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Analogues for Characterization of cyclic GMP Binding Proteins

Fig. 1: Positions for the chemical modification of cyclic GMP

Meaningful selected analogues of cyclic GMP are extremely useful for mapping studies of different cGMP receptor proteins in order to get information about the essential corresponding molecular forces and their positions in the cyclic GMP moiety:

Besides important insights in the binding principles of the receptor, the practical results of successful mapping studies include the determination of positions where a spacer for affinity chromatography is tolerated, where fluorescent markers can be attached and which chemical modifications are allowed for potential analogues.

BIOLOG offers so many different analogues of cyclic GMP, that modifications for nearly each position of the second messenger are available.

The following table gives examples for analogues suitable for mapping studies: