What is the Difference between Viagra and Cialis?

Viagra and Cialis belong to the drug class phosphodiesterase type 5 (PDE5) inhibitor that works for treating erectile dysfunction (ED), or the inability to attain and maintain an erection, in men. The main difference of the two is how long they stay in your system. Cialis (tadalafil) has the longest duration among widely used ED drugs in the market; its effect is said to last up to 36 hours compared to four- to six-hour duration of Viagra (sildenafil). Because Cialis can remain in your system longer, you don’t have to limit your sexual activity within a short timeframe. However, it can be a downside if you are taking other medications that may interact with the drug.

PDE5 inhibitors work by improving blood flow to the penis. Erection is attained when the chambers of the penis called corpora cavernosa are filled with blood. The spongy tissues inside these chambers allows the pooling of blood, which leads to an erection. A person with erectile dysfunction may have certain conditions affecting the nerves or blood vessels that supply the penis. Viagra and Cialis improve blood flow to the penis by relaxing the smooth muscle cells, which results to the dilatation (widening) of blood vessels. However, both drugs rely on the substance nitric oxide (NO) to work. NO is only released following sexual arousal. Without physical or mental sexual stimulation, PDE5 inhibitors will not work.

The role of nitric oxide in penile erection

With the help of an enzyme called guanylate cyclase, nitric oxide promotes the production of cyclic guanosine monophosphate (cGMP), which is primary responsible for the process of erection by regulating the amount of blood that goes in and out of the penis. But cGMP is normally degraded by another enzyme called phosphodiesterase type 5. Cialis and Viagra block the action of PDE5 to prevent the destruction of cGMP, so that it can stay longer, prolonging the engorgement of the penis. Coadministration with nitrate-containing medications is dangerous for Viagra and Cialis because they can increase the hypotensive effects of nitrates.

Side effects comparison

Having the same mechanism of action means sildenafil and tadalafil have similar adverse effects. Common side effects associated with these ED drugs include: facial flushing (reddening), headaches, stomach pain, diarrhea, nausea, dizziness, and visual disturbances. Cyanopsia is a lesser-known side effect of Viagra. It is characterized by seeing everything tinted with blue; hence, it is also referred to as blue vision. Cialis does not cause blue vision because it specifically inhibits PDE5. Viagra also inhibits PDE6, which is found in the retina. On the contrary, muscle pains are only experienced by Cialis users and not Viagra patients.

Dosage and indication comparison

Some men with ED have found symptom relief by incorporating lifestyle changes and treating an underlying medical condition, such as high blood pressure. Those who do not respond to a simple lifestyle change may benefit from ED medications. Right now, PDE5 inhibitors are the first-line treatment for erectile dysfunction. Cialis is the only drug approved for the treatment of both ED and benign prostatic hyperplasia or prostate enlargement.

For ED, Cialis and Viagra are taken orally before planned sexual activity. The recommended dose for Cialis is 10mg to be taken as needed, at least 30 minutes before sexual activity. A low dose of 5mg once daily can also be used for benign hyperplastic hyperplasia and those who anticipate frequent sexual activity. Do not take a higher daily dose of Cialis without consulting your doctor. The usually prescribed dose for Viagra is 50mg to be taken as needed, at least one hour before planned sexual activity. Avoid taking Viagra with a high-fat meal, as it delays its absorption. Cialis can be taken with or without food, but it’s better to take it on an empty stomach if you want faster absorption and earlier onset of action.

Effectiveness and success rate comparison

The success rate for both drugs is approximately 70%. Compared with Cialis, there is extensive data available for Viagra composed of thousands of peer-reviewed articles, while there is limited data on Cialis. Simply put, Viagra has an excellent track record being the first PDE5 inhibitor to be released in the market. But, the long half-life of Cialis (17.5 hours) is noteworthy. A single dose of Cialis would still be effective after a day or so.

Drug features comparison chart

Brand Name

Viagra

Cialis

Generic name

sildenafil

tadalafil

Generic equivalent availability

Available from Teva and Pfizer

Currently not available

Manufacturer

Pfizer

Eli Lilly

Indication

Erectile dysfunction

Erectile dysfunction
Benign prostatic hyperplasia

Approval Date

March 27, 1998

November 21, 2003

Available Strengths

25mg, 50mg, 100mg

2.5mg, 5mg, 10mg, 20mg

Dosage

50mg taken as needed

10mg as needed or
5mg once daily

Onset of action

Works within 30 minutes

Works within 16–45 minutes

Biological half-life

3–5 hours

17.5 hours

Duration of action

4–6 hours

Up to 36 hours in some cases

Food interaction

Should be taken on an empty stomach.
Do not take with grapefruit or grapefruit juice.

May be taken with or without food.
Do not take with grapefruit or grapefruit juice.

In 2015, the FDA approved flibanserin (Addyi), also known as “female Viagra,” for marketing after two previously failed attempts. Based on the theory that low libido in women, which is dubbed hypoactive sexual desire disorder (HSDD), is a result of an imbalance of neurotransmitters in the brain, flibanserin works by manipulating a variety of serotonin receptors, with some manipulated by excitation, while others are manipulated via inhibition. According to the prescribing information from Valeant Pharmaceuticals, the “mechanism of action in the treatment of premenopausal women with hypoactive sexual desire disorder is not known.”
How does flibanserin (Addyi) work?
Yes, this is true. But this is true for a lot of medications. Almost one in five medications lack a well-defined mechanism of action. However, flibanserin does not work anything like sildenafil (Viagra), (vardenafil) Levitra, and tadalafil (Cialis) do, which is by causing increased bl ...

While it may still be taboo to talk about erection problems, finding help has never been easier. However, not all erectile dysfunction (ED) treatments are equal. Pharmacologically, PDE5 (phosphodiesterase type 5) inhibitors still rule the market. Sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) are the popular options. Though they all belong to the same drug class, they are not the same and should not be used interchangeably, unless there’s a go signal from your doctor.
Pfizer has achieved a game-changing feat worldwide for releasing Viagra. Some people call it the “vitamin V” but it is still not the super drug ED sufferers believed it to be. After all, you need to plan your sexual activity within 4 hours of taking it, leaving no room for spontaneity. When Cialis, aptly nicknamed The Weekend Pill, was introduced as having a half-life of 17.5 hours, it was granted FDA approval the next year.
What a longer half-life means
Biological ...

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