Introduction: Specialized registry in the NICU (neonatal intensive care unit) is necessary to gather process and report data in an accurate and timely manner. An electronic registry could enable the mother and infant to be monitored and traced through complete and comprehensive data.

Aim: Registry has been developed on the basis of a literature study and view point of participants about effectiveness and efficiency was evaluated.

Materials and Methods: A situational analysis was performed to achieve a clear view from current status of NICU data collecting and reporting, then a customized three tier architecture was proposed to design and implement a specialized registry. User satisfaction was evaluated by system usability scale among 30 participants to assess userís attitude about system.

Results: A comprehensive data model with seven categories was defined by 65 entities, which actually retains part of the infants information. System usability scale was in a high range about 70%. The highest agreement is on reduced registration error. The advantages of system were perceived by users and they had positive attitude about it.

Conclusion: The use of a suitable architecture and standard templates lead to enhanced acceptability, effectiveness, performance and functionality. Quality of data and health promotion has a direct relationship with system usability. These systems have a great potential to increase safety of patients by providing fast and easy access to information, monitoring and decision support operations.