As is the case for all administrative supplements, research proposed under this announcement must be within the original scope of the parent grant. Applicants should propose research that, if successful, would contribute to a greater understanding of the implications of sex/gender differences (or similarities) in human health or disease outcomes. Applicants may use the following approaches to address sex/gender comparisons:

The addition of another group of subjects (human or animal) of the opposite sex when subjects of only one sex were used in the original study for comparative analyses of sex/gender. Applicants proposing to use subjects of only one sex/gender will be considered non-responsive UNLESS the data will be compared with those from the opposite sex within the administrative supplement period;

The addition of more subjects (human or animal) of both sexes to sufficiently power a study that was insufficiently powered to conduct or detect a sex/gender difference (or similarity) in the original study; or

The analyses of preexisting data where sex-specific data are included and power is sufficient, but a sex/gender analysis was not performed as part of the original study.

The National Institute on Drug Abuse (NIDA) at the National Institutes of Health is an agency of the United States Department of Health and Human Services