My favourite-ever Simpsons frame was in an early episode where Bart joined the 'Bright' class and blew up the lab, and the Groening Gang had the lab-rats making an orderly escape across the bottom of the screen beneath the inferno. sweet.

Bart's half-pigeom may have been inspired by the birdwoman in Tod Browning's FREAKS - Gabba gabba hey! You are one of us! (1932? Olga Baclanova?)