Title

Author

Date of Award

2011

Document type

Thesis

Degree Name

PhD (Doctor of Philosophy)

First Supervisor

Professor Mauro Adamo.

Keywords

Chemistry, Pharmaceutical.

Abstract

The present work dealt with the preparation of some key intermediates and their use for the generation of chemical diversity. In Chapter 2 we described a Catalytic Asymmetric Conjugate Addition of isocyanoacetates to 4-nitro-5-styrylisoxmles. In Chapter 3 we described a new strategy for the preparation of medium sized oxepanes oxocanes and oxonanes. In Chapter 4 we described a novel route to alkene-hctionalised monobactams and their potential in diversity oriented synthesis is still in progress.