Insulin-like growth factor 1 receptor (show IGF1R Proteins) blockade can inhibit glioblastoma growth by different mechanisms, including direct effects on the tumor cells as well as indirect anti-angiogenic effects.

HIF-2alpha (show EPAS1 Proteins) acts as an important negative regulator of hepatic lymphangiogenesis in vitro and in vivo by inducing IGFBP1.

gene expression analysis of human breast tumors showed that high expression of IGFBP mRNA was strongly correlated with good prognosis but not when MMP9 (show MMP9 Proteins) mRNA was also highly expressed

During the two week starvation period, both the levels of plasma IGF-1 (show IGF1 Proteins) and IGFBP-1 decreased.

These results show that RTEF-1 (show TEAD4 Proteins)-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 (show TEAD4 Proteins) attenuates blood glucose levels.

Global deletion of Igfbp1 in a c-Myc (show MYC Proteins) transgenic model did not accelerate the development of prostate cancer. Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass.

IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals

IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK (show MAPK1 Proteins) and C/EBP beta (show CEBPB Proteins) activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways.

Induction of IFGBP1 expression by amino acid deprivation of HepG2 hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR.

high concentrations of circulating IGFBP-1 are sufficient to cause fetal growth restriction in an animal model

the IGFBP-1 gene is a primary target of peroxisome proliferator-activated receptors

Insulin-Like Growth Factor Binding Protein 1 (IGFBPI) Protein Profile

Protein Summary

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.