Methods :
A consecutive series of 11 eyes of 10 healthy subjects with acute CSC were included. In all subjects, best-corrected visual acuity was obtained followed by a full clinical examination including slit lamp biomicroscopy as well as funduscopic evaluation. All patients underwent fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTa). FA and ICGA and OCTa images were evaluated for depicting the serous detachments of the neurosensory retina and the leakage points. OCT images were evaluated by two retina specialists for depicting the serous detachments and retinal pigment epithelium (RPE) detachment as a surrogate parameter for possible leakage according to a standardized grading protocol.

Results :
FA images were able to identify the leakage point in every included study eye and serous retinal detachments in 4 out of 11 eyes. ICGA images could identify the leakage point in five out of 11 eyes and serous retinal detachments in five out of 11 eyes due to a visible “demarcation line”. SD-OCT scans revealed RPE detachment in eight out of 11 study eyes and serous retinal detachment in every included eye. OCTa images through the inner, medium, outer retina or choriocapillaris could not identify leakage points in any of the included eyes. In four out of 11 eyes, it was possible to detect detached retina adjacent to the leakage point through a visible “contour line” seen in OCTa images of the outer retina. In five out of 11 eyes we observed irregular flow patterns in OCTa images through the choriocapillaris.

Conclusions :
Non-invasive OCTa contributes little to diagnose acute CSC compared to current invasive (FA and ICGA) as well as non-invasive (OCT) imaging techniques. Detection of leakage points is not reproducable nevertheless we observed a irregular flow patterns in OCTa in five out of 11 eyes in the choriocapillaris layer.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.