Tumor necrosis factor alpha (TNF-alpha) is a key cytokine
regulator of the immune process and of the tissue homeostasis.
The production of TNF-alpha is mainly controlled
post-trascriptionally by cis-elements located in the
3'-UTR and which regulate mRNA stability and translation
efficency. In addition to a class II AU-rich element
(ARE2) previously found in the 3'-UTR of TNF-alpha mRNA,
another RNA binding motif has been characterized
about 150 nt downstream. This element contains ......