Ganetespib (STA-9090) is an investigational drug. It is an Hsp90 inhibitor: It works by blocking Hsp90 (heat shock protein 90), a molecular chaperone that plays a role in cell signaling. Hsp90 has been studied in previous trials that have enrolled patients with HER2-positive tumors. It may also be an effective way to treat triple negative (ER-,PR- and HER2-) breast cancer. The purpose of this study is to determine if ganetespib is effective in the treatment of patients with HER2+ or triple negative breast cancer who have not received prior systemic treatment for metastatic disease.hibition may be an important new approach to treating triple negative breast cancer.
This is a Phase II trial