Medical Xpress news tagged with:malignant cellshttp://medicalxpress.com/
en-usMedical Xpress internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine.A traditional Japanese art inspires a futuristic innovation: Brain 'organoids'The ancient Japanese art of flower arranging was the inspiration for a groundbreaking technique to create tiny "artificial brains" that could be used to develop personalized cancer treatments.http://medicalxpress.com/news/2016-12-traditional-japanese-art-futuristic-brain.html
Medical researchMon, 05 Dec 2016 11:22:45 ESTnews400159351The cell of origin in childhood brain tumors affects susceptibility to therapyChildren that are diagnosed with the severe the brain tumour malignant glioma often have a very poor prognosis. Knowledge about how pediatric malignant glioma arises and develops is still limited. New findings from Uppsala University show that in mice glioma development and glioma cell properties are affected by both age and the cell type from which the tumour has arisen. The tumour cell of origin was also important for the susceptibility of the tumour cells towards cancer drugs.http://medicalxpress.com/news/2016-11-cell-childhood-brain-tumors-affects.html
CancerThu, 17 Nov 2016 13:49:08 ESTnews398612942Active agent from the Caribbean sea cucumber could improve treatment for malignant pleural mesotheliomaResearchers at the Comprehensive Cancer Center of MedUni Vienna and Vienna General Hospital have discovered a new option for treating malignant pleural mesothelioma. For the first time in the world, they were able to show in a preclinical study, both in the cell culture and in the animal model, that trabectedin, a chemotherapy drug that is already successfully used for other types of cancer, is also effective against malignant pleural mesothelioma. The active agent originally occurs in the Caribbean sea cucumber, a marine-dwelling tunicate. The study results were recently published in Molecular Cancer Therapeutics, the therapy-oriented journal of the American Association for Cancer Research (AACR). The initial interim results of a clinical study from Italy confirm these results and show that they are transferable to clinical practice.http://medicalxpress.com/news/2016-10-agent-caribbean-sea-cucumber-treatment.html
CancerMon, 24 Oct 2016 07:29:58 ESTnews396512990Fission yeast may be used to find the next cancer cureCancer is a notoriously difficult disease to treat. Not only do a wide variety of cancers exist, requiring specialized treatments for each type, but cancer cells within an individual can morph and render previously potent therapeutics ineffective. Thus, there is a continual need to discover new, effective drugs. Research from Dr. Norihiko Nakazawa in the G0 Cell Unit at the Okinawa Institute of Science and Technology Graduate University (OIST) led by Prof. Mitsuhiro Yanagida, may help make the discovery process easier. This research was published in Genes to Cells.http://medicalxpress.com/news/2016-10-fission-yeast-cancer.html
CancerFri, 21 Oct 2016 09:50:01 ESTnews396260650Estrogen signaling impacted immune response in cancerWhile the role of estrogen signaling in tumor development is well understood in breast and ovarian cancer, its role in anti-tumor immunity has not been extensively studied. However, new research from The Wistar Institute showed that estrogen signaling was responsible for immunosuppressive effects in the tumor microenvironment across cancer types.http://medicalxpress.com/news/2016-10-estrogen-impacted-immune-response-cancer.html
CancerMon, 17 Oct 2016 11:28:14 ESTnews395922484Low oxygen, high risk: How tumors adapt to become more aggressiveOne of the many reasons tumors are so difficult to treat is that they are able to adapt whenever they are exposed to unfavorable conditions. Hypoxia, or a lack of oxygen, is one example of a phenomenon that should weaken the tumor, but instead, the malignant cells are able to compensate and drive more aggressive disease behavior.http://medicalxpress.com/news/2016-08-oxygen-high-tumors-aggressive.html
CancerMon, 08 Aug 2016 12:00:05 ESTnews389876130Blocking the migration of cancer cells to destroy themLymphoma is a cancer that affects lymphocytes, a type of white blood cell. The disease originates in a lymphoid organ (lymph node, spleen, or bone marrow) before spreading through the blood to infiltrate not only other lymphoid organs but also other tissues. Every year, nearly 2,000 people in Switzerland are diagnosed with lymphoma, a disease that can be very aggressive, resisting standard treatments with chemotherapeutic drugs. Today, researchers at the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG), Switerland, give a new hope to patients. Their innovative approach consists in using an antibody able to neutralize a specific protein to block the migration of lymphoma cells, thus preventing the disease from developing. This still experimental immunotherapeutic strategy paves the way for new treatments against lymphoma. The results can be read in the Journal of Leukocyte Biology.http://medicalxpress.com/news/2016-08-blocking-migration-cancer-cells.html
CancerThu, 04 Aug 2016 08:38:36 ESTnews389518705The do-nothing dilemma—surveillance vs. surgery for cancerImagine for a moment that you have a tiny but worrisome lung nodule or, say, a growing bulge in a crucial blood vessel. You have no choice but to continue with normal life: going to work, running errands, paying taxes, negotiating with your kids over screen time. But you're always living, at least to some degree, under the looming shadow of a medical question mark.http://medicalxpress.com/news/2016-08-do-nothing-dilemmasurveillance-surgery-cancer.html
CancerTue, 02 Aug 2016 06:10:01 ESTnews389336630Novel drug therapy kills pancreatic cancer cells by reducing levels of antioxidantsReducing levels of antioxidants in pancreatic cancer cells can help kill them, newly published research reveals, suggesting an entirely new treatment strategy for the notoriously lethal illness, in which less than 5 percent of patients survive 5 years.http://medicalxpress.com/news/2016-07-drug-therapy-pancreatic-cancer-cells.html
CancerThu, 28 Jul 2016 12:00:09 ESTnews388917001Immunotherapy benefits relapsed stem cell transplant recipientsFor many patients with advanced blood cancers, a stem-cell transplant can drive the disease into remission. However, about one-third of these patients experience a relapse and face a very poor prognosis.http://medicalxpress.com/news/2016-07-immunotherapy-benefits-relapsed-stem-cell.html
CancerWed, 13 Jul 2016 17:00:02 ESTnews387629543Researchers take new approach to determining risk of cancer reoccurringWhat is the likelihood of a patient developing cancer again after having a tumour removed? This is the question that experts in medicine and medical informatics at Friedrich-Alexander-Universität (FAU) aim to find answers to in a new research project in which they will be researching micrometastases that can form new tumours years after skin cancer, for example, has been treated successfully. The project will be funded with a total of 1.3 million euros over the next three years.http://medicalxpress.com/news/2016-07-approach-cancer-reoccurring.html
CancerMon, 11 Jul 2016 11:52:03 ESTnews387456713A new way of looking at cancerClusters of circulating cells commonly found in the blood of cancer patients have long been the subject of research on cancer. These clusters have been regarded for more than 50 years as malignant cells that have broken off from the primary tumor, spreading cancer to other parts of the body. Now, researchers at the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR have reported that these clusters are unlike what others have assumed previously, potentially opening up new ways to detect and inhibit the spread of cancer.http://medicalxpress.com/news/2016-07-cancer.html
CancerMon, 11 Jul 2016 06:30:02 ESTnews387436807Mechanisms, therapeutic targets of microRNA-associated chemoresistance in epithelial ovarian cancerEpithelial ovarian cancer (EOC) is the most lethal disease among gynecologic malignancies. Patients with an advanced disease often relapse due to the development of chemoresistance. Chemotherapy failure is a consequence of acquired drug resistance which may potentially be due to multiple mechanisms including miRNA-mediated gene regulation.http://medicalxpress.com/news/2016-06-mechanisms-therapeutic-microrna-associated-chemoresistance-epithelial.html
CancerThu, 16 Jun 2016 15:27:33 ESTnews385309642Natural killer cells have memoryResearchers at the University of Bonn and the Ludwig-Maximilians-Universität of Munich have decoded a new mechanism of how the immune system can specifically attack pigmented cells of the skin. It was previously believed that so-called natural killer cells did not have an immunological memory for the body's own tissues. However, the scientists have now been able to show that these special immune cells can indeed "remember" pigmented cells when they come into more frequent contact with a specific contact allergen. These results may provide new insights into the development of the skin-depigmenting disease vitiligo but may also offer new options for the treatment of malignant melanoma. These results have now been published in the renowned scientific journal Immunity.http://medicalxpress.com/news/2016-06-natural-killer-cells-memory.html
ImmunologyTue, 07 Jun 2016 13:04:59 ESTnews384523489Cancer can be combated with reprogrammed macrophage cellsResearchers at Karolinska Institutet have generated antibodies that reprogramme a type of macrophage cell in the tumour, making the immune system better able to recognise and kill tumour cells. The study, which is published in the journal Cell Reports, could lead to a new therapy and provide a potentially important diagnostic tool for breast cancer and malignant melanoma.http://medicalxpress.com/news/2016-05-cancer-combated-reprogrammed-macrophage-cells.html
CancerFri, 20 May 2016 07:07:07 ESTnews382946772Taking on melanoma, one cell at a timeSingle-cell analysis is a groundbreaking approach now being used across biological fields to explore a common problem: how to study cellular diversity in cell environments with heterogeneous populations. Such diversity can have profound implications for cell survival and proliferation, response to drug therapies and interventions, as well as myriad other biological processes. Single-cell techniques have already been used for a variety of studies—for instance, to explore heterogeneity of immune response in autoimmune disease, to examine host-pathogen interactions in infectious disease, and to survey the human transcriptome. It is now being used to probe cancer tissue—a diverse and complex cellular environment that has often stymied researchers.http://medicalxpress.com/news/2016-04-melanoma-cell.html
CancerFri, 08 Apr 2016 06:25:19 ESTnews379315503Researcher synthesizes hybrid molecule that delivers a blow to malignant cellsA new hybrid molecule developed in the lab at the NYU Tandon School of Engineering shows promise for treating breast cancer by serving as a "shipping container" for cytotoxic—or cell-destroying—chemotherapeutic agents. The protein/polymer-gold nanoparticle (P-GNP) composite can load up with these drugs, carry them to malignant cells, and unload them where they can do the most damage with the least amount of harm to the patient.http://medicalxpress.com/news/2016-04-hybrid-molecule-malignant-cells.html
CancerFri, 01 Apr 2016 12:20:35 ESTnews378731999'Nano-sensing' drives melanoma cells' invasionA new study sheds light on how melanoma cells change from benign to malignant, and how the complex interaction between the cells and their surrounding environment affects outcomes of the cancer.http://medicalxpress.com/news/2016-03-nano-sensing-melanoma-cells-invasion.html
CancerTue, 15 Mar 2016 07:41:43 ESTnews377246494A new weapon in the fight against children's brain tumorsChildren with brain cancer may soon get some help from mice with the same disease, thanks to new research from University of Michigan Medical School scientists and their colleagues.http://medicalxpress.com/news/2016-03-weapon-children-brain-tumors.html
CancerWed, 02 Mar 2016 14:54:14 ESTnews376152783Biochemical alteration responsible for brain tumour resistance identifiedResearchers from the Institute of Neuroscience (INc) of the Universitat Autonoma de Barcelona (UAB) have identified the biochemical and molecular alteration that causes resistance to radiotherapy and chemotherapy in the glioblastoma , the most aggressive of brain tumours. This finding could enable new, more effective therapies.http://medicalxpress.com/news/2016-02-biochemical-responsible-brain-tumour-resistance.html
CancerFri, 19 Feb 2016 10:01:46 ESTnews375098498Few want to receive skin cancer biopsy results face-to-face(HealthDay)—For patients with suspected malignant melanoma or squamous cell carcinoma, most patients are happy to receive biopsy results by letter or telephone, according to a research letter published online Feb. 8 in the British Journal of Dermatology.http://medicalxpress.com/news/2016-02-skin-cancer-biopsy-results-face-to-face.html
CancerMon, 15 Feb 2016 07:50:07 ESTnews374743969Scientists create a multifunctional endoscopeCancer is a malignant force of nature that holds no prejudice when it invades tissue, permeates and forms new body sites. Ninety percent of deaths caused by cancer are due to tumors spreading throughout the body, a process called metastasis. Individual cancer cells detach from a tumor and pervade a body through blood vessels, a large quantity of the cancerous cells die in transit but the successful cells migrate through a body before leaving blood vessels and reproducing in a new location.http://medicalxpress.com/news/2015-12-scientists-multifunctional-endoscope.html
Medical researchTue, 01 Dec 2015 07:58:53 ESTnews368179123Research team describes novel tumor treatmentIn the first published results from a $386,000 National Cancer Institute grant awarded earlier this year, a paper by Scott Verbridge and Rafael Davalos in Scientific Reports has been published.http://medicalxpress.com/news/2015-11-team-tumor-treatment.html
CancerTue, 24 Nov 2015 05:00:04 ESTnews367558845Phase I clinical trial of anti-cancer drug FF-10101 in patients with relapsed or refractory acute myeloid leukemiaFUJIFILM Corporation today announced to conduct a clinical trial of its anti-cancer drug FF-10101 in patients with relapsed or refractory acute myeloid leukemia (AML) in the United States next year. FF-10101 is a new drug candidate discovered by Fujifilm, tapping into its advanced technology to synthesize and design chemical compounds nurtured through the photographic film business.http://medicalxpress.com/news/2015-11-phase-clinical-trial-anti-cancer-drug.html
CancerTue, 10 Nov 2015 08:10:01 ESTnews366364197Drugs with directed molecules increase life expectancy by five years in breast cancer patientsClinical studies show that new drugs that target malignant cells of HER2-positive breast cancer, such as Pertuzumab and Trastuzumab Emtansine (T-DM1), increase life expectancy in patients with advanced breast cancer.http://medicalxpress.com/news/2015-11-drugs-molecules-life-years-breast.html
CancerThu, 05 Nov 2015 07:49:19 ESTnews365932147Skin cancer causing fusion gene identifiedAngiosarcoma is a malignant cancer of the endothelial cells of blood or lymphatic vessels. Cutaneous angiosarcoma, a form of skin cancer, commonly occurs on the scalp of elderly people and can rapidly metastasize to the liver, lungs or lymph nodes. Its five-year survival rate is famously poor at 20-30%, meaning that new diagnostic and therapeutic approaches are highly sought after.http://medicalxpress.com/news/2015-11-skin-cancer-fusion-gene.html
CancerSun, 01 Nov 2015 11:55:25 ESTnews365601315Case of basal cell carcinoma described within port wine stain(HealthDay)—A case of basal cell carcinoma (BCC) has been described within a port wine stain (PWS), with no preceding treatment, according to a case report published in the October issue of The Journal of Dermatology.http://medicalxpress.com/news/2015-10-case-basal-cell-carcinoma-port.html
CancerMon, 26 Oct 2015 12:50:01 ESTnews365082051Massive screen of drug combinations may find treatment for resistant, BRAF-mutant melanomaA team of Massachusetts General Hospital (MGH) investigators has discovered a new combination of drugs that may be effective against one of the deadliest cancers, malignant melanoma. The combination - pairing a drug targeted against mutations in the BRAF gene with a second drug that targets another important signaling pathway - was discovered through one of the largest screens of cancer drug combinations conducted to date. Findings from the study conducted at the MGH Cutaneous Biology Research Center and Center for Molecular Therapeutics have been published in the open-access journal PLOS ONE.http://medicalxpress.com/news/2015-10-massive-screen-drug-combinations-treatment.html
CancerMon, 26 Oct 2015 11:51:10 ESTnews365079063Metabolism may keep cancer cells in checkResearchers have found that a long-known tumor suppressor, whose mechanism of holding cell growth in check has remained murky for over 40 years, works in part by keeping the cell's energy metabolism behaving in grown-up fashion.http://medicalxpress.com/news/2015-10-metabolism-cancer-cells.html
CancerFri, 16 Oct 2015 17:30:01 ESTnews364231315Targeted cancer treatment—new dual strategy halts cell divisionA team of researchers at the MedUni Vienna has confirmed in a recent study its new concept for the targeted treatment of ovarian cancer. The concept is intended to better control the development of resistance and improve treatment outcomes. The strategy focuses on halting tumour growth by inhibiting two signal networks instead of just one. The results are extremely promising and were presented at the ECC2015, which was held from the 25th to the 29th of September in Vienna. The next stage involves the verification of the concept in in vivo studies.http://medicalxpress.com/news/2015-09-cancer-treatmentnew-dual-strategy-halts.html
CancerTue, 29 Sep 2015 05:59:32 ESTnews362725159