Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) hits his 499th career home run during the first inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) hits his 499th home run during the first inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) celebrates after he hits his 500th home run during the fifth inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) hits a fly ball to center for an out in his second at bat as Tampa Bay Rays catcher J.P. Arencibia (40) and Umpire Adam Hamari (right) watch during the third inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) hits his 500th home run during the fifth inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) celebrates as umpire Adam Hamari looks on after Ortiz hits his 500th home run during the fifth inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) hits his 500th home run during the fifth inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) rounds third base after he hits his 500th home run during the fifth inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) rounds second base after he hits his 500th home run during the fifth inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

Sep 12, 2015; St. Petersburg, FL, USA; Boston Red Sox designated hitter David Ortiz (34) hits a single to center during the seventh inning of a baseball game against the Tampa Bay Rays at Tropicana Field. Mandatory Credit: Reinhold Matay-USA TODAY Sports

ST. PETERSBURG, Fla. — Boston designated hitter David Ortiz on Saturday became the 27th player in major league history to hit 500 home runs.

Ortiz belted a 2-2 pitch from Tampa Bay left-hander Matt Moore well into the right-field seats in the fifth inning for his second home run of the game and 34th of the season to give Boston an 8-0 lead.

Ortiz became the fourth player to reach 500 home runs in a Red Sox uniform, joining Jimmy Foxx, Ted Williams and Manny Ramirez.