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Sayangi Dirimu, Dadah Membunuh

Sayangi Dirimu, Jauhi Dadah

06 August 2015

The brain disease model of addiction is strongly supported by scientific evidence, according to a commentary published today in The Lancet Psychiatry by NIDA Director Dr. Nora Volkow and NIAAA Director Dr. George Koob.

The two NIH Institute Directors point out that animal and human
studies have shown that critical brain structures and behaviors are
disrupted by chronic exposure to drugs and alcohol. These findings,
along with ongoing research, are helping to explain how drugs and
alcohol affect brain processes associated with loss of control,
compulsive drug taking, inflexible behavior, and negative emotional
states associated with addiction.

Understanding these processes has
already resulted in several effective medicines, as well as new and
promising medication targets to treat drug and alcohol addiction. The
authors add that this process of discovery within a disease framework
has also led to the development of promising brain stimulation
treatments and behavioral interventions, and has had a positive impact
on public policy.

The commentary, co-authored by Nora D. Volkow, M.D., director of the
National Institute on Drug Abuse (NIDA), and George Koob, Ph.D.,
director of the National Institute on Alcohol Abuse and Alcoholism
(NIAAA), was written in response to the Personal View article, by Wayne Hall and colleagues. NIDA and NIAAA are part of the National Institutes of Health.

Reference: “Brain disease model of addiction: why is
it so controversial?” by Nora D. Volkow, M.D., Director, National
Institute on Drug Abuse and George Koob, Ph.D., Director, National
Institute on Alcohol Abuse and Alcoholism published online July 29, 2015 in The Lancet Psychiatry. It will also appear in the August print issue of The Lancet Psychiatry journal.