Proceedings Paper

Synthesis of a series of model ether-bonded porphyrin-chlorin dimers with graded amphiphility as advantageous sensitizers for photodynamic therapy has been performed. Two macrocycles have been condensed via porphyrin-o1 trifluoroacetate. Hydroxyoctaethylporphyrin has been chosen as hydrophobic moiety and purpurin 18 derivatives have been chosen as hydrophilic components. New dimers have intense absorption maxima in the range of 665 - 700 nm, as well as weaker peaks at 622 - 624 nm that allows us to work with these sensitizers following new laser techniques which permit deeper light penetration into the tissues. The presence of hydrophobic octaethylporphyrin moiety and hydrophilic tri-carboxychlorin part in one molecule allows us to select structure with optimal amphiphility for sensitizer penetration and accumulation.