Study selection and assessment:

randomised controlled trials (RCTs) that compared mild therapeutic hypothermia (local or systemic therapeutic cooling [using
a fluid filled cooling blanket, a “Bear Hugger” air cooling device, ice water lavage, or combination, or other method] to
a target temperature ⩽34–35°C for ⩾12 hours beginning on admission to the intensive care unit or when intracranial pressure
[ICP] became uncontrollable by conventional management) with control (open or normothermia) in patients with any closed head
injury requiring hospital admission. Individual study quality was assessed based on allocation concealment and blinding …