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On Wednesday, a monitoring group reported that air strikes by U.S.-led international forces in Syria have killed 865 people, including 50 civilians, since the start of the campaign in late September against the Islamic State’s (IS/ISIS) militants.

The Syrian Observatory for Human Rights said the majority of the deaths, 746, were IS militant fighters and that the actual figure could be much higher.

The radical group has seized tracts of territory in Syria and neighboring Iraq, where it has also been targeted by U.S.-led strikes since July.

According to the Observatory, 68 members of al-Qaeda-affiliated Nusra Front (Jabhat al-Nusra) were also killed in the air strikes in Syria, which started early on Sept. 23.

The international coalition’s airstrikes have hit the Syrian provinces of Aleppo, Deir ez-Zor, Raqqa, Hasakah and Idlib.

The United States has said it takes reports of civilian casualties seriously and says it has a process to investigate each allegation.

Washington justified its action in Syria under Article 51 of the U.N. Charter, which covers an individual or collective right to self-defense against armed attacks.