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Click here for the manuel. It will walk you through cleaning the cartriges. In most cases using the built in self-clean will take care of the smudge. You can also try removing the cartige and cleaning it and the housing with a damp q-tip or cotton swab.

Two things to check,
1- clean the laser by opening the front cover, pull forward the green lever on the R/H side, take off the little panel on the R/H side of the printer and pull out/push in the lens cleaning "stick". Replace panel and push the lever back in, close the front and try a test print.
If that didn't work:
2- Open the lid, lift the orange lever and remove the photoconductor. Be careful with it as it is easily scratched. Inside the printer rotate the toner cartridges and check that the cartridge lock levers are fully locked as even a couple of millimeters can block the laser.

Often, this would just be the sensor falsely thinking that the cover B is still open. You could try checking if the cover is slightly misaligned hence the tab is not triggering the senor/switch. Or try opening and closing and making sure that you hear/feel the latching of the switch.

I also use a Mac, (OSX 10.3.9) does this printer show up in the list when you activate the Printer Setup Utility (PSU) Do you get any error message from the Mac such as Printing Stopped etc. What shows when you click on the PSU after clicking on print etc.