Introduction: Teaching and learning are interdependent in educational process. Teaching effectiveness, therefore, should be investigated both from teachers' and learners' viewpoints in order to achieve a better education. This study was conducted to determine and compare the factors related to effective clinical education from teachers' and students' viewpoint in School of rehabilitation in Isfahan University of Medical Sciences. Methods: In this descriptive cross-sectional study, 23 faculty members and 107 senior students selected through census sampling method. The data collection tool was a researcher made questionnaire consisted of demographic information and factors related to clinical education which contained 5 general areas (individual features of the learner, individual features of clinical teacher, clinical environment, educational planning, and clinical evaluation). 32 questions related to these areas were scored based on a five point likert scale. The data was analyzed by SPSS 18 software. Results: Individual features of clinical teachers (3.04±0.74) and students (2.96±0.67) got the most scores in two groups (faculty members and students). The effect of clinical environment and clinical evaluation were found to be significantly different between students and teachers (p <0.05). Students’ scores were higher than teachers in term of clinical environment (2.49±1.14 vs. 1.90±0.8) and clinical evaluation (2.56±1.09 vs. 1.99±0.98). Conclusion: Two areas of individual features of clinical teachers and students are ،more influential on clinical teaching than other areas. Therefore, attention to and strengthen the individual features of clinical teachers and students, systematic providing and revision of curriculum, providing proper clinical environment (in term of facilities and personnel) ،regular and accurate evaluation of internship course and giving feedback to the educational authorities could be important in the effectiveness of clinical education.