Comparison of intradermal and intramuscular injection technique in the treatment of inferior periorbital rhytidsChun-tang Chiu Wu-hui Chang Kuo-Chia Yang
Dermatol Sinica 25: 88-94, 2007
Botulinum toxin type A (Botox(r)) is well documented as a useful therapy for smoothening dynamic facial rhytids of the upper face. Most controlled studies have focused on the treatment of glabellar frown lines, horizontal forehead lines, and crow’s feet1. Reports of Botulinum toxin type A use in the inferior periorbital rhytids are few and anecdotal2, 3.
We present our experience comparing intradermal and intramuscular injection with Botulinum toxin type A in inferior periorbital region for ..................More

Clinical Analysis of Psoriatic Inpatients－A 10-year Retrospective StudyMing-HsiungYeh , Tsen-Fang Tsai
Dermatol Sinica 25: 103-111, 2007
Psoriasis is a common chronic inflammatory skin disease that is usually managed in outpatient clinic. There is a trend to reduce hospitalization for psoriasis globally in recent years. To analyze the reasons necessitating hospitalization for psoriasis, especially the causes of acute exacerbation, a retrospective study was carried out in psoriatic inpatients admitted to National Taiwan University Hospital between April 1996 and April 2006. Available data were obtained from 120 patients. On averag ..................More

Case Report

Rose Spots in Non-typhoidal Salmonellosis － a case reportChang-Lin Tsai , Lin-Hui Su , Cheng-Hsiang Hsiao , Yu-Ling Hsu, Ying-Jui Chang
Dermatol Sinica 25: 112-114, 2007
Rose spots are known as one of the symptoms of the untreated typhoidal salmonellosis patients. However, they are rarely seen or reported in patients with bacteremia caused by other species of salmonella. In this article, we report a man who manifested with productive cough, mild fever, general weakness, and drowsiness. Pneumonia, urinary tract infection and anemia were impressed initially. After admission, he developed fever, diarrhea, and leukocytosis. Erythematous papules were noted over the t ..................More

Nail-splinting Method With Plastic Tubes for Ingrown ToenailsSheng-Cheng Tsai , Han-Nan Liu , Chao-Wen Hsueh
Dermatol Sinica 25: 115-118, 2007
ngrown toenail is a common disorder in the great toe. Many factors involved include a combination of chronic trauma from tight shoes and improper trimming of the nail. Many treatments have been described for ingrown nails. But they have many disadvantages, such as a prolonged wound-healing period, the production of an unsightly nail, or the restriction of normal activities. We performed a modified method of lateral nail manipulation with placement of splints on 6 patients who gained instant reli ..................More

MonilethrixChih-Chieh Chan , Cheng-Hsiang Hsiao , Tsen-Fang Tsai
Dermatol Sinica 25: 119-123, 2007
Monilethrix, a rare congenital trichodystrophy, is characterized by fragility of scalp hair with partial or total alopecia. Affected individuals may have a variable degree of follicular hyperkeratosis and nail changes. Some monilethrix has been reported to be associated with genetic mutations on human keratins. Mutation in DSG4 has also been reported. Some patients could find a family association. To date, several treatments have been introduced. However, there is still no effective treatment fo ..................More

Syringoid Eccrine Carcinoma - A Case ReportJohn Tsai , Chieh-Shan Wu , Gwo-Shing Chen
Dermatol Sinica25: 124-127, 2007
Syringoid eccrine carcinoma (SEC) is a rare cutaneous malignant tumor thought to be derived from eccrine sweat apparatus. They may be locally aggressive and have an infiltrative growth pattern. Because of their rarity, the origin and differentiation of this tumor has not been confirmed completely. Variable clinical appearance and diverse histologic findings often makes diagnosis difficult. We report a 71-year-old female with an asymptomatic brownish nodule located on the medial side of right ..................More

A Novel Splicing Mutation of the CYLD Gene in a Taiwanese Family with Multiple Familial TrichoepitheliomaChien-Te Lin , J. Yu-Yun Lee , Sheau-Chiou Chao
Dermatol Sinica 25: 128-131, 2007
Multiple familial trichoepithelioma (MFT) is an autosomal dominant skin disorder that is characterized by childhood onset of numerous skin-colored papules and nodules on the central face that originate from hair follicles. Mutations in CYLD, the disease gene of familial cylindromatosis, have recently been detected in several families presented with MFT phenotype. CYLD has been shown to be a tumor suppressor gene. CYLD functions as a negative regulator of the transcription factor NF-B, which p ..................More

Hailey-Hailey Disease Successfully Treated with Carbon Dioxide Laser － A Case ReportYu Chuan Lin , Chung Hsing Chang
Dermatol Sinica 25: 132-135, 2007
A 45-year-old man presented with erythematous vesicles and erosions on an erythematous background of his axillae, groin, and popliteal fossae. He had been treated with corticosteroid ointments for several years, but the clinical course waxed and waned, and the lesions never completely disappeared. A skin biopsy specimen from his left axilla revealed suprabasal acantholysis (a "dilapidated brick wall"). Diagnosis of recurrent Hailey-Hailey disease (HHD) was made after careful analysis of the cli ..................More

Mucinous Nevus－A Case Report and Reviewof LiteratureHsiu-Hui Chiu , Wen-Yu Chang , Gwo-Shing Chen
Dermatol Sinica 25: 147-152, 2007
Mucinous nevus (MN) is a very rare entity and can be classified as both a cutaneous
mucinosis (CM) and a connective tissue nevus (CTN). We describe the clinicopathologic features of an unusual case of mucinous nevus in a 9-year-old Taiwanese boy who presented with multiple grouped flesh-colored nodules with band-like distribution on his right thigh since birth. Histopathological examination of the skin lesion showed alcian blue (pH 2.5) and toluidine blue(pH 2.5) positive mucin deposited betwe ..................More

Association of HPV type 16 and 49 in Multiple Acral Squamous Cell CarcinomasHsiao-Feng Liao , Ming-Hsiu Lin , Cheng-Hsiang Hsiao , Yi-Hua Liao
Dermatol Sinica 25:153-158, 2007
We report a case with multiple acral squamous cell carcinomas (SCCs) associated with human papillomavirus (HPV) type 49 and 16 infection in separate lesions. HPV 49 belongs to the epidermodysplasia verruciformis (EV)-HPV group. It has only been detected in flat warts and one SCC in a renal transplant patient in the past literature. We report showed the first case of SCC associated with HPV 49 in an immunocompetent patient. In addition, the high risk mucosal HPV 16 DNA was also detected in a palm ..................More

Recurrent Dermatofibrosarcoma Protuberans of the Scalp followed by Brain Metastasis- A Case Report with Literature ReviewYi-Chien Yang , Yu-Wen Cheng
Dermatol Sinica 25: 159-164, 2007
Dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor of intermediate malignancy. It is characterized by a locally aggressive growth and a high rate of local recurrence. Metastases are very rare and the most common sites of metastasis are the lungs and lymph nodes. We report a 53-year-old female patient with a DFSP on the scalp. She developed local recurrence of DFSP 4 years after simple excision and right frontal lobe metastasis in the sixth year. The pathological examinations reve ..................More

Squamous Cell Carcinoma of the Scalp Arising from Chronic Discoid Lupus Erythematosus with Scarring AlopeciaChu-Sung Hu , Yu-Wen Chen , Gwo-Shing Chen , Shih-Tsung Cheng
Dermatol Sinica 25: 165-170, 2007
Neoplasms have rarely been reported in lesions of lupus erythematosus (LE) and have included basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and atypical fibroxanthoma. We here report a case of SCC of the scalp arising from a patch of scarring alopecia secondary to chronic discoid lupus erythematosus (DLE). Surgical excision of the tumor with a 1cm margin was performed, showing a deeply invasive SCC extending to the deep fascia. A series of staging investigations were undertaken, incl ..................More

Correspondence

Use of CO2 Laser in the Treatment of Periungual Fibromas of Tuberous Sclerosis ComplexChen-Hsi Hung , Kuo-Chia Yang
Dermatol Sinica 25: 171-172, 2007
CASE REPORT
A 47-year-old woman came to our dermatological out-patient department due to multiple tender tumors on her toes for years. On physical examination, she was found to have firm, discrete, red-brown, telangiectatic papules, extending from the nasolabial furrows to the cheeks (Fig. 1). In addition, firm, flesh-colored excrescences emerging from the toenail folds were present (Fig. 2). She developed these extensive facial tumors when she was in the kindergarten. The periungual papules f ..................More

Resident Forum

Numerous Minute Round Glistening Papules on Photodistributed Skin in a 4-year-old BoyChien-Te Lin , Kung-Kai Lin , Gwo-Shing Chen
Dermatol Sinica 25: 173-174, 2007
CASE REPORT
A 4-year-old boy experienced numerous minute, round, glistening, flat-topped, flesh-colored to pink or reddish-brown papules, 1 to 3 mm in diameter, on the face, dorsa of hands, extensor aspects of forearms and lower legs of 2 year’s duration (Fig. 1). There was a history of summer exacerbation with occasional pruritus. No other part of the body was affected. The palms, soles, nails, mucous membranes, and scalp were spared. He had been in good health and there was no previous his ..................More

Several Erythematous Papules with a 1.5-cm Sized Nodule Scattering on the Face of an Old WomanShiou-Han Wang , Tsen-Fang Tsai
Dermatol Sinica 25: 175-176, 2007
CASE REPORT
A 67-year-old woman presented with a 4-month history of asymptomatic papules on the face. She was a housewife with unremarkable past medical history. On physical examination, these dome-shaped papules were variably sized with erythematous hue, and some of them showed tendency to confluence. They were disseminated on the periorbital and paranasal regions. Both cheeks were also involved. A large brownish red nodule measuring 1x1.5-cm in size was noted on the right upper eyelid. Some ..................More