Abstract

Background

We propose that a computerized, internet-based graphical description language for
systems biology will be essential for describing, archiving and analyzing complex
problems of biological function in health and disease.

Results

We outline here a conceptual basis for designing such a language and describe BioD,
a prototype language that we have used to explore the utility and feasibility of this
approach to functional biology. Using example models, we demonstrate that a rather
limited lexicon of icons and arrows suffices to describe complex cell-biological systems
as discrete models that can be posted and linked on the internet.

Conclusions

Given available computer and internet technology, BioD may be implemented as an extensible,
multidisciplinary language that can be used to archive functional systems knowledge
and be extended to support both qualitative and quantitative functional analysis.