Eosinophilic cholecystitis is a rare form of cholecystitis. It is believed that eosinophilic cholecystitis is associated with eosinophilic cystitis, parasitic infections, eosinophilic gastroenteritis, and drugs. We report the case of a 23-year-old female who presented with the clinical complaints of pain in epigastrium and burning sensation for 1 month. Ultrasound showed the presence of cholelithiasis. Open cholecystectomy was done. Histopathological report showed the presence of eosinophilic cholecystitis and xanthogranulomatous cholecystitis. Both these entities are rare and their association has not been reported in the literature so far. We report this case because of the rarity of its association.