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Sources tell The Hollywood Reporter that the network is strongly considering abandoning the plan to keep the struggling series alive in the wake of star Christina Applegate's exit last week. As a planned one-episode reboot of the show has stalled, co-star Will Arnett is being seriously courted by CBS to star in a Greg Garcia-written comedy, among others.

In addition, sources tell THR that co-star Maya Rudolph has informed NBC that she is pregnant with her fourth child with director Paul Thomas Anderson. These sources say the show's writers planned to incorporate the pregnancy into the revised version of the series, but that issue could now be moot. The show's writing staff is said to be seeking new jobs.

NBC and reps for the actors declined to comment.

Initially, the network hoped to salvage the Lorne Michaels-produced comedy, hiring veteran James Burrows to tape one episode of a largely re-imagined show with Arnett and Rudolph. (It was not clear whether the Applegate role would be recast after her abrupt decision to quit.) But that reboot has hit snags and Arnett is said to be ready to move on.NBC has not released Arnett or Rudolph from their contracts for the original Up All Night, a single-camera show that the network hoped to transform into a multi-camera, behind-the-scenes look at a struggling television series. The show is not officially dead, though presumably the stars' exits are being negotiated.

The chaos comes at a key time for Arnett and Rudolph, with casting on the nearly 100 broadcast pilots already under way and both actors rocketing to the top of many network wish lists. Both Arnett and Rudolph have already received second-position offers for a number of broadcast pilots. CBS' Les Moonves in particular is said to want Arnett for an untitled comedy written and executive produced by Garcia about a recently divorced man whose parents move in with him. ABC also is high on the actor.

In the past two months, Up All Night has seen creator Emily Spivey and showrunner Tucker Cawley exit, with new showrunner Linda Wallem (Nurse Jackie) charged with retooling the series.

NBC announced in December that Up All Night would resume production in February following a three-month hiatus, with five episodes scheduled to begin in April or May. That plan was later changed to a one-episode reboot. The creative changes would have marked the latest for the comedy this season after Rudolph's talk-show format was ditched in the season two premiere earlier this fall.

Someone at NBC has been watching reruns of "Cheers," "The Hogan Family" and "Laverne & Shirley." Apparently, the network thinks that continuing "Up All Night" without Christina Applegate is a possibility. According to Deadline, plans are still afoot to convert the single-camera sitcom to a multi-camera, studio-audience situation. (This change appears to be what caused both Applegate and creator Emily Spivey to quit on Friday.)

It is not known whether Applegate will be replaced, although former "Friends" star Lisa Kudrow is the rumored frontrunner to join Will Arnett and Maya Rudolph if she is.

NBC realizes that suddenly losing the mom in an established sitcom about two parents raising a kid could be a problem. (Nothing gets by NBC.) So, according to Deadline, it has scaled back its new episode order from five to one. In other words, it's treating the show as just another pilot for next season.

In addition, it has hired James Burrows to direct the episode, which is significant because the veteran director has helmed episodes of "Cheers" (which successfully replaced Shelley Long with Kirstie Alley, and which Burrows also co-created), "The Hogan Family" (which was born when Sandy Duncan successfully replaced Valerie Harper in "Valerie"), and "Laverne & Shirley" (which actually shot a final season without Shirley).

Well, two out of three ain't bad.

Deadline notes that both Arnett and Rudolph are reportedly fielding other pilot offers. And wouldn't you, too?

Christina Applegate is leaving "Up All Night," the new-parent sitcom built around her and co-star Will Arnett, in what amounts to a no-confidence vote in its latest attempt at reinvention.

The departure comes as the Lorne Michaels-produced series was to have gone back into production this month with a new format. But Applegate has left before the show could resume taping.

“It’s been a great experience working on 'Up All Night,' but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors," said Applegate, who begins filming "Anchorman 2" this month. "Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always.”

Applegate's exit may be the final blow for the stuggling comedy as NBC decides if it can or should be saved. It faces a series of difficult questions: Should it recast Applegate's role? Write off the mother of a newborn? Or just call it quits?

There was no immediate word from the network Friday.

The comedy has already been dealt a slew of changes, including the exit of creator Emily Spivey. It also increased co-star Maya Rudolph's role before it debuted in fall 2011, in part because of her role in the hit "Bridesmaids."

NBC announced in October that the series would shut down for three months and use that time to convert the show from a single-camera to multi-camera comedy.

It was scheduled to go back into production this month to shoot five new episodes that, for the first time, would have been taped before a live audience.

Other shows -- most recently CBS's "Two and a Half Men" -- have pressed on after losing lead actors. But most of those shows were hits. "Up All Night" has earned barely passable ratings since debuting last season.

In a Television Critics Association panel last month, NBC entertainment president Jennifer Salke was asked why NBC didn't just junk the show and find a new vehicle for its cast, which also includes Maya Rudolph.

"There’s a lot of thought that went into all of that and conversation with all the talent involved," Salke replied. "That was a show that wasn’t performing the way we needed it to. We are not fools. We know that that talented cast of actors, they’re not growing on trees. They still felt like there were stories to tell in that world and were collectively really passionate about continuing to tell them, as well as Lorne Michaels and that group. So we started looking at the show and thinking what was the best format for it, given that they felt a little tied down by the format they were in and the creative direction of the show."

When NBC announced the format change for "Up All Night" in October, entertainment chairman Bob Greenblatt said the network and Michaels agreed it would "infuse the show with more energy."

Greenblatt noted that both Rudolph and Applegate had recently hosted Michaels' "Saturday Night Live" and "love the reaction from a live audience." He also said he believed the show could "make a seamless tradition to the new format."

He also suggested the change was essential to the show's survival, saying, "this will give us another show to consider for next season in this new format."

I don't know why they just don't morph it into an entirely new series starring Rudolph & Farrell as 2 non-romantic BFFs with NO paternal skills who are left to raise a kid together (kinda like a take on My Two Dads or Full House).

It's too bad because I thought the show could have had real potential. It just never grabbed me. GREAT cast though.

I agree that they can remodel the show around Maya Rudolph for next season and I was going to tune in to see the cam switch. Write out Reagan and Chris and focus on Ava. Didn't her talk show get dropped? Have her attempt another "comeback" that season could write itself (I don't know what the character has been doing this season).

Applegate-free 'Up All Night' not canceledReport: Revamped sitcom apparently to be treated as a new pilot

Someone at NBC has been watching reruns of "Cheers," "The Hogan Family" and "Laverne & Shirley." Apparently, the network thinks that continuing "Up All Night" without Christina Applegate is a possibility. According to Deadline, plans are still afoot to convert the single-camera sitcom to a multi-camera, studio-audience situation. (This change appears to be what caused both Applegate and creator Emily Spivey to quit on Friday.)

It is not known whether Applegate will be replaced, although former "Friends" star Lisa Kudrow is the rumored frontrunner to join Will Arnett and Maya Rudolph if she is.

NBC realizes that suddenly losing the mom in an established sitcom about two parents raising a kid could be a problem. (Nothing gets by NBC.) So, according to Deadline, it has scaled back its new episode order from five to one. In other words, it's treating the show as just another pilot for next season.

In addition, it has hired James Burrows to direct the episode, which is significant because the veteran director has helmed episodes of "Cheers" (which successfully replaced Shelley Long with Kirstie Alley, and which Burrows also co-created), "The Hogan Family" (which was born when Sandy Duncan successfully replaced Valerie Harper in "Valerie"), and "Laverne & Shirley" (which actually shot a final season without Shirley).

Well, two out of three ain't bad.

Deadline notes that both Arnett and Rudolph are reportedly fielding other pilot offers. And wouldn't you, too?

Sources tell The Hollywood Reporter that the network is strongly considering abandoning the plan to keep the struggling series alive in the wake of star Christina Applegate's exit last week. As a planned one-episode reboot of the show has stalled, co-star Will Arnett is being seriously courted by CBS to star in a Greg Garcia-written comedy, among others.

In addition, sources tell THR that co-star Maya Rudolph has informed NBC that she is pregnant with her fourth child with director Paul Thomas Anderson. These sources say the show's writers planned to incorporate the pregnancy into the revised version of the series, but that issue could now be moot. The show's writing staff is said to be seeking new jobs.

NBC and reps for the actors declined to comment.

Initially, the network hoped to salvage the Lorne Michaels-produced comedy, hiring veteran James Burrows to tape one episode of a largely re-imagined show with Arnett and Rudolph. (It was not clear whether the Applegate role would be recast after her abrupt decision to quit.) But that reboot has hit snags and Arnett is said to be ready to move on.NBC has not released Arnett or Rudolph from their contracts for the original Up All Night, a single-camera show that the network hoped to transform into a multi-camera, behind-the-scenes look at a struggling television series. The show is not officially dead, though presumably the stars' exits are being negotiated.

The chaos comes at a key time for Arnett and Rudolph, with casting on the nearly 100 broadcast pilots already under way and both actors rocketing to the top of many network wish lists. Both Arnett and Rudolph have already received second-position offers for a number of broadcast pilots. CBS' Les Moonves in particular is said to want Arnett for an untitled comedy written and executive produced by Garcia about a recently divorced man whose parents move in with him. ABC also is high on the actor.

In the past two months, Up All Night has seen creator Emily Spivey and showrunner Tucker Cawley exit, with new showrunner Linda Wallem (Nurse Jackie) charged with retooling the series.

NBC announced in December that Up All Night would resume production in February following a three-month hiatus, with five episodes scheduled to begin in April or May. That plan was later changed to a one-episode reboot. The creative changes would have marked the latest for the comedy this season after Rudolph's talk-show format was ditched in the season two premiere earlier this fall.