Mutation details: The mouse metallothionein-1 promoter drives expression of the human p190 BCR/ABL fusion gene that has the ABL oncogene fused head to tail with the 5' exons of the BCR gene with the break occurring in the first intron. This fusion gene produces the p190 protein with abnormal tyrosin kinase activity. Founder 623 was used to generate the transgenic line.
(J:91174)