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Who did Cain marry?As to the topic of genetic problems associated with inbreeding, 200+ generations ago that would have been less of an issue. It also depends on a person's acceptance of the Biblical flood. Was it worldwide? How many people were killed? If all but one family was involved, suddenly the gene pool is drastically reduced. Lifespans are suddenly recorded as being much shorter. Etc. Now we need laws to prohibit close family marriages.