Research news

Researchers from the Wellcome Trust Sanger Institute have completed a detailed study of 98.3% of the sequence of human chromosome 13.
The analysis - published in Nature - shows that there are only 633 genes in this sequence - fewer than on chromosome
22, which is less than half the size of chromosome 13.

Recently developed tools and databases allowed the team to look deeper into non-coding
regions to find microRNA genes, which are thought to be involved in gene regulation.

Andy Dunham, leader of the team at The Sanger Institute, said: "Chromosome 13 has
a dramatic genomic landscape, in the centre of which is a huge 'desert' of only 47
genes. Normally we would expect about 180 genes in such a region of DNA."

Much remains to be uncovered: there are regions on chromosome 13 that appear to play
an important role in leukaemias and lymphomas, but the genes involved have not yet
been identified from the sequence - although chromosome 13 does include the well-known
BRCA2 breast-cancer predisposition gene.