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Located in the Faculty of Medicine in the heart of Nice, it provides a high-quality scientific environment with access to all required core facilities as well as interaction with clinicians.The research activities of the team are focused on the cellular interactions between immune and non-immune cells in the bone marrow. Among these cells, osteoclasts are the bone-resorbing cells responsible for bone destruction in many chronic inflammatory diseases. We have recentlyshown that their function is not limited to bone resorption and that depending on their origin and environment, they induce immunosuppressive or inflammatory responses. The post-doc will participate to the ORIOS project "Origin and role of inflammatory osteoclasts, novel therapeutic targets in rheumatic diseases" recently founded by the French National Research Agency (ANR). The objectives of this project are an in-depth characterization of inflammatory and tolerogenic osteoclasts in terms of their origin, function and specific markers to understand their contribution to inflammatory responses and to modifications of the bone marrow integrity. The project combines analysis in vitro, in vivo in murine models of chronic diseases associated with bone destruction and in patients. The aim is to identify new clues for diagnosis and therapeutic strategies as well as novel information on a neglected aspect of osteoclast biology.

Qualifications:We are seeking a highly motivated and talented post-doc with a strong background in osteoimmunology, immunology or bone biology, assessed by publications. She/ he must have a strong experience in cell biology, flow cytometry and animal experimentation. Ability to work independently, and excellent team, communication and organization skills are essential. French or English practice is mandatory. The salary is according to the rules of the French public service and depends on the experience.

The position is founded for 2 years with a possibility to extend for 1 more year depending on the results. It represents an excellent opportunity for a young scientist to develop/extend expertise in osteoimmunology. In addition to an excellent scientific production, if independent thinking and capacity to undertake responsibility as project leader are proven, the postdoc will be supported to apply for a permanent position in the team.

To Apply:Applicants should submit (in French or in English) their CV and publication list, the name and email of 3 references and a brief statement of past achievements and research interests to Dr Blin-Wakkach (blinunice.fr).