S. Polinder (Suzanne)http://repub.eur.nl/ppl/22270/
List of Publicationsenhttp://repub.eur.nl/eur_signature.pnghttp://repub.eur.nl/
RePub, Erasmus University RepositoryReconstructive surgery after burns: A 10-year follow-up studyhttp://repub.eur.nl/pub/70827/
Wed, 11 Jun 2014 00:00:01 GMT<div>M.J. Hop</div><div>L.C. Langenberg</div><div>J. Hiddingh</div><div>C.M. Stekelenburg</div><div>M.B.A. van der Wal</div><div>C.J. Hoogewerf</div><div>M.L.J. van Koppen</div><div>S. Polinder</div><div>P.P.M. van Zuijlen</div><div>M.E. van Baar</div><div>E. Middelkoop</div>
Background: There is minimal insight into the prevalence of reconstructive surgery after burns. The objective of this study was to analyse the prevalence, predictors, indications, techniques and medical costs of reconstructive surgery after burns. Methods: A retrospective cohort study was conducted in the three Dutch burn centres. Patients with acute burns, admitted from January 1998 until December 2001, were included. Data on patient and injury characteristics and reconstructive surgery details were collected in a 10-year follow-up period. Results: In 13.0% (n = 229/1768) of the patients with burns, reconstructive surgery was performed during the 10-year follow-up period. Mean number of reconstructive procedure per patient were 3.6 (range 1-25). Frequently reconstructed locations were hands and head/neck. The most important indication was scar contracture and the most applied technique was release plus random flaps/skin grafting. Mean medical costs of reconstructive surgery per patient over 10-years were €8342. Conclusions: With this study we elucidated the reconstructive needs of patients after burns. The data presented can be used as reference in future studies that aim to improve scar quality of burns and decrease the need for reconstructive surgery.Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013http://repub.eur.nl/pub/56654/
Mon, 05 May 2014 00:00:01 GMT<div>N.J. Kassebaum</div><div>A. Bertozzi-Villa</div><div>M.S. Coggeshall</div><div>K.A. Shackelford</div><div>C. Steiner</div><div>K.R. Heuton</div><div>D. Gonzalez-Medina</div><div>R. Barber</div><div>T.T. Huynh</div><div>D. Dicker</div><div>B. Templin</div><div>T.M. Wolock</div><div>A.A. Ozgoren</div><div>F. Abd-Allah</div><div>S.F. Abera</div><div>T. Achoki</div><div>A. Adelekan</div><div>Z. Ademi</div><div>A.K. Adou</div><div>J.C. Adsuar</div><div>E.E. Agardh</div><div>D. Akena</div><div>D. Alasfoor</div><div>G. Alemu</div><div>R. Alfonso-Cristancho</div><div>S. Alhabib</div><div>R. Ali</div><div>M.J. Al Kahbouri</div><div>F. Alla</div><div>P.J. Allen</div><div>M.A. AlMazroa</div><div>U. Alsharif</div><div>E. Alvarez</div><div>N. Alvis-Guzman</div><div>A.A. Amankwaa</div><div>A.T. Amare</div><div>H. Amini</div><div>K.A. Ammar</div><div>C.A.T. Antonio</div><div>P. Anwari</div><div>J. Ärnlöv</div><div>V.S.A. Arsenijevic</div><div>A. Artaman</div><div>M.M. Asad</div><div>R.J. Asghar</div><div>R. Assadi</div><div>L.S. Atkins</div><div>A. Badawi</div><div>K. Balakrishnan</div><div>A. Basu</div><div>S. Basu</div><div>J. Beardsley</div><div>A.S. Bedi</div><div>T. Bekele</div><div>M.L. Bell</div><div>E. Bernabe</div><div>T.J. Beyene</div><div>Z.A. Bhutta</div><div>A. Bin Abdulhak</div><div>J.D. Blore</div><div>B.B. Basara</div><div>D. Bose</div><div>N. Breitborde</div><div>R. Cárdenas</div><div>C.A. Castañeda-Orjuela</div><div>R.E. Castro</div><div>F. Catalá-López</div><div>A. Cavlin</div><div>J.-C. Chang</div><div>J. Che</div><div>C.A. Christophi</div><div>S.S. Chugh</div><div>E. Cirillo</div><div>S.M. Colquhoun</div><div>L.T. Cooper</div><div>C. Cooper</div><div>I. da Costa Leite</div><div>L. Dandona</div><div>R. Dandona</div><div>A. Davis</div><div>A. Dayama</div><div>F. Degenhardt</div><div>D. de Leo</div><div>B. Del Pozo-Cruz</div><div>K. Deribe</div><div>M. Dessalegn</div><div>G. Deveber</div><div>S.D. Dharmaratne</div><div>U. Dilmen</div><div>E.L. Ding</div><div>R.E. Dorrington</div><div>J.M. Driscoll</div><div>S. Ermakov</div><div>A. Esteghamati</div><div>E.J.A. Faraon</div><div>F. Farzadfar</div><div>A.C. Felicio</div><div>S.-M. Fereshtehnejad</div><div>G.M.F. de Lima</div><div>M.H. Forouzanfar</div><div>E.B. França</div><div>L. Gaffikin</div><div>K. Gambashidze</div><div>F.G. Gankpé</div><div>A.C. Garcia</div><div>J.M. Geleijnse</div><div>K.B. Gibney</div><div>M. Giroud</div><div>E.L. Glaser</div><div>K. Goginashvili</div><div>P. Gona</div><div>D. González-Castell</div><div>A. Goto</div><div>H.N. Gouda</div><div>H.C. Gugnani</div><div>R. Gupta</div><div>R. Gupta</div><div>N. Hafezi-Nejad</div><div>R.R. Hamadeh</div><div>M. Hammami</div><div>G.J. Hankey</div><div>H.L. Harb</div><div>R. Havmoeller</div><div>S.I. Hay</div><div>I.B.H. Pi</div><div>H.W. Hoek</div><div>H.D. Hosgood</div><div>D.G. Hoy</div><div>A. Husseini</div><div>B.T. Idrisov</div><div>K. Innos</div><div>M. Inoue</div><div>K.H. Jacobsen</div><div>E. Jahangir</div><div>S.H. Jee</div><div>P.N. Jensen</div><div>V. Jha</div><div>G. Jiang</div><div>K. Juel</div><div>E.K. Kabagambe</div><div>H. Kan</div><div>V. Karam</div><div>F. Karch</div><div>C.K. Karema</div><div>A. Kaul</div><div>N. Kawakami</div><div>K. Kazanjan</div><div>D.S. Kazi</div><div>A.G. Kemp</div><div>A.P. Kengne</div><div>M. Kereselidze</div><div>Y.S. Khader</div><div>S.E.A.H. Khalifa</div><div>E.A. Khan</div><div>Y.-H. Khang</div><div>L. Knibbs</div><div>Y. Kokubo</div><div>S. Kosen</div><div>B.K. Defo</div><div>C. Kulkarni</div><div>V.S. Kulkarni</div><div>G.A. Kumar</div><div>K. Kumar</div><div>R.B. Kumar</div><div>G.F. Kwan</div><div>T. Lai</div><div>R. Lalloo</div><div>H. Lam</div><div>V.C. Lansingh</div><div>A. Larsson</div><div>J.-T. Lee</div><div>P.N. Leigh</div><div>M. Leinsalu</div><div>R. Leung</div><div>X. Li</div><div>Y. Li</div><div>Y. Li</div><div>J. Liang</div><div>X. Liang</div><div>S.S. Lim</div><div>H.-H. Lin</div><div>S.E. Lipshultz</div><div>S. Liu</div><div>Y. Liu</div><div>B.K. Lloyd</div><div>S.J. London</div><div>P.A. Lotufo</div><div>J. Ma</div><div>S. Ma</div><div>V.M.P. Machado</div><div>N.K. Mainoo</div><div>M. Majdan</div><div>C.C. Mapoma</div><div>W. Marcenes</div><div>M.B. Marzan</div><div>A.J. Mason-Jones</div><div>M.M. Mehndiratta</div><div>F. Mejia-Rodriguez</div><div>Z.A. Memish</div><div>W. Mendoza</div><div>T.R. Miller</div><div>E.J. Mills</div><div>A.H. Mokdad</div><div>G.L. Mola</div><div>L. Monasta</div><div>J. de la Cruz Monis</div><div>J.C.M. Hernandez</div><div>A.R. Moore</div><div>R. Mori</div><div>U.O. Mueller</div><div>M. Mukaigawara</div><div>A. Naheed</div><div>K.S. Naidoo</div><div>D. Nand</div><div>M. Nangia</div><div>J.H.E. Nash</div><div>C. Nejjari</div><div>R.D. Nelson</div><div>S.P. Neupane</div><div>C. Newton</div><div>M. Ng</div><div>M. Nieuwenhuijsen</div><div>M.I. Nisar</div><div>S. Nolte</div><div>O.F. Norheim</div><div>L. Nyakarahuka</div><div>I.-H. Oh</div><div>T. Ohkubo</div><div>B.O. Olusanya</div><div>S.B. Omer</div><div>J.N. Opio</div><div>O.E. Orisakwe</div><div>N.G. Pandian</div><div>C. Papachristou</div><div>J.-H. Park</div><div>M.S. Caicedo</div><div>J. Patten</div><div>V.K. Paul</div><div>B.I. Pavlin</div><div>N. Pearce</div><div>D.M. Pereira</div><div>K. Pesudovs</div><div>M. Petzold</div><div>D. Poenaru</div><div>G.V. Polanczyk</div><div>S. Polinder</div><div>D. Pope</div><div>F. Pourmalek</div><div>D. Qato</div><div>D.A. Quistberg</div><div>A. Rafay</div><div>K. Rahimi</div><div>V. Rahimi-Movaghar</div><div>S. ur Rahman</div><div>M. Raju</div><div>S.M. Rana</div><div>A. Refaat</div><div>L. Ronfani</div><div>N. van Roy</div><div>T.G.S. Pimienta</div><div>M.A. Sahraian</div><div>J.A. Salomon</div><div>U. Sampson</div><div>I.S. Santos</div><div>M.S. Sawhney</div><div>F. Sayinzoga</div><div>I.J.C. Schneider</div><div>A. Schumacher</div><div>D.C. Schwebel</div><div>S. Seedat</div><div>S.G. Sepanlou</div><div>E.E. Servan-Mori</div><div>M. Shakh-Nazarova</div><div>S. Sheikhbahaei</div><div>K. Shibuya</div><div>H.H. Shin</div><div>I. Shiue</div><div>I.D. Sigfusdottir</div><div>D.H. Silberberg</div><div>A.P. Silva</div><div>J.A. Singh</div><div>V. Skirbekk</div><div>K. Sliwa</div><div>S.S. Soshnikov</div><div>L.A. Sposato</div><div>C.T. Sreeramareddy</div><div>K. Stroumpoulis</div><div>L. Sturua</div><div>B.C. Sykes</div><div>K.M. Tabb</div><div>R.T. Talongwa</div><div>F. Tan</div><div>P.J. Teixeira</div><div>E.Y. Tenkorang</div><div>A.S. Terkawi</div><div>A.L. Thorne-Lyman</div><div>D.L. Tirschwell</div><div>J.A. Towbin</div><div>B.X. Tran</div><div>M. Tsilimbaris</div><div>U.S. Uchendu</div><div>K.N. Ukwaja</div><div>E.A. Undurraga</div><div>S.B. Uzun</div><div>S.R. Vallely</div><div>C.H. van Gool</div><div>T.J. Vasankari</div><div>M.S. Vavilala</div><div>N. Venketasubramanian</div><div>S. Villalpando</div><div>F.S. Violante</div><div>V.V. Vlassov</div><div>T. Vos</div><div>P. Waller</div><div>H. Wang</div><div>L. Wang</div><div>S.X. Wang</div><div>Y. Wang</div><div>S. Weichenthal</div><div>E. Weiderpass</div><div>R.G. Weintraub</div><div>R. Westerman</div><div>J.D. Wilkinson</div><div>S.M. Woldeyohannes</div><div>J.B. Wong</div><div>M.A. Wordofa</div><div>G. Xu</div><div>Y.C. Yang</div><div>K.-I. Yano</div><div>G.K. Yentur</div><div>P. Yip</div><div>N. Yonemoto</div><div>S.-J. Yoon</div><div>M. Younis</div><div>C. Yu</div><div>K.Y. Jin</div><div>M. El Sayed Zaki</div><div>Y. Zhao</div><div>Y. Zheng</div><div>M. Zhou</div><div>J. Zhu</div><div>X.N. Zou</div><div>A.D. Lopez</div><div>M. Naghavi</div><div>C.J.L. Murray</div><div>R. Lozano</div>
Background: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100 000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery. Methods: We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basis of a systematic review of the relative risk of dying during pregnancy for HIV-positive women compared with HIV-negative women. We also estimated the fraction of these deaths aggravated by pregnancy on the basis of a systematic review. To estimate the numbers of maternal deaths due to nine different causes, we identified 61 sources from a systematic review and 943 site-years of vital registration data. We also did a systematic review of reports about the timing of maternal death, identifying 142 sources to use in our analysis. We developed estimates for each country for 1990-2013 using Bayesian meta-regression. We estimated 95% uncertainty intervals (UIs) for all values. Findings: 292 982 (95% UI 261 017-327 792) maternal deaths occurred in 2013, compared with 376 034 (343 483-407 574) in 1990. The global annual rate of change in the MMR was -0·3% (-1·1 to 0·6) from 1990 to 2003, and -2·7% (-3·9 to -1·5) from 2003 to 2013, with evidence of continued acceleration. MMRs reduced consistently in south, east, and southeast Asia between 1990 and 2013, but maternal deaths increased in much of sub-Saharan Africa during the 1990s. 2070 (1290-2866) maternal deaths were related to HIV in 2013, 0·4% (0·2-0·6) of the global total. MMR was highest in the oldest age groups in both 1990 and 2013. In 2013, most deaths occurred intrapartum or postpartum. Causes varied by region and between 1990 and 2013. We recorded substantial variation in the MMR by country in 2013, from 956·8 (685·1-1262·8) in South Sudan to 2·4 (1·6-3·6) in Iceland. Interpretation: Global rates of change suggest that only 16 countries will achieve the MDG 5 target by 2015. Accelerated reductions since the Millennium Declaration in 2000 coincide with increased development assistance for maternal, newborn, and child health. Setting of targets and associated interventions for after 2015 will need careful consideration of regions that are making slow progress, such as west and central Africa. Funding: Bill & Melinda Gates Foundation.HUMeral Shaft Fractures: MEasuring Recovery after Operative versus Non-operative Treatment (HUMMER): A multicenter comparative observational studyhttp://repub.eur.nl/pub/57394/
Tue, 11 Feb 2014 00:00:01 GMT<div>K.C. Mahabier</div><div>E.M.M. van Lieshout</div><div>H.W. Bolhuis</div><div>P.K. Bos</div><div>M.W.G.A. Bronkhorst</div><div>M.M.M. Bruijninckx</div><div>J. de Haan</div><div>W. Deenik</div><div>B.J. Dwars</div><div>M.G. Eversdijk</div><div>J.C. Goslings</div><div>R. Haverlag</div><div>M.J. Heetveld</div><div>A.J.H. Kerver</div><div>K.A. Kolkman</div><div>K. Leenhouts</div><div>S.A.G. Meylaerts</div><div>W. Onstenk</div><div>H. Poeze</div><div>R.W. Poolman</div><div>B.J. Punt</div><div>W.H. Roerdink</div><div>G.R. Roukema</div><div>J.B. Sintenie</div><div>N.M.R. Soesman</div><div>A.F.K. Tanka</div><div>E.J.T. ten Holder</div><div>M. van der Elst</div><div>F.H.W.M. van der Heijden</div><div>F.M. van der Linden</div><div>P. van der Zwaal</div><div>J.P. van Dijk</div><div>H.P.W. van Jonbergen</div><div>E.J.M.M. Verleisdonk</div><div>J.P.A.M. Vroemen</div><div>M. Waleboer</div><div>P. Wittich</div><div>W.P. Zuidema</div><div>S. Polinder</div><div>M.H.J. Verhofstad</div><div>D. den Hartog</div>
Background: Fractures of the humeral shaft are associated with a profound temporary (and in the elderly sometimes even permanent) impairment of independence and quality of life. These fractures can be treated operatively or non-operatively, but the optimal tailored treatment is an unresolved problem. As no high-quality comparative randomized or observational studies are available, a recent Cochrane review concluded there is no evidence of sufficient scientific quality available to inform the decision to operate or not. Since randomized controlled trials for this injury have shown feasibility issues, this study is designed to provide the best achievable evidence to answer this unresolved problem. The primary aim of this study is to evaluate functional recovery after operative versus non-operative treatment in adult patients who sustained a humeral shaft fracture. Secondary aims include the effect of treatment on pain, complications, generic health-related quality of life, time to resumption of activities of daily living and work, and cost-effectiveness. The main hypothesis is that operative treatment will result in faster recovery. Methods/design. The design of the study will be a multicenter prospective observational study of 400 patients who have sustained a humeral shaft fracture, AO type 12A or 12B. Treatment decision (i.e., operative or non-operative) will be left to the discretion of the treating surgeon. Critical elements of treatment will be registered and outcome will be monitored at regular intervals over the subsequent 12 months. The primary outcome measure is the Disabilities of the Arm, Shoulder, and Hand score. Secondary outcome measures are the Constant score, pain level at both sides, range of motion of the elbow and shoulder joint at both sides, radiographic healing, rate of complications and (secondary) interventions, health-related quality of life (Short-Form 36 and EuroQol-5D), time to resumption of ADL/work, and cost-effectiveness. Data will be analyzed using univariate and multivariable analyses (including mixed effects regression analysis). The cost-effectiveness analysis will be performed from a societal perspective. Discussion. Successful completion of this trial will provide evidence on the effectiveness of operative versus non-operative treatment of patients with a humeral shaft fracture. Trial registration. The trial is registered at the Netherlands Trial Register (NTR3617).Costs of burn care: A systematic reviewhttp://repub.eur.nl/pub/57516/
Wed, 01 Jan 2014 00:00:01 GMT<div>M.J. Hop</div><div>S. Polinder</div><div>C.H. van der Vlies</div><div>E. Middelkoop</div><div>M.E. van Baar</div>
Burn care is traditionally considered expensive care. However, detailed information about the costs of burn care is scarce despite the increased need for this information and the enhanced focus on healthcare cost control. In this study, economic literature on burn care was systematically reviewed to examine the problem of burn-related costs. Cost or economic evaluation studies on burn care that had been published in international peer-reviewed journals from 1950 to 2012 were identified. The methodology of these articles was critically appraised by two reviewers, and cost results were extracted. A total of 156 studies met the inclusion criteria. Nearly all of the studies were cost studies (n=153) with a healthcare perspective (n=139) from high-income countries (n=127). Hospital charges were often used as a proxy for costs (n=44). Three studies were cost-effectiveness analyses. The mean total healthcare cost per burn patient in high-income countries was $88,218 (range $704-$717,306; median $44,024). A wide variety of methodological approaches and cost prices was found. We recommend that cost studies and economic evaluations employ a standard approach to improve the quality and harmonization of economic evaluation studies, optimize comparability, and improve insight into burn care costs and efficiency.Health-related quality of life in Guillain-Barré syndrome patients: A systematic reviewhttp://repub.eur.nl/pub/65319/
Wed, 01 Jan 2014 00:00:01 GMT<div>S.K.L. Darweesh</div><div>S. Polinder</div><div>M.J.H.L. Mulder</div><div>C.P. Baena</div><div>N. van Leeuwen</div><div>O.H. Franco Duran</div><div>B.C. Jacobs</div><div>P.A. van Doorn</div>
Guillain-Barré syndrome (GBS) encompasses a broad spectrum of health-related quality of life (HRQL) determinants, including mobility, fatigue, pain, and depression. We systematically reviewed the literature on functional outcome domains in which GBS patients experience limitations in the short and long terms and evaluated determinants of HRQL in GBS patients. MEDLINE and EMBASE were systematically searched by two independent reviewers for articles covering HRQL data of GBS patients. Of 730 abstracts screened, 17 articles covering data of 14 studies matched the selection criteria. The included articles showed that many GBS patients experienced physical limitations, even years after the acute phase of the disease, while results were inconsistent for perceived levels of pain, fatigue, and general mental well-being. Only three papers covered HRQL assessments at more than one time point, generally showing large improvements in HRQL in the first year after GBS onset, but not thereafter. We appraised the methodological quality of included studies using a 13-item checklist; none of the articles fulfilled all items and only seven articles presented data on correlations between HRQL and determinants. In conclusion, the majority of studies on HRQL in GBS patients are cross-sectional and of low methodological quality. This paper provides guidance for much needed high-quality studies on patterns of patient-perceived recovery after GBS onset.A systematic review on the influence of pre-existing disability on sustaining injuryhttp://repub.eur.nl/pub/72011/
Wed, 01 Jan 2014 00:00:01 GMT<div>S. Yung</div><div>J.A. Haagsma</div><div>S. Polinder</div>
Objective To systematically review studies measuring the influence of pre-existing disability on the risk of sustaining an injury. Design Systematic review. Data sources Electronic databases searched included Medline (Pubmed), ProQuest, Ovid and EMBASE. Inclusion criteria Studies (1990-2010) in international peer-reviewed journals were identified with main inclusion criteria being that the study assessed involvement of injury sustained by persons with and without pre-existing disability. Methods Studies were collated by design and methods, and evaluation of results. Results Twenty-two studies met the inclusion criteria of our review. All studies found that persons with disabilities were at a significantly higher risk of sustaining injuries than those without. Persons with disability had a 30-450% increased odds (odds ratio 1.3-5.5) of sustaining injury compared to persons without disability. Among persons with pre-existing disability, the high risk groups of sustaining an injury are children and elderly. Conclusions People with disabilities experience a higher risk to sustain an injury in comparison to the healthy population. There is a high need for large epidemiological studies of injury among persons with disability, to better address these unique risk profiles in order to prevent additional disability or secondary conditions.Cost study of dermal substitutes and topical negative pressure in the surgical treatment of burnshttp://repub.eur.nl/pub/66837/
Fri, 13 Sep 2013 00:00:01 GMT<div>M.J. Hop</div><div>H.G. Bloemen</div><div>M.E. van Baar</div><div>M. Nieuwenhuis</div><div>P.P.M. van Zuijlen</div><div>S. Polinder</div><div>E. Middelkoop</div>
Background: A recently performed randomised controlled trial investigated the clinical effectiveness of dermal substitutes (DS) and split skin grafts (SSG) in combination with topical negative pressure (TNP) in the surgical treatment of burn wounds. In the current study, medical and non-medical costs were investigated, to comprehensively assess the benefits of this new treatment. Methods: The primary outcome was mean total costs of the four treatment strategies: SSG with or without DS, and with or without TNP. Costs were studied from a societal perspective. Findings were evaluated in light of the clinical effects on scar elasticity. Results: Eighty-six patients were included. Twelve months post-operatively, highest elasticity was measured in scars treated with DS and TNP (p = 0.027). The initial cost price of treatment with DS and TNP was €2912 compared to treatment with SSG alone €1703 (p < 0.001). However, mean total costs per patient did not differ significantly between groups (range €29 097-€43 774). Discussion: Costs of the interventional treatment contributed maximal 7% to the total costs and total costs varied widely within and between groups, but were not significantly different. Therefore, in the selection of the most optimal type of surgical intervention, cost considerations should not play an important role.Systematic review of foodborne burden of disease studies: Quality assessment of data and methodologyhttp://repub.eur.nl/pub/73372/
Fri, 16 Aug 2013 00:00:01 GMT<div>J.A. Haagsma</div><div>S. Polinder</div><div>C. Stein</div><div>A.H. Havelaar</div>
Burden of disease (BoD) studies aim to identify the public health impact of different health problems and risk factors. To assess BoD, detailed knowledge is needed on epidemiology, disability and mortality in the population under study. This is particularly challenging for foodborne disease, because of the multitude of causative agents and their health effects. The purpose of this study is to systematically review the methodology of foodborne BoD studies. Three key questions were addressed: 1) which data sources and approaches were used to assess mortality, morbidity and disability?, 2) which methodological choices were made to calculate Disability Adjusted Life Years (DALY), and 3) were uncertainty analyses performed and if so, how? Studies (1990-June 2012) in international peer-reviewed journals and grey literature were identified with main inclusion criteria being that the study assessed disability adjusted life years related to foodborne disease. Twenty-four studies met our inclusion criteria. To assess incidence or prevalence of foodborne disease in the population, four approaches could be distinguished, each using a different data source as a starting point, namely 1) laboratory-confirmed cases, 2) cohort or cross-sectional data, 3) syndrome surveillance data and 4) exposure data. Considerable variation existed in BoD methodology (e.g. disability weights, discounting, age-weighting). Almost all studies analyzed the effect of uncertainty as a result of possible imprecision in the parameter values. Awareness of epidemiological and methodological rigor between foodborne BoD studies using the DALY approach is a critical priority for advancing burden of disease studies. Harmonization of methodology that is used and of modeling techniques and high quality data can enlarge the detection of real variation in DALY outcomes between pathogens, between populations or over time. This harmonization can be achieved by identifying substantial data gaps and uncertainty and establish which sequelae of foodborne disease agents should be included in BoD calculations.Validating and Improving Injury Burden Estimates Study: The Injury-VIBES study protocolhttp://repub.eur.nl/pub/76321/
Tue, 06 Aug 2013 00:00:01 GMT<div>B.J. Gabbe</div><div>R.A. Lyons</div><div>J.E. Harrison</div><div>F.P. Rivara</div><div>S. Ameratunga</div><div>G.J. Jolley</div><div>S. Polinder</div><div>S. Derrett</div>
Background: Priority setting, identification of unmet and changing healthcare needs, service and policy planning, and the capacity to evaluate the impact of health interventions requires valid and reliable methods for quantifying disease and injury burden. The methodology developed for the Global Burden of Disease (GBD) studies has been adopted to estimate the burden of disease in national, regional and global projects. However, there has been little validation of the methods for estimating injury burden using empirical data. Objective: To provide valid estimates of the burden of non-fatal injury using empirical data. Setting: Data from prospective cohort studies of injury outcomes undertaken in the UK, USA, Australia, New Zealand and The Netherlands. Design and participants: Meta-analysis of deidentified, patient-level data from over 40 000 injured participants in six prospective cohort studies: Victorian State Trauma Registry, Victorian Orthopaedic Trauma Outcomes Registry, UK Burden of Injury study, Prospective Outcomes of Injury study, National Study on Costs and Outcomes of Trauma and the Dutch Injury Patient Survey. Analysis: Data will be systematically analysed to evaluate and refine injury classification, development of disability weights, establishing the duration of disability and handling of cases with more than one injury in burden estimates. Developed methods will be applied to incidence data to compare and contrast various methods for estimating non-fatal injury burden. Contribution to the field: The findings of this international collaboration have the capacity to drive how injury burden is measured for future GBD estimates and for individual country or region-specific studies.Cost analysis of surgically treated pressure sores stage III and IVhttp://repub.eur.nl/pub/40494/
Wed, 05 Jun 2013 00:00:01 GMT<div>A. Filius</div><div>T.H.C. Damen</div><div>K.P. Schuijer-Maaskant</div><div>S. Polinder</div><div>S.E.R. Hovius</div><div>E.T. Walbeehm</div>
Health-care costs associated with pressure sores are significant and their financial burden is likely to increase even further. The aim of this study was to analyse the direct medical costs of hospital care for surgical treatment of pressure sores stage III and IV. We performed a retrospective chart study of patients who were surgically treated for stage III and IV pressure sores between 2007 and 2010. Volumes of health-care use were obtained for all patients and direct medical costs were subsequently calculated. In addition, we evaluated the effect of location and number of pressure sores on total costs. A total of 52 cases were identified. Average direct medical costs in hospital were €20,957 for the surgical treatment of pressure sores stage III or IV; average direct medical costs for patients with one pressure sore on an extremity (group 1, n = 5) were €30,286, €10,113 for patients with one pressure sore on the trunk (group 2, n = 32) and €40,882 for patients with multiple pressure sores (group 3, n = 15). The additional costs for patients in group 1 and group 3 compared to group 2 were primarily due to longer hospitalisation. The average direct medical costs for surgical treatment of pressure sores stage III and IV were high. Large differences in costs were related to the location and number of pressure sores. Insight into the distribution of these costs allows identification of high-risk patients and enables the development of specific cost-reducing measures. Trends in incidence and costs of injuries to the shoulder, arm and wrist in the Netherlands between 1986 and 2008http://repub.eur.nl/pub/62192/
Wed, 05 Jun 2013 00:00:01 GMT<div>S. Polinder</div><div>G.I.T. Iordens</div><div>M.J.M. Panneman</div><div>D. Eygendaal</div><div>P. Patka</div><div>D. den Hartog</div><div>E.M.M. van Lieshout</div>
Background: Upper extremity injuries account for a large proportion of attendances to the Emergency Department. The aim of this study was to assess population-based trends in the incidence of upper extremity injuries in the Dutch population between 1986 and 2008, and to give a detailed overview of the associated health care costs. Methods. Age-standardized incidence rates of upper extremity injuries were calculated for each year between 1986 and 2008. The average number of people in each of the 5-year age classes for each year of the study was calculated and used as the standard (reference) population. Injury cases were extracted from the National Injury Surveillance System (non-hospitalized patients) and the National Medical Registration (hospitalized patients). An incidence-based cost model was applied in order to estimate associated direct health care costs in 2007. Results: The overall age-adjusted incidence of upper extremity injuries increased from 970 to 1,098 per 100,000 persons (13%). The highest incidence was seen in young persons and elderly women. Total annual costs for all injuries were 290 million euro, of which 190 million euro were paid for injuries sustained by women. Wrist fractures were the most expensive injuries (83 million euro) due to high incidence, whereas upper arm fractures were the most expensive injuries per case (4,440 euro). Major cost peaks were observed for fractures in elderly women due to high incidence and costs per patient. Conclusions: The overall incidence of upper extremity injury in the Netherlands increased by 13% in the period 1986-2008. Females with upper extremity fractures and especially elderly women with wrist fractures accounted for a substantial share of total costs.Epidemiology and health-care utilisation of wrist fractures in older adults in The Netherlands, 1997-2009http://repub.eur.nl/pub/39311/
Mon, 01 Apr 2013 00:00:01 GMT<div>C.E. de Putter</div><div>R.W. Selles</div><div>S. Polinder</div><div>K.A. Hartholt</div><div>C.W.N. Looman</div><div>M.J.M. Panneman</div><div>J.A.N. Verhaar</div><div>S.E.R. Hovius</div><div>E.F. van Beeck</div>
Introduction: Wrist fractures are common in older adults and are expected to increase because of ageing populations worldwide. The introduction of plate and screw fixation has changed the management of this trauma in many patients. For policymaking it is essential to gain insight into trends in epidemiology and healthcare utilisation. The purpose of this study was to determine trends in incidence, hospitalisation and operative treatment of wrist fractures. Methods: A population-based study of patients aged 50 years and older using the Dutch National Injury Surveillance System and the National Hospital Discharge Registry. Data on emergency department visits, hospitalisations and operative treatment for wrist fractures within the period 1997-2009 were analysed. Results: In women, the age-standardised incidence rate of wrist fractures decreased from 497.2 per 100,000 persons (95% confidence interval, 472.3-522.1) in 1997 to 445.1 (422.8-467.4) in 2009 (P for trend <0.001). In men, no significant trends were observed in the same time period. Hospitalisation rates increased from 30.1 (28.3-31.9) in 1997 to 78.9 (75.1-82.8) in 2009 in women (P < 0.001), and from 6.4 (6.0-6.8) to 18.4 (17.3-19.5) in men (P < 0.001). There was a strong increase in operative treatment of distal radius fractures, especially due to plate fixation techniques in all age groups. Conclusion: Incidence rates of wrist fractures decreased in women and remained stable in men, but hospitalisation rates strongly increased due to a steep rise in operative treatments. The use of plate and screw fixation techniques for distal radius fractures increased in all age groups. Cost-effectiveness of laser Doppler imaging in burn care in the Netherlandshttp://repub.eur.nl/pub/73481/
Tue, 05 Feb 2013 00:00:01 GMT<div>M.J. Hop</div><div>J. Hiddingh</div><div>C.M. Stekelenburg</div><div>H.C. Kuipers</div><div>E. Middelkoop</div><div>M. Nieuwenhuis</div><div>S. Polinder</div><div>M.E. van Baar</div>
Background: Early accurate assessment of burn depth is important to determine the optimal treatment of burns. The method most used to determine burn depth is clinical assessment, which is the least expensive, but not the most accurate.Laser Doppler imaging (LDI) is a technique with which a more accurate (>95%) estimate of burn depth can be made by measuring the dermal perfusion. The actual effect on therapeutic decisions, clinical outcomes and the costs of the introduction of this device, however, are unknown. Before we decide to implement LDI in Dutch burn care, a study on the effectiveness and cost-effectiveness of LDI is necessary. Methods/design. A multicenter randomised controlled trial will be conducted in the Dutch burn centres: Beverwijk, Groningen and Rotterdam. All patients treated as outpatient or admitted to a burn centre within 5 days post burn, with burns of indeterminate depth (burns not obviously superficial or full thickness) and a total body surface area burned of ≤ 20% are eligible. A total of 200 patients will be included. Burn depth will be diagnosed by both clinical assessment and laser Doppler imaging between 2-5 days post burn in all patients. Subsequently, patients are randomly divided in two groups: 'new diagnostic strategy' versus 'current diagnostic strategy'. The results of the LDI-scan will only be provided to the treating clinician in the 'new diagnostic strategy' group. The main endpoint is the effect of LDI on wound healing time.In addition we measure: a) the effect of LDI on other patient outcomes (quality of life, scar quality), b) the effect of LDI on diagnostic and therapeutic decisions, and c) the effect of LDI on total (medical and non-medical) costs and cost-effectiveness. Discussion. This trial will contribute to our current knowledge on the use of LDI in burn care and will provide evidence on its cost-effectiveness. Trial registration. NCT01489540.Prevalence rate, predictors and long-term course of probable posttraumatic stress disorder after major trauma: A prospective cohort studyhttp://repub.eur.nl/pub/39590/
Thu, 27 Dec 2012 00:00:01 GMT<div>J.A. Haagsma</div><div>A.N. Ringburg</div><div>E.M.M. van Lieshout</div><div>E.F. van Beeck</div><div>P. Patka</div><div>I.B. Schipper</div><div>S. Polinder</div>
Background: Among trauma patients relatively high prevalence rates of posttraumatic stress disorder (PTSD) have been found. To identify opportunities for prevention and early treatment, predictors and course of PTSD need to be investigated. Long-term follow-up studies of injury patients may help gain more insight into the course of PTSD and subgroups at risk for PTSD. The aim of our long-term prospective cohort study was to assess the prevalence rate and predictors, including pre-hospital trauma care (assistance of physician staffed Emergency Medical Services (EMS) at the scene of the accident), of probable PTSD in a sample of major trauma patients at one and two years after injury. The second aim was to assess the long-term course of probable PTSD following injury.Methods: A prospective cohort study was conducted of 332 major trauma patients with an Injury Severity Score (ISS) of 16 or higher. We used data from the hospital trauma registry and self-assessment surveys that included the Impact of Event Scale (IES) to measure probable PTSD symptoms. An IES-score of 35 or higher was used as indication for the presence of probable PTSD.Results: One year after injury measurements of 226 major trauma patients were obtained (response rate 68%). Of these patients 23% had an IES-score of 35 or higher, indicating probable PTSD. At two years after trauma the prevalence rate of probable PTSD was 20%. Female gender and co-morbid disease were strong predictors of probable PTSD one year following injury, whereas minor to moderate head injury and injury of the extremities (AIS less than 3) were strong predictors of this disorder at two year follow-up. Of the patients with probable PTSD at one year follow-up 79% had persistent PTSD symptoms a year later.Conclusions: Up to two years after injury probable PTSD is highly prevalent in a population of patients with major trauma. The majority of patients suffered from prolonged effects of PTSD, underlining the importance of prevention, early detection, and treatment of injury-related PTSD. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010http://repub.eur.nl/pub/57559/
Sat, 01 Dec 2012 00:00:01 GMT<div>C.J. Murray</div><div>T. Vos</div><div>R. Lozano</div><div>M. Naghavi</div><div>A.D. Flaxman</div><div>S. Michaud</div><div>M. Ezzati</div><div>K. Shibuya</div><div>J.A. Salomon</div><div>S. Abdalla</div><div>V. Aboyans</div><div>J. Abraham</div><div>M. Ackerman</div><div>R. Aggarwal</div><div>S.Y. Ahn</div><div>M.K. Ali</div><div>M. Alvarado</div><div>H.R. Anderson</div><div>L.M. Anderson</div><div>K.G. Andrews</div><div>C. Atkinson</div><div>L.M. Baddour</div><div>A.N. Bahalim</div><div>S. Barker-Collo</div><div>L.H. Barrero</div><div>D.H. Bartels</div><div>M-G. Basáñez</div><div>A. Baxter</div><div>M.L. Bell</div><div>E.J. Benjamin</div><div>D. Bennett</div><div>E. Bernabe</div><div>P.L. Bhalla</div><div>M. Bhandari</div><div>B. Bikbov</div><div>A.B. Abdulhak</div><div>G. Birbeck</div><div>J.A. Black</div><div>H. Blencowe</div><div>J.D. Blore</div><div>F. Blyth</div><div>I. Bolliger</div><div>A. Bonaventure</div><div>S. Boufous</div><div>R. Bourne</div><div>M. Boussinesq</div><div>T. Braithwaite</div><div>C. Brayne</div><div>L. Bridgett</div><div>C. Brooker</div><div>P. Brooks</div><div>T.S. Brugha</div><div>C. Bryan-Hancock</div><div>C. Bucello</div><div>R. Buchbinder</div><div>P. Buckle</div><div>C.M. Budke</div><div>V.C. Burch</div><div>P.G. Burney</div><div>D. Burstein</div><div>B. Calabria</div><div>B. Campbell</div><div>C.E. Canter</div><div>H. Carabin</div><div>J. Carapetis</div><div>L. Carmona</div><div>M. Cella</div><div>F. Charlson</div><div>H. Chen</div><div>A.T.-A. Cheng</div><div>Y.F. Chou</div><div>S.S. Chugh</div><div>L.E. Coffeng</div><div>S.D. Colan</div><div>S. Colquhoun</div><div>P. Colson</div><div>J. Condon</div><div>L. Connor</div><div>L.T. Cooper</div><div>M. Corriere</div><div>M. Cortinovis</div><div>K.C. de Vaccaro</div><div>W. Couser</div><div>M.R. Cowie</div><div>M. Criqui</div><div>M. Cross</div><div>K.C. Dabhadkar</div><div>M. Dahiya</div><div>N. Dahodwala</div><div>J. Damsere-Derry</div><div>G. Danaei</div><div>A. Davis</div><div>D. de Leo</div><div>F. Degenhardt</div><div>A. Dellavalle</div><div>A. Delossantos</div><div>J. Denenberg</div><div>S. Derrett</div><div>D.C. Des Jarlais</div><div>S.D. Dharmaratne</div><div>M. Dherani</div><div>C. Díaz-Torné</div><div>H. Dolk</div><div>M. Dorsey</div><div>J.M. Driscoll</div><div>H. Duber</div><div>B. Ebel</div><div>K. Edmond</div><div>A. Elbaz</div><div>S.E. Ali</div><div>H. Erskine</div><div>M.L. Erwin</div><div>P. Espindola</div><div>S.E. Ewoigbokhan</div><div>F. Farzadfar</div><div>V. Feigin</div><div>D. Felson</div><div>A. Ferrari</div><div>R. Ferri</div><div>E.M. Fèvre</div><div>F.M. Finucane</div><div>S. Flaxman</div><div>L. Flood</div><div>K. Foreman</div><div>M.H. Forouzanfar</div><div>F.G.R. Fowkes</div><div>M.P. Fransen</div><div>M.K. Freeman</div><div>B.J. Gabbe</div><div>S.E. Gabriel</div><div>E. Gakidou</div><div>H.A. Ganatra</div><div>B. Garcia</div><div>F. Gaspari</div><div>R.F. Gillum</div><div>G. Gmel</div><div>D. Gonzalez-Medina</div><div>R. Gosselin</div><div>C.I. Grainger</div><div>B. Grant</div><div>M. Groeger</div><div>F. Guillemin</div><div>D. Gunnell</div><div>R. Gupta</div><div>J.A. Haagsma</div><div>H. Hagan</div><div>Y.A. Halasa</div><div>W. Hall</div><div>D. Haring</div><div>J.M. Haro</div><div>J.E. Harrison</div><div>R. Havmoeller</div><div>R.J. Hay</div><div>H. Higashi</div><div>C. Hill</div><div>B. Hoen</div><div>H. Hoffman</div><div>P.J. Hotez</div><div>D.G. Hoy</div><div>J. Huang</div><div>S.E. Ibeanusi</div><div>K.H. Jacobsen</div><div>S.L. James</div><div>D.L. Jarvis</div><div>R. Jasrasaria</div><div>S. Jayaraman</div><div>B. Johns</div><div>J.B. Jonas</div><div>G. Karthikeyan</div><div>N.J. Kassebaum</div><div>N. Kawakami</div><div>A. Keren</div><div>J.-P. Khoo</div><div>C.H. King</div><div>L.M. Knowlton</div><div>O. Kobusingye</div><div>A. Koranteng</div><div>R. Krishnamurthi</div><div>F. Laden</div><div>R. Lalloo</div><div>M. Laslett</div><div>T. Lathlean</div><div>J.L. Leasher</div><div>Y.Y. Lee</div><div>P.N. Leigh</div><div>D.F. Levinson</div><div>S.S. Lim</div><div>E. Limb</div><div>J.K. Lin</div><div>M. Lipnick</div><div>S.E. Lipshultz</div><div>W. Liu</div><div>M. Loane</div><div>S.L. Ohno</div><div>R.A. Lyons</div><div>J. Mabweijano</div><div>M.F. MacIntyre</div><div>R. Malekzadeh</div><div>L. Mallinger</div><div>S. Manivannan</div><div>W. Marcenes</div><div>K. March</div><div>D.J. Margolis</div><div>G.B. Marks</div><div>R. Marks</div><div>A. Matsumori</div><div>R. Matzopoulos</div><div>B.M. Mayosi</div><div>R.J. McAnulty</div><div>M.M. McDermott</div><div>N. McGill</div><div>J. McGrath</div><div>M.E. Medina-Mora</div><div>M. Meltzer</div><div>F.K.F. Mensah</div><div>A. Merriman</div><div>A.-C. Meyer</div><div>V. Miglioli</div><div>M. Miller</div><div>T.R. Miller</div><div>P.B. Mitchell</div><div>C. Mock</div><div>A.O. Mocumbi</div><div>T.E. Moffitt</div><div>A.H. Mokdad</div><div>L. Monasta</div><div>M. Montico</div><div>M. Moradi-Lakeh</div><div>A. Moran</div><div>L. Morawska</div><div>R. Mori</div><div>M.E. Murdoch</div><div>M.K. Mwaniki</div><div>K. Naidoo</div><div>M.N. Nair</div><div>L. Naldi</div><div>K.M.V. Narayan</div><div>P.K. Nelson</div><div>R.D. Nelson</div><div>M.C. Nevitt</div><div>C. Newton</div><div>S. Nolte</div><div>P.E. Norman</div><div>R. Norman</div><div>M. O'Donnell</div><div>S. O'Hanlon</div><div>C. Olives</div><div>S.B. Omer</div><div>K.F. Ortblad</div><div>R.H. Osborne</div><div>D. Ozgediz</div><div>A. Page</div><div>B. Pahari</div><div>N.G. Pandian</div><div>F.B.P. Rivero</div><div>J. Patten</div><div>N. Pearce</div><div>R.P. Padilla</div><div>F. Perez-Ruiz</div><div>N. Perico</div><div>K. Pesudovs</div><div>D.E. Phillips</div><div>M.R. Phillips</div><div>A. Pierce</div><div>S.D.S. Pion</div><div>G.V. Polanczyk</div><div>S. Polinder</div><div>C.A. Pope III</div><div>S. Popova</div><div>E. Porrini</div><div>F. Pourmalek</div><div>M. Prince</div><div>R.L. Pullan</div><div>K.D. Ramaiah</div><div>S. Ranganathan</div><div>H. Razavi</div><div>M. Regan</div><div>J. Rehm</div><div>D.B. Rein</div><div>G. Remuzzi</div><div>K. Richardson</div><div>F.P. Rivara</div><div>T. Roberts</div><div>C. Robinson</div><div>F.R. de Leòn</div><div>L. Ronfani</div><div>R. Room</div><div>L.C. Rosenfeld</div><div>L. Rushton</div><div>R.L. Sacco</div><div>S. Saha</div><div>U. Sampson</div><div>L. Sanchez-Riera</div><div>E. Sanman</div><div>D.C. Schwebel</div><div>J. Scott</div><div>M. Segui-Gomez</div><div>S. Shahraz</div><div>D.S. Shepard</div><div>H. Shin</div><div>R. Shivakoti</div><div>D. Singh</div><div>G.M. Singh</div><div>J.A. Singh</div><div>J. Singleton</div><div>D.A. Sleet</div><div>K. Sliwa</div><div>E. Smith</div><div>J.L. Smith</div><div>N.J.C. Stapelberg</div><div>C.D. Steer</div><div>T. Steiner</div><div>W.A. Stolk</div><div>L. Stovner</div><div>C. Sudfeld</div><div>N. Syed</div><div>G. Tamburlini</div><div>M. Tavakkoli</div><div>H.R. Taylor</div><div>J.A. Taylor</div><div>W.J. Taylor</div><div>B. Thomas</div><div>W.M. Thomson</div><div>G.D. Thurston</div><div>I.M. Tleyjeh</div><div>M. Tonelli</div><div>J.A. Towbin</div><div>T. Truelsen</div><div>M. Tsilimbaris</div><div>C. Ubeda</div><div>E.A. Undurraga</div><div>M.J. van der Werf</div><div>J. van Os</div><div>M.S. Vavilala</div><div>N. Venketasubramanian</div><div>M. Wang</div><div>W. Wang</div><div>K. Watt</div><div>D.J. Weatherall</div><div>M.A. Weinstock</div><div>R. Weintraub</div><div>M.G. Weisskopf</div><div>M.M. Weissman</div><div>R.G. White</div><div>H. Whiteford</div><div>N. Wiebe</div><div>S.T. Wiersma</div><div>J.D. Wilkinson</div><div>H.C. Williams</div><div>S.R.M. Williams</div><div>E. Witt</div><div>F. Wolfe</div><div>A.D. Woolf</div><div>S. Wulf</div><div>P.-H. Yeh</div><div>M.A. Zaidi</div><div>Z.-J. Zheng</div><div>D. Zonies</div><div>A.D. Lopez</div>
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010http://repub.eur.nl/pub/60141/
Sat, 01 Dec 2012 00:00:01 GMT<div>T. Vos</div><div>A.D. Flaxman</div><div>M. Naghavi</div><div>R. Lozano</div><div>S. Michaud</div><div>M. Ezzati</div><div>K. Shibuya</div><div>J.A. Salomon</div><div>S. Abdalla</div><div>V. Aboyans</div><div>J. Abraham</div><div>M. Ackerman</div><div>R. Aggarwal</div><div>S.Y. Ahn</div><div>M.K. Ali</div><div>M. Alvarado</div><div>H.R. Anderson</div><div>L.M. Anderson</div><div>K.G. Andrews</div><div>C. Atkinson</div><div>L.M. Baddour</div><div>A.N. Bahalim</div><div>S. Barker-Collo</div><div>L.H. Barrero</div><div>D.H. Bartels</div><div>M-G. Basáñez</div><div>A. Baxter</div><div>M.L. Bell</div><div>E.J. Benjamin</div><div>D. Bennett</div><div>E. Bernabe</div><div>P.L. Bhalla</div><div>M. Bhandari</div><div>B. Bikbov</div><div>A.B. Abdulhak</div><div>G. Birbeck</div><div>J.A. Black</div><div>H. Blencowe</div><div>J.D. Blore</div><div>F. Blyth</div><div>I. Bolliger</div><div>A. Bonaventure</div><div>S. Boufous</div><div>R. Bourne</div><div>M. Boussinesq</div><div>T. Braithwaite</div><div>C. Brayne</div><div>L. Bridgett</div><div>C. Brooker</div><div>P. Brooks</div><div>T.S. Brugha</div><div>C. Bryan-Hancock</div><div>C. Bucello</div><div>R. Buchbinder</div><div>P. Buckle</div><div>C.M. Budke</div><div>V.C. Burch</div><div>P.G. Burney</div><div>D. Burstein</div><div>B. Calabria</div><div>B. Campbell</div><div>C.E. Canter</div><div>H. Carabin</div><div>J. Carapetis</div><div>L. Carmona</div><div>M. Cella</div><div>F. Charlson</div><div>H. Chen</div><div>A.T.-A. Cheng</div><div>Y.F. Chou</div><div>S.S. Chugh</div><div>L.E. Coffeng</div><div>S.D. Colan</div><div>S. Colquhoun</div><div>P. Colson</div><div>J. Condon</div><div>L. Connor</div><div>L.T. Cooper</div><div>M. Corriere</div><div>M. Cortinovis</div><div>K.C. de Vaccaro</div><div>W. Couser</div><div>M.R. Cowie</div><div>M. Criqui</div><div>M. Cross</div><div>K.C. Dabhadkar</div><div>M. Dahiya</div><div>N. Dahodwala</div><div>J. Damsere-Derry</div><div>G. Danaei</div><div>A. Davis</div><div>D. de Leo</div><div>F. Degenhardt</div><div>A. Dellavalle</div><div>A. Delossantos</div><div>J. Denenberg</div><div>S. Derrett</div><div>D.C. Des Jarlais</div><div>S.D. Dharmaratne</div><div>M. Dherani</div><div>C. Díaz-Torné</div><div>H. Dolk</div><div>M. Dorsey</div><div>J.M. Driscoll</div><div>H. Duber</div><div>B. Ebel</div><div>K. Edmond</div><div>A. Elbaz</div><div>S.E. Ali</div><div>H. Erskine</div><div>M.L. Erwin</div><div>P. Espindola</div><div>S.E. Ewoigbokhan</div><div>F. Farzadfar</div><div>V. Feigin</div><div>D. Felson</div><div>A. Ferrari</div><div>R. Ferri</div><div>E.M. Fèvre</div><div>F.M. Finucane</div><div>S. Flaxman</div><div>L. Flood</div><div>K. Foreman</div><div>M.H. Forouzanfar</div><div>F.G.R. Fowkes</div><div>R. Franklin</div><div>M.P. Fransen</div><div>M.K. Freeman</div><div>B.J. Gabbe</div><div>S.E. Gabriel</div><div>E. Gakidou</div><div>H.A. Ganatra</div><div>B. Garcia</div><div>F. Gaspari</div><div>R.F. Gillum</div><div>G. Gmel</div><div>D. Gonzalez-Medina</div><div>R. Gosselin</div><div>C.I. Grainger</div><div>B. Grant</div><div>M. Groeger</div><div>F. Guillemin</div><div>D. Gunnell</div><div>R. Gupta</div><div>J.A. Haagsma</div><div>H. Hagan</div><div>Y.A. Halasa</div><div>W. Hall</div><div>D. Haring</div><div>J.M. Haro</div><div>J.E. Harrison</div><div>R. Havmoeller</div><div>R.J. Hay</div><div>H. Higashi</div><div>C. Hill</div><div>B. Hoen</div><div>H. Hoffman</div><div>P.J. Hotez</div><div>D.G. Hoy</div><div>J. Huang</div><div>S.E. Ibeanusi</div><div>K.H. Jacobsen</div><div>S.L. James</div><div>D.L. Jarvis</div><div>R. Jasrasaria</div><div>S. Jayaraman</div><div>B. Johns</div><div>J.B. Jonas</div><div>G. Karthikeyan</div><div>N.J. Kassebaum</div><div>N. Kawakami</div><div>A. Keren</div><div>J.-P. Khoo</div><div>C.H. King</div><div>L.M. Knowlton</div><div>O. Kobusingye</div><div>A. Koranteng</div><div>R. Krishnamurthi</div><div>F. Laden</div><div>R. Lalloo</div><div>M. Laslett</div><div>T. Lathlean</div><div>J.L. Leasher</div><div>Y.Y. Lee</div><div>P.N. Leigh</div><div>D.F. Levinson</div><div>S.S. Lim</div><div>E. Limb</div><div>J.K. Lin</div><div>M. Lipnick</div><div>S.E. Lipshultz</div><div>W. Liu</div><div>M. Loane</div><div>S.L. Ohno</div><div>R.A. Lyons</div><div>J. Ma</div><div>J. Mabweijano</div><div>M.F. MacIntyre</div><div>R. Malekzadeh</div><div>L. Mallinger</div><div>S. Manivannan</div><div>W. Marcenes</div><div>K. March</div><div>D.J. Margolis</div><div>G.B. Marks</div><div>R. Marks</div><div>A. Matsumori</div><div>R. Matzopoulos</div><div>B.M. Mayosi</div><div>R.J. McAnulty</div><div>M.M. McDermott</div><div>N. McGill</div><div>J. McGrath</div><div>M.E. Medina-Mora</div><div>M. Meltzer</div><div>F.K.F. Mensah</div><div>A. Merriman</div><div>A.-C. Meyer</div><div>V. Miglioli</div><div>M. Miller</div><div>T.R. Miller</div><div>P.B. Mitchell</div><div>C. Mock</div><div>A.O. Mocumbi</div><div>T.E. Moffitt</div><div>A.H. Mokdad</div><div>L. Monasta</div><div>M. Montico</div><div>A. Moran</div><div>L. Morawska</div><div>R. Mori</div><div>M.E. Murdoch</div><div>M.K. Mwaniki</div><div>K. Naidoo</div><div>M.N. Nair</div><div>L. Naldi</div><div>K.M.V. Narayan</div><div>P.K. Nelson</div><div>R.D. Nelson</div><div>M.C. Nevitt</div><div>C. Newton</div><div>S. Nolte</div><div>P.E. Norman</div><div>R. Norman</div><div>M. O'Donnell</div><div>S. O'Hanlon</div><div>C. Olives</div><div>S.B. Omer</div><div>K.F. Ortblad</div><div>R.H. Osborne</div><div>D. Ozgediz</div><div>A. Page</div><div>B. Pahari</div><div>N.G. Pandian</div><div>F.B.P. Rivero</div><div>J. Patten</div><div>N. Pearce</div><div>R.P. Padilla</div><div>F. Perez-Ruiz</div><div>N. Perico</div><div>K. Pesudovs</div><div>D.E. Phillips</div><div>M.R. Phillips</div><div>A. Pierce</div><div>S.D.S. Pion</div><div>G.V. Polanczyk</div><div>S. Polinder</div><div>C.A. Pope III</div><div>S. Popova</div><div>E. Porrini</div><div>F. Pourmalek</div><div>M. Prince</div><div>R.L. Pullan</div><div>K.D. Ramaiah</div><div>S. Ranganathan</div><div>H. Razavi</div><div>M. Regan</div><div>J. Rehm</div><div>D.B. Rein</div><div>G. Remuzzi</div><div>K. Richardson</div><div>F.P. Rivara</div><div>T. Roberts</div><div>C. Robinson</div><div>F.R. de Leòn</div><div>L. Ronfani</div><div>R. Room</div><div>L.C. Rosenfeld</div><div>L. Rushton</div><div>R.L. Sacco</div><div>S. Saha</div><div>U. Sampson</div><div>L. Sanchez-Riera</div><div>E. Sanman</div><div>D.C. Schwebel</div><div>J. Scott</div><div>M. Segui-Gomez</div><div>S. Shahraz</div><div>D.S. Shepard</div><div>H. Shin</div><div>R. Shivakoti</div><div>D. Singh</div><div>G.M. Singh</div><div>J.A. Singh</div><div>J. Singleton</div><div>D.A. Sleet</div><div>K. Sliwa</div><div>E. Smith</div><div>J.L. Smith</div><div>N.J.C. Stapelberg</div><div>C.D. Steer</div><div>T. Steiner</div><div>W.A. Stolk</div><div>L. Stovner</div><div>C. Sudfeld</div><div>N. Syed</div><div>G. Tamburlini</div><div>M. Tavakkoli</div><div>H.R. Taylor</div><div>J.A. Taylor</div><div>W.J. Taylor</div><div>B. Thomas</div><div>W.M. Thomson</div><div>G.D. Thurston</div><div>I.M. Tleyjeh</div><div>M. Tonelli</div><div>J.A. Towbin</div><div>T. Truelsen</div><div>M. Tsilimbaris</div><div>C. Ubeda</div><div>E.A. Undurraga</div><div>M.J. van der Werf</div><div>J. van Os</div><div>M.S. Vavilala</div><div>N. Venketasubramanian</div><div>M. Wang</div><div>W. Wang</div><div>K. Watt</div><div>D.J. Weatherall</div><div>M.A. Weinstock</div><div>R. Weintraub</div><div>M.G. Weisskopf</div><div>M.M. Weissman</div><div>R.G. White</div><div>H. Whiteford</div><div>N. Wiebe</div><div>S.T. Wiersma</div><div>J.D. Wilkinson</div><div>H.C. Williams</div><div>S.R.M. Williams</div><div>E. Witt</div><div>F. Wolfe</div><div>A.D. Woolf</div><div>S. Wulf</div><div>P.-H. Yeh</div><div>M.A. Zaidi</div><div>Z.-J. Zheng</div><div>D. Zonies</div><div>A.D. Lopez</div><div>C.J. Murray</div><div>M. Moradi-Lakeh</div>
Systematic review of general burden of disease studies using disability-adjusted life yearshttp://repub.eur.nl/pub/75200/
Thu, 01 Nov 2012 00:00:01 GMT<div>S. Polinder</div><div>J.A. Haagsma</div><div>C. Stein</div><div>A.H. Havelaar</div>
Objective: To systematically review the methodology of general burden of disease studies. Three key questions were addressed: 1) what was the quality of the data, 2) which methodological choices were made to calculate disability adjusted life years (DALYs), and 3) were uncertainty and risk factor analyses performed? Furthermore, DALY outcomes of the included studies were compared.Methods: Burden of disease studies (1990 to 2011) in international peer-reviewed journals and in grey literature were identified with main inclusion criteria being multiple-cause studies that quantified the burden of disease as the sum of the burden of all distinct diseases expressed in DALYs. Electronic database searches included Medline (PubMed), EMBASE, and Web of Science. Studies were collated by study population, design, methods used to measure mortality and morbidity, risk factor analyses, and evaluation of results.Results: Thirty-one studies met the inclusion criteria of our review. Overall, studies followed the Global Burden of Disease (GBD) approach. However, considerable variation existed in disability weights, discounting, age-weighting, and adjustments for uncertainty. Few studies reported whether mortality data were corrected for missing data or underreporting. Comparison with the GBD DALY outcomes by country revealed that for some studies DALY estimates were of similar magnitude; others reported DALY estimates that were two times higher or lower.Conclusions: Overcoming " error" variation due to the use of different methodologies and low-quality data is a critical priority for advancing burden of disease studies. This can enlarge the detection of true variation in DALY outcomes between populations or over time.Excess weight among colorectal cancer survivors: Target for interventionhttp://repub.eur.nl/pub/63891/
Sat, 01 Sep 2012 00:00:01 GMT<div>I. Soerjomataram</div><div>M.S.Y. Thong</div><div>I.J. Korfage</div><div>S. Polinder</div><div>A. van der Heide</div><div>E. de Vries</div><div>J.A.C. Rietjens</div><div>S.J. Otto</div><div>L.V. van de Poll-Franse</div>
Background Healthy lifestyle might improve outcome among colorectal cancer (CRC) survivors. In this study we investigated the proportion of survivors who meet recommended lifestyle and weight guidelines and compared this to the general population. Factors that predict current behaviour were also assessed. Method A random sample of CRC survivors diagnosed between 1998 and 2007 were surveyed. Percentages of current smokers, alcohol consumers, excess weight and clustering of these variables were calculated. Using logistic regression we assessed demographical and clinical factors that predict current lifestyle and excess weight. Results We included 1349 (74% response rate) survivors in this study of whom only 8 and 16% of male and female survivors met the recommended lifestyle and body weight. Among male survivors up to 10% had at least two unhealthy lifestyle factors and among women, up to 19%. The proportion of smokers and those who had ever consumed alcohol was lower compared to the general population (13 vs. 31%, 82 vs. 86% respectively), but excess weight (BMI at least 25 kg/m2) was more prevalent among survivors (69 vs. 53% respectively). Having received chemotherapy was significantly associated with being overweight (adjusted odd ratio 1.5, 95% confidence interval 1.05-2.3). Younger patients, male gender and survivors of lower socioeconomic status were more likely to show non-compliance to healthy lifestyle recommendations. Conclusion The observed clustering of unhealthy lifestyle warrants interventions targeting multiple behaviours simultaneously. Reducing excess weight should be one of the most important targets of interventions, particularly for males, those who had chemotherapy and survivors of lower socioeconomic status.Costs of falls in an ageing population: A nationwide study from the Netherlands (2007-2009)http://repub.eur.nl/pub/39363/
Sun, 01 Jul 2012 00:00:01 GMT<div>K.A. Hartholt</div><div>S. Polinder</div><div>T.J.M. van der Cammen</div><div>M.J.M. Panneman</div><div>N. van der Velde</div><div>E.M.M. van Lieshout</div><div>P. Patka</div><div>E.F. van Beeck</div>
Background: Falls are a common mechanism of injury in the older population, putting an increasing demand on scarce healthcare resources. The objective of this study was to determine healthcare costs due to falls in the older population. Methods: An incidence-based cost model was used to estimate the annual healthcare costs and costs per case spent on fall-related injuries in patients ≥65 years, The Netherlands (2007-2009). Costs were subdivided by age, gender, nature of injury, and type of resource use. Results: In the period 2007-2009, each year 3% of all persons aged ≥65 years visited the Emergency Department due to a fall incident. Related medical costs were estimated at €675.4 million annually. Fractures led to 80% (€540 million) of the fall-related healthcare costs. The mean costs per fall were €9370, and were higher for women (€9990) than men (€7510) and increased with age (from €3900 at ages 65-69 years to €14,600 at ages ≥85 year). Persons ≥80 years accounted for 47% of all fall-related Emergency Department visits, and 66% of total costs. The costs of long-term care at home and in nursing homes showed the largest age-related increases and accounted together for 54% of the fall-related costs in older people. Discussion: Fall-related injuries are leading to a high healthcare consumption and related healthcare costs, which increases with age. Programmes to prevent falls and fractures should be further implemented in order to reduce costs due to falls in the older population and to avoid that healthcare systems become overburdened. Improved and standardized method for assessing years lived with disability after injuryhttp://repub.eur.nl/pub/69354/
Sun, 01 Jul 2012 00:00:01 GMT<div>J.A. Haagsma</div><div>S. Polinder</div><div>R.A. Lyons</div><div>J. Lund</div><div>V. Ditsuwan</div><div>M. Prinsloo</div><div>J.L. Veerman</div><div>E.F. van Beeck</div>