This video aims to demonstrate the management of various surgical challenges encountered during surgery of persistent fetal vasculature (PFV). PFV cases in which the visual axis is clear can be given refractive correction and put on regular follow-up. Preoperative evaluation includes color Doppler, which helps to access bloodflow that might require hemostasis during surgery. Preoperative salmon-patch sign is helpful to detect the cases requiring hemostasis. A plasma blade uses pulses of plasma that are generated around its tip to cut and cauterize tissue without extensive collateral tissue damage. The same can be achieved using diathermy.