Article Figures & Data

Figures

Sequences of the CDRs of anti-HCMV and anti–S. pneumoniae Abs. (A) Sequences of the κ L chains. (B) Sequences of the γ H chains. Residues listed in red letters result from the addition of untemplated bases by the enzyme TdT. *, residue Ser52A(H) in CDRH2. Gene names and numbers are available at: http://www.imgt.org.

Superimposition of the backbone tracings of anti-HCMV and anti–S. pneumoniae Abs. α-Carbon backbone tracings of the variable regions of anti-23F Fabs 023.102 (purple), C05 (magenta), anti-HCMV Fabs KE5 (dark blue), and 8F9 (cyan). Also displayed are the disulfide bonds (yellow) of the CDRH3 loops of Fab C05 and Fab 8F9. Major conformational differences are restricted to the CDR3 loops. Note that the conformation of the CDRL1 of Fab 023.102, probably due to disorder, deviates from the consensus conformation.