Normally, I wouldn't presume to give my opinions, but since I've got a team playing in San Antonio that's in first by 10 games, I'll take a shot... Priority on offense is getting as many free bases as possible, so batting eye, base running and bunting become more important. HR to LF is the only thing not negatively impacted by the park, so any slow guys should have good power to left (need to know batting hand and push pull tendency). Defensively,, avoid free bases (wow this is profound). For catchers, throwing arm and accuracy are much more important than pitch calling here - the park will limit baserunners on it's own, so you want to keep them where they're at. It's very important that defenders, especially up the middle meet at least minimum ratings for position, There is no safe place to hide a fielder with a supbar rating here, unless maybe a rock with a rocket in RF. For pitching, you can accept somewhat lower splits than normal (though Diego Bennet should not be in the majors, anywhere), but you need high control (again, no free baserunners) As for the scouting question, go opposite of whatever most others in the league do.

My theory is a bit more simple: Hitters park, their hitters have the same advantages as your hitters do. Pitchers park, their pitchers have the same advantages as your pitchers do. And vice-versa on disadvantages.

True only half your games are home games. The other half are played in 15 different parks. Some of those parks will also be pitchers parks (if not as extreme). So if you maximize for your home park, you give yourself a slight edge in 81+ games, depending on how many people chose similar parks in your world. As for the pitching question, don't bother. Lefties are not neccesarrily going to hit to right field - push/pull is also a factor. Just put your best possible pitchers out there and don't worry about throwing hand.