Learn how Dr. des Etages utilized IPA to investigate the metabolic and signaling pathways affected by insulin resistance in adipose tissue. Insulin resistance is a key component of Type II Diabetes. Essentially, it reflects the state in which peripheral tissues such as liver, muscle and adipose become less responsive to insulin. The increased insulin output required to maintain glucose homeostasis eventually leads to loss of pancreatic islet function and frank diabetes. Sears et al. published a study examining adipose and muscle samples extracted from insulin-sensitive and insulin-resistant subjects at baseline, and then at 3 months after thiazolidinedione (TZD) treatment. In this presentation, you will see how IPA was used to filter and explore existing data to investigate affected pathways and ultimately identify a transcription factor that may serve as a link between TLR2 signaling and adiponectin levels.

Register to attend this webinar on Tuesday, September 20. Engage with Ph.D. scientists across the globe that are working with IPA and metabolomics data, and learn how to utilize IPA to discover your targets faster and validate previous results.

Dr. des Etages presented a version of this talk in June in Massachusetts at the Ingenuity Customer Showcase Seminar. At this event, scientists educated peers on how they have utilized IPA for their research discovery. Ingenuity has hosted two customer showcase seminars in 2011, in New Jersey and Massachusetts. Watch Dr. des Etages’ pre-recorded talk.