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He used to be a ruffian roaming the streets of London, robbing the people who were unfortunate enough to be in the wrong place, at the wrong time. One day, he happened to meet one man, who quickly disposed of his accomplices and proceeded to knock him down with a swift kick, after showing Speedwagon that he was willing to risk a few wounds because he had come for his father. Then Speedwagon noticed one thing. The man held back. Speedwagon, having asked why, he got the answer from the man that he was thinking of the possibility that Speedwagon have a family. Touched by such kindness, he decided to follow the man, named Jonathan Joestar. And he did his best to help him, like helping Jonathan to unveil the plot of Jonathan's enemy, Dio Brando, then find Dio's location after that awry incident that led to the death of Jonathan's father and the destruction of the Joestar estate. Etc...

His loyalty extended well beyond the eventual death of Jonathan to reach Jonathan's descendants. Just to say so much about his loyalty, he never tried to court Jonathan's wife, and now widow, Erina, née Pendleton, Joestar, even tho the temptation might have been here.
His final fate, I will let the people who are discovering the franchise to find out.

Thus, my pick is Hinata from Angel Beats. I loved his friendship with Otonashi...even though it was short-lived...I thought he acted a lot more like a best friend should act and the moments they shared were heartfelt and genuine.
Bromance at its best!!

Male wise, I'd have to agree he is a great one probably my favorite. (I would say it's Fukube from Hyouka, but he's too much of a MC to me to simply count as "MC's best friend" role ).

Though my favorite overall be female between Sayuri (kanon) to Mai if she counts and Miku (Symphogear) for sure.

Yeah. She's the one major protagonist that kind of got screwed over by the plot in Strawberry Panic, imo. And the sad thing is that of all the Strawberry Panic girls she struck me as the most well-balanced and not totally obsessed with any one person or issue to the point that nothing else seemed to matter to her. And yet, it was her being well-balanced this way that arguably contributed to her not getting a happier ending.