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A. Personal Statement

I am a Board Certified neurologist who has
been working in aging and Alzheimers disease (AD) research for 15 years. My work
has been focused on early diagnosis and treatment of AD, in particular, developing
neuroimaging markers, including functional and structural MRI and PET amyloid
imaging, for early detection of brain dysfunction and potential outcome markers
for clinical trials. I serve as the Director of the Center for Alzheimer
Research and Treatment at Brigham and Womens Hospital, and the Director of the
Neuroimaging Core at the Massachusetts Alzheimers Disease Research Center
(ADRC) at Massachusetts General Hospital. I also had the honor of chairing the
National Institute on Aging/Alzheimers Association Workgroup on Preclinical
AD, and currently lead a large NIA Program Project, the Harvard Aging Brain
Study, working to differentiate the earliest stages of preclinical AD from healthy
aging, and an R01 developing functional imaging measures to track progression
in Mild Cognitive Impairment. I have been actively working on the design and
execution of potential disease-modifying trials in Alzheimers disease for the
past 10 years. I am the Project Leader for the recently funded ADCS
Anti-Amyloid Treatment in Asymptomatic AD (the A4) trial, a 1000 subject
secondary prevention trial in clinically normal older individuals with evidence
of amyloid pathology.

The overall goals of the PPG are to elucidate the biological
significance of amyloid deposition in the aging brain and determine if
cognitively normal older individuals are on the trajectory towards prodromal
AD.

Evolution of memory-related fMRI activation
over the course of MCI and AD

The major goal of this study is to develop functional MRI
as a biomarker for clinical trials and longitudinal studies of disease
progression in MCI and AD. The goal of the supplement is to investigate
relationship of amyloid deposition to memory dysfunction in MCI.

The overall goal
of the A4 study is to determine whether decreasing amyloid burden in clinically
normal older individuals will delay the progression of neurodegeneration and
cognitive decline.

Role: Project
Leader

P50 AG00513421 Hyman (PI) Sperling (PL)

4/30/2009 - 3/31/2014 NIH/NIA

Massachusetts Alzheimer's Disease Research Center Neuroimaging Program
and Project 1

The major goal of this project is to capture all ADRC related
neuroimaging in an electronic database and provide support to ADRC related
imaging projects.Project 1 goal is to
study cognitively normal older subjects participating in ADRC cohort with PiB
and MRI imaging to investigate markers of prodromal AD.

Role: Principal Investigator- Project 1; NeuroImaging Program Leader

10/1/10
9/30/15 NIH/NIA

Mentoring Imaging Research in Early AD

The overall goal of this Career Development Award is to provide
support for mentoring early investigators training in clinical and imaging
research in Alzheimers disease.

R01AG034556 (Buckner, PI)

7/1/09-6/30/14 NIH/NIA

Neural Processes Underlying Cognitive Aging

The major goal of this project is to investigate age-related
changes in fronto-parietal large scale networks