In the present study in vitro measurements were
performed to evaluate the accuracy and reproducibility
of GABA detection with
1
H-MEGA-PRESS.
Spectra were acquired in a phantom containing several
metabolites of defined concentrations emulating their
composition in the brain. The obtained spectra were used
to simulate in vivo conditions by reducing SNR
GABA
and
broadening linewidths. It was figured out that for
sufficiently small CVs (< 7 %) a SNR
GABA
of
at least 2 is required, whereas for SNR
GABA
>
6 the CVs remain independent of FWHM. These results were
compared to an in vivo investigation in one healthy
volunteer.

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