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Current Positions in the Pai Lab

This 2-3 year fellowship is an individualized program to foster development of quantitative research skills required of an infectious diseases clinical pharmacology scientist. State-of-the-art equipment and resources are available at the University of Michigan, including our dedicated shared resource laboratory (www.pkcore.org), where specific opportunities exist to gain exposure to pre-clinical experimental and analytical methods to support translational research. The overarching goal of the fellowship is to foster the development of translational scientific skills that position the fellow for a career in academia, industry, or regulatory science. Some of the skills and experiences available through the program include:

Drug metabolism and pharmacokinetics (DMPK) techniques

Principles and applications of mass-spectrometry

Short- and long-term animal pharmacokinetic studies to support lead optimization

Phase 1 and 2 clinical trial design

Grantsmanship (Industry, NIH, DoD, FDA, AHRQ, Internal Mechanisms)

Regulatory submissions (IACUC and IRB)

Budget development

Protocol development

Study management

Project reporting and documentation

Sponsor engagement and communication

Manuscript preparation and publication

Presentation at professional meetings

Fellows will have immediate opportunities to evaluate existing clinical and non-clinical data during their independent study development period in order to begin to cultivate research skills. Additionally, the fellow will learn how to use multiple software platforms (PMetrics®, ADAPT 5, and PK-SIM) to perform population (PPK) and physiology-based pharmacokinetic/pharmacodynamic (PBPK) modeling and simulation.

Application Requirements

PharmD, MD, DO, or PhD from an accredited university or equivalent

Experience and coursework in pharmacokinetics

Good oral and written communication skills, ethics, professionalism and ability to work in a team-based environment

If you are interested in learning more about this program, please contact Dr. Pai (amitpai@med.umich.edu) for additional information.