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Oscar-winning director Sydney Pollack died of cancer yesterday at his home in Los Angeles. He was 73.

Though previously nominated for directing “They Shoot Horses Don’t They” and directing and producing “Tootsie,” Pollack finally won Oscars for directing and producing “Out of Africa” with Meryl Streep and Robert Redford.

Pollack got an Oscar nomination this year for producing “Michael Clayton,” where he was on screen as George Clooney’s boss. Among many other roles, Sydney Pollack acted opposite Tom Cruise in “Eyes Wide Shut.”

On TV, he played Eric McCormack’s father in “Will and Grace.”

Pollack’s latest movie, “Made of Honor,” where he plays Patrick Dempsey’s father, is in theaters now.