Currently, hydroxyurea (HU), a potent inducer of fetal hemoglobin (Hb F), is the only approved drug for the management of sickle cell disease (SCD).Although the mechanism of induction of Hb F by HU is still unknown, but ...

Human T-cell lymphoma/leukemia virus (HTLV) is the etiological agent of adult T-cell lymphoma (ATL). Over10-20 million
people are infected with HTLV, which is endemic in regions of Japan, the Caribbean, South America, ...

Certified nursing assistants (CNAs) are frontline caregivers for the elderly with chronic physical and cognitive disabilities in nursing homes (NHs). The pool of CNAs available to deliver this complex care in NHs is ...

The vertebrate body plan is characterized by a segmented organization, which is clearly visible at the level of the vertebral column, its associated muscles and the peripheral nervous system. This basic organization is ...

Background: Alzheimer’s disease (AD) is the most common cause of memory loss in the world today. Non-invasive neuroimaging techniques have been explored to help diagnose and perhaps predict AD before the onset of symptoms. ...

The hypothesis of this project was that extended exposure to microgravity has a negative impact on the ability of the male
mammalian species to reproduce. Previous research showed that simulated microgravity using hindlimb ...

Nerve injury resulting from trauma frequently leads to loss of function due to neuronal degeneration and cell death. The
molecular mechanisms involved in neuronal cell death are poorly understood, but are thought to ...

Each year there are tens of millions of unplanned pregnancies and subsequent abortions worldwide. The WHO, NIH and IOM
have identified the need for the development of an effective reversible male contraceptive agent. ...

Oleanolic acid (OA) is a triterpenoid compound, which is a natural ingredient in some Chinese herbal medicines used for the treatment of hepatitis. OA has previously been shown in our laboratory to diminish the hepatotoxicity ...

Docosohexaenoic acid (DHA; 226n-3) is an omega-3 fatty acid critical for normal brain function. DHA in humans is
incorporated late in gestation and postnatally, during periods of rapid brain development. We hypothesized ...

As nursing homes become a dominant setting for death in the United States, palliative care must be integrated into daily nursing home practices. Improvements in this area will be better evaluated if researchers can assess ...

Introduction.
Alpha activity during wakefulness is thought to represent perceptual disengagement and a state of relaxation. Patients with primary insomnia (PIs) have often been observed exhibiting less alpha activity ...

High throughput gene expression analysis before and after the LH surge has provided insight into the diversity of ovarian
genes involved in oocyte maturation, ovulation, and luteinization. However, steady state gene ...

Quinpirole sensitization is used as an animal model of obsessive-compulsive disorder (OCD), a psychiatric disorder characterized by excessive, repetition of an obsession and/or compulsion. Clorgyline, an MAOA inhibitor, ...

Breast and ovarian cancer are leading causes of cancer-related deaths among women, responsible for over 56,000 fatalities annually in the United States. Women at increased risk for breast cancer are often also at increased ...

Junctional kyphosis may be a common finding in patients that undergo spinal instrumentation and fusion since there is an abrupt transition between fixed and mobile spinal segments. This excess motion may occur at either ...

Background: It has been shown that people with lesions of the basal ganglia including Parkinson’s disease (PD) have impaired
procedural learning, but the functional significance of this deficit is uncertain. Purpose: The ...