The Rehabilitation Institute of Chicago announced a multimillion-dollar donation from Pat and Shirley Ryan on Wednesday that will put her name on an innovative new research hospital in Streeterville.

The AbilityLab, a $550 million, 1.2-million-square-foot research hospital under construction at 355 E. Erie, will be named the Shirley Ryan AbilityLab after the donation from the founder and former executive chairman of Aon and his wife.

Pat Ryan said the gift is the couple’s largest single gift ever but would not disclose the amount, nor would the RIC provide details. Recent naming gifts at major institutions, including the Ann and Robert H. Lurie Children's Hospital of Chicago and the Northwestern University Pritzker School of Law, have reached the $100 million mark.