Jeffrey Tambor has left the acclaimed series “Transparent” following sexual harassment claims made against the Emmy-winning actor.

Tambor, who played trans woman Maura Pfefferman on the Amazon show, said in a statement, “Playing Maura Pfefferman on Transparent has been one of the greatest privileges and creative experiences of my life. What has become clear over the past weeks, however, is that this is no longer the job I signed up for four years ago.

“I’ve already made clear my deep regret if any action of mine was ever misinterpreted by anyone as being aggressive, but the idea that I would deliberately harass anyone is simply and utterly untrue. Given the politicized atmosphere that seems to have afflicted our set, I don’t see how I can return to Transparent.”

According to The Hollywood Reporter, Tambor’s departure caught Amazon Studios, as well as “Transparent” creator Jill Soloway, by surprise. Apparently he informed neither of his plans. But sources told THR last week that Soloway was considering writing Tambor out of the drama — and potentially killing off his character.

Sunday’s news comes after Tambor was accused of sexual harassment by his former personal assistant, a trans woman named Van Barnes, in a private Facebook post on Nov. 8, causing Amazon to open an investigation into the allegations. On Thursday, guest star Trace Lysette came forward with further alleged incidents of inappropriate behavior, claiming he “got physical” at one point on the set.

In this file photo, Actor Trace Lysette celebrates achievements in the LGBTQ community at the 28th Annual GLAAD Media Awards, sponsored by LGBTQ ally, Ketel One Vodka, in Beverly Hills on April 1, 2017. (Photo by Neilson Barnard/Getty Images for Ketel One Vodka) Working with the actor “has been a roller coaster,” she told THR. “One minute Jeffrey is lovely, the next it’s a temper tantrum or flirtation.” (Tambor, in a statement, acknowledged that he can be “volatile and ill-tempered” to work with, “but I have never been a predator — ever.”)

Tambor, who was born in San Francisco and attended San Francisco State, has enjoyed a long film and television career with notable roles in among other projects, “The Larry Sanders Show” and “Arrested Development.” But it was “Transparent” that brought him substantial acclaim, delivering Emmy and Golden Globe victories and critical adoration.

The show, in which he played a transgender, divorced, Jewish parent of three, also put Amazon Prime on the television map, signaling that the streaming company could be a player, along with Netflix, when it came to quality scripted material.