Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human MRP2 aa 1500 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: Q92887

Target

Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.

Involvement in disease

Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.