Overdosage of clarithromycin can cause gastrointestinal symptoms such as abdominal pain,vomiting, nausea, and diarrhea.

Adverse reactions accompanying overdosage should be treated by the prompt elimination ofunabsorbed drug and supportive measures. As with other macrolides, clarithromycin serumconcentrations are not expected to be appreciably affected by hemodialysis or peritoneal dialysis.