I agree with the above posters. I started out with such a low dose that I didn't think it could POSSIBLY have an effect.....and it did. I think that if you get any kind of "start-up effect" you should hold steady at the very least. I agree with Rich, though - it's probably best to decrease the dose/frequency of dose. Good luck!

Yes I had horrible start up nervous tension and also buzzing, and after 6 weeks had to stop the methylation meds as it was unbearable. It also triggered off intense food hunger and I put on 12 kilos in weight. It is now 12 months later and the tension is still there a little bit. I would like to do as Determined has done and start on minute amounts of the meds but so far am too scared to try it.

I had been increasing my dose but have stopped for a time being. The agitation is the only symptom or sign of taking the B12 protocol. I had already been on the support supplements for months.

The first day I (two weeks ago) I took the b's i noticed a drop in energy, took the potassium and all was good. But it does not seem to help the anger. I am going to stop titrating up and see if it goes away with time.

Unfortunately, this is the only sign I have gotten from the protocol.

Even stranger, I only get this way when I am on steroids!

Is it possible to get worse? I am high functioning, I go to work and am able to workout three times a week. But only with a whole lot of meds! Nothing what I was doing (16 hour days and running marathons)

There is another effect I have seen is that i see colors more vividly. Which is something that intensifies when I am on SAMe (im NOT taking this at the moment). I know it sounds strange but the colors are so intense.

Second, I do have the munchies! just like when I take steroids. Weird, what physiological process would act like steroids???

I am excited that something is happening! EVen though I have to start every new conversation with friends as...." I just want to let you know Im on some meds that turn me into debby downer, we can not talk about religion, government or politics"

Anger, intense food cravings, and depression are what happen to me when something seriously affects my serotonin levels. ...Since I'm apparently not so great at breaking down serotonin, that can include things that are supposed to raise it. I also sometimes get headaches when this happens.

Not sure how that might help you, but it might be another piece of the puzzle.

The types of foods you're craving might give you some clues to what's going on. The body seems to definitely have some strong feelings about what it needs sometimes.

Anger, intense food cravings, and depression are what happen to me when something seriously affects my serotonin levels. ...Since I'm apparently not so great at breaking down serotonin, that can include things that are supposed to raise it. I also sometimes get headaches when this happens.

Not sure how that might help you, but it might be another piece of the puzzle.

The types of foods you're craving might give you some clues to what's going on. The body seems to definitely have some strong feelings about what it needs sometimes.

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I agree with you Sparrow! Craving truely can be good indicators. Interpreting them is yet another challenge though. Sometimes I crave means your body is needing something (serotonin? dopamine? iron?). Other times you should definitely avoid that craving like the plague!! (food sensitivity craving paradox). I experience both these on a regular basis.

Just wanted to post that my angry face did not show today!!! Not sure if I should keep this dose or move on up, I'm not sure what's around the corner =) I had a crazy, I mean crazy amount of energy today.

In the past, When I had an upswing of energy, I was going to be really sick... I guess time will tell:worried:

To tell the truth, each time I start a methyl group I get more aggressive, and thats not my normal nature. I have the uncontrollable feelng that I want to hit my kids (I don't) and the sound of my husband chewing makes me want to stick a fork in his eye! (I don't) But when its been a few weeks these go away (unless you increase the dose!).

I agree with Hixxy, don't put that sort of pressure on yourself, or you're likely to fail. I did that and had to go off everything and start back at square one! I lost at least 6 months of my time that way.

Anxiety and anger, rage, fearfullness, not finding thrilling risk sports or thrill entertainment (roller coasters etc) thrilling, or rather fearful may all be due to b12 and carnitine deficiency damage to the neuronal mitochondria and then damage to the cells that is then irritated (damaged) by either mitochondria brought back to funtioning and/or the nerve itself waking up in a damaged state. Damage to other areas of the brain cause pain, or cognitive or memory difficulties.