Claims for Patent: 4,438,138

Claims for Patent: 4,438,138

Title:

Reduction of cholesterol with meta-chloro .alpha.-t-butylaminopropiophenone

Abstract:

A method of treatment for reducing cholesterol in humans by the administration of the compound of the formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof in a non-toxic, effective therapeutic amount (calculated as base) to a human in need thereof.

Inventor(s):

Stern; Warren C. (Raleigh, NC)

Assignee:

Burroughs Wellcome Co. (Research Triangle Park, NC)

Application Number:

06/447,412

Patent Claims:

1. A method of reducing cholesterol levels in a human in need thereof, which comprises administering to said human an effective, non-toxic, cholesterol-lowering amount of a compound of
the formula (I) ##STR3## or a pharmaceutically acceptable acid addition salt thereof.

2. The method of claim 1 in which a pharmaceutically acceptable acid addition salt thereof is administered.

3. The method of claim 2 in which the salt is the hydrochloride salt.

4. The method of claim 1, 2 or 3 in which the compound or salt is administered in a pharmaceutically acceptable carrier therefor.

5. The method of claim 1, 2, or 3 in which the compound or salt is administered orally.

6. The method of claim 5 in which the compound or salt is administered in a pharmaceutically acceptable carrier therefor.

7. The method of claim 1, 2, or 3 in which the human has an initial cholesterol level greater than 250 mg/100 ml serum.

8. The method of claim 1, 2, or 3 in which the human has an above normal cholesterol level.

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