Reproducibility

The Reproducibility Project: Cancer Biology – Experiments have begun

The RPCB is a first of its kind attempt to directly replicate a subset of high-impact, pre-clinical cancer biology papers. Importantly, the methodology, quality control steps and replication data will be open and accessible on the Open Science Framework.

We are very excited to report that 13 Registered Reports have been accepted in eLife, and experiments from 12 of those studies are underway. These include:

Before each replicating lab begins experimental work, critical reagents (often kindly shared by authors of the original studies) are quality checked. For example, all of the cell lines are authenticated and mycoplasma tested, plasmid sequences are sequenced, and rodents are pathogen tested. These quality check steps will be included on the Open Science Framework along with the data for the replication experiments themselves.

Tracking Our Progress

Keep track here as we continue to move projects forward. Our current status as of July 2015 is described below:

Phase:

Replication experiments identified for each original paper

Protocols drafted

Protocols transferred to Registered Report format

Review and feedback from original authors (requests for necessary reagents)