According to the designed routine, we synthesized the target compound starting with 3,5-dimethoxybenzoic acid, which undergoes five steps including reduction, bromination, Arbuzov rearranment, Wittig-Horner reaction and demethylation with an overall yield of 35.0%.

The uniform design was applied to technological study of the title compound, starting from ethyl acetate and diamine hydrate,followed by reaction with carbon disulfide,the title compound was synthesized in one step. The overall yield amounts to 75.5% .

NZB/WF1 mice were chronically treated with the compound starting from the ninth week of age, sacrificed at different times and their spleen cells transferred to 9 weeks old, syngeneic mice.

A new synthesis of the title compound starting from abietic acid is described.

A safe and convenient method is described for the synthesis of the title compounds starting from glycine and an azomethine. The amino group of glycine is protected by reaction with ethyl acetoacetate and the carboxyl group is activated through the formation of a mixed anhydride. Condensation between these glycine derivatives and imino compounds in the presence of triethylamine leads to stereospecific synthesis of 3-(α-methyl-β-carbonyl-vinylamino)-2-azetidinones in about 50% yield. The vinylamino...

A safe and convenient method is described for the synthesis of the title compounds starting from glycine and an azomethine. The amino group of glycine is protected by reaction with ethyl acetoacetate and the carboxyl group is activated through the formation of a mixed anhydride. Condensation between these glycine derivatives and imino compounds in the presence of triethylamine leads to stereospecific synthesis of 3-(α-methyl-β-carbonyl-vinylamino)-2-azetidinones in about 50% yield. The vinylamino side chain can be hydrolyzed under mild condition to form 3-amino-2-azetidinones which are acylated to form α-amido-β-lactams. Sixteen title compounds have been synthesized and five of them show inhibitory activity against β-lactamase.

The described automatic generation of virtual bio - active compounds starts from pharmacophore and pre - selected fragments. The generation process consists of three stages: selection of fragments, assemblage of fragments and conformation flexible searching. This method is demonstrated by an example that sixteen virtual bio - active compounds were generated starting from HIV - 1 protease inhibitors pharmacophore in this work. The results of conformation analysis showed that the pharmacophore...

The described automatic generation of virtual bio - active compounds starts from pharmacophore and pre - selected fragments. The generation process consists of three stages: selection of fragments, assemblage of fragments and conformation flexible searching. This method is demonstrated by an example that sixteen virtual bio - active compounds were generated starting from HIV - 1 protease inhibitors pharmacophore in this work. The results of conformation analysis showed that the pharmacophore is contained in the favorite conformers of the generated structure. It was showed that this method could generate virtual bio - active structure effectively. In comparing of the results from 3D structure searching, the generated structures have novel structural features and they are easier to be synthesized.

Based on the comparison of small refrigeration equipment.This paper analyzes the mode of starting with low voltage.It gives the significance、assumed design and the theoretical basis of developing compound starting mode and this mode's architecture and working principle.Through experiments on the starting of compressor with low voltages,it studies the best starting capatinance by way of critical state comparison and starting time comparison.It analyzes the matching of starting...

Based on the comparison of small refrigeration equipment.This paper analyzes the mode of starting with low voltage.It gives the significance、assumed design and the theoretical basis of developing compound starting mode and this mode's architecture and working principle.Through experiments on the starting of compressor with low voltages,it studies the best starting capatinance by way of critical state comparison and starting time comparison.It analyzes the matching of starting relay,heat protective device and the compressor.Experiments show that compound starting mode can protect the compressor while lowering the floor level starting voltage to 140 V,lower than that of 187 V of similar products in China.