Protein Information

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).

HMGB2 has been related to DNA unwinding and stress response. In mice, HMGB2 and other HMG chromosomal proteins have been shown to suffer alterations at various levels during ageing [ 2325444], though HMGB2 has not been directly related to human ageing.

References

MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.

Prasad S, Thakur MK:Effects of spermine and sodium butyrate on the in vitro phosphorylation of HMG non-histone proteins of the liver of young and old rats.Arch Gerontol Geriatr. 1990; 10: 231-8.PubMed (ID: 15374498)