Right now, it’s unclear what will happen with Denver LB D.J. Williams, who was charged early Friday morning with a DUI – his second alcohol-related charge since 2005. He didn’t practice Friday, and coach Josh McDaniels expressed disappointment with Williams – who’s been one of the best defenders on the squad this season.

He could play this Sunday, but he’s looking at discipline from the NFL at some point and probably from the Broncos as well. That said, he very well could be out there this weekend. You’ll remember that when Braylon Edwards was charged with DWI in September, he played the very next week.

Kansas City rookie WR Dexter McCluster – who’s missed the past two games with a high ankle sprain – is listed as questionable and will be a gametime decision. He was limited at practice all week, and if he could play Sunday, he’d be a big boon to the Chiefs. Aside from McCluster, OG Brian Waters, S Kendrick Lewis and S Jon McGraw are questionable.

The big blow for the Giants will be that WR Steve Smith won’t play because of a partially torn pectoral muscle he suffered in Thursday’s practice (luckily for him and his team, it doesn’t appear to be a season-ending injury). His team will miss his production, and Hakeem Nicks will miss Smith’s ability to take some of the opposing secondary’s attention off him. Mario Manningham should get more playing time in place of Smith.

We also could see the return of T Will Beatty, who’s been out since mid-September with a broken foot. This week, he started doing agility and footwork drills for the first time since his surgery, and he’s listed as questionable on the injury report. RB Brandon Jacobs, who missed Wednesday’s practice with an illness, is probable.

For Dallas, CB Terence Newman hasn’t been himself since he hurt his ribs three weeks ago, and he’s been burned for big gains and big touchdowns because he’s having a tough time accelerating. Considering the Cowboys are thin in the secondary, Newman likely will continue to play. He had full participation in practice all week and is probable.

Arizona RB Beanie Wells just cannot seem to get healthy. Once again, he’s listed as questionable this week after missing practices Wednesday and Thursday (he was limited Friday) with continued swelling in his knee. It’s not just the fact he’s hurt. He’s also missing valuable practice time, and that combination does not bode well for him. He played last week, but carried just once for minus-two yards. Until he’s healthy, Tim Hightower will get the bulk of the carries.

DL Darnell Dockett, one of the Cardinals most important defenders, suffered a shoulder stinger in last week’s loss to Minnesota, and he’s questionable. He practiced all week (albeit in a limited fashion), but he seems likely to play. LB Paris Lenon, who aggravated an ankle injury last week, also is questionable to play. But he progressed well this week, and he very well could play as well.

Seattle, once again, could miss first-round pick LT Russell Okung, who’s been battling injuries all season. Now, he’s dealing with an ankle injury, and the Seahawks listed him as questionable to play. Without him, the Seahawks likely will start G Chester Pitts in his place.

Obviously, the big absence for San Francisco is starting QB Alex Smith, who is out with a left shoulder injury. Troy Smith will get the start in his place. Considering he helped lead San Francisco to a big win against the Broncos two weeks ago in London, Troy Smith deserves another shot this week against San Francisco. Plus, as LB Takeo Spikes told me recently in Five Questions (or More), Smith’s presence in the pocket was a comfort to the team.