METHOD FOR PREPARING LEVETIRACETAM
Provides is a method for preparing levetiracetam. The method comprises producing (R/S)-α-ethyl-2-oxo-1-pyrrolidine acetate under the action of an alkaline reagent using 2-bromobutyrate and 2-pyrrolidinone as raw materials, performing re...

METHODS FOR MAKING L-GLUFOSINATE
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deaminat...

BIOCATALYTIC PROCESSES FOR THE PREPARATION OF VILANTEROL
A process for preparing Vilanterol includes a biocatalytic conversion of a ketone substrate to its corresponding alcohol, and then converting the obtained alcohol into Vilanterol. Polypeptides may be used for the biocatalytic conversion ...

PROCESS
There is described a process for the preparation of a stereospecific form of flurbiprofen, or a pharmaceutically acceptable salt thereof, which comprises subjecting a flurbiprofen ester, comprising a mixture (R)-(-)-flurbiprofen and (S)-...

OMEGA-TRANSAMINASE OF R CONFIGURATION AND USE THEREOF
Provided is an omega-transaminase of R-configuration. The omega-transaminase of R-configuration has the amino acid sequences as shown in SEQ ID NO: 2, or has at least 80% identity to the amino acid sequences as shown in SEQ ID NO: 2, or ...

(R)-PRAZIQUANTEL PREPARATION METHOD
The present invention relates to an (R)-praziquantel preparation method, comprising steps of using (R,S)-tetrahydroisoquinoline-1-formate or salts thereof, or 1-(S)-tetrahydroisoquinoline-1-formate or salts thereof as a raw material to p...

LACTATE PRODUCTION PROCESS
A process for producing alkyl R-lactate and alkyl S,S-lactyllactate is provided. The process comprises:(a) admixing (i) a first mixture comprising R,R-and S,S-lactide with (ii) a second mixture comprising a C1-C8 alkyl alcohol, the corre...

METHOD OF ENZYMATIC RESOLUTION OF SERINE RACEMIC DERIVATIVE
The method of enzymatic resolution of the racemic derivative of α- methylserine involves acylation of N-blocked-a-substituted serine ester in a homogeneous system with the use of an acyl group donor in a solvent selected from among pola...

METHOD FOR SYNTHESIZING LEVO-PRAZIQUANTEL
Provided is a method for synthesizing levo-praziquantel, comprising subjecting a chemically synthesized raceme or a certain enantiomer to a dynamic kinetic resolution catalyzed with a nitrile hydratase to produce an optically pure chiral...

WO/2014/129538A1

PRODUCTION METHOD FOR α-AMINO NITRILE COMPOUND
The purpose of the present invention is to provide a method of efficiently producing an α-amino nitrile compound from a non-cyclic amine compound. The production method for an α-alkylamino nitrile compound according to the present i...

LACTATE PRODUCTION PROCESS
A process for producing a compound of formula (I) is provided. The process comprises reacting a mixture comprising a compound of formula (IIA) and a compound of formula (IIB) with an alkyl alcohol in the presence of a Candida antarctica ...

WO/2014/041372A1

LIPASES, POLYNUCLEOTIDES ENCODING THEM AND THEIR USES
A lipase comprising a polypeptide or peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-19 and the polynucleotides encoding the lipases is disclosed. The lipases and nucleic acid sequences encodi...