This hypothesis has been refuted by respected medical journals like Science and Nature based on several studies. Koprowski's vaccine was made form monkeys not chimpanzee kidneys. Tests done on the vaccine showed no contamination from HIV or SIV.

The hypothesis is contrary to HIV epidemiology. It is known that the AIDS epidemic was well underway between 1910-1930. These vaccine trials were conducted in late 50s and early 60s.