Remember, describe the 'big picture' idea, then try to break it down into smaller projects. First look at large pieces - what kinds of abilities would you need (bind to X, produce Y, destroy Z) to accomplish the big picture? Next, think about how you'd produce those abilities (protein α will bind to X, pathway β would produce Y, etc). Bonus points if you can break it down into five separate mini-projects. More bonus points if things would still work with less-than-total success (we need A and B to work to declare success, but C and D would make it cooler. E would be awesome and interesting even if nothing else worked).