Other Tests That May Prove Helpful Diagnostically

Skeletal X-rays will demonstrate evidence of osteomalacia in adults and rickets in children in patients with long-standing hypophosphatemia. On occasion, hypophosphatemia is due to tumors which elaborate substances that induce urinary phosphate wasting. Such tumors can sometimes be detected by radiological methods.

Tumors causing hypophosphatemia are generally small but can be detected by whole-body magnetic resonance scanning, computed X-ray tomography (CT), technetium 99m scintigraphy, radiolabeled octreotide scanning, or F-18 fluorodeoxyglucose positron emission tomography. If a mass can be palpated or detected by various scanning methods, biopsy and histological examination may show the presence of histology typical for mesenchymal phosphaturic tumors.

Management and Treatment of the Disease

Every effort should be made to identify the cause of hypophosphatemia and to avoid situations that would precipitate it. Besides the administration of phosphorus, therapy will need to be tailored to the underlying cause of the hypophosphatemia. Comments which follow pertain to the administration of phosphorus in individuals who may have phosphorus deficits as a result of nutritional impairment.

Emergent treatment

Severe hypophosphatemia (less than 1 mg/dL) can occur even though body phosphorus stores are not severely depleted. Furthermore, it is difficult to estimate overall deficits based on serum phosphorus concentrations. If the patient is symptomatic and the hypophosphatemia is of recent origin, phosphorus should be administered orally at an initial dose of 0.08 mmol per kilogram body weight (2.5 mg per kilogram body weight).

If the hypophosphatemia is prolonged in duration and has multiple causes, an initial oral dose of 0.16 mmol per kilogram body weight (5 mg per kilogram body weight) can be administered. Parenteral therapy can be given if the patient is severely symptomatic and serum phosphorus concentrations are less than 1 mg/dL (0.32 millimoles per liter).

In these circumstances, an initial dose of 0.08 mmol per kilogram body weight (2.5 mg per kilogram body weight) intravenously over a period of 6 hours can be administered. Serum phosphorus and serum calcium concentrations should be checked every 2 hours after the initiation of parenteral phosphorus therapy. No more than 0.24 mmol per kilogram body weight (7.5 mg per kilogram body weight) or a total of 16.9 mmol (525 mg) for a 70 kg adult should be administered.

Some investigators have used higher doses of parenteral phosphorus. For example, in the context of critically ill patient is receiving parenteral nutrition, IV doses of phosphorus were given according to the serum concentration of phosphorus: 0.73-0.96 mmol/L (0.32 mmol/kg, low dose), 0.51-0.72 mmol/L (0.64 mmol/kg, moderate dose), and 0.5 mmol/L or less (1 mmol/kg, high dose). According to the report, none of the patients develop hypocalcemia or other complications. While higher doses of phosphorus can be given parenterally, this author uses more conservative and lower amount of phosphorus intravenously.

Chronic therapy

In chronic hypophosphatemia, phosphate therapy can be given orally so as to administer initially 1 g of phosphate per day (approximately 33 mmol per day). Depending upon the response, phosphorus intake can be increased to 2-3 g per day. If correction of renal phosphorus losses does not occur with oral phosphorus supplements, calcitriol (1, 25-dihydroxyvitamin D) can be added at doses of between 0.5 and 2 mcg per day.