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I-25 between Cheyenne and Denver is prairie. I-25 between Denver and Colorado Springs goes up to 7,300' on Monument Hill but the grades are gentle and traffic congestion will be your biggest concern.

I-70 from Denver to Grand Junction has steep grades up to the Eisenhower Tunnel, down into Silverthorne, and over Vail Pass, and is windy through Glenwood and Debeque Canyons, but none of those sections are what I would consider treacherous.

US-24 from Colorado Springs to Woodland Park is windy with tight turns from Manitou Springs to Cascade, but it's a 4-lane divided highway through there and isn't bad.

When we lived in Parker, CO, one time we drove into RMNP and took Trail Ridge Road all the way up to the Summit. Part of the way, there was no guard rails and, when I'd look to my left, as the driver, all I seen was tree tops. Actually, my wife cried twice going up, but she made it and was very happy once we got up on top (the Summit). At one point, where we were able to pull off of the road and get out, it really looked like we were at the top of the Rocky Mountains. It was pretty cool looking! After we left the Summit, we came down by way of Granby Lake. Not as exciting as going up, but still exciting. Heck, we even seen a moose cow and her calf, just after passing over the Continental Divide.

The east side of Independence Pass has a short section that will make you grip the steering wheel a bit tighter.
The west side has a real short section where the center line disappears because, well, there isn't room for two cars.
Don't worry, neither one of these are on your planned route.

Other than those two, I can't really recall too many other sections of road that are bad.

If you go to Grand Junction, make sure you drive through the Colorado National Monument. It is spectacular.

One of only two one way jeep trails in the state. Red Cone/Webster Pass being the other.

IMO, any road can be dangerous. Some CO roads only look the part because of the sometimes steep drop offs along side. Except for some cases, like Independence Pass mentioned above, in most cases, the lanes are the same width as they are in any other state. Exercise your best defensive driving skills; be aware of your location in the road and other vehicles around you and you 'll be fine.

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