Simply move the probe to Bregma and touch the zeroing button. Once all displays read zero, move the probe until each of the three axes displays the desired coordinates.

Leica manipulators include a low mounted manual fine drive on the dorsal ventral manipulator to minimize hand generated vibration of the probe, and avoid overshoot. In addition, this manipulator includes a high torque compression clamp system on the tilt mechanism for the greatest stability.