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For the last three to four years neurologists have been talking about the coming of a much more effective drug for MS. That drug was first called Antegren and then Tysabri. The story of Tysabri illustrates some risky and unsavory aspects of the search for an effective drug for MS.

Tysabri is a humanized, monoclonal antibody that is produced by transgenic goats in their milk. A ...

Came across this article on monoclonal antibodies. Interesting to say the least.

Harry

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Nature Biotechnology 23, 1025 (2005)
doi:10.1038/nbt0905-1025
King in the kingdom of uncertainty

Monoclonal antibodies (mAbs) are not good drugs, at least they are not good drugs in any conventional sense. Many of the fundamental qualities of mAbs are just the sort of characteristics that used to make pharmaceutical manufacturers run a mile.

Most fundamentally, they are biological molecules and hence intrinsically ...

CAMBRIDGE, Mass. --The head of Biogen Idec Inc. said in an interview Wednesday his company will recommend to regulators within a month that the warning label be strengthened on a multiple sclerosis drug the company hopes to return to the market despite safety ...

After months of waiting, Biogen Idec (nasdaq: BIIB - news - people ) and Elan (nyse: ELN - news - people ) are finally having a good day--but investors should be careful not to be too exuberant about hopes for their beleaguered drug.

The two biotech firms have finished their safety review of Tysabri, the multiple sclerosis drug that ...

Thought I would point out that the New England Journal of Medicine out today has three articles following up on Tysabri and PML along with an editorial. I only get the abstracts and can't really tell what the key points are, but maybe one of you has better access or better insight into what is written.

Please read this one (above) carefully. MY question from reading this is: Did this woman even ever have MS at all??? Did the autopsy ever find lesions indicative of MS at all? Her neurological examination and symptom(s) presentation is/was almost exactly ...

Here is another Boston Globe press release that just provides a tad bit more detail as to the allegations contained in the lawsuit against Biogen/Elan .

It almost sounds like me talking (a few months ago). How odd, huh? I will highlight.

Please also note below some clarification regarding "informed consent" (i.e. clinical "waivers") that I tried to explain many times in the past (very passionately, I might add), and which I just answered ...

'Biogen Idec, the US biotech company, sold a new factory to Genentech, a US rival for $408 million (£223 million). It was built to make Tysabri, the multiple sclerosis drug withdrawn amid brain disease fears'.

Perhaps this indicates that Biogen is not confident of the drug returning in the near future.

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