Figure 1115

Lupusnephritis class III. A, Segmental necrotizing lesion surrounded by an increased number of epithelial cells. B, Immunofluorescence. Next to mesangial deposits of immuno-globulin G there also are deposits in the periphery of some loops (arrows). C, Immunofluorescence. Fibrin deposits in a necrotizing lesion. According to the 1995 modified World Health Organization classification, this is a characteristic immuno-pathologic lesion of class III lupus nephritis. (Panel A, methenamine silver. Original magnification X400, X400, X520, respectively.)