Opened in 2001, the Four Seasons Hotel San Francisco is a child of the hotel boom that kicked off the beginning of the new millennium. The hotel encompasses twelve floors of a 42-story skyscraper in the heart of the Yerba Buena district, just a few steps from Union Square and the Museum of Modern Art. The entire interior is an ode to contemporary elegance, but the highlight is the view: The 277 rooms have floor-to-ceiling windows that frame a fantastic prospect of San Francisco.