The authors showed that Cryptosporidium can infect epithelial organoids derived from human small intestine and lung. The parasite propagates within the organoids and completes its complex life cycle. [Nat Microbiol]
Abstract | Press Release

LUNG CANCER

Cell migration, invasion, epithelial-mesenchymal transition and autophagy were elevated when lung cancer cells were treated with cigarette smoke extract (CSE) and PM2.5 in combination. A lncRNA, named lung cancer progression-association transcript 1 (LCPAT1), was up-regulated after the treatment of CSE and PM2.5, and knocking down the lncRNA impaired the effect of CSE and PM2.5 on lung cancer cells. [Cell Physiol Biochem]
Full Article

The authors altered the endogenous miR-198 using mimics or inhibitors to examine the effects of miR-198 on 4 Gy-irradiated A549 and SPCA-1 cells in vitro. Upregulating miR-198 was shown to inhibit cell proliferation, migration, and invasion and induce apoptosis. [J Cell Biochem]
Abstract

The authors discuss the basis that sustain the role of CFTR in modulating the extracellular pH, and the recent results sustaining the different points of view. Finding the mechanisms of CFTR signaling that determine the susceptibility to infections is crucial to understand the pathophysiology of CF and related lung diseases. [Eur J Cell Biol]
Abstract

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Vertex Pharmaceuticals Incorporated announced that Health Canada approved PrSYMDEKO™ for treating the underlying cause of cystic fibrosis in people ages 12 and older who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, or who have one copy of the F508del mutation and one of several mutations in the CFTR gene. [Vertex Pharmaceuticals Incorporated]
Press Release

Galectin Therapeutics, Inc. announced that the company has received notice of issuance of U.S. Patent Number 9,968,631 titled “Method and Treatment of Pulmonary Fibrosis”. [Galectin Therapeutics, Inc.]
Press Release

For many first-time congressional candidates with science and technology backgrounds, fundraising can be a major obstacle. Not to Brian Forde, who was once a senior technology adviser to former-President Barack Obama. [ScienceInsider]
Editorial

The Karolinska Institute in Stockholm has finally, officially, found disgraced surgeon Paolo Macchiarini guilty of scientific misconduct. However, the verdict is a bitter pill for the four people who raised the alarm about Macchiarini’s fraud. [ScienceInsider]
Editorial

he travel restrictions now vary by country, and include some exemptions for students. But data from the Department of Justice reveal that the government issued just 289 visas to students from Iran, Libya, Yemen and Somalia in the first three months of this year. [Nature News]
Editorial