No display after driver install WX 7100

I have been working on a CAD machine for a civil engineering company. I have built multiple machines for them, but this machine has been a struggle. Attached are some basic specs. After I install any version of Radeon Pro drivers, the machine will not display upon reboot. I have to go into safe mode, uninstall the drivers, and then I can see the display in its normal mode using the generic driver. I have tried: older versions of drivers, reseating the gpu, reinstalling windows, and running sfc. So far, I've been stuck in this loop. I'm just hoping I didn't get a lemon of a card. Any suggestions would be helpful. Thank you!

I'm not currently in that office so I can't name both of the monitor models tested, but one of them is a Dell 22" (approx.) monitor with a resolution of 1680x1050 tested with a DP to DVI adapter. The other monitor is a Dell U2417H tested with a DP to DP cable, and a DP to MiniDP cable. The former monitor has been in use for some time and is undoubtedly operating correctly. The latter was purchased for this build and is not validated to be perfectly functional. All windows updates have been applied, chipset drivers have been installed according to my recollection of setup (can check tomorrow when I should be back in that office). I haven't tried the DDU program, so I will give that a shot when I am on-site. I will post an additional update after those options have been tried. Thank you for the quick response!

The monitor is a Dell 2209WAf. I have now verified that Windows is up to date and that chipset drivers are also installed. I used DDU in safe mode then rebooted into normal mode and installed 16.Q4, but the same issues still present themselves. Trying to boot into low resolution mode still has no video. Do you have any other suggestions or does it look like I may have to do a RMA?