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Will Carrier 58MVC AND 25HNA6 work with Nest?

My unit is connected to the Infinity Control thermostat that uses the ABCD wires. I did notice that both my furnace and heat pump both support 24V thermostat hook-up. Please see attached diagram. Can I just pull out my Infinity Control unit and replace it with Nest? Do I need to configure any jumpers and the 24V thermostat hookup? Also, is the 24V thermostat designed to work with non-carrier thermostats? Here is the details on Nest:

You may be talking about the first generation unit. I am talking about the 2nd generation that just came out. So, I am sure you have not installed it yet. If you have installed the old one do you know the answer to my question?

I am not asking for advice on weather or not Nest is junk or not. I just want to know if it will work. Can someone please tell me if I stop using the ABCD connector, can I just wire my Nest to the 24V ports? Is this a transparent change? Will I need to adjust any jumpers?