Can Kindling-Induced Sleep Pathology be Corrected by Phenobarbital?

Abstract

Kindled seizure susceptibility, as indicated by the incidence of interictal discharge (IID) and the development of kindled convulsion with an ‘all-or-none’ response to threshold stimulation, is known to persist in amygdaloid (AM) kindled cats for more than 12-months without applying stimulation.1 Many antiepileptic drugs such as Phenobarbital (PB), Phenytoin, Carbamazepine, Valproic Acid and Primidone have been shown to exert either a prophylactic effect on kindling or an anticonvulsive effect on established kindled seizure.2–8 However, the question of whether medication with these drugs can reverse the once established kindled seizure susceptibility remains unanswered.