At the end of the 1950s, Schifano began painting in the “informal art” style, later moving on to the creation of monochrome works using industrial enamels. The wide variety of techniques he employed included painting, collage, photography and video. In 1964, he was invited to exhibit at the Venice Biennale, and the following year took part in Studio Marconi’s inaugural exhibition, becoming one of the Studio’s most representative artists.

His work has been widely exhibited, both in Italy and internationally, and is included in important international museums and private collections.