Abstract : The UCLA/USC Tissue Bank was established to provide research investigators with a ready source of human tissue samples for basic and clinical research projects directed at a greater understanding of various aspects of human breast cancer. The bank has been successful at accruing some 1020 tissue samples to 5 of the 6 subcomponent banks comprising the main bank. Of these tissues, 371 are breast cancer specimens while the remaining represent specimens from premalignant and non-malignant breast tissue, normal breast tissue, normal non-breast tissue and bone marrow and peripheral stem cells from patients with active breast cancer. Over the course of the past 12 months some 13 investigators have utilized material from this bank. In the coming year we expect expanded utilizing of the bank by a greater number of investigators as well as continued accrual to the bank.