La Jolla residents Eileen and John “Jack” R. Anderson IV have donated $25 million to Scripps Health for construction of a medical building and outpatient clinic in memory of their adult son, who died of cancer in 2004.

Scripps said Tuesday that the John R. Anderson V Medical Pavilion will be built on the Scripps Memorial Hospital La Jolla campus, with construction expected to start early next year and be completed in 2016. The six-story, 175,000-square-foot facility will be home to Scripps Clinic Medical Group specialists in cardiology, gastroenterology, pulmonology, neurology, nephrology and endocrinology. The building will include four cardiac catheterization labs.

John Anderson IV, 90, is a retired structural engineer who owned John R. Anderson and Associates, a Pasadena-based architect and engineering company.

The Andersons declined to be interviewed Tuesday, and details about their son were not available.

The couple seem to have focused their philanthropy on Scripps Health. Since 1985, Anderson and his 83-year-old wife have supported programs in cardiology, orthopedics, internal medicine and urgent care at Scripps Clinic and Scripps Green Hospital, according to Scripps officials, although they would not say how much the couple has donated overall.

In a news release, John Anderson said, “We felt this donation would be an appropriate way to pay tribute to our son John and give others the opportunity to benefit from the medical expertise that our family has trusted over the past three decades.

“John had a lot of things in common with Scripps — he was very smart, innovative and could fix just about anything.”

The gift comes as Scripps Memorial in La Jolla is undergoing a 25-year, $2 billion reconstruction and expansion that includes three new hospital towers. The first seven-story tower, the Prebys Cardiovascular Institute, is under construction and expected to open in 2015. That $456 million building is named for developer and philanthropist Conrad Prebys, who donated $45 million toward its construction.

The Andersons’ gift is among the largest that Scripps Health has received after the Prebys donation.

“We are extremely grateful for the long-standing philanthropic support of the Anderson family, and are thrilled by this most recent contribution,” said Scripps Health Chief Executive Chris Van Gorder. The building “will serve as an integral part of the 25-year master plan to rebuild Scripps Memorial Hospital La Jolla and will help serve the community’s health care needs well into the 21st century.”