Determined by its ability to stimulate human IL-8 production by human PBMC using a concentration range of 10.0-25.0 ng/mL. Results may vary with PBMC donors.

Recommend Usage:

Activity assaySDS-PAGEThe optimal working dilution should be determined by the end user.

Storage Buffer:

Lyophilized from 20 mM Sodium Citrate, pH 3.0.

Storage Instruction:

Store at -20°C.Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex.For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq