That is not a huge space so the M22s should (if all specs and stories are to be believed, since I don't personally own any) sound equally awesome to the M80s but with the added might of dual subwoofers. An easy choice for me.

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With great power comes Awesome irresponsibility.

My HT utilizes two M22s that use two mid-grade Velodyne 10" subs as stands. This combo sounds marvelous to me for movies and audio as well.

I would think that a couple of EP500s (being much higher end gear) with M22s, would be a killer combo.

I've always been a proponent of satellites and sub combos; however, since I've experienced my new M2s combined with my outstanding EP400 sub in my audio only system, I highly recommend going this route.

I bought the M22's a couple weeks ago. I like a bookshelf type speaker for HT and subs.I didn't think the M22 would cut it as my movie room is going to be 13.5 x 18.5.

Well I was very surprised and so wasn't a friend. I took those speakers to my place of work, we have a boardroom 16 x 25 x 10 and not only did it fill the room but he went to the bottom floor ( two floor building ) and he can hear them plan as day.

JohnK has M22's and Dual 500's... Maybe he will post a photo of his room... He really likes his setup a lot. I think that dual M22's and a pair of 500's would be better and nearly indistinguishable between a pair of 80's and a single sub, in some respects....

I will attest that Dual subs is WAY better than a single sub... So, i say go for the M22/Dual EP 500 setup.

Daniel, M22s supported in the low bass by a good sub or subs cover the entire audible range in a superb fashion. One area where the M80s could play louder would be the upper bass(say about 80-200Hz)where they have two 6 1/2" drivers compared to two 5 1/4". However, the M22s can certainly cover this range with enough volume for nearly all home use.

If you use two subs the maximum benefit in smoothing overall bass response is had when the subs are separated(your comment about not enough "room" implies that you may be thinking of placing the speakers and subs all close together)in certain locations. Typically this would be at the midpoints of the opposite sidewalls or front and back wall or in diagonally opposite corners. If you can place the subs efficiently, M22s plus two EP500s would serve you very well.