Anna Eleanor Roosevelt (11 October, 1884 – 7 November, 1962) was the First Lady of the United States from 1933 to 1945. She supported the New Deal policies of her husband, Franklin Delano Roosevelt, and became an advocate for civil rights. After her husband's death in 1945, Roosevelt continued to be an international author, speaker, politician, and activist for the New Deal coalition.

In the first known incarnation of the universe, she died at 78 years old. In the current incarnation of the universe, due to alterations in the Timeline, she died earlier, presumably sometime in the 1930s. Professor Farnsworth had invented a forward time machine that accidentally sent him along with Fry and Bender thousands of years into the future. The forward time travel allowed them to visit various periods of time. The Professor stopped the machine in the 20th century AD of the third universe to shoot Adolf Hitler, but while he succeeded in the first go-round, he missed and shot Roosevelt by mistake on the third. It is unknown who handled her husband's presidential affairs when his polio made him borderline incapable until succumbing to the disease.