Primary purpose of the trial is to demonstrate the arisen of focal cortical atrophy, localized in the ipsilateral primary motor area, measured in mm, three months after infarction of internal capsule.

The patient is compared to himself between day zero to ten and three months.

The study hypotheses are:

A focal cortical atrophy of the ipsilesional primary motor area occurs after cerebral infarction of the internal capsule. It is measurable accurately and reproducibly by MRI at three months. Other brain areas within the voluntary motor system will also be explored (supplementary motor area, pre motor area).

This atrophy is correlated with achievement of pyramidal tract, assessed by the fractional anisotropy of its fibers.

This atrophy is correlated with disability at three months, assessed by Rankin score.

Twenty-two patients with ischemic stroke, subcortical, involving the internal capsule, will be included.

Each patient will be compared to himself, on day zero to ten and three months.

An MRI will be performed between day zero and ten, then three months of infarction sequences with traditional threeD enabling acquisition and tractography and The measurement of cortical thickness is in mm The measurement of fractional anisotropy of the pyramidal tract A clinical evaluation will be done between Day zero and Day ten then three months, using a neurological score (NIHSS), a score of functional disability (Rankin) and more analytical and sensitive tests such as dynamometer, the Finger Tapping test and test new plugs.

Eligibility

Ages Eligible for Study:

18 Years to 90 Years (Adult, Senior)

Genders Eligible for Study:

Both

Accepts Healthy Volunteers:

No

Criteria

Inclusion Criteria:

Patients of 18 to 90 years old.

Subcortical stroke

Achievement of the internal capsule, according to MRI

Ability to perform MRI within 10 days after the onset of symptoms

NIHSS over or equal 2 and < 20

Rankin Score over or equal 1 and ≤ 5

Written informed consent after information about the protocol, from patients or reliable person if patient is in incapacity to sign

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01862172