Levocetirizine (Includes Levrix) ↔ renal impairment

The use of levocetirizine is contraindicated in patients with end-stage renal disease (CrCl < 10 mL/min), and in patients undergoing hemodialysis. It is also contraindicated in pediatric patients (ages 6 months to 11 years) with impaired renal function. Levocetirizine is excreted by the kidneys and the risk of adverse reactions is greater in patients with renal impairment. Caution is advised.

Moderate

Levocetirizine (Includes Levrix) ↔ urinary retention

Urinary retention has been reported postmarketing in patients using levocetirizine. Caution is advised in patients with predisposing factors of urinary retention such as patients with prostatic hyperplasia, or spinal cord lesions.