For the draw of the 1st round the 80 teams will be divided into 8 groups of 10 teams. Each group consists of 5 seeded and 5 unseeded teams.

Below it is assumed that the seeded teams of the 2nd qualifying round of the UEFA Cup, and the unseeded teams of the 3rd qualifying round of the Champions League advance to the 1st round. Actually teams with lower or higher coefficients may qualify.
Round 1 (80 teams)

Once the first round has been completed, the 40 remaining clubs are drawn into 8 groups of 5 teams in accordance with the seeding principles, based on the UEFA list of club coefficients. The 40 teams will be allocated to five pots. Pot 1 will comprise the top eight clubs in the club coefficient rankings, Pot 2 the following eight clubs in the rankings, and so on for pots 3, 4 and 5. Clubs from the same association will not be drawn into the same group.

When the draw concludes and there are 8 groups of 5 teams, a computer draw will take place to determine the fixture schedule with factors such as stadium clashes and climatic conditions (it is not possible to play in some northern countries in mid-December) taken into account. Each club plays home and away alternately in its group. The following match sequence applies:
1st match day: D v B C not playing
E v A

The 24 clubs qualified from the group stage will be joined by the eight clubs that finish the group stage of the UEFA Champions League in third position. The round of 32 pairings are determined by means of a draw according to the following principles:
Clubs from the same association shall not be drawn against each other.
The group-winners of a given group shall be drawn against one of the third-placed teams from another group.
The runners-up of a given group shall be drawn against one of the eight clubs joining the competition from the group stage of the UEFA Champions League.
Group-winners and runners-up shall play the return leg at home.
Round 3 (32 teams)

1st in UC group 3rd in UC group
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2nd in UC group 3rd in CL group
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For the draw of the 4th round, quarter-finals and semi-finals no clubs will be seeded.
KEY:
* = team started in 1st qualification round
** = team started in 2nd qualification round
*** = team eliminated in 3rd qualification round Champions League
@ = qualified through Intertoto Cup
# = qualified for round 3 from group stage of the Champions League