The Regional Centre of Advanced Technologies and Materials (RCPTM) is a scientific and research centre associated with the Faculty of Science, Palacký University, Olomouc. Its mission is to carry out advanced research and to transfer high-tech products and technologies to medical, industrial and environmental practice. We emphasize on connecting the Centre to international networks and collaborations and on involvement of early carrier stage researchers in our projects.

The structure of the eight research divisions is in accordance with the eight research programmes of the Centre. Every research division is headed by the Head of the Group who is appointed by the General Director of the Centre and is responsible to him/her. When dealing with issues of planning the research activities, he/she closely cooperates with the Scientific Director of the Centre.

Mgr. Martina Šaradínová

Publication in PLOS ONE

The publication “Enantiospecific Effects of Ketoconazole on Aryl Hydrocarbon Receptor“ was recently published in the respected journal Plos ONE (PLoS One. 2014 Jul 7;9(7):e101832, IF2012 = 3,73). The work studies enantiospecific effects of antifungal drug ketoconazole (KET) that is clinically used as a racemic mixture of two cis-enantiomers (2R,4S)-(+)-KET a (2S,4R)-(2)-KET on aryl hydrocarbon receptor (AhR) signaling pathway. The results revealed that both enantiomers are weak ligands for AhR but (+)-KET has stronger effect on induction of AhR target genes compared to (-)-KET both in human hepatoma cells HepG2 and in primary human hepatocytes.