It's Week 17 in the NFL, and we are presented with a number of intriguing matchups as the regular season—and meaningful football for more than half of the league—comes to an end.

While the stakes are different for each team, one thing that remains the same—there are point spreads that demand our attention.

Which teams are going to take care of business on Sunday, both against the opposition and the spread?

Let's take a look.

Denver Broncos (-11) vs. Kansas City Chiefs

Denver only won by eight points the last time these AFC West foes faced each other, but the Broncos will get that extra field goal this time around.

The Broncos are the hottest team in the NFL, in the midst of a 10-game winning streak that has seen Peyton Manning and company beat the opposition by an average of 13.6 points per game.

That's nearly a two-touchdown margin of victory.

With home field advantage in the playoffs on the line, do you really expect John Fox to take his team's foot off of the pedal?

Me either.

Denver wins this one convincingly.

Denver 31, Kansas City 13

Philadelphia Eagles (+7) vs New York Giants

While the Eagles have been awful in 2012, the Giants' recent level of play has been equally as putrid.

Tom Coughlin and Eli Manning are playing for their playoff lives while their counterparts across the field, Andy Reid and Michael Vick, are playing for jobs elsewhere in 2013.

While he's been out of action for quite some time, Vick has a 6-2 record in eight career starts against New York, completing 61 percent of his passes for 1,218 yards, six touchdowns and three interceptions.

Besides, the vast majority of games between these hated rivals are hotly contested and come down to the wire, Matter of fact, the average margin of victory over the pair's last two games has only been 4.5 points, and two points separated the pair back in Week 4, a 19-17 Eagles victory.

The birds will be flying high once again after this one.

Philadelphia 21, New York 17

New Orleans (-4.5) vs Carolina Panthers

There's no hiding the fact that the Saints defense is just not very good. Whether against the run or the pass, opposing teams have had success against the unit all season long, and Week 17 will be no different.

Cam Newton and the Panthers are going to find the end zone.

But for as bad as the Saints defense has been, the team's offense still functions like a well-oiled machine, one that has Drew Brees at the controls.

Carolina might have gotten the better of the Saints when they last met in the second game of the season, but that was against a Saints team still reeling from the bounty scandal.

This is a much different Saints squad that Carolina will be facing on Sunday.

Coupled with the fact that the Saints are playing in front of Who Dat Nation and that currently exiled head coach Sean Payton has worked out a new multi-year deal with the team (h/t ESPN), the Saints are going to be a fired up bunch.

Drew Brees will finish the season strong, bringing the Saints to a .500 record (8-8) and heading into the offseason with an optimistic outlook on next year,