This paper describes the design of an ultrasonic transducer using different lead free piezo-electric materials and evaluates their performance with different glucose levels in the human blood. COMSOL Multiphysics 4.2a was used for the simulation study using 2D axis symmetric model of piezoelectric transducer which was designed with lead free piezoelectric materials such as Barium Sodium Niobate (BNN), Barium Titanate (BT) and Lithium Niobate (LN). These piezoelectric materials are capable of being used as thin films. The potential of 10 Volt with 140 KHz frequency was applied to the device.The ultrasonic transducer with these piezo materials was observed showing different transducer response to different blood density and therefore, it can be used to measure the glucose levels in human blood.