Adults:IV 360 mg/m2 on day 1 every 4 wk if neutrophil count is at least 2,000/mm3 and platelet count is at least 100,000/mm3 .

Ovarian Carcinoma (Combination Therapy with Cyclophosphamide)

Adults:IV Carboplatin 300 mg/m2 plus cyclophosphamide 600 mg/m2 , both on day 1 every 4 wk for 6 cycles. Do not repeat intermittent courses of the combination until the neutrophil count is at least 2,000/mm3 and the platelet count is at least 100,000/mm3 .

Calvert Formula Dosing

Adults:IV Carboplatin may be dosed to achieve a target AUC based on the patient’s glomerular filtration rate (GFR) using the Calvert formula. The desired target AUC depends on the disease and the patient’s treatment status. The Calvert formula calculates the carboplatin dose in mg as follows: Total dose (mg) = target AUC (mg/mL•min) × (GFR [mL/min] + 25).

Dosage Adjustments Based on Lowest Posttreatment Blood Counts

Adults:IV If platelets above 100,000/mm3 and neutrophils above 2,000/mm3 , then give 125% of adjusted dose from prior course. If platelets are 50,000 to 100,000/mm3 and neutrophils are 500 to 2,000/mm3 , no dosage adjustment is necessary. If platelets below 50,000/mm3 and neutrophils below 500/mm3 , then give 75% of adjusted dose from prior course. Doses above 125% of the starting dose are not recommended.