Topic(s):

Zaproszenie do składania wniosków:

System finansowania:

RIA - Research and Innovation action

Cel

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers.

The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.

Powiązane informacje

Open Access

Koordynator

NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS

Italy

Wkład UE: EUR 833 487,50

VIALE MEDAGLIE D'ORO 30500136 ROMEItaly

Activity type: Research Organisations

Uczestnicy

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH

Austria

Wkład UE: EUR 972 708,75

DONAU CITY STRASSE 1 TECH GATE VIENNA1220 WIENAustria

Activity type: Research Organisations

USTAV FOTONIKY A ELEKTRONIKY AV CR V.V.I.

Czech Republic

Wkład UE: EUR 313 125

KOBYLISY CHABERSKA 57182 51 PRAHA 8Czech Republic

Activity type: Research Organisations

ISTITUTI FISIOTERAPICI OSPITALIERI

Italy

Wkład UE: EUR 407 375

VIA CHIANESI 5300144 ROMAItaly

Activity type: Research Organisations

UNIVERSITEIT TWENTE

Netherlands

Wkład UE: EUR 343 750

DRIENERLOLAAN 57522 NB ENSCHEDENetherlands

Activity type: Higher or Secondary Education Establishments

UNIVERSITAET SIEGEN

Germany

Wkład UE: EUR 307 300

HERRENGARTEN 357072 SIEGENGermany

Activity type: Higher or Secondary Education Establishments

UNIVERSITA DEGLI STUDI DI FERRARA

Italy

Wkład UE: EUR 213 750

VIA ARIOSTO 3544121 FERRARAItaly

Activity type: Higher or Secondary Education Establishments

Teknologian tutkimuskeskus VTT Oy

Finland

Wkład UE: EUR 630 536,25

VUORIMIEHENTIE 302150 EspooFinland

Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)