Fuck my Friends.
Someone who has completely distanced himself from his friends, becoming someone who no longer has any. For whatever reason, he/she has decided to fuck having/talking to their friends, hence the term, Fuck my Friends.

Dude what the fuck is wrong with Kyle?
Lol damn, I guess Kyle is going FMF

fuck me friday - commonly occurs sometime late morning or early afternoon on a work friday when you've set cruise control, thinking about the weekend, when some work related shit show happens to ruin the vibe.

I can't believe that my as swipe boss gave me all this shit that has to be finished by end of day today, and it's already friday afternoon; fuck me! This is classic FMF.