Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3’-untranslated regions (3’UTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. Mice deficient in TTP develop a complex syndrome of inflammatory diseases.