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Research

Three-year follow-up of serum 25-hydroxyvitamin D, parathyroid hormone, and bone mineral density in nursing home residents who had received 12 months of daily bread fortification with 125 μg of vitamin D3

Abstract

Background

Methods

At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin
D (25(OH)D), parathyroid hormone (PTH) and bone mineral density were measured in 23
of the original study subjects, aged 60-82 years who had consumed bread buns (100 g)
fortified with 320 mg elemental calcium and 125 μg (5,000 IU) vitamin D3 daily for
one year.

Conclusion

Vitamin D nutritional status exhibits a long half-life in the body, and a true steady-state
plateau may not even be reached 1 year after a discontinuation in dose. Furthermore,
once the need for vitamin D has been established, based on a low baseline serum 25(OH)D
concentrations, the appropriate action is to maintain corrective vitamin D supplementation
over the long term.