--------------"But it's disturbing to think someone actually thinks creationism -- having put it's hand on the hot stove every day for the last 400 years -- will get a different result tomorrow." -- midwifetoad

The three-dimensional shape of a protein is determined by interactions between various amino acids. During evolution, the structure and activity of proteins often remain the same across species, even if the amino acid sequences have changed. This is because pairs of amino acids that interact with each other tend to ‘co-evolve’; that is, if one amino acid changes, then the second amino acid also changes in order to accommodate it. By identifying these pairs of co-evolving amino acids, it is possible to work out which amino acids are close to each other in the three-dimensional structure of the protein. This information can be used to generate a structural model of a protein using computational methods.

Now, Ovchinnikov et al. developed a new method to predict the structures of proteins that combines data on the co-evolution of amino acids, as identified by GREMLIN with the structural prediction software called Rosetta....

The seemingly limitless diversity of proteins in nature arose from only a few thousand domain prototypes, but the origin of these themselves has remained unclear. We are pursuing the hypothesis that they arose by fusion and accretion from an ancestral set of peptides active as co-factors in RNA-dependent replication and catalysis. Should this be true, contemporary domains may still contain vestiges of such peptides, which could be reconstructed by a comparative approach in the same way in which ancient vocabularies have been reconstructed by the comparative study of modern languages. To test this, we compared domains representative of known folds and identified 40 fragments whose similarity is indicative of common descent, yet which occur in domains currently not thought to be homologous. These fragments are widespread in the most ancient folds and enriched for iron-sulfur- and nucleic acid-binding. We propose that they represent the observable remnants of a primordial RNA-peptide world

--------------"[...] the type of information we find in living systems is beyond the creative means of purely material processes [...] Who or what is such an ultimate source of information? [...] from a theistic perspective, such an information source would presumably have to be God."