Decrease in oxygen resulting in the failure to nourish the tissues at the capillary level. (Tissue perfusion problems can exist without decreased cardiac output; however, there may be a relationship between cardiac output and tissue perfusion)

Related Factors

Interruption of Flow – arterial, venous

Exchange Problems

Hypervolemia, hypovolemia

Mechanical reduction of venous and/or arterial blood flow

Decreased Hb concentration in blood

Altered affinity of hemoglobin for O2; enzyme poisoning

Impaired transport of the O2 across alveolar and/or capillary membrane