AbstractNeurobrucellosis (NB) is a rare complication seen in 2-7% of brucellosis cases. Nervous system involvement can cause many neurological and psychiatric disorders and symptoms such as encephalitis, meningoencephalitis, myelitis/myelopathy, spinal epidural abscess, pseudotumor cerebri, Parkinsonism, dementia, neuropathies, subarachnoid hemorrhage, depression, agitation, psychosis, personality disorder, euphoria, and nightmares. These varied manifestations make the diagnosis difficult. We present a case admitted for severe major depression and radiculopathy where the patient recovered rapidly with antibiotherapy.