A RET mutation in exon 13 was confirmed in the latter; thus, it is unclear whether this patient had an unusual presentation of MEN2B or an overlap of MEN2A/2B, as the patient also had macular amyloidosis.

There are many conditions which need to be considered before making a diagnosis of acquired macular hyperpigmentation like erythema dyschromicum perstans, lichen planus pigmentosus, macular amyloidosis, tar and frictional melanosis, post-inflammatory hyperpigmentation, Berloque dermatitis, Riehl's melanosis and drugs and chemicals.

INTRODUCTION: Macular amyloidosis (MA) is a common variant of primary localized cutaneous amyloidosis with a characteristic female preponderance [1-7] and the age of onset ranging between 21 and 50 years.

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