Conclusions: Our observations not only depict a role for MSCs’ MVs in NSCLC phenotype but also display distinct differences between the primary and metastatic niches and may emphasize specific factors that shape disease progression. Further studies into the mechanism underlying the MVs-NSCLC cells’ contact and cargo transfer may promote the design of a therapeutic approach that will sabotage the dialogue between NSCLC cells and MSCs.

Clinical trial identification:

Legal entity responsible for the study: Meir Medical Center

Funding: Has not received any funding

Disclosure: All authors have declared no conflicts of interest.

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