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At some point, when Kylie Griffin began working as a Ghostbuster, she hired Eduardo to work at Ray's Occult. Despite advice from everyone around him to stay away from the Ghostbusters, Eduardo took up the job offer. [2] During a case in Mamaroneck, Kylie attempted to negotiate time and a half for coming along with Peter Venkman. After some back and forth, Peter offered 20% and he wouldn't tell Ray Stantz Kylie hired a "functional illiterate" to watch his store. [3] Months later, Eduardo went to a Day of the Dead celebration at the intersection of Central Avenue and Bleecker Street in Bushwick. He was one of many witnesses to see a projection of Santa Muerte.

One afternoon, Eduardo was watching Ray's Occult alone and signed for a package. Thinking it was Peter Venkman's latest order, Eduardo tried to call him but got no answer. He opened the package and realized it wasn't Peter's order anyway. As he looked in the arcane tome, three ancient letters rose up and Eduardo had an out of body experience. He found himself in an ancient place. Naturally, Eduardo began to freak out when it appeared nobody could hear or see him. However, Tiamat took notice of Eduardo and tasked him with delivering a message to the people of Earth. Earth was beneath her notice until the Ghostbusters defeated her brother Gozer and their escape from the Collectors' Limbo. She was coming to "play." Tiamat then blasted Eduardo and sent him back to his body. Ray Stantz and Kylie Griffin found Eduardo on the floor and called an ambulance, thinking he had missed an insulin shot. [4] Eduardo remembered the book but when he looked around, it was gone. He revealed to them there was one word in his head, "Tiamat."

Eduardo continued to insist he should get hazard pay for the emotional distress he suffered from the encounter. Weeks later, Eduardo had a shift at Ray's Occult when Special Agent Melanie Ortiz visited the shop to hear Kylie's research on Tiamat. After listening to her findings, Eduardo saw the danger mounting and suggested it was time to bring Ray in on the investigation despite Dana Barrett's wishes to keep it quiet. Kylie agreed then flipped out and yelled at him to stop shuffling his deck of cards. Eduardo was dusting around the store while Kylie took a call from Egon Spengler, who was looking for a copy of "The Johansen Argument." Eduardo appeared in the Ray's Occult segment of the Ghostbusters 101 commercial.