At the 2007 French Open he reached the third round, as a wildcard, after a second-round victory against CzechRadek Štěpánek in five sets, 3–6, 6–1, 0–6, 6–4, 6–4. He also reached the third round at Wimbledon, beating 24th seed Juan Ignacio Chela in straight sets along the way, and made the top 100 for the first time as a result. On 16 July 2007 he reached a career-best ranking of 82.

In 2012, Roger-Vasselin had considerable success on the ATP Tour in doubles. He won tournaments in Montpellier, Marseille, and Metz, all partnered with Nicolas Mahut. He also made it to the quarterfinals at Wimbledon for the first time teamed with James Cerretani. They were defeated by the eventual champions Jonathan Marray and Frederik Nielsen in five sets.

At the DelRay Beach International Championships, Roger-Vasselin defeated four opponents including top seed John Isner to reach his first ATP tournament final. He lost to Ernests Gulbis for the title. In doubles, he won two titles, at the Hall of Fame Classic in Newport, Rhode Island partnering Nicolas Mahut and in Atlanta partnering Dutchman Igor Sijsling.

He made the semifinals in doubles at Wimbledon partnering Rohan Bopanna.

Vasselin made a breakthrough in the indoor part of the season when he has reached semifinals of the ATP 500 event in Basel, upsetting home favorite Stanislas Wawrinka in the first round. He lost to Juan Martin Del Potro, after winning the first set. He finished the year a career-high no. 53.[1]

Roger-Vasselin had a good beginning to his singles campaign, reaching the final in Chennai (l. to Stan Wawrinka). He reached the quarterfinals in Montpellier and Marseille, losing to Jerzy Janowicz and Jo-Wilfried Tsonga, respectively. He also reached the quarterfinals on grass in Eastbourne, losing to Denis Istomin. The rest of his singles season was relatively disappointing.

The pair won the title in Marseille in February, beating Paul Hanley and Jonathan Marray in the final. Another quarterfinal followed in Acapulco, where they lost to Treat Huey and Dominic Inglot. Then, they went out in the round of 16 in both Indian Wells and Miami. The pair made another quarterfinal, this time at a Masters 1000 event, in Monte Carlo, losing to the Bryan brothers. They followed this up with a semifinal appearance in Nice.

The highlight of his year was the French Open, which he and Benneteau won against the Spanish pair of Marcel Granollers and Marc López.

Won tournament; or reached Final; Semifinal; Quarter-final; Round 4, 3, 2, 1; competed at a Round Robin stage; lost in Qualification Round; absent from tournament event; played in a Davis Cup Zonal Group (with its number indication) or Play-off; won a bronze, silver (F or S) or gold medal at the Olympics; a downgraded Masters Series/1000 tournament (Not a Masters Series); or a tournament that was Not Held in a given year.

To avoid confusion and double counting, these charts are updated either at the conclusion of a tournament, or when the player's participation in the tournament has ended.