Question 4: Short-term Objective F

$7,575,212.03
Fiscal Year: 2010

4SF. Launch five randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes, in each of the following groups:

Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years.

Three randomized controlled trials of interventions for school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years.

Three trials for adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.

Objective Cumulative Funding Table

IACC Strategic Plan Objective

2008

2009

2010

2011

2012

Total

Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups:

Progress: The investment in projects under this objective is making good progress toward the recommended amount, with more than 20 projects funded in 2011 and 2012.

Remaining Gaps, Needs, and Opportunities: Current projects in this area are restricted to small pilot studies, which are essential to establishing a foundation prior to expansion to larger scale work. Thus, increased investment in this area is important. It should be noted that most RCTs in the future will incorporate some aspect of biological signatures (thus potentially presenting a challenge to future coding of projects).