Used in the treatment of severe hypertension and in the topical treatment of andronic alopecia.

Mechanism Of Action and Pharmacodynamic Effects

Activates ERK and Akt and increases the ratio of BCl-2/Bax. This has the effect of promoting the survival of human dermal papillary cells through proliferative and anti-apoptotic means. Also opens ATP-sensitive potassium channels in vascular smooth muscle cells which may improve the viability of hair cells or hair follicles.