sixtyforce is an emulator that runs Nintendo 64 games. It does this by dynamically translating the code that a Nintendo 64 uses into something your Mac understands. Nearly every part of a Nintendo 64 has been painstakingly recreated entirely out of software to pull off such an amazing feat. Download sixtyforce and try it yourself!

One of the better options for Mac users looking to emulate the Nintendo 64, Sixtyforce unfortunately receives irregular updates.

OpenEmu is an open source project to bring game emulation to OS X as a first class citizen, leveraging modern OS X technologies such as Cocoa, Core Animation and Quartz, and 3rd party libraries like Sparkle for auto-updating. OpenEmu is based on a modular architecture, allowing for game emulators as plugins, this means OpenEmu can support a host of different emulation engines and back-ends while retaining a familiar OS X native front-end.

DeSmuME is software that allows you to emulate a Nintendo DS system. Think of it as a Swiss-Army knife for Nintendo DS emulation, giving you access to many powerful tools for testing DS features, from viewing ROM properties to managing Action Replay cheats. And best of all, this software is completely free and open-source.

OpenEmulator, which is not to be confused with Open Emu, is a component/framework-based emulator of legacy computer systems. It currently supports only the Apple I computer and its peripherals, although Apple II emulation is also planned.