There was an NYC MU that was my first foray into WOD MUs (okay, it was really HM, but I never had RP there or felt invested)... it had it's issues, but they were their own, and probably avoidable. Most notably, make sure that one staffer doesn't RP as the sheriff of sheriff-equivalent for every sphere and try to grope or diablerize you in front of non-chalant prince/heirarchs.

I'm surprised we don't get more NYC games. If someone gets it vaguely wrong, we think of NYC to be more or less like Metropolis anyhow. If we removed Superman from it, then bam, done.

This is not true for most other locations. Without staff pushing flavor and setting (normally that staff is build staff), it all becomes a generalized thought of a city anyhow, and if that city is Metropolis then there's little harm done.

“If you wish to make an apple pie from scratch, you must first invent the universe.”
― Carl Sagan, Cosmos