ORIENTATION: Job burnout is a serious problem in the hospitality industry. Therefore, employees require ongoing job and personal resources to cope with job burnout. RESEARCH PURPOSE: The study investigated the influence of psycho-organisational variables (i.e. perceived organisational support, self-efficacy and age) on job burnout amongst hotel workers. MOTIVATION FOR THE STUDY: Investigating the independent and joint influence of psycho-organisational variables on burnout will assist in pulling together psycho-organisational factors influencing burnout and its dimensions cohesively in systematic theory building and intervention plans. RESEARCH DESIGN, APPROACH AND METHOD: This is a cross-sectional survey designed to investigate perceived organisational support, self-efficacy and age as predictors of job burnout amongst 268 hotel workers from 10 registered hotels in some metropolitan cities in Ondo State, south-western Nigeria. Structural equation modelling techniques were conducted to test the proposed hypotheses. MAIN FINDINGS: Structural equation modelling revealed that perceived organisational support and self-efficacy have inverse relationships with burnout syndrome and its dimensions. PRACTICAL/MANAGERIAL IMPLICATIONS: These findings imply that it is possible for different stakeholders in the hotel industry in Nigeria to reduce the incidence of high burnout amongst hotel workers by providing adequate organisational support to cope with difficult job demands and organising self-efficacy training to improve individuals' confidence in their abilities to deal with job burnout. Such intervention can be individual-oriented, organisation-oriented or a combination. CONTRIBUTION/VALUE-ADD: This study contributes to literature by confirming that organisational support and self-efficacy are relevant in coping with burnout.