d in E. coli. The scientists reasoned that they could find the protein... We designed a computer-based search that filtered out proteins that l...They found the two missing proteins of a pathway that ferries one of t...Members of Silhavy's laboratory use E. coli as a model system to bette......

d in E. coli. The scientists reasoned that they could find the protein containing the instructions for building the germ's outer casing.

"We designed a computer-based search that filtered out proteins that lacked the characteristics essential for outer membrane construction," Ruiz said. "In the end, only two of the 564 proteins remained."

They found the two missing proteins of a pathway that ferries one of the key components of the outer shell, called LPS, to the cell surface.

Members of Silhavy's laboratory use E. coli as a model system to better understand the workings of the cell, such as how it senses changes in its environment. Silhavy is a bacterial geneticist who has made fundamental contributions to the field of cell biology.

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