits that are available to anyone, at any time.

It means having a brain that is readily capable of performing all of its vital functions. This includes basic functions, like regulating the involuntary functions of the autonomic nervous system, and higher-level functions, such as facilitating cognition and decision-making, and coordinating fine and gross motor skills. While the brain is necessarily an incredibly complex organ, the process of neuroplasticity, which describes the brain’s ability to undergo physical and chemical changes in response to stimuli, affords us a significant degree of control over the health of our brain. In other words, the lifestyle choices we make today have a very real impact on our brain’s current and future health; whether that impact is positive or negative depends on how we live our lives.

As stated above, neuroplasticity can work for or against you. While the natural process of aging more or less handles the “working against you” side of that equation, it is completely within our abilities to harness the power of neuroplasticity to maintain or improve overall brain health. Taking an active role in improving the health of the brain can help fortify the body from some of the most debilitating chronic illnesses we face — the likes of Alzheimer’s, dementia, Parkinson’s, and multiple sclerosis. Fortunately, science has shined a light on numerous factors that have the potential to mitigate the effects of aging and improve overall brain health. To that end, I wanted to highlight six of the most effective ways you can maximize your brain’s potential.

Where are we in terms of treating Alzheimer’s disease? To answer this question, I turn to one of the most well-respected, peer-reviewed medical journal dealing with clinical neurology.

In a recent editorial in the journal Neurology, Drs. Michal Schnaider Beeri, and Joshua Sonnen stated:

Despite great scientific efforts to find treatments for Alzheimer disease (AD), only 5 medications are marketed, with limited beneficial effects on symptoms, on a limited proportion of patients, without modification of the disease course. The prevalence of AD doubles every 5 years, reaching the alarming rate of 50% in those aged 85 years and older. In the context of the demographic trends of modern society, where the elderly are the fastest growing segment of the population, identification of new therapeutic targets that may prevent, delay, or cure AD is critically needed.

I so agree. The editorial goes on to describe how the body produces a growth hormone, BDNF, that is associated with reduced risk for cognitive decline and describes how looking at the genetic control for BDNF might enhance cognitive reserve.

I have spoken at length about the importance of exercise for increasing the gene expression of BDNF, a protein that increases the growth of new brain cells. As previously mentioned, research has shown that people with higher levels of BDNF are at a lower risk of developing dementia.

In this new study, exercise in people age 50 or over is demonstrated to have significant effects on cognition. The report is a meta-analysis, meaning a review of other research publications (in this case, 39 studies). It’s a comprehensive look at how exercise impacts the brain!

Dr. Perlmutter is the leading integrative medicine neurologist in North America today. His ability to fully integrate conventional medicine diagnosis and treatment with the latest innovations in nutritional and environmental medicine is phenomenal. As a teacher and clinician, he has fundamentally changed how physicians and patients think about neurological degeneration and, happily, regeneration.