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open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Abstract

Background:

Hepatitis B (HBV) vaccination is an important preventive intervention for HIV-infected population. Data regarding booster HBV vaccine for persons with low HBV surface antibody (sAb) titers after vaccination in this immunocompromised population is lacking.

Methods:

We randomized 60 HIV-infected subjects lacking HBV protection after completion of 3 doses of HBV vaccine to receive a booster dose of HBV vaccine with 250mcg GM-CSF as an adjuvant or booster vaccine alone.

Results:

GM-CSF was safe with expected side effects. However, only 35% of persons receiving GM-CSF developed protective sAb while 50% in vaccine only arm developed protection (P = 0.47). Overall, only 28% of subjects maintained protective sAb 1 year after vaccination.

Conclusions:

GM-CSF failed to improve responses to the booster HBV vaccination. Overall, response was poor with only 42% of persons responding at one month post-vaccination confirming booster vaccination with the current HBV vaccine has poor immunogenicity among HIV-infected persons. Further research is needed to develop optimal vaccination strategies in HIV-infected persons.

About the Editor

Biography of Marco Ciotti

I got my degree in Medicine 1n 1989, at the University of Rome “La Sapienza”. Following my degree, I specialized in Oncology in 1994 at the University of Rome “Tor Vergata”. In the same University, I specialized in Microbiology and Virology in 2001.

I spent a period of research at the National Institute of Health, MD, USA, where I worked in the laboratory of Genetic Disorders of Drug Metabolism, Heritable Disorders Branch, National Institute of Child Health and Human Development.

Since 2002, I work in the laboratory of molecular virology of the Polyclinic Tor Vergata Foundation, Rome, Italy.

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Three more Bentham Science Journals indexed in The Emerging Sources Citation Index (ESCI) by Thomson Reuters

News release date: June 6, 2017

Description:

Thomson Reuters has selected the following Journals published by Bentham Science Publishers for coverage in The Emerging Sources Citation Index (ESCI). ESCI is a new index launched by Thomson Reuters, extending the universe of publications in Web of Science to include high-quality, peer-reviewed publications of regional importance and in emerging scientific fields.

The Emerging Sources Citation Index (ESCI) is a new index launched by Thomson Reuters, extending the universe of publications in Web of Science to include high-quality, peer-reviewed publications of regional importance and in emerging scientific fields.

Adolescent Psychiatry publishes original research, critical reviews of topics relevant to practitioners, clinical observations with analysis and discussion, analysis of philosophical, ethical or social aspects of the fields of psychiatry and mental health, case reports with discussions, letters, and position papers.

Clarivate Analytics (formerly Thomson Reuters Intellectual Property & Science business) has selected the Bentham Science journal Current Molecular Pharmacology for coverage in the Science Citation Index (SCI). The Science Citation Index (SCI) is a citation index originally produced by the Institute for Scientific Information (ISI) and is made available online through different platforms, such as the Web of Science and SciSearch.

Current Molecular Pharmacology publishes the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action.

Clarivate Analytics (formerly Thomson Reuters Intellectual Property & Science business) has selected the Bentham Science journal Current Psychiatry Reviews for coverage in The Emerging Sources Citation Index (ESCI). ESCI is a new index, extending the universe of publications in Web of Science to include high-quality, peer-reviewed publications of importance in emerging scientific fields.

Current Psychiatry Reviews publishes frontier review articles and guest edited issues dedicated to clinical research on all the latest advances on clinical psychiatry and its related areas e.g. pharmacology, epidemiology, clinical care and therapy. The journal is essential reading for all clinicians, psychiatrists and researchers in psychiatry.

MEDLINE indexes Pharmaceutical Nanotechnology

News release date: March 10, 2017

Description:

Pharmaceutical Nanotechnology, an important journal published by Bentham Science, is accepted to be included in MEDLINE. MEDLINE is the U.S. National Library of Medicine® (NLM) premier bibliographic database that contains more than 23 million references to journal articles in life sciences with a concentration on biomedicine. A distinctive feature of MEDLINE is that the records are indexed with NLM Medical Subject Headings (MeSH®). For more information, view: https://www.nlm.nih.gov/pubs/factsheets/medline.html/

Pharmaceutical Nanotechnology publishes original manuscripts, reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterization and pharmaceutical (or diagnostic) application of materials at the nanoscale.

Bentham Science among Top 14 Publishers indexed in Scopus

News release date: February 08, 2017

Description:

Scopus recently released information about the published content hosted by the service. According to the information presented, Bentham Science is among the top 14 publishers which have their publications indexed in Scopus.

Bentham Science will continue to expand on its product portfolio in line with its mission to facilitate the publication of latest research around the globe. We are also committed to increasing the exposure of researchers who publish their work with us.

About Scopus

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings. Delivering a comprehensive overview of the world's research output in the fields of science, technology, medicine, social sciences, and arts and humanities, Scopus features smart tools to track, analyze and visualize research.

Bentham Science Publishers is a major publisher of over 100 peer reviewed journals and 600 eBooks. Some of the notable Bentham Science journals that have received ISI Impact factor (IF) rankings are Current Neuropharmacology (IF 3.75) Current Cancer Drug Targets (IF 3.71), Recent Patents on Anti-Cancer Drug Discovery, (IF 3.53), Current Medicinal Chemistry (IF 3.46) among other titles.

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