Sample solution: Pass a portion of the solution under test through a fiberglass filter of 0.45-µm pore size.

Analysis: Determine the amount of C15H22FN3O6 dissolved by selecting a wavelength with appropriate sensitivity between 300 and 330 nm on portions of the Sample solution, suitably diluted with Medium, if necessary, in comparison with the appropriate Standard solution, using a 1-mm quartz cell. Calculate the percentage of C15H22FN3O6 dissolved in each Tablet:

Result = (AU/AS) × CS × (V/L) × 100

AU

=

= absorbance of the Sample solution

AS

=

= absorbance of the Standard solution

CS

=

= concentration of capecitabine in the Standard solution (mg/mL)

V

=

= volume of medium, 900 mL

L

=

= Tablet label claim (mg)

Tolerances: NLT 80% (Q) of the labeled amount of C15H22FN3O6 is dissolved.