Andy Roddick burst onto the scene at the US Open more than a decade ago, firing serves and forehands at speeds and with accuracy never previously witnessed. He charged to the quarterfinals as a teenager and claimed the trophy as a 21-year-old. Today, he could be playing in his last match on his favorite stage. On his 30th birthday yesterday, Roddick announced that the 2012 US Open would be the final tournament of his illustrious career, and he brings with him a countless number of great matches and memorable moments to his encounter tonight against the youngest player in the Top 100, Australian Bernard Tomic.

As Roddick prepares to depart, a number of careers are just getting started, with two-time defending NCAA women's doubles champion Mallory Burdette, two-time defending NCAA men's singles champion Steve Johnson and 2010 men's NCAA singles winner Bradley Klahn all eyeing US Open milestones. Burdette faces 2006 champion Maria Sharapova looking to become just the fifth women's wild card to reach the fourth round at the US Open; Johnson attempts to become the first man in 17 years to win the NCAA title and advance to the third round of the US Open in the same year; and Klahn tries to become the first qualifying wild card in recorded US Open history to advance to the third round.

Also pursuing a spot in the record books is USTA Boys' 18s champion Dennis Novikov, who is bidding to become the first Boys' 18s champion since Jay Berger in 1985 to advance past the second round. Not to be forgotten, one of the leaders of the American youth movement, 20-year-old Ryan Harrison, takes on 2009 champion Juan Martin Del Potro attempting to advance to the US Open third round for the first time. Also today, John Isner revisits his 2007 US Open breakthrough against Jarkko Nieminen, Brian Baker looks to pad his resume for Comeback Player of the Year against No. 8 seed Janko Tipsarevic, and Varvara Lepchenko attempts to match her best Grand Slam result against defending champion Samantha Stosur.