The Nebelwerfer 41 appears in Call of Duty 2: Big Red One. It is seen in Kasserine, being fired at Americans by the Germans using it.

They are later seen in Elmendorf Ridge, in which they are firing down on Roland Roger and other GIs around him. The whole level is made as an attempt getting rid of the "Screaming Mimis". Nebelwerfers are unusable by the player.