Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )

Length:

111

Sequences:

513

Seq/Len:

4.62

HH_delta:

0.704 (20Jul13)

GREMLIN Results:
Residue pairs sorted by strength in covariance:Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

i

j

Raw Score

Scaled Score

88_H

98_A

0.51129

3.759

32_K

35_S

0.38826

2.855

36_N

39_R

0.35084

2.580

40_N

43_T

0.29961

2.203

87_I

106_N

0.24636

1.811

11_R

15_D

0.22973

1.689

101_V

105_I

0.22845

1.680

104_I

108_Y

0.22589

1.661

98_A

102_S

0.21818

1.604

20_A

81_V

0.21557

1.585

99_L

102_S

0.21329

1.568

49_E

96_K

0.19362

1.424

23_L

90_A

0.18844

1.386

88_H

91_M

0.1845

1.357

47_I

85_L

0.18424

1.355

48_K

51_S

0.18357

1.350

74_G

77_Q

0.18153

1.335

12_R

28_G

0.18068

1.328

53_E

56_I

0.17487

1.286

73_N

77_Q

0.1727

1.270

83_P

106_N

0.16879

1.241

101_V

104_I

0.16763

1.233

70_K

73_N

0.16611

1.221

99_L

103_K

0.16526

1.215

46_L

85_L

0.16299

1.198

24_C

89_Y

0.16271

1.196

83_P

87_I

0.16248

1.195

42_S

49_E

0.15991

1.176

91_M

102_S

0.15846

1.165

46_L

99_L

0.15807

1.162

55_N

58_K

0.15522

1.141

46_L

98_A

0.14797

1.088

51_S

58_K

0.14784

1.087

33_R

36_N

0.14741

1.084

46_L

102_S

0.1464

1.076

69_I

75_R

0.14485

1.065

9_I

12_R

0.14444

1.062

96_K

100_K

0.14415

1.060

51_S

55_N

0.14367

1.056

41_K

45_E

0.14273

1.049

34_P

76_I

0.14119

1.038

19_N

82_H

0.14109

1.037

34_P

89_Y

0.14103

1.037

46_L

88_H

0.14038

1.032

37_W

43_T

0.13864

1.019

7_E

17_Y

0.13785

1.014

66_S

72_K

0.13536

0.995

91_M

98_A

0.13522

0.994

72_K

77_Q

0.13482

0.991

70_K

74_G

0.13469

0.990

92_W

96_K

0.13366

0.983

24_C

32_K

0.13158

0.967

18_I

21_T

0.13066

0.961

54_Y

58_K

0.13051

0.960

74_G

89_Y

0.13034

0.958

23_L

101_V

0.1297

0.954

84_E

103_K

0.12892

0.948

44_K

47_I

0.12871

0.946

9_I

14_E

0.12817

0.942

32_K

36_N

0.12782

0.940

24_C

34_P

0.12646

0.930

9_I

15_D

0.12573

0.924

49_E

92_W

0.12564

0.924

69_I

72_K

0.12515

0.920

82_H

105_I

0.12387

0.911

24_C

36_N

0.12361

0.909

35_S

40_N

0.12343

0.908

52_E

55_N

0.12223

0.899

7_E

11_R

0.12194

0.897

35_S

44_K

0.12157

0.894

21_T

24_C

0.12129

0.892

71_G

77_Q

0.11949

0.879

17_Y

21_T

0.11786

0.867

81_V

86_A

0.11694

0.860

19_N

105_I

0.11621

0.854

87_I

102_S

0.11577

0.851

37_W

80_Y

0.11569

0.851

44_K

48_K

0.11506

0.846

68_V

73_N

0.11492

0.845

35_S

39_R

0.11486

0.845

79_T

99_L

0.11472

0.843

95_P

98_A

0.11395

0.838

88_H

102_S

0.11345

0.834

27_F

93_I

0.11344

0.834

97_F

101_V

0.1128

0.829

11_R

14_E

0.11073

0.814

26_A

90_A

0.11023

0.810

39_R

44_K

0.1102

0.810

83_P

102_S

0.10989

0.808

17_Y

82_H

0.10973

0.807

71_G

79_T

0.10972

0.807

81_V

91_M

0.10876

0.800

50_L

55_N

0.10856

0.798

18_I

81_V

0.10841

0.797

53_E

57_S

0.10701

0.787

8_V

19_N

0.10515

0.773

52_E

57_S

0.10504

0.772

37_W

47_I

0.10477

0.770

24_C

91_M

0.1043

0.767

7_E

25_K

0.10286

0.756

23_L

26_A

0.10268

0.755

23_L

93_I

0.10233

0.752

81_V

89_Y

0.10186

0.749

100_K

107_E

0.10179

0.748

16_G

83_P

0.10152

0.746

9_I

106_N

0.10103

0.743

49_E

95_P

0.10068

0.740

106_N

109_H

0.10036

0.738

84_E

89_Y

0.10007

0.736

51_S

54_Y

0.09988

0.734

40_N

65_I

0.09985

0.734

68_V

74_G

0.09974

0.733

68_V

77_Q

0.09967

0.733

71_G

74_G

0.09878

0.726

21_T

79_T

0.0985

0.724

19_N

22_K

0.09812

0.721

23_L

91_M

0.09784

0.719

36_N

53_E

0.09778

0.719

46_L

91_M

0.09732

0.716

51_S

57_S

0.09732

0.716

84_E

99_L

0.09728

0.715

48_K

55_N

0.0971

0.714

86_A

90_A

0.09706

0.714

28_G

33_R

0.09631

0.708

51_S

56_I

0.09608

0.706

7_E

12_R

0.09591

0.705

53_E

65_I

0.0958

0.704

105_I

108_Y

0.09579

0.704

46_L

49_E

0.0954

0.701

92_W

97_F

0.09537

0.701

50_L

58_K

0.09487

0.698

84_E

106_N

0.09478

0.697

25_K

44_K

0.09455

0.695

17_Y

83_P

0.09442

0.694

8_V

11_R

0.09433

0.694

94_S

97_F

0.09427

0.693

90_A

97_F

0.09416

0.692

65_I

71_G

0.09386

0.690

8_V

17_Y

0.09335

0.686

32_K

93_I

0.09255

0.680

Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.

HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits: Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)