Princess Leia ’s Daughter Almost Played This Major Star Wars Role

Carrie Fisher’s daughter, Billie Lourd, did make an appearance in Star Wars: The Force Awakens, but apparently not in the role she was initially gunning for.
During a Monday appearance on The Ellen DeGeneres Show, Lourd revealed that she met with director J. J. Abrams to discuss following in her mother’s Princess Leia footsteps by playing the lead in Episode VII of the galaxy far, far away saga.
“J.J. Abrams called me to come in for Star Wars because he couldn’t find someone for the lead,” she explained, referring to the role of Rey. “He ended up finding Daisy Ridley, who’s an incredible actress — so talented! But I went in and he ended up giving me this tiny role with a couple lines. I was super excited.”
Lourd also spoke about how much it meant to her to act alongside Fisher — who passed away in December at the age of 60 after suffering a heart attack — as a Resistance fighter in the film. “It was incredible,” she said. “I’m a big believer in things happening for a reason and I think I ended up in that movie for a reason. It was really incredible for us to have that experience together.”
Watch the full clip below.

AbstractPoor homing of cells after transplantation is an unresolved common issue in cardiac cell therapies. To enhance stem cell homing, the ligand CXC motif chemokine 12 (CXCL12) and its specific receptor CXC receptor type 4 (CXCR4) have been employed as a system in this study to show that induced expression of the endogenous CXCR4 gene in mouse-induced pluripotent stem cells (iPSCs) improved the cell migration. Loci-specific epigenome editing in the form of CpG demethylation at CXCR4 promoter region of the mouse iPSCs was accomplished with CXCR4b-TAL-Tet1c, chimeric fusion proteins of the catalytic domain of ten-eleven t...

In this study, we aim to investigate the effect of StemBell therapy on atherosclerotic plaques in an atherosclerotic mouse model after MI. Methods. MI was induced in atherosclerotic Apolipoprotein E–deficient mice that were fed a high-fat Western diet. Six days post-MI, the mice received either 5 × 105/100 µL StemBells or vehicle intravenously. The effects of StemBell treatment on the size and stability of aortic root atherosclerotic plaques and the infarcted heart were determined 28 days post-MI via (immuno)histological analyses. Moreover, monocyte subtypes and lipids in the blood were studied. ...

Publication date: Available online 11 August 2018Source: Cor et VasaAuthor(s): Ondřej Černý, Tomáš Roubíček, Jindřich Kupec, Rostislav PolášekAbstractDespite tremendous achievements in myocardial infarction therapy, thromboembolic complications remain very serious and its prognosis often fatal. Postinfarction cardioembolic stroke is the most frequent and has the highest mortality of all ischemic stroke subtypes. In this case report we describe cardioembolic stroke from postinfarction apical left ventricular aneurysm as a first symptom of myocardial infarction. In brief literatu...

CONCLUSIONS: In our cohort, DSE had a low sensitivity but high NPV in predicting perioperative MACE post OLT. A similar trend was noted for DSE in predicting 1-year MACE post OLT. We reiterate the need of a better screening and risk stratification tool for OLT.
PMID: 30088354 [PubMed - as supplied by publisher]