Use "DIS10" Discount code to get 10% discount on your order. Minimum order amount should be $20.

SPECIAL NOTICE TO ALL: Never take a medication without first consulting and getting permission from your MD.Medicina Mexico knows that keeping your customers happy, secure and safe is more important than making money and will always result in repeat customers.

By checking your online account, you will see your current and prior orders including your Order Number and
any and all payments received.

Because our staff is so busy processing orders from all over the world 24/7, we were forced to make some tough decisions.We are no longer taking phone calls, nor are we updating or adding shipping information into our web servers.

We do answer all emails within 5 hours and that will never stop.

All order are shipped within 48 hours of receipt of funds unless we are out of stock on a medicine and in those cases, we are now
informing our customers of orders by email. Please do not send an email asking if your order has shipped
or requesting a tracking number. as we are too busy packaging and shipping new orders. In short, we will
not answer you unless your order is late by 30 days.
If we took the time to look up this information for all our customers, then nothing would be shipped on time.

Please NOTE: Funds received without an order number are placed into our SUSPENSE ACCOUNT until we can determine the correct owner and order number. To avoid this, please always send an email to: sales@meds.com.mx along with your order number and the fact that you made a payment.

The UNITED STATES and some other countries require a prescription on all medication sold from Mexico. They further require documentation in
English and an invoice of all medicines sold for customs. For these countries,
Medicina Mexico is now delivering your medicines to Dr. Isaac Reyes, MD (Ced. Federal 644884) (Ced. Estatal 1537-02/05)
along with the required documentation including documentation on each medication sold in English is from Wolters Kluwer.
Dr. Reyes upon receipt of your medication will issue a prescription and provide for shipping pursuant to your order.
If for any reason, Dr. Reyes fails to issue a prescription for a specific medication, then you will receive a refund or credit.

Medicina Mexico is required under Mexican law to retain the original prescription issued by Dr. Reyes.

Licensed pharmacies in Mexico are only allowed to sell medications, either brands or generics, from an approved pharmaceutical which has passed testing and has subsequently been authorized by the Mexican Government.

If you look on the left-hand side of any of our web pages at (About US) you will see our licenses, permits and our Regulatory Body.

Thiamine hydrochloride, pyridoxine hydrochloride,cyanocobalamin and involved in the metabolism of all cells in the body, buttheir main activity is exerted on nervous system cells, therefore they havebeen termed neurotropic vitamins.

Thiamine (vitamin B 1): Gastrointestinal absorption ofthiamine is ingested with food going through an active transport mechanism, andwhen administered in large doses, is absorbed by passive diffusion. The maximumabsorption limit of 8 to 15 mg per day, but this amount can be easily overcomewhen ingested in divided doses with food. The total degradation fabrics madeâ€‹â€‹from about 1 mg per day of thiamine.

When intake is less than this amount, thiamine is notexcreted in the urine, but when intake exceeds this amount, first saturatetissue deposits and subsequently appears unchanged or with its catabolite, thepyrimidine.

The functionally active form of thiamine is thiamine pyrophosphatewhich is involved in the metabolism of carbohydrates as dehydrogenases factor(ketoacidotic branched chain dehydrogenase complex piruvatodeshidrogenasa oralpha-ketoglutarate dehydrogenase) and transcetolasas. Among metabolicprocesses are affected thiamine deficiency during energy intake is inhibitedneuronal the degradation of carbohydrates, which prevents regeneration of theaxon membrane (J Nutr, 1995, 125: 189-194). In addition to participating in theprocess of synthesis of acetylcholine, thiamine pyrophosphate involved inneurotransmitter release this presynaptic membrane, since high concentrationswere found in the phosphorylated thiamine cholinergic nerve endings (Ann Neurol1993; 34: 724-726).

Pyridoxine (vitamin B 6): pyridoxine, pyridoxal andpyridoxamine are readily absorbed through the gastrointestinal system after itshydrolysed products are phosphorylated.

It is considered that the pyridoxal is the primary form thatcrosses cell membranes. The main product of excretion is 4-pyridoxic acid,formed by the action on the liver aldehidooxidasa free pyridoxal.

Cyanocobalamin (Vitamin B12): Vitamin B 12 is ingested withfood binds to intrinsic factor (glycoprotein with molecular mass of 59,000), inthe presence of gastric acid and pancreatic proteases. The vitamin B 12 complexintrinsic factor reaches the distal ileum, where it interacts with a specificreceptor located on the iliac mucosal cells and from there, is transported tothe circulation.

Besides the intrinsic factor requires the presence of bileand sodium carbonate (an appropriate pH) for the transport of vitamin B 12through the ileum.

The development of vitamin B12 deficiency, commonly, notfrom a lack in the diet if a defect in gastrointestinal absorption.

Once absorbed, vitamin B 12 binds to a plasma betaglobulinacalled transcobalamin II, for transport to the tissues.

Vitamin B 12 linked to transcobalamin II is rapidly removedfrom the plasma and stored in liver cells, so that up to 90% of body stores ofvitamin B 12 in the normal adult, or 1 to 10 mg are in the liver. Vitamin B 12is stored as active coenzyme, with a turnover rate of 0.5 to 0.8 mcg per daydepending on the body shell capacity. The minimum requirement for the vitaminper day is 1 mcg.

Approximately 3 mcg of vitamin B 12 are secreted each daythrough the bile and 50 to 60% of that amount is not intended to re-sorption.This prevents the enterohepatic cycle during bowel disease, it interferes withthe absorption, which can result in continuous depletion of hepatic stores ofvitamin. Metabolically active forms of vitamin B 12 are methylcobalamin and5-deoxyadenosylcobalamin, which are critical for growth and cell replication.

Methylcobalamin involved in transforming homocysteine â€‹â€‹tomethionine and its derivative, S-adenosinmetionina as well as the conversion of5-methyltetrahydrofolate to tetrahydrofolate.

The 5-deoxyadenosylcobalamin intervenes in the isomerizationof L-metilmalonilcoenzima A succinilcoenzima A, which promotes the synthesis offatty acids.

These metabolic actions within the nervous system leading tothe generation of ATP that is necessary for a) the synthesis of mitochondrialDNA neurons, b) for the formation of melanin axonal sheath, c) to provide thebiochemical components of neurotransmission d) to maintain the constancy of theinternal environment neuronal necessary to generate action potentials and allowtransmission at synapses (Neurology, 1995, 45: 11-16).

Plasma concentrations are directly proportional to the dose.The area under the concentration curve obtained when administered at the samedose, corresponds approximately to twice that obtained when it is applied byoral or rectal route, as the active principle is metabolized almost 50% duringits first passage through the liver (first pass effect), when administered bythe routes mentioned. The drug is extensively bound to plasma proteins (99.7%),mainly albumin and plasma half-life is about one to two hours.

Diclofenac is widely distributed in the body so thatsystemic bioavailability is only 50%, found in the highest concentrations inliver and kidney.

The drug is metabolized in the liver by cytochrome P-450isozyme subfamily 4-hidroxidiclofenaco CYP2C as a major metabolite, and otherhydroxylated forms.

After glucuronidation and sulfation, the metabolites areexcreted in the urine (65%) and bile (35%). Repeated doses produced noaccumulation of diclofenac in the normal adult. The excretion half-life is 1.2to 2.0 hours.

Diclofenac is a cyclooxygenase inhibitor, which is theenzyme that converts arachidonic acid into prostaglandins. Its power issubstantially greater than that of indomethacin, naproxen and other NSAIDs.Prostaglandins are whose synthesis is inhibited PGE 2 (50%), thromboxane TXB 1(60%) and PGF (30%).

Furthermore, the drug appears to reduce intracellularconcentrations of free arachidonate in leukocytes, possibly modifying therelease or uptake of the fatty acid.

In addition to its peripheral effect, diclofenac and othernonsteroidal antiinflammatory analgesics may have a contraceptive effect(analgesic) in the central nervous system acting on the release ofprostaglandins and / or through the neuronal systems which use andcatecholamines neurotransmitter serotonin (Pain, 1994, 57: 197-205).

WHEN NOT TO USE!

Hypersensitivity to the components of theformula. Polycythemia vera. Vitamin B 12 is not to be used in early Leber'sdisease (hereditary optic nerve atrophy).

Gastroduodenal peptic ulcer. In patients whoseattacks of bronchial asthma, urticaria or acute rhinitis are caused by aspirinor its derivatives.

PRECAUTIONS

Diclofenac: diclofenac preparations can cause allergicreactions such as swelling of the eyelids, lips, pharynx and larynx, urticaria,asthma, and bronchospasm, sometimes increased blood pressure.

Diclofenac and other drugs in its class may rarely cause gastrointestinaleffects such as bleeding and rarely hepatotoxicity, which can lead tohospitalization. Diclofenac is used in the maintenance of arthritis, but itsmain effect is as an analgesic.

Thiamine: Occasionally, individually administered thiaminecan cause hypersensitivity, especially after repeated doses, cigarillo,urticaria, nausea, cyanosis, have also been reported. Patients should beadvised that they should take proper diet, as there may be a relapse upon dosereduction or to suspend it.

Pyridoxine: Pyridoxine should not be administered topatients already receiving levodopa, because it is an antagonist of pyridoxine.However, occasionally pyridoxine may be administered in patients receivingcarbodopa jointly and levodopa. The administration of preparations withpyridoxine may cause drowsiness, paraesthesia and low levels of folic acid.

Cyanocobalamin: Patients with pernicious anemia shouldreceive monthly cyanocobalamin to maintain their levels, if it does not, cancause anemia resubmit therefore develops a degeneration in the spinal nerves.

Patients should be advised that replacing vitamin B 12 folicacid, which could cause a progressive subacute combined degeneration.

RESTRICTIONS OF USEDURING PREGNANCY AND BREASTFEEDING

Do not take during pregnancy or breastfeeding. Before takingthis medicine, you should investigate the state of the digestive, liver andkidney.

ADVERSE REACTIONS

There have been isolated reports of reactions by thelong-term parenteral administration of thiamine and vitamin B 12, which may bedue, probably, to rare cases of hypersensitivity. The mega-dose administrationof pyridoxine may cause certain sensory neuropathic syndromes, but nohistopathological studies have shown that these syndromes are associated withsome degree of neuronal degeneration. When stopping pyridoxine neuronalspreading slowly improving, until patients recover completely. Rash and other hypersensitivityreactions to any component of the formula.

DOSAGE ANDADMINISTRATION

Intramuscular deep.

A light bulb and a bulb No. 1 No. 2, mixed in the samesyringe, once a day for 2 days.

STORAGERECOMMENDATIONS

Store at room temperature to not more than 30 ° C. Protect from light.